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PubMed:11004363 JSONTXT

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sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-115 Sentence denotes Downregulation of a mitogen-activated protein kinase signaling pathway in the placentas of women with preeclampsia.
TextSentencer_T2 116-126 Sentence denotes OBJECTIVE:
TextSentencer_T3 127-406 Sentence denotes To investigate whether the activity of the three mitogen-activated protein kinases (Jun aminoterminal kinase, extracellular regulated kinase, and p38) is altered in placental tissue of women with preeclampsia and hemolysis, elevated liver enzymes, low platelets (HELLP) syndrome.
TextSentencer_T4 407-415 Sentence denotes METHODS:
TextSentencer_T5 416-760 Sentence denotes Placental activity (measured by immunoprecipitation-kinase assay) and protein expression (measured by western blot) of Jun aminoterminal kinase, extracellular regulated kinase, and p38 mitogen-activated protein kinase were measured in four groups of eight women each with preeclampsia, HELLP syndrome, and normal vaginal or cesarean deliveries.
TextSentencer_T6 761-1121 Sentence denotes To further characterize the Jun aminoterminal kinase signal transduction pathway, phosphorylation of c-Jun, a downstream effector of Jun aminoterminal kinase- mitogen-activated protein kinase, was analyzed by western blotting, and the activity of Rac1, an upstream activator of the Jun aminoterminal kinase signaling pathway, was determined by pull-down assay.
TextSentencer_T7 1122-1130 Sentence denotes RESULTS:
TextSentencer_T8 1131-1394 Sentence denotes The activity of Jun aminoterminal kinase was significantly lower in placentas of women with preeclampsia or HELLP syndrome compared with those who had normal vaginal or cesarean delivery, whereas levels of Jun aminoterminal kinase protein expression were similar.
TextSentencer_T9 1395-1671 Sentence denotes Phosphorylation of the transcription factor c-Jun and Rac1 activity also were significantly lower in women with preeclampsia and HELLP than in controls. p38 mitogen-activated protein kinase activity was significantly higher in women with preeclampsia than with HELLP syndrome.
TextSentencer_T10 1672-1775 Sentence denotes There was no change in extracellular regulated kinase activity or protein expression between subgroups.
TextSentencer_T11 1776-1787 Sentence denotes CONCLUSION:
TextSentencer_T12 1788-1941 Sentence denotes In placentas of women with preeclampsia or HELLP syndrome, a Rac1-Jun aminoterminal kinase-c-Jun-dependent signal transduction pathway was downregulated.
T1 0-115 Sentence denotes Downregulation of a mitogen-activated protein kinase signaling pathway in the placentas of women with preeclampsia.
T2 116-126 Sentence denotes OBJECTIVE:
T3 127-406 Sentence denotes To investigate whether the activity of the three mitogen-activated protein kinases (Jun aminoterminal kinase, extracellular regulated kinase, and p38) is altered in placental tissue of women with preeclampsia and hemolysis, elevated liver enzymes, low platelets (HELLP) syndrome.
T4 407-415 Sentence denotes METHODS:
T5 416-760 Sentence denotes Placental activity (measured by immunoprecipitation-kinase assay) and protein expression (measured by western blot) of Jun aminoterminal kinase, extracellular regulated kinase, and p38 mitogen-activated protein kinase were measured in four groups of eight women each with preeclampsia, HELLP syndrome, and normal vaginal or cesarean deliveries.
T6 761-1121 Sentence denotes To further characterize the Jun aminoterminal kinase signal transduction pathway, phosphorylation of c-Jun, a downstream effector of Jun aminoterminal kinase- mitogen-activated protein kinase, was analyzed by western blotting, and the activity of Rac1, an upstream activator of the Jun aminoterminal kinase signaling pathway, was determined by pull-down assay.
T7 1122-1130 Sentence denotes RESULTS:
T8 1131-1394 Sentence denotes The activity of Jun aminoterminal kinase was significantly lower in placentas of women with preeclampsia or HELLP syndrome compared with those who had normal vaginal or cesarean delivery, whereas levels of Jun aminoterminal kinase protein expression were similar.
T9 1395-1671 Sentence denotes Phosphorylation of the transcription factor c-Jun and Rac1 activity also were significantly lower in women with preeclampsia and HELLP than in controls. p38 mitogen-activated protein kinase activity was significantly higher in women with preeclampsia than with HELLP syndrome.
T10 1672-1775 Sentence denotes There was no change in extracellular regulated kinase activity or protein expression between subgroups.
T11 1776-1787 Sentence denotes CONCLUSION:
T12 1788-1941 Sentence denotes In placentas of women with preeclampsia or HELLP syndrome, a Rac1-Jun aminoterminal kinase-c-Jun-dependent signal transduction pathway was downregulated.

