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PubMed:11108718 / 0-1903 JSONTXT

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sentences

Id Subject Object Predicate Lexical cue
T1 0-215 Sentence denotes Vascular endothelial growth factor expression of intercellular adhesion molecule 1 (ICAM-1), vascular cell adhesion molecule 1 (VCAM-1), and E-selectin through nuclear factor-kappa B activation in endothelial cells.
T2 216-326 Sentence denotes Vascular endothelial growth factor (VEGF) induces adhesion molecules on endothelial cells during inflammation.
T3 327-545 Sentence denotes Here we examined the mechanisms underlying VEGF-stimulated expression of intercellular adhesion molecule 1 (ICAM-1), vascular cell adhesion molecule 1 (VCAM-1), and E-selectin in human umbilical vein endothelial cells.
T4 546-650 Sentence denotes VEGF (20 ng/ml) increased expression of ICAM-1, VCAM-1, and E-selectin mRNAs in a time-dependent manner.
T5 651-1020 Sentence denotes These effects were significantly suppressed by Flk-1/kinase-insert domain containing receptor (KDR) antagonist and by inhibitors of phospholipase C, nuclear factor (NF)-kappaB, sphingosine kinase, and protein kinase C, but they were not affected by inhibitors of mitogen-activated protein/extracellular signal-regulated kinase kinase (MEK) 1/2 or nitric-oxide synthase.
T6 1021-1262 Sentence denotes Unexpectedly, the phosphatidylinositol (PI) 3'-kinase inhibitor wortmannin enhanced both basal and VEGF-stimulated adhesion molecule expression, whereas insulin, a PI 3'-kinase activator, suppressed both basal and VEGF-stimulated expression.
T7 1263-1331 Sentence denotes Gel shift analysis revealed that VEGF stimulated NF-kappaB activity.
T8 1332-1419 Sentence denotes This effect was inhibited by phospholipase C, NF-kappaB, or protein kinase C inhibitor.
T9 1420-1537 Sentence denotes VEGF increased VCAM-1 and ICAM-1 protein levels and increased leukocyte adhesiveness in a NF-kappaB-dependent manner.
T10 1538-1756 Sentence denotes These results suggest that VEGF-stimulated expression of ICAM-1, VCAM-1, and E-selectin mRNAs was mainly through NF-kappaB activation with PI 3'-kinase-mediated suppression, but was independent of nitric oxide and MEK.

Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 522-526 http://purl.obolibrary.org/obo/MAT_0000037 denotes vein

Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-215 Sentence denotes Vascular endothelial growth factor expression of intercellular adhesion molecule 1 (ICAM-1), vascular cell adhesion molecule 1 (VCAM-1), and E-selectin through nuclear factor-kappa B activation in endothelial cells.
T2 216-326 Sentence denotes Vascular endothelial growth factor (VEGF) induces adhesion molecules on endothelial cells during inflammation.
T3 327-545 Sentence denotes Here we examined the mechanisms underlying VEGF-stimulated expression of intercellular adhesion molecule 1 (ICAM-1), vascular cell adhesion molecule 1 (VCAM-1), and E-selectin in human umbilical vein endothelial cells.
T4 546-650 Sentence denotes VEGF (20 ng/ml) increased expression of ICAM-1, VCAM-1, and E-selectin mRNAs in a time-dependent manner.
T5 651-1020 Sentence denotes These effects were significantly suppressed by Flk-1/kinase-insert domain containing receptor (KDR) antagonist and by inhibitors of phospholipase C, nuclear factor (NF)-kappaB, sphingosine kinase, and protein kinase C, but they were not affected by inhibitors of mitogen-activated protein/extracellular signal-regulated kinase kinase (MEK) 1/2 or nitric-oxide synthase.
T6 1021-1262 Sentence denotes Unexpectedly, the phosphatidylinositol (PI) 3'-kinase inhibitor wortmannin enhanced both basal and VEGF-stimulated adhesion molecule expression, whereas insulin, a PI 3'-kinase activator, suppressed both basal and VEGF-stimulated expression.
T7 1263-1331 Sentence denotes Gel shift analysis revealed that VEGF stimulated NF-kappaB activity.
T8 1332-1419 Sentence denotes This effect was inhibited by phospholipase C, NF-kappaB, or protein kinase C inhibitor.
T9 1420-1537 Sentence denotes VEGF increased VCAM-1 and ICAM-1 protein levels and increased leukocyte adhesiveness in a NF-kappaB-dependent manner.
T10 1538-1756 Sentence denotes These results suggest that VEGF-stimulated expression of ICAM-1, VCAM-1, and E-selectin mRNAs was mainly through NF-kappaB activation with PI 3'-kinase-mediated suppression, but was independent of nitric oxide and MEK.
T1 0-215 Sentence denotes Vascular endothelial growth factor expression of intercellular adhesion molecule 1 (ICAM-1), vascular cell adhesion molecule 1 (VCAM-1), and E-selectin through nuclear factor-kappa B activation in endothelial cells.
T2 216-326 Sentence denotes Vascular endothelial growth factor (VEGF) induces adhesion molecules on endothelial cells during inflammation.
T3 327-545 Sentence denotes Here we examined the mechanisms underlying VEGF-stimulated expression of intercellular adhesion molecule 1 (ICAM-1), vascular cell adhesion molecule 1 (VCAM-1), and E-selectin in human umbilical vein endothelial cells.
T4 546-650 Sentence denotes VEGF (20 ng/ml) increased expression of ICAM-1, VCAM-1, and E-selectin mRNAs in a time-dependent manner.
T5 651-1020 Sentence denotes These effects were significantly suppressed by Flk-1/kinase-insert domain containing receptor (KDR) antagonist and by inhibitors of phospholipase C, nuclear factor (NF)-kappaB, sphingosine kinase, and protein kinase C, but they were not affected by inhibitors of mitogen-activated protein/extracellular signal-regulated kinase kinase (MEK) 1/2 or nitric-oxide synthase.
T6 1021-1262 Sentence denotes Unexpectedly, the phosphatidylinositol (PI) 3'-kinase inhibitor wortmannin enhanced both basal and VEGF-stimulated adhesion molecule expression, whereas insulin, a PI 3'-kinase activator, suppressed both basal and VEGF-stimulated expression.
T7 1263-1331 Sentence denotes Gel shift analysis revealed that VEGF stimulated NF-kappaB activity.
T8 1332-1419 Sentence denotes This effect was inhibited by phospholipase C, NF-kappaB, or protein kinase C inhibitor.
T9 1420-1537 Sentence denotes VEGF increased VCAM-1 and ICAM-1 protein levels and increased leukocyte adhesiveness in a NF-kappaB-dependent manner.
T10 1538-1756 Sentence denotes These results suggest that VEGF-stimulated expression of ICAM-1, VCAM-1, and E-selectin mRNAs was mainly through NF-kappaB activation with PI 3'-kinase-mediated suppression, but was independent of nitric oxide and MEK.

