PubMed:10981959 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/10981959","sourcedb":"PubMed","sourceid":"10981959","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/10981959","text":"ICSBP directs bipotential myeloid progenitor cells to differentiate into mature macrophages.\nDuring hematopoiesis, myeloid progenitor cells give rise to granulocytes and macrophages. To study the role for ICSBP, a hematopoietic cell-specific transcription factor in myeloid cell development, the gene was introduced into myeloid progenitor cells established from ICSBP-/- mice. ICSBP retrovirus-transduced cells differentiated into mature macrophages with phagocytic activity, which coincided with the induction of specific target DNA binding activity. Similar to macrophages in vivo, ICSBP-transduced cells were growth arrested, expressed many macrophage-specific genes, and responded to macrophage activation signals. Contrary to this, ICSBP transducion led to repression of granulocyte-specific genes and inhibited G-CSF-mediated granulocytic differentiation in these and other myeloid progenitor cells. Together, ICSBP has a key role in the myeloid cell lineage selection and macrophage maturation.","tracks":[]}