PubMed:11058588
Annnotations
GlyCosmos6-Glycan-Motif-Image
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 806-820 | Glycan_Motif | denotes | sialyl-Lewis a | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81971FM|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00053MO |
| T3 | 813-820 | Glycan_Motif | denotes | Lewis a | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G39023AU|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00047MO |
| T5 | 904-918 | Glycan_Motif | denotes | sialyl-Lewis x | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00054MO |
| T6 | 911-918 | Glycan_Motif | denotes | Lewis x | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G01187XC|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00051MO |
| T8 | 1371-1390 | Glycan_Motif | denotes | N-acetyllactosamine | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00055MO |
| T9 | 1395-1409 | Glycan_Motif | denotes | sialyl-Lewis x | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00054MO |
| T10 | 1402-1409 | Glycan_Motif | denotes | Lewis x | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G01187XC|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00051MO |
| T12 | 1867-1881 | Glycan_Motif | denotes | sialyl-Lewis a | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81971FM|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00053MO |
| T14 | 1874-1881 | Glycan_Motif | denotes | Lewis a | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G39023AU|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00047MO |
sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-223 | Sentence | denotes | beta 1,3-Galactosyltransferase beta 3Gal-T5 acts on the GlcNAcbeta 1-->3Galbeta 1-->4GlcNAcbeta 1-->R sugar chains of carcinoembryonic antigen and other N-linked glycoproteins and is down-regulated in colon adenocarcinomas. |
| T2 | 224-427 | Sentence | denotes | We attempted to determine whether beta1,3-galactosyltransferase beta3Gal-T5 is involved in the biosynthesis of a specific subset of type 1 chain carbohydrates and expressed in a cancer-associated manner. |
| T3 | 428-743 | Sentence | denotes | We transfected Chinese hamster ovary (CHO) cells expressing Fuc-TIII with beta3Gal-T cDNAs and studied the relevant glycoconjugates formed. beta3Gal-T5 directs synthesis of Lewis type 1 antigens in CHO cells more efficiently than beta3Gal-T1, whereas beta3Gal-T2, -T3, and -T4 are almost unable to direct synthesis. |
| T4 | 744-1056 | Sentence | denotes | In the clone expressing Fuc-TIII and beta3Gal-T5 (CHO-FT-T5), sialyl-Lewis a synthesis is strongly inhibited by swainsonine but not by benzyl-alpha-GalNAc, and sialyl-Lewis x is absent, although it is detected in the clones expressing Fuc-TIII and beta3Gal-T1 (CHO-FT-T1) or Fuc-TIII and beta3Gal-T2 (CHO-FT-T2). |
| T5 | 1057-1306 | Sentence | denotes | Endo-beta-galactosidase treatment of N- glycans prepared from clone CHO-FT-T5 releases (+/-NeuAcalpha2-->3)Galbeta1-->3[Fucalpha1-->4]GlcNAcbeta1-->3Gal but not GlcNAcbeta1-->3Gal or type 2 chain oligosaccharides, which are found in CHO-FT-T1 cells. |
| T6 | 1307-1433 | Sentence | denotes | This result indicates that beta3Gal-T5 expression prevents poly-N-acetyllactosamine and sialyl-Lewis x synthesis on N-glycans. |
| T7 | 1434-1559 | Sentence | denotes | Kinetic studies confirm that beta3Gal-T5 prefers acceptors having the GlcNAcbeta1-->3Gal end, including lactotriosylceramide. |
| T8 | 1560-1740 | Sentence | denotes | Competitive reverse transcriptase mediated-polymerase chain reaction shows that the beta3Gal-T5 transcript is expressed in normal colon mucosa but not or poorly in adenocarcinomas. |
| T9 | 1741-1964 | Sentence | denotes | Moreover, recombinant carcinoembryonic antigen purified from a CHO clone expressing Fuc-TIII and beta3Gal-T5 reacts with anti-sialyl-Lewis a and carries type 1 chains on oligosaccharides released by endo-beta-galactosidase. |
| T10 | 1965-2104 | Sentence | denotes | We conclude that beta3Gal-T5 down-regulation plays a relevant role in determining the cancer-associated glycosylation pattern of N-glycans. |
