> top > docs > PubMed:11063736 > annotations

PubMed:11063736 JSONTXT

Annnotations TAB JSON ListView MergeView

c_corpus

Id Subject Object Predicate Lexical cue
T1 14-20 UBERON:0000922 denotes embryo
T2 36-39 CVCL_D569 denotes CAG
T3 55-65 SO:0000781 denotes transgenic
T4 55-70 10090 denotes transgenic mice
T5 55-70 D008822 denotes transgenic mice
T6 66-70 PR:000005054 denotes mice
T8 66-70 O89094 denotes mice
T14 84-104 D006816 denotes Huntington's disease
T15 84-104 D006816 denotes Huntington's disease
T18 105-109 SO:0000704 denotes gene
T19 160-173 CHEBI:74953 denotes trinucleotide
T20 185-190 D006801 denotes human
T21 191-198 D004194 denotes disease
T22 191-198 D004194 denotes disease
T23 277-290 CHEBI:74953 denotes trinucleotide
T24 277-307 SO:0002165 denotes trinucleotide repeat expansion
T26 377-380 CVCL_D569 denotes CAG
T27 381-394 CHEBI:74953 denotes trinucleotide
T28 395-401 SO:0001068 denotes repeat
T29 407-416 SO:0000902 denotes transgene
T31 432-436 SO:0000147 denotes exon
T30 432-436 PR:P33696 denotes exon
T32 454-459 D006801 denotes human
T37 460-480 D006816 denotes Huntington's disease
T38 460-480 D006816 denotes Huntington's disease
T41 486-490 SO:0000704 denotes gene
T42 515-520 10090 denotes mouse
T43 515-520 D051379 denotes mouse
T44 568-572 UBERON:0003101 denotes male
T45 568-572 CHEBI:30780 denotes male
T46 615-618 CVCL_D569 denotes CAG
T47 619-625 SO:0001068 denotes repeat
T48 645-650 D006801 denotes human
T49 654-658 SO:0000704 denotes gene
T51 675-679 CHEBI:30780 denotes male
T50 675-679 UBERON:0003101 denotes male
T52 684-690 UBERON:0003100 denotes female
T53 754-760 SO:0001068 denotes repeat
T54 804-810 SO:0001068 denotes repeat
T55 865-868 CVCL_D569 denotes CAG
T56 914-920 UBERON:0000922 denotes embryo
T58 1035-1038 CHEBI:16991 denotes DNA
T60 1035-1038 D004247 denotes DNA
T59 1035-1038 SO:0000352 denotes DNA
T57 1035-1038 GO:0005574 denotes DNA
T61 1046-1052 UBERON:0000922 denotes embryo
T62 1079-1085 UBERON:0000922 denotes embryo
T63 1138-1145 D004194 denotes disease
T64 1138-1145 D004194 denotes disease

UseCases_ArguminSci_Discourse

Id Subject Object Predicate Lexical cue
T1 0-110 DRI_Outcome denotes Gender of the embryo contributes to CAG instability in transgenic mice containing a Huntington's disease gene.
T2 111-199 DRI_Background denotes Gender is known to influence the transmission of trinucleotide repeats in human disease.
T3 200-321 DRI_Approach denotes However, the molecular basis for the parent-of-origin effect associated with trinucleotide repeat expansion is not known.
T4 322-491 DRI_Approach denotes We have followed, during transmission, the fate of the CAG trinucleotide repeat in a transgene containing the exon 1 portion of the human Huntington's disease (HD) gene.
T5 492-583 DRI_Background denotes Similar to humans, the mouse transmits expansions predominantly through the male germ line.
T6 584-722 DRI_Outcome denotes Surprisingly, we find that the CAG repeat size of the mutant human HD gene is different in male and female progeny from identical fathers.
T7 723-811 DRI_Approach denotes Males predominantly expand the repeat whereas females predominantly contract the repeat.
T8 812-921 DRI_Approach denotes In contrast to the classic definition of imprinting, CAG expansion is influenced by the gender of the embryo.
T9 922-1053 DRI_Outcome denotes Our results raise the possibility that there are X- or Y-encoded factors that influence repair or replication of DNA in the embryo.
T10 1054-1189 DRI_Background denotes Gender dependence in the embryo may explain why expansion in HD from premutation to disease primarily occurs through the paternal line.