PubMed:11030748 / 999-1410 JSONTXT

{"project":"Glycan-Motif","denotations":[{"id":"T29","span":{"begin":107,"end":110},"obj":"https://glytoucan.org/Structures/Glycans/G61168WC"},{"id":"T30","span":{"begin":107,"end":110},"obj":"https://glytoucan.org/Structures/Glycans/G79389NT"},{"id":"T31","span":{"begin":228,"end":231},"obj":"https://glytoucan.org/Structures/Glycans/G56516VH"},{"id":"T32","span":{"begin":228,"end":231},"obj":"https://glytoucan.org/Structures/Glycans/G91237TK"},{"id":"T33","span":{"begin":245,"end":248},"obj":"https://glytoucan.org/Structures/Glycans/G61168WC"},{"id":"T34","span":{"begin":245,"end":248},"obj":"https://glytoucan.org/Structures/Glycans/G79389NT"}],"text":"Comparison of cell lines stably expressing these chimeras revealed that the in vivo functional activity of GM2 synthase decreased progressively as the enzyme was targeted to earlier compartments; specifically, the percentage of GM3 converted to GM2 was 83-86% for wild type enzyme, 70% for the medial Golgi targeted enzyme, 13% for the ER and cis Golgi targeted enzyme, and only 1.7% for the ER targeted enzyme."}

{"project":"GlyCosmos6-Glycan-Motif-Image","denotations":[{"id":"T30","span":{"begin":107,"end":110},"obj":"Glycan_Motif"},{"id":"T32","span":{"begin":228,"end":231},"obj":"Glycan_Motif"},{"id":"T34","span":{"begin":245,"end":248},"obj":"Glycan_Motif"}],"attributes":[{"id":"A30","pred":"image","subj":"T30","obj":"https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G79389NT"},{"id":"A31","pred":"image","subj":"T30","obj":"https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G61168WC"},{"id":"A32","pred":"image","subj":"T32","obj":"https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G91237TK"},{"id":"A33","pred":"image","subj":"T32","obj":"https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G56516VH"},{"id":"A34","pred":"image","subj":"T34","obj":"https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G79389NT"},{"id":"A35","pred":"image","subj":"T34","obj":"https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G61168WC"}],"text":"Comparison of cell lines stably expressing these chimeras revealed that the in vivo functional activity of GM2 synthase decreased progressively as the enzyme was targeted to earlier compartments; specifically, the percentage of GM3 converted to GM2 was 83-86% for wild type enzyme, 70% for the medial Golgi targeted enzyme, 13% for the ER and cis Golgi targeted enzyme, and only 1.7% for the ER targeted enzyme."}

{"project":"Glycosmos6-MAT","denotations":[{"id":"T2","span":{"begin":294,"end":300},"obj":"http://purl.obolibrary.org/obo/MAT_0000490"}],"text":"Comparison of cell lines stably expressing these chimeras revealed that the in vivo functional activity of GM2 synthase decreased progressively as the enzyme was targeted to earlier compartments; specifically, the percentage of GM3 converted to GM2 was 83-86% for wild type enzyme, 70% for the medial Golgi targeted enzyme, 13% for the ER and cis Golgi targeted enzyme, and only 1.7% for the ER targeted enzyme."}

{"project":"sentences","denotations":[{"id":"TextSentencer_T6","span":{"begin":0,"end":411},"obj":"Sentence"},{"id":"T4","span":{"begin":0,"end":411},"obj":"Sentence"},{"id":"T6","span":{"begin":0,"end":411},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Comparison of cell lines stably expressing these chimeras revealed that the in vivo functional activity of GM2 synthase decreased progressively as the enzyme was targeted to earlier compartments; specifically, the percentage of GM3 converted to GM2 was 83-86% for wild type enzyme, 70% for the medial Golgi targeted enzyme, 13% for the ER and cis Golgi targeted enzyme, and only 1.7% for the ER targeted enzyme."}

