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PubMed:11054569 JSONTXT

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LitCoin-entities

Id Subject Object Predicate Lexical cue db_id
380 0-5 GeneOrGeneProduct denotes Rab6c NCBIGene:84084
381 27-30 GeneOrGeneProduct denotes rab NCBIGene:5870|NCBIGene:84084
382 78-87 CellLine denotes MCF7/AdrR NCBITaxon:9606
383 101-105 GeneOrGeneProduct denotes Rab6 NCBIGene:5870
384 120-125 GeneOrGeneProduct denotes Rab6c NCBIGene:84084
385 207-212 OrganismTaxon denotes human NCBITaxon:9606
386 239-252 DiseaseOrPhenotypicFeature denotes breast cancer MESH:D001943
387 264-273 CellLine denotes MCF7/AdrR NCBITaxon:9606
388 361-366 GeneOrGeneProduct denotes Rab6c NCBIGene:84084
389 402-411 CellLine denotes MCF7/AdrR NCBITaxon:9606
390 416-426 CellLine denotes MES-SA/Dx5 NCBITaxon:9606
391 430-435 OrganismTaxon denotes human NCBITaxon:9606
392 440-455 DiseaseOrPhenotypicFeature denotes uterine sarcoma MESH:D014594
393 516-525 CellLine denotes MCF7/AdrR NCBITaxon:9606
394 557-562 GeneOrGeneProduct denotes Rab6c NCBIGene:84084
395 627-638 ChemicalEntity denotes doxorubicin MESH:D004317
396 640-643 ChemicalEntity denotes DOX MESH:D004317
397 646-651 ChemicalEntity denotes taxol MESH:D017239
398 653-664 ChemicalEntity denotes vinblastine MESH:D014747
399 670-681 ChemicalEntity denotes vincristine MESH:D014750
400 821-824 ChemicalEntity denotes DOX MESH:D004317
401 892-897 GeneOrGeneProduct denotes Rab6c NCBIGene:84084
402 927-932 GeneOrGeneProduct denotes Rab6c NCBIGene:84084
403 967-976 CellLine denotes MCF7/AdrR NCBITaxon:9606

LitCoin-entities-OrganismTaxon-PD

Id Subject Object Predicate Lexical cue db_id
T1 207-212 OrganismTaxon denotes human NCBItxid:9606
T2 430-435 OrganismTaxon denotes human NCBItxid:9606

LitCoin-sentences

Id Subject Object Predicate Lexical cue
T1 0-94 Sentence denotes Rab6c, a new member of the rab gene family, is involved in drug resistance in MCF7/AdrR cells.
T2 95-360 Sentence denotes A new Rab6 homolog cDNA, Rab6c, was discovered by a hypermethylated DNA fragment probe that was isolated from a human multidrug resistant (MDR) breast cancer cell line, MCF7/AdrR, by the methylation sensitive-representational difference analysis (MS-RDA) technique.
T3 361-515 Sentence denotes Rab6c was found to be under-expressed in MCF7/AdrR and MES-SA/Dx5 (a human MDR uterine sarcoma cell line) compared with their non-MDR parental cell lines.
T4 516-734 Sentence denotes MCF7/AdrR cells expressing the exogenous Rab6c exhibited less resistance to several anti-cancer drugs, such as doxorubicin (DOX), taxol, vinblastine, and vincristine, than the control cells containing the empty vector.
T5 735-898 Sentence denotes Flow cytometry experiments confirmed that the transfectants' diminished resistance to DOX was caused by increased drug accumulation induced by the exogenous Rab6c.
T6 899-983 Sentence denotes These results indicate that Rab6c is involved in drug resistance in MCF7/AdrR cells.

LitCoin_Mondo

Id Subject Object Predicate Lexical cue mondo_id
T1 239-252 DiseaseOrPhenotypicFeature denotes breast cancer 0007254
T2 246-252 DiseaseOrPhenotypicFeature denotes cancer 0004992
T3 448-455 DiseaseOrPhenotypicFeature denotes sarcoma 0005089
T4 605-611 DiseaseOrPhenotypicFeature denotes cancer 0004992