Preeclampsia

Id Subject Object Predicate Lexical cue
PD-Preeclampsia-B_T1 102-114 ORPHA:275555 denotes preeclampsia
PD-Preeclampsia-B_T2 323-335 ORPHA:275555 denotes preeclampsia
PD-Preeclampsia-B_T3 390-405 ORPHA:275555 denotes HELLP) syndrome
PD-Preeclampsia-B_T4 688-700 ORPHA:275555 denotes preeclampsia
PD-Preeclampsia-B_T5 702-716 ORPHA:275555 denotes HELLP syndrome
PD-Preeclampsia-B_T6 1223-1235 ORPHA:275555 denotes preeclampsia
PD-Preeclampsia-B_T7 1239-1253 ORPHA:275555 denotes HELLP syndrome
PD-Preeclampsia-B_T8 1507-1519 ORPHA:275555 denotes preeclampsia
PD-Preeclampsia-B_T9 1633-1645 ORPHA:275555 denotes preeclampsia
PD-Preeclampsia-B_T10 1656-1670 ORPHA:275555 denotes HELLP syndrome
PD-Preeclampsia-B_T11 1815-1827 ORPHA:275555 denotes preeclampsia
PD-Preeclampsia-B_T12 1831-1845 ORPHA:275555 denotes HELLP syndrome

preeclampsia_genes

Id Subject Object Predicate Lexical cue
PD-PreeclampsiaGenes-B_T1 20-52 HGNC:MAPK9 denotes mitogen-activated protein kinase
PD-PreeclampsiaGenes-B_T2 176-209 HGNC:MAPK9 denotes mitogen-activated protein kinases
PD-PreeclampsiaGenes-B_T3 601-633 HGNC:MAPK9 denotes mitogen-activated protein kinase
PD-PreeclampsiaGenes-B_T4 920-952 HGNC:MAPK9 denotes mitogen-activated protein kinase
PD-PreeclampsiaGenes-B_T5 1552-1584 HGNC:MAPK9 denotes mitogen-activated protein kinase
PD-PreeclampsiaGenes-B_T6 20-52 HGNC:MAPK6 denotes mitogen-activated protein kinase
PD-PreeclampsiaGenes-B_T7 176-209 HGNC:MAPK6 denotes mitogen-activated protein kinases
PD-PreeclampsiaGenes-B_T8 601-633 HGNC:MAPK6 denotes mitogen-activated protein kinase
PD-PreeclampsiaGenes-B_T9 920-952 HGNC:MAPK6 denotes mitogen-activated protein kinase
PD-PreeclampsiaGenes-B_T10 1552-1584 HGNC:MAPK6 denotes mitogen-activated protein kinase
PD-PreeclampsiaGenes-B_T11 20-52 HGNC:MAPK1 denotes mitogen-activated protein kinase
PD-PreeclampsiaGenes-B_T12 176-209 HGNC:MAPK1 denotes mitogen-activated protein kinases
PD-PreeclampsiaGenes-B_T13 601-633 HGNC:MAPK1 denotes mitogen-activated protein kinase
PD-PreeclampsiaGenes-B_T14 920-952 HGNC:MAPK1 denotes mitogen-activated protein kinase
PD-PreeclampsiaGenes-B_T15 1552-1584 HGNC:MAPK1 denotes mitogen-activated protein kinase
PD-PreeclampsiaGenes-B_T16 20-52 HGNC:MAPK8 denotes mitogen-activated protein kinase
PD-PreeclampsiaGenes-B_T17 176-209 HGNC:MAPK8 denotes mitogen-activated protein kinases
PD-PreeclampsiaGenes-B_T18 601-633 HGNC:MAPK8 denotes mitogen-activated protein kinase
PD-PreeclampsiaGenes-B_T19 920-952 HGNC:MAPK8 denotes mitogen-activated protein kinase
PD-PreeclampsiaGenes-B_T20 1552-1584 HGNC:MAPK8 denotes mitogen-activated protein kinase
PD-PreeclampsiaGenes-B_T21 20-52 HGNC:MAPK13 denotes mitogen-activated protein kinase
PD-PreeclampsiaGenes-B_T22 176-209 HGNC:MAPK13 denotes mitogen-activated protein kinases
PD-PreeclampsiaGenes-B_T23 601-633 HGNC:MAPK13 denotes mitogen-activated protein kinase
PD-PreeclampsiaGenes-B_T24 920-952 HGNC:MAPK13 denotes mitogen-activated protein kinase
PD-PreeclampsiaGenes-B_T25 1552-1584 HGNC:MAPK13 denotes mitogen-activated protein kinase
PD-PreeclampsiaGenes-B_T26 20-52 HGNC:MAPK12 denotes mitogen-activated protein kinase
PD-PreeclampsiaGenes-B_T27 176-209 HGNC:MAPK12 denotes mitogen-activated protein kinases
PD-PreeclampsiaGenes-B_T28 601-633 HGNC:MAPK12 denotes mitogen-activated protein kinase
PD-PreeclampsiaGenes-B_T29 920-952 HGNC:MAPK12 denotes mitogen-activated protein kinase
PD-PreeclampsiaGenes-B_T30 1552-1584 HGNC:MAPK12 denotes mitogen-activated protein kinase
PD-PreeclampsiaGenes-B_T31 20-52 HGNC:MAPK14 denotes mitogen-activated protein kinase
PD-PreeclampsiaGenes-B_T32 176-209 HGNC:MAPK14 denotes mitogen-activated protein kinases
PD-PreeclampsiaGenes-B_T33 601-633 HGNC:MAPK14 denotes mitogen-activated protein kinase
PD-PreeclampsiaGenes-B_T34 920-952 HGNC:MAPK14 denotes mitogen-activated protein kinase
PD-PreeclampsiaGenes-B_T35 1552-1584 HGNC:MAPK14 denotes mitogen-activated protein kinase
PD-PreeclampsiaGenes-B_T36 20-52 HGNC:MAPK15 denotes mitogen-activated protein kinase
PD-PreeclampsiaGenes-B_T37 176-209 HGNC:MAPK15 denotes mitogen-activated protein kinases
PD-PreeclampsiaGenes-B_T38 601-633 HGNC:MAPK15 denotes mitogen-activated protein kinase
PD-PreeclampsiaGenes-B_T39 920-952 HGNC:MAPK15 denotes mitogen-activated protein kinase
PD-PreeclampsiaGenes-B_T40 1552-1584 HGNC:MAPK15 denotes mitogen-activated protein kinase
PD-PreeclampsiaGenes-B_T41 20-52 HGNC:MAPK10 denotes mitogen-activated protein kinase
PD-PreeclampsiaGenes-B_T42 176-209 HGNC:MAPK10 denotes mitogen-activated protein kinases
PD-PreeclampsiaGenes-B_T43 601-633 HGNC:MAPK10 denotes mitogen-activated protein kinase
PD-PreeclampsiaGenes-B_T44 920-952 HGNC:MAPK10 denotes mitogen-activated protein kinase
PD-PreeclampsiaGenes-B_T45 1552-1584 HGNC:MAPK10 denotes mitogen-activated protein kinase
PD-PreeclampsiaGenes-B_T46 20-52 HGNC:MAPK11 denotes mitogen-activated protein kinase
PD-PreeclampsiaGenes-B_T47 176-209 HGNC:MAPK11 denotes mitogen-activated protein kinases
PD-PreeclampsiaGenes-B_T48 601-633 HGNC:MAPK11 denotes mitogen-activated protein kinase
PD-PreeclampsiaGenes-B_T49 920-952 HGNC:MAPK11 denotes mitogen-activated protein kinase
PD-PreeclampsiaGenes-B_T50 1552-1584 HGNC:MAPK11 denotes mitogen-activated protein kinase
PD-PreeclampsiaGenes-B_T51 1418-1438 HGNC:TCF4 denotes transcription factor

