PubMed:11018080 JSONTXT

{"project":"PMID_GLOBAL","denotations":[{"id":"T1","span":{"begin":190,"end":205},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T2","span":{"begin":207,"end":213},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T3","span":{"begin":262,"end":277},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T4","span":{"begin":563,"end":578},"obj":"DiseaseOrPhenotypicFeature"},{"id":"T5","span":{"begin":1095,"end":1119},"obj":"DiseaseOrPhenotypicFeature"}],"attributes":[{"id":"A1","pred":"mondo_id","subj":"T1","obj":"0005148"},{"id":"A2","pred":"mondo_id","subj":"T2","obj":"0011027"},{"id":"A3","pred":"mondo_id","subj":"T3","obj":"0005148"},{"id":"A4","pred":"mondo_id","subj":"T4","obj":"0005148"},{"id":"A5","pred":"mondo_id","subj":"T5","obj":"0005148"}],"text":"A calpain-10 gene polymorphism is associated with reduced muscle mRNA levels and insulin resistance.\nPrevious linkage studies in Mexican-Americans localized a major susceptibility locus for type 2 diabetes, NIDDM1, to chromosome 2q. This evidence for linkage to type 2 diabetes was recently found to be associated with a common G--\u003eA polymorphism (UCSNP-43) within the CAPN10 gene. The at-risk genotype was homozygous for the UCSNP-43 G allele. In the present study among Pima Indians, the UCSNP-43 G/G genotype was not associated with an increased prevalence of type 2 diabetes. However, Pima Indians with normal glucose tolerance, who have a G/G genotype at UCSNP-43, were found to have decreased rates of postabsorptive and insulin-stimulated glucose turnover that appear to result from decreased rates of glucose oxidation. In addition, G/G homozygotes were found to have reduced CAPN10 mRNA expression in their skeletal muscle. A decreased rate of insulin-mediated glucose turnover, or insulin resistance, is one mechanism by which the polymorphism in CAPN10 may increase susceptibility to type 2 diabetes mellitus in older persons."}

{"project":"DisGeNET5_gene_disease","denotations":[{"id":"11018080-7#124#130#gene11132","span":{"begin":1057,"end":1063},"obj":"gene11132"},{"id":"11018080-7#162#186#diseaseC0011860","span":{"begin":1095,"end":1119},"obj":"diseaseC0011860"}],"relations":[{"id":"124#130#gene11132162#186#diseaseC0011860","pred":"associated_with","subj":"11018080-7#124#130#gene11132","obj":"11018080-7#162#186#diseaseC0011860"}],"text":"A calpain-10 gene polymorphism is associated with reduced muscle mRNA levels and insulin resistance.\nPrevious linkage studies in Mexican-Americans localized a major susceptibility locus for type 2 diabetes, NIDDM1, to chromosome 2q. This evidence for linkage to type 2 diabetes was recently found to be associated with a common G--\u003eA polymorphism (UCSNP-43) within the CAPN10 gene. The at-risk genotype was homozygous for the UCSNP-43 G allele. In the present study among Pima Indians, the UCSNP-43 G/G genotype was not associated with an increased prevalence of type 2 diabetes. However, Pima Indians with normal glucose tolerance, who have a G/G genotype at UCSNP-43, were found to have decreased rates of postabsorptive and insulin-stimulated glucose turnover that appear to result from decreased rates of glucose oxidation. In addition, G/G homozygotes were found to have reduced CAPN10 mRNA expression in their skeletal muscle. A decreased rate of insulin-mediated glucose turnover, or insulin resistance, is one mechanism by which the polymorphism in CAPN10 may increase susceptibility to type 2 diabetes mellitus in older persons."}

{"project":"DisGeNET","denotations":[{"id":"T0","span":{"begin":953,"end":960},"obj":"gene:723961"},{"id":"T1","span":{"begin":1095,"end":1119},"obj":"disease:C0011860"},{"id":"T2","span":{"begin":953,"end":960},"obj":"gene:3630"},{"id":"T3","span":{"begin":1095,"end":1119},"obj":"disease:C0011860"},{"id":"T4","span":{"begin":991,"end":998},"obj":"gene:723961"},{"id":"T5","span":{"begin":1095,"end":1119},"obj":"disease:C0011860"},{"id":"T6","span":{"begin":991,"end":998},"obj":"gene:3630"},{"id":"T7","span":{"begin":1095,"end":1119},"obj":"disease:C0011860"},{"id":"T8","span":{"begin":1057,"end":1063},"obj":"gene:11132"},{"id":"T9","span":{"begin":1095,"end":1119},"obj":"disease:C0011860"}],"relations":[{"id":"R1","pred":"associated_with","subj":"T0","obj":"T1"},{"id":"R2","pred":"associated_with","subj":"T2","obj":"T3"},{"id":"R3","pred":"associated_with","subj":"T4","obj":"T5"},{"id":"R4","pred":"associated_with","subj":"T6","obj":"T7"},{"id":"R5","pred":"associated_with","subj":"T8","obj":"T9"}],"namespaces":[{"prefix":"gene","uri":"http://www.ncbi.nlm.nih.gov/gene/"},{"prefix":"disease","uri":"http://purl.bioontology.org/ontology/MEDLINEPLUS/"}],"text":"A calpain-10 gene polymorphism is associated with reduced muscle mRNA levels and insulin resistance.\nPrevious linkage studies in Mexican-Americans localized a major susceptibility locus for type 2 diabetes, NIDDM1, to chromosome 2q. This evidence for linkage to type 2 diabetes was recently found to be associated with a common G--\u003eA polymorphism (UCSNP-43) within the CAPN10 gene. The at-risk genotype was homozygous for the UCSNP-43 G allele. In the present study among Pima Indians, the UCSNP-43 G/G genotype was not associated with an increased prevalence of type 2 diabetes. However, Pima Indians with normal glucose tolerance, who have a G/G genotype at UCSNP-43, were found to have decreased rates of postabsorptive and insulin-stimulated glucose turnover that appear to result from decreased rates of glucose oxidation. In addition, G/G homozygotes were found to have reduced CAPN10 mRNA expression in their skeletal muscle. A decreased rate of insulin-mediated glucose turnover, or insulin resistance, is one mechanism by which the polymorphism in CAPN10 may increase susceptibility to type 2 diabetes mellitus in older persons."}