PubMed:110440 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/110440","sourcedb":"PubMed","sourceid":"110440","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/110440","text":"The induction of sister chromatid exchanges by dihydrodiols derived from 7,12-dimethylbenz[a]anthracene and 3-methylcholanthrene.\nThe in vitro induction of sister chromatid exchanges (SCEs) in Chinese hamster ovary (CHO) cells by the polycyclic hydrocarbons, 7,12-dimethylbena[a]anthracene and 3-methylcholanthrene and some of the related dihydrodiols was investigated. Increased numbers of SCEs were seen in the chromosomes of cells exposed to non-K-region dihydrodiols. The most active compounds were the 3,4-dihydrodiol of 7,12-dimethylbenza[a]anthracene and the 7,8- and 9,10-dihydrodiols of 3-methylcholanthrene: the parent hydrocarbons and their corresponding K-region dihydrodiols were relatively less active. The results are consistent with others that suggest that the metabolic activation of both hydrocarbons proceeds through the conversion of non-K-region dihydrodiols into vicinal diol-epoxides.","tracks":[{"project":"LitCoin-PubTator-for-Tuning","denotations":[{"id":"3","span":{"begin":47,"end":59},"obj":"ChemicalEntity"},{"id":"4","span":{"begin":73,"end":103},"obj":"ChemicalEntity"},{"id":"5","span":{"begin":108,"end":128},"obj":"ChemicalEntity"},{"id":"22","span":{"begin":201,"end":214},"obj":"DiseaseOrPhenotypicFeature"},{"id":"23","span":{"begin":234,"end":257},"obj":"ChemicalEntity"},{"id":"24","span":{"begin":259,"end":276},"obj":"ChemicalEntity"},{"id":"25","span":{"begin":279,"end":289},"obj":"ChemicalEntity"},{"id":"26","span":{"begin":294,"end":314},"obj":"ChemicalEntity"},{"id":"27","span":{"begin":339,"end":351},"obj":"ChemicalEntity"},{"id":"28","span":{"begin":458,"end":470},"obj":"ChemicalEntity"},{"id":"29","span":{"begin":507,"end":522},"obj":"ChemicalEntity"},{"id":"30","span":{"begin":526,"end":557},"obj":"ChemicalEntity"},{"id":"31","span":{"begin":566,"end":592},"obj":"ChemicalEntity"},{"id":"32","span":{"begin":596,"end":616},"obj":"ChemicalEntity"},{"id":"33","span":{"begin":629,"end":641},"obj":"ChemicalEntity"},{"id":"34","span":{"begin":675,"end":687},"obj":"ChemicalEntity"},{"id":"35","span":{"begin":807,"end":819},"obj":"ChemicalEntity"},{"id":"36","span":{"begin":868,"end":880},"obj":"ChemicalEntity"},{"id":"37","span":{"begin":886,"end":907},"obj":"ChemicalEntity"}],"attributes":[{"id":"A4","pred":"tao:has_database_id","subj":"4","obj":"MESH:D015127"},{"id":"A33","pred":"tao:has_database_id","subj":"33","obj":"MESH:D006838"},{"id":"A5","pred":"tao:has_database_id","subj":"5","obj":"MESH:D008748"},{"id":"A23","pred":"tao:has_database_id","subj":"23","obj":"MESH:D006844"},{"id":"A35","pred":"tao:has_database_id","subj":"35","obj":"MESH:D006838"},{"id":"A3","pred":"tao:has_database_id","subj":"3","obj":"MESH:C507866"},{"id":"A28","pred":"tao:has_database_id","subj":"28","obj":"MESH:C507866"},{"id":"A25","pred":"tao:has_database_id","subj":"25","obj":"MESH:C034020"},{"id":"A27","pred":"tao:has_database_id","subj":"27","obj":"MESH:C507866"},{"id":"A36","pred":"tao:has_database_id","subj":"36","obj":"MESH:C507866"},{"id":"A22","pred":"tao:has_database_id","subj":"22","obj":"MESH:D010051"},{"id":"A26","pred":"tao:has_database_id","subj":"26","obj":"MESH:D008748"},{"id":"A34","pred":"tao:has_database_id","subj":"34","obj":"MESH:C507866"},{"id":"A32","pred":"tao:has_database_id","subj":"32","obj":"MESH:D008748"},{"subj":"3","pred":"source","obj":"LitCoin-PubTator-for-Tuning"},{"subj":"4","pred":"source","obj":"LitCoin-PubTator-for-Tuning"},{"subj":"5","pred":"source","obj":"LitCoin-PubTator-for-Tuning"},{"subj":"22","pred":"source","obj":"LitCoin-PubTator-for-Tuning"},{"subj":"23","pred":"source","obj":"LitCoin-PubTator-for-Tuning"},{"subj":"24","pred":"source","obj":"LitCoin-PubTator-for-Tuning"},{"subj":"25","pred":"source","obj":"LitCoin-PubTator-for-Tuning"},{"subj":"26","pred":"source","obj":"LitCoin-PubTator-for-Tuning"},{"subj":"27","pred":"source","obj":"LitCoin-PubTator-for-Tuning"},{"subj":"28","pred":"source","obj":"LitCoin-PubTator-for-Tuning"},{"subj":"29","pred":"source","obj":"LitCoin-PubTator-for-Tuning"},{"subj":"30","pred":"source","obj":"LitCoin-PubTator-for-Tuning"},{"subj":"31","pred":"source","obj":"LitCoin-PubTator-for-Tuning"},{"subj":"32","pred":"source","obj":"LitCoin-PubTator-for-Tuning"},{"subj":"33","pred":"source","obj":"LitCoin-PubTator-for-Tuning"},{"subj":"34","pred":"source","obj":"LitCoin-PubTator-for-Tuning"},{"subj":"35","pred":"source","obj":"LitCoin-PubTator-for-Tuning"},{"subj":"36","pred":"source","obj":"LitCoin-PubTator-for-Tuning"},{"subj":"37","pred":"source","obj":"LitCoin-PubTator-for-Tuning"}]},{"project":"LitCoin-PubTator_CellLine","denotations":[{"id":"T1","span":{"begin":216,"end":219},"obj":"CellLine"}],"attributes":[{"id":"A1","pred":"cellosaurus_accession_id","subj":"T1","obj":"CVCL_0213"},{"subj":"T1","pred":"source","obj":"LitCoin-PubTator_CellLine"}]}],"config":{"attribute types":[{"pred":"source","value type":"selection","values":[{"id":"LitCoin-PubTator-for-Tuning","color":"#ec9493","default":true},{"id":"LitCoin-PubTator_CellLine","color":"#93acec"}]}]}}