{"project":"GlyCosmos6-Glycan-Motif-Structure","denotations":[{"id":"T29","span":{"begin":107,"end":110},"obj":"https://glytoucan.org/Structures/Glycans/G61168WC"},{"id":"T30","span":{"begin":107,"end":110},"obj":"https://glytoucan.org/Structures/Glycans/G79389NT"},{"id":"T31","span":{"begin":228,"end":231},"obj":"https://glytoucan.org/Structures/Glycans/G56516VH"},{"id":"T32","span":{"begin":228,"end":231},"obj":"https://glytoucan.org/Structures/Glycans/G91237TK"},{"id":"T33","span":{"begin":245,"end":248},"obj":"https://glytoucan.org/Structures/Glycans/G61168WC"},{"id":"T34","span":{"begin":245,"end":248},"obj":"https://glytoucan.org/Structures/Glycans/G79389NT"}],"text":"Comparison of cell lines stably expressing these chimeras revealed that the in vivo functional activity of GM2 synthase decreased progressively as the enzyme was targeted to earlier compartments; specifically, the percentage of GM3 converted to GM2 was 83-86% for wild type enzyme, 70% for the medial Golgi targeted enzyme, 13% for the ER and cis Golgi targeted enzyme, and only 1.7% for the ER targeted enzyme."}

{"project":"GlycoBiology-FMA","denotations":[{"id":"_T31","span":{"begin":0,"end":18},"obj":"FMAID:223408"},{"id":"_T32","span":{"begin":0,"end":18},"obj":"FMAID:223407"},{"id":"_T33","span":{"begin":182,"end":194},"obj":"FMAID:183399"},{"id":"_T34","span":{"begin":182,"end":194},"obj":"FMAID:76700"},{"id":"_T35","span":{"begin":182,"end":194},"obj":"FMAID:183854"},{"id":"_T36","span":{"begin":294,"end":300},"obj":"FMAID:171165"},{"id":"_T37","span":{"begin":294,"end":300},"obj":"FMAID:49444"}],"namespaces":[{"prefix":"FMAID","uri":"http://purl.org/sig/ont/fma/fma"}],"text":"Comparison of cell lines stably expressing these chimeras revealed that the in vivo functional activity of GM2 synthase decreased progressively as the enzyme was targeted to earlier compartments; specifically, the percentage of GM3 converted to GM2 was 83-86% for wild type enzyme, 70% for the medial Golgi targeted enzyme, 13% for the ER and cis Golgi targeted enzyme, and only 1.7% for the ER targeted enzyme."}

{"project":"uniprot-human","denotations":[{"id":"T1","span":{"begin":336,"end":338},"obj":"http://www.uniprot.org/uniprot/P03372"},{"id":"T2","span":{"begin":392,"end":394},"obj":"http://www.uniprot.org/uniprot/P03372"}],"text":"Comparison of cell lines stably expressing these chimeras revealed that the in vivo functional activity of GM2 synthase decreased progressively as the enzyme was targeted to earlier compartments; specifically, the percentage of GM3 converted to GM2 was 83-86% for wild type enzyme, 70% for the medial Golgi targeted enzyme, 13% for the ER and cis Golgi targeted enzyme, and only 1.7% for the ER targeted enzyme."}

{"project":"uniprot-mouse","denotations":[{"id":"T2","span":{"begin":343,"end":346},"obj":"http://www.uniprot.org/uniprot/Q62225"},{"id":"T3","span":{"begin":336,"end":338},"obj":"http://www.uniprot.org/uniprot/P19785"},{"id":"T4","span":{"begin":392,"end":394},"obj":"http://www.uniprot.org/uniprot/P19785"}],"text":"Comparison of cell lines stably expressing these chimeras revealed that the in vivo functional activity of GM2 synthase decreased progressively as the enzyme was targeted to earlier compartments; specifically, the percentage of GM3 converted to GM2 was 83-86% for wild type enzyme, 70% for the medial Golgi targeted enzyme, 13% for the ER and cis Golgi targeted enzyme, and only 1.7% for the ER targeted enzyme."}

{"project":"GlycoBiology-NCBITAXON","denotations":[{"id":"T6","span":{"begin":343,"end":346},"obj":"http://purl.bioontology.org/ontology/NCBITAXON/245896"}],"text":"Comparison of cell lines stably expressing these chimeras revealed that the in vivo functional activity of GM2 synthase decreased progressively as the enzyme was targeted to earlier compartments; specifically, the percentage of GM3 converted to GM2 was 83-86% for wild type enzyme, 70% for the medial Golgi targeted enzyme, 13% for the ER and cis Golgi targeted enzyme, and only 1.7% for the ER targeted enzyme."}

