PubMed:11042189 JSON TXT

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Id	Subject	Object	Predicate	Lexical cue
T1	0-78	Sentence	denotes	Identification and characterization of a novel MAP kinase kinase kinase, MLTK.
T2	79-212	Sentence	denotes	The MAPK cascades regulate a wide variety of cellular functions, including cell proliferation, differentiation, and stress responses.
T3	213-416	Sentence	denotes	Here we have identified a novel MAP kinase kinase kinase (MAPKKK), termed MLTK (for MLK-like mitogen-activated protein triple kinase), whose expression is increased by activation of the ERK/MAPK pathway.
T4	417-491	Sentence	denotes	There are two alternatively spliced forms of MLTK, MLTKalpha and MLTKbeta.
T5	492-612	Sentence	denotes	When overexpressed in cells, both MLTKalpha and MLTKbeta are able to activate the ERK, JNK/SAPK, p38, and ERK5 pathways.
T6	613-746	Sentence	denotes	Moreover, both MLTKalpha and MLTKbeta are activated in response to osmotic shock with hyperosmolar media through autophosphorylation.
T7	747-905	Sentence	denotes	Remarkably, expression of MLTKalpha, but not MLTKbeta, in Swiss 3T3 cells results in the disruption of actin stress fibers and dramatic morphological changes.
T8	906-969	Sentence	denotes	A kinase-dead form of MLTKalpha does not cause these phenomena.
T9	970-1089	Sentence	denotes	Inhibition of the p38 pathway significantly blocks MLTKalpha-induced stress fiber disruption and morphological changes.
T10	1090-1212	Sentence	denotes	These results suggest that MLTK is a stress-activated MAPKKK that may be involved in the regulation of actin organization.

Id	Subject	Object	Predicate	Lexical cue	hp_id
T1	688-693	Phenotype	denotes	shock	HP:0031273