LitCoin-GeneOrGeneProduct-v0

Id Subject Object Predicate Lexical cue
T1 0-5 GeneOrGeneProduct denotes Rab6c
T2 27-30 GeneOrGeneProduct denotes rab
T3 59-74 GeneOrGeneProduct denotes drug resistance
T4 88-93 GeneOrGeneProduct denotes cells
T5 101-105 GeneOrGeneProduct denotes Rab6
T6 106-113 GeneOrGeneProduct denotes homolog
T7 114-118 GeneOrGeneProduct denotes cDNA
T8 120-125 GeneOrGeneProduct denotes Rab6c
T9 213-232 GeneOrGeneProduct denotes multidrug resistant
T10 234-237 GeneOrGeneProduct denotes MDR
T11 253-257 GeneOrGeneProduct denotes cell
T12 258-262 GeneOrGeneProduct denotes line
T13 342-344 GeneOrGeneProduct denotes MS
T14 361-366 GeneOrGeneProduct denotes Rab6c
T15 436-439 GeneOrGeneProduct denotes MDR
T16 456-460 GeneOrGeneProduct denotes cell
T17 461-465 GeneOrGeneProduct denotes line
T18 491-494 GeneOrGeneProduct denotes MDR
T19 504-508 GeneOrGeneProduct denotes cell
T20 509-514 GeneOrGeneProduct denotes lines
T21 526-531 GeneOrGeneProduct denotes cells
T22 557-562 GeneOrGeneProduct denotes Rab6c
T23 700-705 GeneOrGeneProduct denotes cells
T24 867-874 GeneOrGeneProduct denotes induced
T25 892-897 GeneOrGeneProduct denotes Rab6c
T26 927-932 GeneOrGeneProduct denotes Rab6c
T27 948-963 GeneOrGeneProduct denotes drug resistance
T28 977-982 GeneOrGeneProduct denotes cells

LitCoin-GeneOrGeneProduct-v2

Id Subject Object Predicate Lexical cue
T1 0-5 GeneOrGeneProduct denotes Rab6c
T2 59-74 GeneOrGeneProduct denotes drug resistance
T3 101-105 GeneOrGeneProduct denotes Rab6
T4 106-113 GeneOrGeneProduct denotes homolog
T5 114-118 GeneOrGeneProduct denotes cDNA
T6 120-125 GeneOrGeneProduct denotes Rab6c
T7 213-232 GeneOrGeneProduct denotes multidrug resistant
T8 234-237 GeneOrGeneProduct denotes MDR
T9 253-257 GeneOrGeneProduct denotes cell
T10 361-366 GeneOrGeneProduct denotes Rab6c
T11 436-439 GeneOrGeneProduct denotes MDR
T12 456-460 GeneOrGeneProduct denotes cell
T13 491-494 GeneOrGeneProduct denotes MDR
T14 504-508 GeneOrGeneProduct denotes cell
T15 509-514 GeneOrGeneProduct denotes lines
T16 557-562 GeneOrGeneProduct denotes Rab6c
T17 892-897 GeneOrGeneProduct denotes Rab6c
T18 927-932 GeneOrGeneProduct denotes Rab6c
T19 948-963 GeneOrGeneProduct denotes drug resistance

LitCoin-Disease-MeSH

Id Subject Object Predicate Lexical cue originalLabel
T1 239-252 DiseaseOrPhenotypicFeature denotes breast cancer D001943
T2 448-455 DiseaseOrPhenotypicFeature denotes sarcoma D012509
T3 605-611 DiseaseOrPhenotypicFeature denotes cancer D009369

LitCoin-GeneOrGeneProduct-v3

Id Subject Object Predicate Lexical cue
T1 0-5 GeneOrGeneProduct denotes Rab6c
T2 101-105 GeneOrGeneProduct denotes Rab6
T3 120-125 GeneOrGeneProduct denotes Rab6c
T4 361-366 GeneOrGeneProduct denotes Rab6c
T5 557-562 GeneOrGeneProduct denotes Rab6c
T6 892-897 GeneOrGeneProduct denotes Rab6c
T7 927-932 GeneOrGeneProduct denotes Rab6c

LitCoin_Mondo_095

Id Subject Object Predicate Lexical cue mondo_id
T1 239-252 DiseaseOrPhenotypicFeature denotes breast cancer 0007254|0004989
T3 294-303 DiseaseOrPhenotypicFeature denotes sensitive 0000605
T4 342-344 DiseaseOrPhenotypicFeature denotes MS 0006861
T5 440-455 DiseaseOrPhenotypicFeature denotes uterine sarcoma 0005210

LitCoin-MeSH-Disease-2

Id Subject Object Predicate Lexical cue ID:
T1 239-252 DiseaseOrPhenotypicFeature denotes breast cancer D001943
T2 448-455 DiseaseOrPhenotypicFeature denotes sarcoma D012509
T3 605-611 DiseaseOrPhenotypicFeature denotes cancer D009369

LitCoin_CellLine

Id Subject Object Predicate Lexical cue cellosaurus_accession_id
T1 78-82 CellLine denotes MCF7 CVCL_0031
T2 264-268 CellLine denotes MCF7 CVCL_0031
T3 402-406 CellLine denotes MCF7 CVCL_0031
T4 416-426 CellLine denotes MES-SA/Dx5 CVCL_2598
T5 516-520 CellLine denotes MCF7 CVCL_0031
T6 967-971 CellLine denotes MCF7 CVCL_0031