{"project":"GO-BP","denotations":[{"id":"T6","span":{"begin":95,"end":119},"obj":"http://purl.obolibrary.org/obo/GO_0003947"},{"id":"T7","span":{"begin":182,"end":208},"obj":"http://purl.obolibrary.org/obo/GO_0007386"}],"text":"Comparison of cell lines stably expressing these chimeras revealed that the in vivo functional activity of GM2 synthase decreased progressively as the enzyme was targeted to earlier compartments; specifically, the percentage of GM3 converted to GM2 was 83-86% for wild type enzyme, 70% for the medial Golgi targeted enzyme, 13% for the ER and cis Golgi targeted enzyme, and only 1.7% for the ER targeted enzyme."}

{"project":"GO-CC","denotations":[{"id":"T19","span":{"begin":301,"end":306},"obj":"http://purl.obolibrary.org/obo/GO_0005794"},{"id":"T20","span":{"begin":347,"end":352},"obj":"http://purl.obolibrary.org/obo/GO_0005794"},{"id":"T27","span":{"begin":14,"end":18},"obj":"http://purl.obolibrary.org/obo/GO_0005623"},{"id":"T28","span":{"begin":336,"end":338},"obj":"http://purl.obolibrary.org/obo/GO_0005783"},{"id":"T29","span":{"begin":392,"end":394},"obj":"http://purl.obolibrary.org/obo/GO_0005783"}],"text":"Comparison of cell lines stably expressing these chimeras revealed that the in vivo functional activity of GM2 synthase decreased progressively as the enzyme was targeted to earlier compartments; specifically, the percentage of GM3 converted to GM2 was 83-86% for wild type enzyme, 70% for the medial Golgi targeted enzyme, 13% for the ER and cis Golgi targeted enzyme, and only 1.7% for the ER targeted enzyme."}

{"project":"UBERON-AE","denotations":[{"id":"T2","span":{"begin":294,"end":300},"obj":"http://purl.obolibrary.org/obo/UBERON_3010194"}],"text":"Comparison of cell lines stably expressing these chimeras revealed that the in vivo functional activity of GM2 synthase decreased progressively as the enzyme was targeted to earlier compartments; specifically, the percentage of GM3 converted to GM2 was 83-86% for wild type enzyme, 70% for the medial Golgi targeted enzyme, 13% for the ER and cis Golgi targeted enzyme, and only 1.7% for the ER targeted enzyme."}

{"project":"EDAM-topics","denotations":[{"id":"T3","span":{"begin":162,"end":170},"obj":"http://edamontology.org/topic_0154"},{"id":"T4","span":{"begin":307,"end":315},"obj":"http://edamontology.org/topic_0154"},{"id":"T5","span":{"begin":353,"end":361},"obj":"http://edamontology.org/topic_0154"},{"id":"T6","span":{"begin":395,"end":403},"obj":"http://edamontology.org/topic_0154"}],"text":"Comparison of cell lines stably expressing these chimeras revealed that the in vivo functional activity of GM2 synthase decreased progressively as the enzyme was targeted to earlier compartments; specifically, the percentage of GM3 converted to GM2 was 83-86% for wild type enzyme, 70% for the medial Golgi targeted enzyme, 13% for the ER and cis Golgi targeted enzyme, and only 1.7% for the ER targeted enzyme."}

{"project":"EDAM-DFO","denotations":[{"id":"T8","span":{"begin":0,"end":10},"obj":"http://edamontology.org/operation_2424"}],"text":"Comparison of cell lines stably expressing these chimeras revealed that the in vivo functional activity of GM2 synthase decreased progressively as the enzyme was targeted to earlier compartments; specifically, the percentage of GM3 converted to GM2 was 83-86% for wild type enzyme, 70% for the medial Golgi targeted enzyme, 13% for the ER and cis Golgi targeted enzyme, and only 1.7% for the ER targeted enzyme."}