2015-BEL-Sample-2

Id Subject Object Predicate Lexical cue
BEL:20043444 0-1903 p(HGNC:INS) decreases p(HGNC:SELE) denotes Vascular endothelial growth factor expression of intercellular adhesion molecule 1 (ICAM-1), vascular cell adhesion molecule 1 (VCAM-1), and E-selectin through nuclear factor-kappa B activation in endothelial cells. Vascular endothelial growth factor (VEGF) induces adhesion molecules on endothelial cells during inflammation. Here we examined the mechanisms underlying VEGF-stimulated expression of intercellular adhesion molecule 1 (ICAM-1), vascular cell adhesion molecule 1 (VCAM-1), and E-selectin in human umbilical vein endothelial cells. VEGF (20 ng/ml) increased expression of ICAM-1, VCAM-1, and E-selectin mRNAs in a time-dependent manner. These effects were significantly suppressed by Flk-1/kinase-insert domain containing receptor (KDR) antagonist and by inhibitors of phospholipase C, nuclear factor (NF)-kappaB, sphingosine kinase, and protein kinase C, but they were not affected by inhibitors of mitogen-activated protein/extracellular signal-regulated kinase kinase (MEK) 1/2 or nitric-oxide synthase. Unexpectedly, the phosphatidylinositol (PI) 3'-kinase inhibitor wortmannin enhanced both basal and VEGF-stimulated adhesion molecule expression, whereas insulin, a PI 3'-kinase activator, suppressed both basal and VEGF-stimulated expression. Gel shift analysis revealed that VEGF stimulated NF-kappaB activity. This effect was inhibited by phospholipase C, NF-kappaB, or protein kinase C inhibitor. VEGF increased VCAM-1 and ICAM-1 protein levels and increased leukocyte adhesiveness in a NF-kappaB-dependent manner. These results suggest that VEGF-stimulated expression of ICAM-1, VCAM-1, and E-selectin mRNAs was mainly through NF-kappaB activation with PI 3'-kinase-mediated suppression, but was independent of nitric oxide and MEK. Thus, VEGF simultaneously activates two signal transduction pathways that have opposite functions in the induction of adhesion molecule expression
BEL:20046068 1420-1670 p(HGNC:VEGFA) increases r(HGNC:ICAM1) denotes VEGF increased VCAM-1 and ICAM-1 protein levels and increased leukocyte adhesiveness in a NF-kappaB-dependent manner. These results suggest that VEGF-stimulated expression of ICAM-1, VCAM-1, and E-selectin mRNAs was mainly through NF-kappaB activatio
BEL:20046070 1420-1670 p(HGNC:VEGFA) increases r(HGNC:SELE) denotes VEGF increased VCAM-1 and ICAM-1 protein levels and increased leukocyte adhesiveness in a NF-kappaB-dependent manner. These results suggest that VEGF-stimulated expression of ICAM-1, VCAM-1, and E-selectin mRNAs was mainly through NF-kappaB activatio
BEL:20046074 1420-1670 p(HGNC:VEGFA) increases r(HGNC:VCAM1) denotes VEGF increased VCAM-1 and ICAM-1 protein levels and increased leukocyte adhesiveness in a NF-kappaB-dependent manner. These results suggest that VEGF-stimulated expression of ICAM-1, VCAM-1, and E-selectin mRNAs was mainly through NF-kappaB activatio

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 313-325 Disease denotes inflammation http://purl.obolibrary.org/obo/MONDO_0021166

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 506-511 OrganismTaxon denotes human 9606

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 197-214 Body_part denotes endothelial cells http://purl.obolibrary.org/obo/CL_0000115
T2 288-305 Body_part denotes endothelial cells http://purl.obolibrary.org/obo/CL_0000115
T3 512-526 Body_part denotes umbilical vein http://purl.obolibrary.org/obo/UBERON_0002066
T4 527-544 Body_part denotes endothelial cells http://purl.obolibrary.org/obo/CL_0000115
T5 940-953 Body_part denotes extracellular http://purl.obolibrary.org/obo/GO_0005576
T6 1482-1491 Body_part denotes leukocyte http://purl.obolibrary.org/obo/CL_0000738

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 522-526 Body_part denotes vein http://purl.obolibrary.org/obo/MAT_0000037

Glycosmos15-CL

Id Subject Object Predicate Lexical cue cl_id
T1 197-214 Cell denotes endothelial cells http://purl.obolibrary.org/obo/CL:0000115
T2 288-305 Cell denotes endothelial cells http://purl.obolibrary.org/obo/CL:0000115
T3 522-544 Cell denotes vein endothelial cells http://purl.obolibrary.org/obo/CL:0002543
T4 1110-1115 Cell denotes basal http://purl.obolibrary.org/obo/CL:0002324
T5 1225-1230 Cell denotes basal http://purl.obolibrary.org/obo/CL:0002324
T6 1482-1491 Cell denotes leukocyte http://purl.obolibrary.org/obo/CL:0000738