GlyCosmos6-Glycan-Motif-Structure
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 806-820 | https://glytoucan.org/Structures/Glycans/G00053MO | denotes | sialyl-Lewis a |
| T2 | 806-820 | https://glytoucan.org/Structures/Glycans/G81971FM | denotes | sialyl-Lewis a |
| T3 | 813-820 | https://glytoucan.org/Structures/Glycans/G00047MO | denotes | Lewis a |
| T4 | 813-820 | https://glytoucan.org/Structures/Glycans/G39023AU | denotes | Lewis a |
| T5 | 904-918 | https://glytoucan.org/Structures/Glycans/G00054MO | denotes | sialyl-Lewis x |
| T6 | 911-918 | https://glytoucan.org/Structures/Glycans/G00051MO | denotes | Lewis x |
| T7 | 911-918 | https://glytoucan.org/Structures/Glycans/G01187XC | denotes | Lewis x |
| T8 | 1371-1390 | https://glytoucan.org/Structures/Glycans/G00055MO | denotes | N-acetyllactosamine |
| T9 | 1395-1409 | https://glytoucan.org/Structures/Glycans/G00054MO | denotes | sialyl-Lewis x |
| T10 | 1402-1409 | https://glytoucan.org/Structures/Glycans/G00051MO | denotes | Lewis x |
| T11 | 1402-1409 | https://glytoucan.org/Structures/Glycans/G01187XC | denotes | Lewis x |
| T12 | 1867-1881 | https://glytoucan.org/Structures/Glycans/G00053MO | denotes | sialyl-Lewis a |
| T13 | 1867-1881 | https://glytoucan.org/Structures/Glycans/G81971FM | denotes | sialyl-Lewis a |
| T14 | 1874-1881 | https://glytoucan.org/Structures/Glycans/G00047MO | denotes | Lewis a |
| T15 | 1874-1881 | https://glytoucan.org/Structures/Glycans/G39023AU | denotes | Lewis a |
Glycosmos6-MAT
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 201-206 | http://purl.obolibrary.org/obo/MAT_0000526 | denotes | colon |
| T2 | 1690-1695 | http://purl.obolibrary.org/obo/MAT_0000526 | denotes | colon |
Glycosmos6-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 806-820 | http://www.glycoepitope.jp/epitopes/EP0008 | denotes | sialyl-Lewis a |
| T2 | 813-820 | http://www.glycoepitope.jp/epitopes/EP0007 | denotes | Lewis a |
| T3 | 904-918 | http://www.glycoepitope.jp/epitopes/EP0012 | denotes | sialyl-Lewis x |
| T4 | 911-918 | http://www.glycoepitope.jp/epitopes/EP0011 | denotes | Lewis x |
| T5 | 1395-1409 | http://www.glycoepitope.jp/epitopes/EP0012 | denotes | sialyl-Lewis x |
| T6 | 1402-1409 | http://www.glycoepitope.jp/epitopes/EP0011 | denotes | Lewis x |
| T7 | 1867-1881 | http://www.glycoepitope.jp/epitopes/EP0008 | denotes | sialyl-Lewis a |
| T8 | 1874-1881 | http://www.glycoepitope.jp/epitopes/EP0007 | denotes | Lewis a |
DisGeNET5_gene_disease
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 11058588-0#118#142#gene1048 | 118-142 | gene1048 | denotes | carcinoembryonic antigen |
| 11058588-0#207#222#diseaseC0001418 | 207-222 | diseaseC0001418 | denotes | adenocarcinomas |
| 11058588-7#84#95#gene10317 | 1644-1655 | gene10317 | denotes | beta3Gal-T5 |
| 11058588-7#164#179#diseaseC0001418 | 1724-1739 | diseaseC0001418 | denotes | adenocarcinomas |
| 118#142#gene1048207#222#diseaseC0001418 | 11058588-0#118#142#gene1048 | 11058588-0#207#222#diseaseC0001418 | associated_with | carcinoembryonic antigen,adenocarcinomas |
| 84#95#gene10317164#179#diseaseC0001418 | 11058588-7#84#95#gene10317 | 11058588-7#164#179#diseaseC0001418 | associated_with | beta3Gal-T5,adenocarcinomas |
DisGeNET
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T0 | 1644-1655 | gene:10317 | denotes | beta3Gal-T5 |
| T1 | 1724-1739 | disease:C0001418 | denotes | adenocarcinomas |
| R1 | T0 | T1 | associated_with | beta3Gal-T5,adenocarcinomas |
GlyCosmos15-Glycan
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 806-820 | Glycan | denotes | sialyl-Lewis a | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00053MO |
| T2 | 892-898 | Glycan | denotes | GalNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL |
| T3 | 904-918 | Glycan | denotes | sialyl-Lewis x | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00054MO |
| T4 | 1395-1409 | Glycan | denotes | sialyl-Lewis x | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00054MO |
