PubMed:11013229
Annnotations
CL-cell
| Id | Subject | Object | Predicate | Lexical cue | cl_id |
|---|---|---|---|---|---|
| T1 | 345-357 | Cell | denotes | cancer cells | http://purl.obolibrary.org/obo/CL:0001064 |
sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-100 | Sentence | denotes | Pituitary tumor transforming gene causes aneuploidy and p53-dependent and p53-independent apoptosis. |
| T2 | 101-191 | Sentence | denotes | The pituitary tumor transforming gene, PTTG, is abundantly expressed in several neoplasms. |
| T3 | 192-328 | Sentence | denotes | We recently showed that PTTG overexpression is associated with apoptosis and therefore have now studied the role of p53 in this process. |
| T4 | 329-484 | Sentence | denotes | In MCF-7 breast cancer cells that express wild type p53, PTTG overexpression caused apoptosis. p53 was translocated to the nuclei in cells expressing PTTG. |
| T5 | 485-637 | Sentence | denotes | Overexpression of p53, along with PTTG, augmented apoptosis, whereas expression of the human papillomavirus E6 protein inhibited PTTG-induced apoptosis. |
| T6 | 638-789 | Sentence | denotes | In MG-63 osteosarcoma cells that are deficient in p53, PTTG caused cell cycle arrest and subsequent apoptosis that was inhibited by caspase inhibitors. |
| T7 | 790-946 | Sentence | denotes | A proteasome inhibitor augmented PTTG expression in stable PTTG transfectants, suggesting that down-regulated PTTG expression is required for cell survival. |
| T8 | 947-1069 | Sentence | denotes | Finally, MG-63 cells expressing PTTG showed signs of aneuploidy including the presence of micronuclei and multiple nuclei. |
| T9 | 1070-1169 | Sentence | denotes | These results indicate that PTTG overexpression causes p53-dependent and p53-independent apoptosis. |
| T10 | 1170-1216 | Sentence | denotes | In the absence of p53, PTTG causes aneuploidy. |
| T11 | 1217-1354 | Sentence | denotes | These results may provide a mechanism for PTTG-induced tumorigenesis whereby PTTG mediates aneuploidy and subsequent cell transformation. |
Glycosmos6-MAT
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-9 | http://purl.obolibrary.org/obo/MAT_0000077 | denotes | Pituitary |
| T2 | 105-114 | http://purl.obolibrary.org/obo/MAT_0000077 | denotes | pituitary |
DisGeNET5_gene_disease
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 11013229-10#42#46#gene9232 | 1259-1263 | gene9232 | denotes | PTTG |
| 11013229-10#77#81#gene9232 | 1294-1298 | gene9232 | denotes | PTTG |
| 11013229-10#55#68#diseaseC0596263 | 1272-1285 | diseaseC0596263 | denotes | tumorigenesis |
| 42#46#gene923255#68#diseaseC0596263 | 11013229-10#42#46#gene9232 | 11013229-10#55#68#diseaseC0596263 | associated_with | PTTG,tumorigenesis |
| 77#81#gene923255#68#diseaseC0596263 | 11013229-10#77#81#gene9232 | 11013229-10#55#68#diseaseC0596263 | associated_with | PTTG,tumorigenesis |
2015-BEL-Sample-2
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| BEL:20044678 | 329-483 | p(HGNC:PTTG1) increases bp(GOBP:"apoptotic process") | denotes | In MCF-7 breast cancer cells that express wild type p53, PTTG overexpression caused apoptosis. p53 was translocated to the nuclei in cells expressing PTTG |
| BEL:20044680 | 329-483 | p(HGNC:PTTG1) increases tloc(p(HGNC:TP53),GOCCID:0005737,GOCCID:0005634) | denotes | In MCF-7 breast cancer cells that express wild type p53, PTTG overexpression caused apoptosis. p53 was translocated to the nuclei in cells expressing PTTG |
DisGeNET
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T0 | 1259-1263 | gene:9232 | denotes | PTTG |
| T1 | 1272-1285 | disease:C0596263 | denotes | tumorigenesis |
| T2 | 1294-1298 | gene:9232 | denotes | PTTG |
| T3 | 1272-1285 | disease:C0596263 | denotes | tumorigenesis |
| R1 | T0 | T1 | associated_with | PTTG,tumorigenesis |
| R2 | T2 | T3 | associated_with | PTTG,tumorigenesis |
Anatomy-MAT
| Id | Subject | Object | Predicate | Lexical cue | mat_id |
|---|---|---|---|---|---|
| T1 | 0-9 | Body_part | denotes | Pituitary | http://purl.obolibrary.org/obo/MAT_0000077 |
| T2 | 105-114 | Body_part | denotes | pituitary | http://purl.obolibrary.org/obo/MAT_0000077 |
HP-phenotype
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T1 | 10-15 | Phenotype | denotes | tumor | HP:0002664 |
| T2 | 115-120 | Phenotype | denotes | tumor | HP:0002664 |
| T3 | 338-351 | Phenotype | denotes | breast cancer | HP:0003002 |
| T4 | 647-659 | Phenotype | denotes | osteosarcoma | HP:0002669 |
mondo_disease
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 0-15 | Disease | denotes | Pituitary tumor | http://purl.obolibrary.org/obo/MONDO_0017611 |
| T2 | 105-120 | Disease | denotes | pituitary tumor | http://purl.obolibrary.org/obo/MONDO_0017611 |
| T3 | 181-190 | Disease | denotes | neoplasms | http://purl.obolibrary.org/obo/MONDO_0005070|http://purl.obolibrary.org/obo/MONDO_0021079 |
| T5 | 338-351 | Disease | denotes | breast cancer | http://purl.obolibrary.org/obo/MONDO_0007254 |
| T6 | 647-659 | Disease | denotes | osteosarcoma | http://purl.obolibrary.org/obo/MONDO_0002623|http://purl.obolibrary.org/obo/MONDO_0009807 |
NCBITAXON
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 572-577 | OrganismTaxon | denotes | human | 9606 |
| T2 | 578-592 | OrganismTaxon | denotes | papillomavirus | 151340 |
Anatomy-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 0-9 | Body_part | denotes | Pituitary | http://purl.obolibrary.org/obo/UBERON_0000007 |
| T2 | 105-114 | Body_part | denotes | pituitary | http://purl.obolibrary.org/obo/UBERON_0000007 |
| T3 | 338-344 | Body_part | denotes | breast | http://purl.obolibrary.org/obo/UBERON_0000310 |
| T4 | 705-715 | Body_part | denotes | cell cycle | http://purl.obolibrary.org/obo/UBERON_2000098 |