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PubMed:11038366 JSON TXT

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PMID_GLOBAL

Id	Subject	Object	Predicate	Lexical cue	mondo_id
T1	1643-1654	DiseaseOrPhenotypicFeature	denotes	sensitivity	0000605

sentences

Id	Subject	Object	Predicate	Lexical cue
T1	0-157	Sentence	denotes	Carboxymethylation of the PP2A catalytic subunit in Saccharomyces cerevisiae is required for efficient interaction with the B-type subunits Cdc55p and Rts1p.
T2	158-299	Sentence	denotes	Protein phosphatase 2A (PP2A) is an essential eukaryotic serine/threonine phosphatase known to play important roles in cell cycle regulation.
T3	300-499	Sentence	denotes	Association of different B-type targeting subunits with the heterodimeric core (A/C) enzyme is known to be an important mechanism of regulating PP2A activity, substrate specificity, and localization.
T4	500-606	Sentence	denotes	However, how the binding of these targeting subunits to the A/C heterodimer might be regulated is unknown.
T5	607-822	Sentence	denotes	We have used the budding yeast Saccharomyces cerevisiae as a model system to investigate the hypothesis that covalent modification of the C subunit (Pph21p/Pph22p) carboxyl terminus modulates PP2A complex formation.
T6	823-849	Sentence	denotes	Two approaches were taken.
T7	850-980	Sentence	denotes	First, S. cerevisiae cells were generated whose survival depended on the expression of different carboxyl-terminal Pph21p mutants.
T8	981-1209	Sentence	denotes	Second, the major S. cerevisiae methyltransferase (Ppm1p) that catalyzes the methylation of the PP2A C subunit carboxyl-terminal leucine was identified, and cells deleted for this methyltransferase were utilized for our studies.
T9	1210-1433	Sentence	denotes	Our results demonstrate that binding of the yeast B subunit, Cdc55p, to Pph21p was disrupted by either acidic substitution of potential carboxyl-terminal phosphorylation sites on Pph21p or by deletion of the gene for Ppm1p.
T10	1434-1563	Sentence	denotes	Loss of Cdc55p association was accompanied in each case by a large reduction in binding of the yeast A subunit, Tpd3p, to Pph21p.
T11	1564-1700	Sentence	denotes	Moreover, decreased Cdc55p and Tpd3p binding invariably resulted in nocodazole sensitivity, a known phenotype of CDC55 or TPD3 deletion.
T12	1701-1810	Sentence	denotes	Furthermore, loss of methylation also greatly reduced the association of another yeast B-type subunit, Rts1p.
T13	1811-1942	Sentence	denotes	Thus, methylation of Pph21p is important for formation of PP2A trimeric and dimeric complexes, and consequently, for PP2A function.
T14	1943-2111	Sentence	denotes	Taken together, our results indicate that methylation and phosphorylation may be mechanisms by which the cell dynamically regulates PP2A complex formation and function.

bionlp-st-epi-2011-training

Id	Subject	Object	Predicate	Lexical cue
T1	140-146	Protein	denotes	Cdc55p
T2	151-156	Protein	denotes	Rts1p
T3	756-762	Protein	denotes	Pph21p
T4	763-769	Protein	denotes	Pph22p
T5	965-971	Protein	denotes	Pph21p
T6	1032-1037	Protein	denotes	Ppm1p
T7	1271-1277	Protein	denotes	Cdc55p
T8	1282-1288	Protein	denotes	Pph21p
T9	1389-1395	Protein	denotes	Pph21p
T10	1427-1432	Protein	denotes	Ppm1p
T11	1442-1448	Protein	denotes	Cdc55p
T12	1546-1551	Protein	denotes	Tpd3p
T13	1556-1562	Protein	denotes	Pph21p
T14	1584-1590	Protein	denotes	Cdc55p
T15	1595-1600	Protein	denotes	Tpd3p
T16	1677-1682	Protein	denotes	CDC55
T17	1686-1690	Protein	denotes	TPD3
T18	1804-1809	Protein	denotes	Rts1p
T19	1832-1838	Protein	denotes	Pph21p

NCBITAXON

Id	Subject	Object	Predicate	Lexical cue	db_id
T1	52-76	OrganismTaxon	denotes	Saccharomyces cerevisiae	4932
T2	638-662	OrganismTaxon	denotes	Saccharomyces cerevisiae	4932
T3	857-870	OrganismTaxon	denotes	S. cerevisiae	4932
T4	999-1012	OrganismTaxon	denotes	S. cerevisiae	4932

Anatomy-UBERON

Id	Subject	Object	Predicate	Lexical cue	uberon_id
T1	277-287	Body_part	denotes	cell cycle	http://purl.obolibrary.org/obo/UBERON_2000098