{"project":"GlycoBiology-MAT","denotations":[{"id":"T2","span":{"begin":294,"end":300},"obj":"http://purl.obolibrary.org/obo/MAT_0000490"}],"text":"Comparison of cell lines stably expressing these chimeras revealed that the in vivo functional activity of GM2 synthase decreased progressively as the enzyme was targeted to earlier compartments; specifically, the percentage of GM3 converted to GM2 was 83-86% for wild type enzyme, 70% for the medial Golgi targeted enzyme, 13% for the ER and cis Golgi targeted enzyme, and only 1.7% for the ER targeted enzyme."}

{"project":"performance-test","denotations":[{"id":"PD-UBERON-AE-B_T2","span":{"begin":294,"end":300},"obj":"http://purl.obolibrary.org/obo/UBERON_3010194"}],"text":"Comparison of cell lines stably expressing these chimeras revealed that the in vivo functional activity of GM2 synthase decreased progressively as the enzyme was targeted to earlier compartments; specifically, the percentage of GM3 converted to GM2 was 83-86% for wild type enzyme, 70% for the medial Golgi targeted enzyme, 13% for the ER and cis Golgi targeted enzyme, and only 1.7% for the ER targeted enzyme."}

{"project":"Anatomy-MAT","denotations":[{"id":"T2","span":{"begin":294,"end":300},"obj":"Body_part"}],"attributes":[{"id":"A2","pred":"mat_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/MAT_0000490"}],"text":"Comparison of cell lines stably expressing these chimeras revealed that the in vivo functional activity of GM2 synthase decreased progressively as the enzyme was targeted to earlier compartments; specifically, the percentage of GM3 converted to GM2 was 83-86% for wild type enzyme, 70% for the medial Golgi targeted enzyme, 13% for the ER and cis Golgi targeted enzyme, and only 1.7% for the ER targeted enzyme."}

{"project":"Glycan-GlyCosmos","denotations":[{"id":"T15","span":{"begin":107,"end":110},"obj":"Glycan"},{"id":"T16","span":{"begin":228,"end":231},"obj":"Glycan"},{"id":"T17","span":{"begin":245,"end":248},"obj":"Glycan"}],"attributes":[{"id":"A15","pred":"glycosmos_id","subj":"T15","obj":"https://glycosmos.org/glycans/show/G79389NT"},{"id":"A34","pred":"image","subj":"T15","obj":"https://api.glycosmos.org/wurcs2image/latest/png/binary/G79389NT"},{"id":"A16","pred":"glycosmos_id","subj":"T16","obj":"https://glycosmos.org/glycans/show/G91237TK"},{"id":"A35","pred":"image","subj":"T16","obj":"https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK"},{"id":"A17","pred":"glycosmos_id","subj":"T17","obj":"https://glycosmos.org/glycans/show/G79389NT"},{"id":"A36","pred":"image","subj":"T17","obj":"https://api.glycosmos.org/wurcs2image/latest/png/binary/G79389NT"}],"text":"Comparison of cell lines stably expressing these chimeras revealed that the in vivo functional activity of GM2 synthase decreased progressively as the enzyme was targeted to earlier compartments; specifically, the percentage of GM3 converted to GM2 was 83-86% for wild type enzyme, 70% for the medial Golgi targeted enzyme, 13% for the ER and cis Golgi targeted enzyme, and only 1.7% for the ER targeted enzyme."}

{"project":"GlyCosmos15-UBERON","denotations":[{"id":"T13","span":{"begin":301,"end":306},"obj":"Body_part"},{"id":"T14","span":{"begin":347,"end":352},"obj":"Body_part"}],"attributes":[{"id":"A13","pred":"uberon_id","subj":"T13","obj":"http://purl.obolibrary.org/obo/GO_0005794"},{"id":"A14","pred":"uberon_id","subj":"T14","obj":"http://purl.obolibrary.org/obo/GO_0005794"}],"text":"Comparison of cell lines stably expressing these chimeras revealed that the in vivo functional activity of GM2 synthase decreased progressively as the enzyme was targeted to earlier compartments; specifically, the percentage of GM3 converted to GM2 was 83-86% for wild type enzyme, 70% for the medial Golgi targeted enzyme, 13% for the ER and cis Golgi targeted enzyme, and only 1.7% for the ER targeted enzyme."}

