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sentences

Id Subject Object Predicate Lexical cue
T1 0-130 Sentence denotes RET finger protein is a transcriptional repressor and interacts with enhancer of polycomb that has dual transcriptional functions.
T2 131-278 Sentence denotes RET finger protein (RFP) belongs to the large B-box RING finger protein family and is known to become oncogenic by fusion with RET tyrosine kinase.
T3 279-399 Sentence denotes Although RFP is reported to be a nuclear protein that is present in the nuclear matrix, its function is largely unknown.
T4 400-510 Sentence denotes Here we show that RFP interacts with Enhancer of Polycomb (EPC) and strongly represses the gene transcription.
T5 511-655 Sentence denotes Yeast two-hybrid assays revealed that the coiled-coil domain of RFP was associated with the EPcA domain and the carboxyl-terminal region of EPC.
T6 656-774 Sentence denotes In addition, both proteins were co-precipitated from the lysates of human cells and mostly colocalized in the nucleus.
T7 775-1015 Sentence denotes Using the luciferase reporter-gene assay, we found that they repress the gene transcription activity independent of the differences of enhancers and promoters used, although the repressive activity of RFP was much stronger than that of EPC.
T8 1016-1270 Sentence denotes The coiled-coil domain of RFP and the carboxyl-terminal region of EPC were most important for the repressive activity of each protein, whereas the EPcA domain had the transcription activating ability that is unique as the Polycomb group protein function.
T9 1271-1490 Sentence denotes These results suggested that RFP may be involved in the epigenetic gene silencing mechanism cooperating with Polycomb group proteins and that EPC is a unique molecule with both repressive and transactivating activities.

bionlp-st-gro-2013-training

Id Subject Object Predicate Lexical cue
T1 0-18 TranscriptionRepressor denotes RET finger protein
T2 24-49 TranscriptionRepressor denotes transcriptional repressor
T6 131-149 TranscriptionRepressor denotes RET finger protein
T7 151-154 TranscriptionRepressor denotes RFP
T8 177-209 ZincCoordinatingDomainTF denotes B-box RING finger protein family
T9 258-277 Enzyme denotes RET tyrosine kinase
T10 288-291 TranscriptionRepressor denotes RFP
T11 312-319 Nucleus denotes nuclear
T12 320-327 Protein denotes protein
T14 418-421 TranscriptionRepressor denotes RFP
T16 437-457 Protein denotes Enhancer of Polycomb
T17 459-462 Protein denotes EPC
T21 553-571 ProteinDomain denotes coiled-coil domain
T22 575-578 Protein denotes RFP
T24 603-614 ProteinDomain denotes EPcA domain
T25 623-647 ProteinDomain denotes carboxyl-terminal region
T26 651-654 Protein denotes EPC
T27 669-682 Protein denotes both proteins
T28 724-729 Eukaryote denotes human
T29 730-735 Cell denotes cells
T31 766-773 Nucleus denotes nucleus
T32 796-809 ReporterGene denotes reporter-gene
T33 831-835 Protein denotes they
T37 910-919 Enhancer denotes enhancers
T38 924-933 Promoter denotes promoters
T39 953-972 TranscriptionRepressorActivity denotes repressive activity
T40 976-979 Protein denotes RFP
T41 1011-1014 Protein denotes EPC
T42 1020-1038 ProteinDomain denotes coiled-coil domain
T43 1042-1045 Protein denotes RFP
T44 1054-1078 ProteinDomain denotes carboxyl-terminal region
T45 1082-1085 Protein denotes EPC
T46 1114-1133 TranscriptionRepressorActivity denotes repressive activity
T47 1142-1149 Protein denotes protein
T48 1163-1174 ProteinDomain denotes EPcA domain
T51 1238-1260 Protein denotes Polycomb group protein
T52 1300-1303 Protein denotes RFP
T54 1380-1403 Protein denotes Polycomb group proteins
T55 1413-1416 Protein denotes EPC
T56 1448-1458 TranscriptionRepressorActivity denotes repressive
T57 1463-1489 TranscriptionActivatorActivity denotes transactivating activities
T59 120-129 Function denotes functions
T13 359-365 CellComponent denotes matrix
T60 351-358 Nucleus denotes nuclear
T4 69-89 Protein denotes enhancer of polycomb
T35 1183-1215 TranscriptionActivatorActivity denotes transcription activating ability
E1 54-63 BindingToProtein denotes interacts
E2 422-431 BindingToProtein denotes interacts
E3 477-486 NegativeRegulation denotes represses
E5 583-593 BindingToProtein denotes associated
E6 747-758 Localization denotes colocalized
E7 836-843 NegativeRegulation denotes repress
E10 1338-1352 GeneSilencing denotes gene silencing
E11 104-119 Transcription denotes transcriptional
E4 491-509 TranscriptionOfGene denotes gene transcription
E8 848-866 TranscriptionOfGene denotes gene transcription
R3 T22 T21 hasPart RFP,coiled-coil domain
R4 T26 T24 hasPart EPC,EPcA domain
R5 T26 T25 hasPart EPC,carboxyl-terminal region
R6 T29 T28 fromSpecies cells,human
R7 E6 T31 locatedIn colocalized,nucleus
R8 T40 T39 hasFunction RFP,repressive activity
R9 T43 T42 hasPart RFP,coiled-coil domain
R10 T45 T44 hasPart EPC,carboxyl-terminal region
R11 T47 T46 hasFunction protein,repressive activity
R13 T55 T56 hasFunction EPC,repressive
R14 T55 T57 hasFunction EPC,transactivating activities
R2 T13 T60 locatedIn matrix,nuclear
R16 T12 T11 locatedIn protein,nuclear
R17 T10 T13 locatedIn RFP,matrix
R1 T4 T59 hasFunction enhancer of polycomb,functions
R12 T48 T35 hasFunction EPcA domain,transcription activating ability
R14 T4 E1 hasPatient enhancer of polycomb,interacts
R15 T1 E1 hasPatient RET finger protein,interacts
R16 T16 E2 hasPatient Enhancer of Polycomb,interacts
R17 T14 E2 hasPatient RFP,interacts
R18 E2 E3 hasAgent interacts,represses
R19 E4 E3 hasPatient gene transcription,represses
R20 T24 E5 hasPatient EPcA domain,associated
R21 T25 E5 hasPatient carboxyl-terminal region,associated
R22 T21 E5 hasPatient coiled-coil domain,associated
R23 T27 E6 hasPatient both proteins,colocalized
R24 T33 E7 hasAgent they,repress
R25 E8 E7 hasPatient gene transcription,repress

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 724-729 OrganismTaxon denotes human 9606

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 4-10 Body_part denotes finger http://purl.obolibrary.org/obo/UBERON_0002389
T2 135-141 Body_part denotes finger http://purl.obolibrary.org/obo/UBERON_0002389
T3 183-194 Body_part denotes RING finger http://purl.obolibrary.org/obo/UBERON_0003624
T4 766-773 Body_part denotes nucleus http://purl.obolibrary.org/obo/GO_0005634|http://purl.obolibrary.org/obo/UBERON_0000125