PubMed:11004688 JSONTXT

{"project":"DisGeNET5_gene_disease","denotations":[{"id":"11004688-0#51#56#gene5972","span":{"begin":508,"end":570},"obj":"gene5972"},{"id":"11004688-0#0#22#diseaseC0020540","span":{"begin":77,"end":99},"obj":"diseaseC0020540"}],"relations":[{"id":"51#56#gene59720#22#diseaseC0020540","pred":"associated_with","subj":"11004688-0#51#56#gene5972","obj":"11004688-0#0#22#diseaseC0020540"}],"text":"Malignant hypertension - the role of the paracrine renin-angiotensin system.\nMalignant hypertension remains one of the life-threatening complications of blood pressure elevation. It is a clinico-pathological syndrome of severe blood pressure elevation combined with malignant vascular injury. This is a characteristic form of vascular damage, with two elements: fibrinoid necrosis and endarteritis proliferans. Although the morphology of these has been well described, the molecular events are not fully understood. This review summarizes the evidence from transgenic animals for a role for the activation of a local paracrine renin-angiotensin system in the pathogenesis of malignant vascular injury. These animal models provide pathological, pharmacological, and genetic evidence supporting the hypothesis that intra-renal generation of angiotensin 2 and exposure of the microcirculation to elevated blood pressure co-operate in causing tissue damage in malignant hypertension."}