Preeclampsia-compare

Id Subject Object Predicate Lexical cue
PD-Preeclampsia-B_T1 102-114 ORPHA:275555 denotes preeclampsia
PD-Preeclampsia-B_T2 323-335 ORPHA:275555 denotes preeclampsia
PD-Preeclampsia-B_T3 390-405 ORPHA:275555 denotes HELLP) syndrome
PD-Preeclampsia-B_T4 688-700 ORPHA:275555 denotes preeclampsia
PD-Preeclampsia-B_T5 702-716 ORPHA:275555 denotes HELLP syndrome
PD-Preeclampsia-B_T6 1223-1235 ORPHA:275555 denotes preeclampsia
PD-Preeclampsia-B_T7 1239-1253 ORPHA:275555 denotes HELLP syndrome
PD-Preeclampsia-B_T8 1507-1519 ORPHA:275555 denotes preeclampsia
PD-Preeclampsia-B_T9 1633-1645 ORPHA:275555 denotes preeclampsia
PD-Preeclampsia-B_T10 1656-1670 ORPHA:275555 denotes HELLP syndrome
PD-Preeclampsia-B_T11 1815-1827 ORPHA:275555 denotes preeclampsia
PD-Preeclampsia-B_T12 1831-1845 ORPHA:275555 denotes HELLP syndrome

UBERON-AE

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 78-87 http://purl.obolibrary.org/obo/UBERON_0001987 denotes placentas
PD-UBERON-AE-B_T2 1199-1208 http://purl.obolibrary.org/obo/UBERON_0001987 denotes placentas
PD-UBERON-AE-B_T3 1791-1800 http://purl.obolibrary.org/obo/UBERON_0001987 denotes placentas
PD-UBERON-AE-B_T4 302-308 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissue
PD-UBERON-AE-B_T5 360-365 http://purl.obolibrary.org/obo/UBERON_0002107 denotes liver

performance-test

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 302-308 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissue
PD-UBERON-AE-B_T2 360-365 http://purl.obolibrary.org/obo/UBERON_0002107 denotes liver
PD-UBERON-AE-B_T3 78-87 http://purl.obolibrary.org/obo/UBERON_0001987 denotes placentas
PD-UBERON-AE-B_T4 292-301 http://purl.obolibrary.org/obo/UBERON_0001987 denotes placental
PD-UBERON-AE-B_T5 1199-1208 http://purl.obolibrary.org/obo/UBERON_0001987 denotes placentas
PD-UBERON-AE-B_T6 1791-1800 http://purl.obolibrary.org/obo/UBERON_0001987 denotes placentas