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PubMed:11107127 JSONTXT

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sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-108 Sentence denotes Resistance to TRAIL-induced apoptosis in neuroblastoma cells correlates with a loss of caspase-8 expression.
TextSentencer_T2 109-120 Sentence denotes BACKGROUND:
TextSentencer_T3 121-249 Sentence denotes Disruption of apoptotic pathways may be involved in tumor formation, regression, and treatment resistance of neuroblastoma (NB).
TextSentencer_T4 250-350 Sentence denotes TNF-related apoptosis-inducing ligand (TRAIL) is a potent inducer of apoptosis in cancer cell lines.
TextSentencer_T5 351-361 Sentence denotes PROCEDURE:
TextSentencer_T6 362-535 Sentence denotes In this study we analyzed the expression and function of TRAIL, its agonistic and antagonistic receptors, and important intracellular signaling elements in 18 NB cell lines.
TextSentencer_T7 536-544 Sentence denotes RESULTS:
TextSentencer_T8 545-651 Sentence denotes Semiquantitative RT-PCR revealed that TRAIL-R2 and TRAIL-R3 are the main TRAIL-receptors used by NB cells.
TextSentencer_T9 652-758 Sentence denotes Sensitivity to TRAIL-induced apoptosis did not correlate with mRNA expression of TRAIL receptors or cFLIP.
TextSentencer_T10 759-846 Sentence denotes Surprisingly, caspase-8 and caspase-10 mRNA was detected in only 5 of 18 NB cell lines.
TextSentencer_T11 847-973 Sentence denotes Interestingly, only these five NB cell lines were susceptible to TRAIL-induced apoptosis in a time- and dose-dependent manner.
TextSentencer_T12 974-986 Sentence denotes CONCLUSIONS:
TextSentencer_T13 987-1187 Sentence denotes Treatment with 5-aza-2'-deoxycytidine restored mRNA expression of caspase-8 and -10 and TRAIL sensitivity of resistant cell lines, suggesting that gene methylation is involved in caspase inactivation.
TextSentencer_T14 1188-1366 Sentence denotes Since many cytotoxic drugs induce caspase-dependent apoptosis, failure to express caspase-8 and/or caspase-10 might be an important mechanism of resistance to chemotherapy in NB.
T1 0-108 Sentence denotes Resistance to TRAIL-induced apoptosis in neuroblastoma cells correlates with a loss of caspase-8 expression.
T2 109-120 Sentence denotes BACKGROUND:
T3 121-249 Sentence denotes Disruption of apoptotic pathways may be involved in tumor formation, regression, and treatment resistance of neuroblastoma (NB).
T4 250-350 Sentence denotes TNF-related apoptosis-inducing ligand (TRAIL) is a potent inducer of apoptosis in cancer cell lines.
T5 351-361 Sentence denotes PROCEDURE:
T6 362-535 Sentence denotes In this study we analyzed the expression and function of TRAIL, its agonistic and antagonistic receptors, and important intracellular signaling elements in 18 NB cell lines.
T7 536-544 Sentence denotes RESULTS:
T8 545-651 Sentence denotes Semiquantitative RT-PCR revealed that TRAIL-R2 and TRAIL-R3 are the main TRAIL-receptors used by NB cells.
T9 652-758 Sentence denotes Sensitivity to TRAIL-induced apoptosis did not correlate with mRNA expression of TRAIL receptors or cFLIP.
T10 759-846 Sentence denotes Surprisingly, caspase-8 and caspase-10 mRNA was detected in only 5 of 18 NB cell lines.
T11 847-973 Sentence denotes Interestingly, only these five NB cell lines were susceptible to TRAIL-induced apoptosis in a time- and dose-dependent manner.
T12 974-986 Sentence denotes CONCLUSIONS:
T13 987-1187 Sentence denotes Treatment with 5-aza-2'-deoxycytidine restored mRNA expression of caspase-8 and -10 and TRAIL sensitivity of resistant cell lines, suggesting that gene methylation is involved in caspase inactivation.
T14 1188-1366 Sentence denotes Since many cytotoxic drugs induce caspase-dependent apoptosis, failure to express caspase-8 and/or caspase-10 might be an important mechanism of resistance to chemotherapy in NB.

PennBioIE

Id Subject Object Predicate Lexical cue
T1 41-54 protein denotes neuroblastoma
T2 87-96 protein denotes caspase-8
T3 230-243 protein denotes neuroblastoma
T4 245-247 protein denotes NB
T5 250-253 protein denotes TNF
T6 521-523 protein denotes NB
T7 583-591 protein denotes TRAIL-R2
T8 596-604 protein denotes TRAIL-R3
T9 642-644 protein denotes NB
T10 752-757 protein denotes cFLIP
T11 773-782 protein denotes caspase-8
T12 787-797 protein denotes caspase-10
T13 832-834 protein denotes NB
T14 878-880 protein denotes NB
T15 1053-1060 protein denotes caspase
T16 1067-1070 protein denotes -10
T17 1166-1173 protein denotes caspase
T18 1222-1229 protein denotes caspase
T19 1270-1279 protein denotes caspase-8
T20 1287-1297 protein denotes caspase-10
T21 1363-1365 protein denotes NB

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
11107127-0#14#19#gene8743 14-19 gene8743 denotes TRAIL
11107127-0#41#54#diseaseC0027819 41-54 diseaseC0027819 denotes neuroblastoma
14#19#gene874341#54#diseaseC0027819 11107127-0#14#19#gene8743 11107127-0#41#54#diseaseC0027819 associated_with TRAIL,neuroblastoma

DisGeNet-2017-sample

Id Subject Object Predicate Lexical cue
T87 14-19 gene:8743 denotes TRAIL
T88 41-54 disease:C0027819 denotes neuroblastoma
R1 T87 T88 associated_with TRAIL,neuroblastoma

DisGeNET

Id Subject Object Predicate Lexical cue
T0 583-591 gene:8795 denotes TRAIL-R2
T1 642-644 disease:C0700095 denotes NB
T2 583-591 gene:8795 denotes TRAIL-R2
T3 642-644 disease:C0027819 denotes NB
T4 596-604 gene:8794 denotes TRAIL-R3
T5 642-644 disease:C0700095 denotes NB
T6 596-604 gene:8794 denotes TRAIL-R3
T7 642-644 disease:C0027819 denotes NB
R1 T0 T1 associated_with TRAIL-R2,NB
R2 T2 T3 associated_with TRAIL-R2,NB
R3 T4 T5 associated_with TRAIL-R3,NB
R4 T6 T7 associated_with TRAIL-R3,NB