| T5 | 1867-1881 | Glycan | denotes | sialyl-Lewis a | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00053MO |
mondo_disease
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 201-222 | Disease | denotes | colon adenocarcinomas | http://purl.obolibrary.org/obo/MONDO_0002271 |
| T2 | 402-408 | Disease | denotes | cancer | http://purl.obolibrary.org/obo/MONDO_0004992 |
| T3 | 1724-1739 | Disease | denotes | adenocarcinomas | http://purl.obolibrary.org/obo/MONDO_0004970 |
| T4 | 2051-2057 | Disease | denotes | cancer | http://purl.obolibrary.org/obo/MONDO_0004992 |
HP-phenotype
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T1 | 402-408 | Phenotype | denotes | cancer | HP:0002664 |
| T2 | 2051-2057 | Phenotype | denotes | cancer | HP:0002664 |
Glycan-GlyCosmos
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 806-820 | Glycan | denotes | sialyl-Lewis a | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00053MO |
| T2 | 892-898 | Glycan | denotes | GalNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL |
| T3 | 904-918 | Glycan | denotes | sialyl-Lewis x | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00054MO |
| T4 | 1395-1409 | Glycan | denotes | sialyl-Lewis x | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00054MO |
| T5 | 1867-1881 | Glycan | denotes | sialyl-Lewis a | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00053MO |
GlyCosmos-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue | glycoepitope_id |
|---|---|---|---|---|---|
| T1 | 806-820 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | sialyl-Lewis a | http://www.glycoepitope.jp/epitopes/EP0008 |
| T2 | 904-918 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | sialyl-Lewis x | http://www.glycoepitope.jp/epitopes/EP0012 |
| T3 | 1395-1409 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | sialyl-Lewis x | http://www.glycoepitope.jp/epitopes/EP0012 |
| T4 | 1867-1881 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | sialyl-Lewis a | http://www.glycoepitope.jp/epitopes/EP0008 |
GlyCosmos15-HP
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T1 | 402-408 | Phenotype | denotes | cancer | HP:0002664 |
| T2 | 2051-2057 | Phenotype | denotes | cancer | HP:0002664 |
GlyCosmos15-CL
| Id | Subject | Object | Predicate | Lexical cue | cl_id |
|---|---|---|---|---|---|
| T1 | 1366-1370 | Cell | denotes | poly | http://purl.obolibrary.org/obo/CL:0000096|http://purl.obolibrary.org/obo/CL:0000775 |
GlyCosmos15-Taxon
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 443-458 | Organism | denotes | Chinese hamster | 10029 |
GlyCosmos15-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 201-222 | Disease | denotes | colon adenocarcinomas | MONDO:0002271 |
| T2 | 402-408 | Disease | denotes | cancer | MONDO:0004992 |
| T3 | 1724-1739 | Disease | denotes | adenocarcinomas | MONDO:0004970 |
| T4 | 2051-2057 | Disease | denotes | cancer | MONDO:0004992 |
GlyCosmos15-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue | glycoepitope_id |
|---|---|---|---|---|---|
| T1 | 806-820 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | sialyl-Lewis a | http://www.glycoepitope.jp/epitopes/EP0008 |
| T2 | 904-918 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | sialyl-Lewis x | http://www.glycoepitope.jp/epitopes/EP0012 |
| T3 | 1395-1409 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | sialyl-Lewis x | http://www.glycoepitope.jp/epitopes/EP0012 |
| T4 | 1867-1881 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | sialyl-Lewis a | http://www.glycoepitope.jp/epitopes/EP0008 |
GlyCosmos15-Sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-223 | Sentence | denotes | beta 1,3-Galactosyltransferase beta 3Gal-T5 acts on the GlcNAcbeta 1-->3Galbeta 1-->4GlcNAcbeta 1-->R sugar chains of carcinoembryonic antigen and other N-linked glycoproteins and is down-regulated in colon adenocarcinomas. |