{"project":"GlyCosmos15-MAT","denotations":[{"id":"T2","span":{"begin":294,"end":300},"obj":"Body_part"}],"attributes":[{"id":"A2","pred":"mat_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/MAT_0000490"}],"text":"Comparison of cell lines stably expressing these chimeras revealed that the in vivo functional activity of GM2 synthase decreased progressively as the enzyme was targeted to earlier compartments; specifically, the percentage of GM3 converted to GM2 was 83-86% for wild type enzyme, 70% for the medial Golgi targeted enzyme, 13% for the ER and cis Golgi targeted enzyme, and only 1.7% for the ER targeted enzyme."}

{"project":"sentences","denotations":[{"id":"TextSentencer_T6","span":{"begin":0,"end":411},"obj":"Sentence"},{"id":"T4","span":{"begin":0,"end":411},"obj":"Sentence"},{"id":"T6","span":{"begin":0,"end":411},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Comparison of cell lines stably expressing these chimeras revealed that the in vivo functional activity of GM2 synthase decreased progressively as the enzyme was targeted to earlier compartments; specifically, the percentage of GM3 converted to GM2 was 83-86% for wild type enzyme, 70% for the medial Golgi targeted enzyme, 13% for the ER and cis Golgi targeted enzyme, and only 1.7% for the ER targeted enzyme."}

{"project":"GlyCosmos15-Sentences","blocks":[{"id":"T4","span":{"begin":0,"end":411},"obj":"Sentence"}],"text":"Comparison of cell lines stably expressing these chimeras revealed that the in vivo functional activity of GM2 synthase decreased progressively as the enzyme was targeted to earlier compartments; specifically, the percentage of GM3 converted to GM2 was 83-86% for wild type enzyme, 70% for the medial Golgi targeted enzyme, 13% for the ER and cis Golgi targeted enzyme, and only 1.7% for the ER targeted enzyme."}

{"project":"GlyCosmos15-Glycan","denotations":[{"id":"T15","span":{"begin":107,"end":110},"obj":"Glycan"},{"id":"T16","span":{"begin":228,"end":231},"obj":"Glycan"},{"id":"T17","span":{"begin":245,"end":248},"obj":"Glycan"}],"attributes":[{"id":"A15","pred":"glycosmos_id","subj":"T15","obj":"https://glycosmos.org/glycans/show/G79389NT"},{"id":"A34","pred":"image","subj":"T15","obj":"https://api.glycosmos.org/wurcs2image/latest/png/binary/G79389NT"},{"id":"A16","pred":"glycosmos_id","subj":"T16","obj":"https://glycosmos.org/glycans/show/G91237TK"},{"id":"A35","pred":"image","subj":"T16","obj":"https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK"},{"id":"A17","pred":"glycosmos_id","subj":"T17","obj":"https://glycosmos.org/glycans/show/G79389NT"},{"id":"A36","pred":"image","subj":"T17","obj":"https://api.glycosmos.org/wurcs2image/latest/png/binary/G79389NT"}],"text":"Comparison of cell lines stably expressing these chimeras revealed that the in vivo functional activity of GM2 synthase decreased progressively as the enzyme was targeted to earlier compartments; specifically, the percentage of GM3 converted to GM2 was 83-86% for wild type enzyme, 70% for the medial Golgi targeted enzyme, 13% for the ER and cis Golgi targeted enzyme, and only 1.7% for the ER targeted enzyme."}

{"project":"Anatomy-UBERON","denotations":[{"id":"T13","span":{"begin":301,"end":306},"obj":"Body_part"},{"id":"T14","span":{"begin":347,"end":352},"obj":"Body_part"}],"attributes":[{"id":"A13","pred":"uberon_id","subj":"T13","obj":"http://purl.obolibrary.org/obo/GO_0005794"},{"id":"A14","pred":"uberon_id","subj":"T14","obj":"http://purl.obolibrary.org/obo/GO_0005794"}],"text":"Comparison of cell lines stably expressing these chimeras revealed that the in vivo functional activity of GM2 synthase decreased progressively as the enzyme was targeted to earlier compartments; specifically, the percentage of GM3 converted to GM2 was 83-86% for wild type enzyme, 70% for the medial Golgi targeted enzyme, 13% for the ER and cis Golgi targeted enzyme, and only 1.7% for the ER targeted enzyme."}