LitCoin-MONDO_bioort2019

Id Subject Object Predicate Lexical cue #label
T1 239-252 DiseaseOrPhenotypicFeature denotes breast cancer D001943
T2 448-455 DiseaseOrPhenotypicFeature denotes sarcoma D012509
T3 605-611 DiseaseOrPhenotypicFeature denotes cancer D009369

LitCoin-Chemical-MeSH-CHEBI

Id Subject Object Predicate Lexical cue ID:
T1 234-237 ChemicalEntity denotes MDR http://purl.obolibrary.org/obo/CHEBI_53218
T2 416-419 ChemicalEntity denotes MES http://purl.obolibrary.org/obo/CHEBI_39010|http://purl.obolibrary.org/obo/CHEBI_39005
T4 436-439 ChemicalEntity denotes MDR http://purl.obolibrary.org/obo/CHEBI_53218
T5 491-494 ChemicalEntity denotes MDR http://purl.obolibrary.org/obo/CHEBI_53218
T6 627-638 ChemicalEntity denotes doxorubicin D004317|http://purl.obolibrary.org/obo/CHEBI_64816|http://purl.obolibrary.org/obo/CHEBI_28748
T9 640-643 ChemicalEntity denotes DOX D004317
T10 646-651 ChemicalEntity denotes taxol D017239|http://purl.obolibrary.org/obo/CHEBI_45863
T12 653-664 ChemicalEntity denotes vinblastine D014747
T13 670-681 ChemicalEntity denotes vincristine D014750|http://purl.obolibrary.org/obo/CHEBI_28445|http://purl.obolibrary.org/obo/CHEBI_143658
T16 821-824 ChemicalEntity denotes DOX D004317

LitCoin-NCBITaxon-2

Id Subject Object Predicate Lexical cue
T1 207-212 OrganismTaxon denotes human
T2 416-422 OrganismTaxon denotes MES-SA
T3 430-435 OrganismTaxon denotes human

LitCoin-training-merged

Id Subject Object Predicate Lexical cue #label ID: cellosaurus_accession_id
T6 967-971 CellLine denotes MCF7 CVCL_0031
T5 516-520 CellLine denotes MCF7 CVCL_0031
T4 416-426 CellLine denotes MES-SA/Dx5 CVCL_2598
T3 402-406 CellLine denotes MCF7 CVCL_0031
T2 264-268 CellLine denotes MCF7 CVCL_0031
T1 78-82 CellLine denotes MCF7 CVCL_0031
T16 821-824 ChemicalEntity denotes DOX D004317
T13 670-681 ChemicalEntity denotes vincristine http://purl.obolibrary.org/obo/CHEBI_143658|http://purl.obolibrary.org/obo/CHEBI_28445|D014750
T12 653-664 ChemicalEntity denotes vinblastine D014747
T10 646-651 ChemicalEntity denotes taxol http://purl.obolibrary.org/obo/CHEBI_45863|D017239
T9 640-643 ChemicalEntity denotes DOX D004317
T90868 627-638 ChemicalEntity denotes doxorubicin http://purl.obolibrary.org/obo/CHEBI_28748|http://purl.obolibrary.org/obo/CHEBI_64816|D004317
T81766 491-494 ChemicalEntity denotes MDR http://purl.obolibrary.org/obo/CHEBI_53218
T87820 436-439 ChemicalEntity denotes MDR http://purl.obolibrary.org/obo/CHEBI_53218
T39013 416-419 ChemicalEntity denotes MES http://purl.obolibrary.org/obo/CHEBI_39005|http://purl.obolibrary.org/obo/CHEBI_39010
T67586 234-237 ChemicalEntity denotes MDR http://purl.obolibrary.org/obo/CHEBI_53218
T7 927-932 GeneOrGeneProduct denotes Rab6c
T3062 892-897 GeneOrGeneProduct denotes Rab6c
T57780 557-562 GeneOrGeneProduct denotes Rab6c
T23734 361-366 GeneOrGeneProduct denotes Rab6c
T48530 120-125 GeneOrGeneProduct denotes Rab6c
T21630 101-105 GeneOrGeneProduct denotes Rab6
T2429 0-5 GeneOrGeneProduct denotes Rab6c
T17223 605-611 DiseaseOrPhenotypicFeature denotes cancer D009369
T24650 448-455 DiseaseOrPhenotypicFeature denotes sarcoma D012509
T59877 239-252 DiseaseOrPhenotypicFeature denotes breast cancer D001943
T95189 430-435 OrganismTaxon denotes human
T73915 416-422 OrganismTaxon denotes MES-SA
T65385 207-212 OrganismTaxon denotes human