| T2 | 224-427 | Sentence | denotes | We attempted to determine whether beta1,3-galactosyltransferase beta3Gal-T5 is involved in the biosynthesis of a specific subset of type 1 chain carbohydrates and expressed in a cancer-associated manner. |
| T3 | 428-743 | Sentence | denotes | We transfected Chinese hamster ovary (CHO) cells expressing Fuc-TIII with beta3Gal-T cDNAs and studied the relevant glycoconjugates formed. beta3Gal-T5 directs synthesis of Lewis type 1 antigens in CHO cells more efficiently than beta3Gal-T1, whereas beta3Gal-T2, -T3, and -T4 are almost unable to direct synthesis. |
| T4 | 744-1056 | Sentence | denotes | In the clone expressing Fuc-TIII and beta3Gal-T5 (CHO-FT-T5), sialyl-Lewis a synthesis is strongly inhibited by swainsonine but not by benzyl-alpha-GalNAc, and sialyl-Lewis x is absent, although it is detected in the clones expressing Fuc-TIII and beta3Gal-T1 (CHO-FT-T1) or Fuc-TIII and beta3Gal-T2 (CHO-FT-T2). |
| T5 | 1057-1306 | Sentence | denotes | Endo-beta-galactosidase treatment of N- glycans prepared from clone CHO-FT-T5 releases (+/-NeuAcalpha2-->3)Galbeta1-->3[Fucalpha1-->4]GlcNAcbeta1-->3Gal but not GlcNAcbeta1-->3Gal or type 2 chain oligosaccharides, which are found in CHO-FT-T1 cells. |
| T6 | 1307-1433 | Sentence | denotes | This result indicates that beta3Gal-T5 expression prevents poly-N-acetyllactosamine and sialyl-Lewis x synthesis on N-glycans. |
| T7 | 1434-1559 | Sentence | denotes | Kinetic studies confirm that beta3Gal-T5 prefers acceptors having the GlcNAcbeta1-->3Gal end, including lactotriosylceramide. |
| T8 | 1560-1740 | Sentence | denotes | Competitive reverse transcriptase mediated-polymerase chain reaction shows that the beta3Gal-T5 transcript is expressed in normal colon mucosa but not or poorly in adenocarcinomas. |
| T9 | 1741-1964 | Sentence | denotes | Moreover, recombinant carcinoembryonic antigen purified from a CHO clone expressing Fuc-TIII and beta3Gal-T5 reacts with anti-sialyl-Lewis a and carries type 1 chains on oligosaccharides released by endo-beta-galactosidase. |
| T10 | 1965-2104 | Sentence | denotes | We conclude that beta3Gal-T5 down-regulation plays a relevant role in determining the cancer-associated glycosylation pattern of N-glycans. |
GlyCosmos15-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 201-206 | Body_part | denotes | colon | http://purl.obolibrary.org/obo/UBERON_0001155 |
| T2 | 459-464 | Body_part | denotes | ovary | http://purl.obolibrary.org/obo/UBERON_0000992 |
| T3 | 1690-1702 | Body_part | denotes | colon mucosa | http://purl.obolibrary.org/obo/UBERON_0000317 |
GlyCosmos15-FMA
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 201-206 | Body_part | denotes | colon | FMA:14543 |
| T2 | 459-464 | Body_part | denotes | ovary | FMA:7209 |
| T3 | 1690-1702 | Body_part | denotes | colon mucosa | FMA:14984 |
GlyCosmos15-MAT
| Id | Subject | Object | Predicate | Lexical cue | mat_id |
|---|---|---|---|---|---|
| T1 | 201-206 | Body_part | denotes | colon | http://purl.obolibrary.org/obo/MAT_0000526 |
| T2 | 1690-1695 | Body_part | denotes | colon | http://purl.obolibrary.org/obo/MAT_0000526 |
NCBITAXON
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 443-458 | OrganismTaxon | denotes | Chinese hamster | 10029 |
Anatomy-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 201-206 | Body_part | denotes | colon | http://purl.obolibrary.org/obo/UBERON_0001155 |
| T2 | 459-464 | Body_part | denotes | ovary | http://purl.obolibrary.org/obo/UBERON_0000992 |
| T3 | 1690-1702 | Body_part | denotes | colon mucosa | http://purl.obolibrary.org/obo/UBERON_0000317 |
Anatomy-MAT
| Id | Subject | Object | Predicate | Lexical cue | mat_id |
|---|---|---|---|---|---|
| T1 | 201-206 | Body_part | denotes | colon | http://purl.obolibrary.org/obo/MAT_0000526 |
| T2 | 1690-1695 | Body_part | denotes | colon | http://purl.obolibrary.org/obo/MAT_0000526 |
CL-cell
| Id | Subject | Object | Predicate | Lexical cue | cl_id |
|---|---|---|---|---|---|
| T1 | 1366-1370 | Cell | denotes | poly | http://purl.obolibrary.org/obo/CL:0000096|http://purl.obolibrary.org/obo/CL:0000775 |