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GlyCosmos6-Glycan-Motif-Image

Id Subject Object Predicate Lexical cue image
T1 12-21 Glycan_Motif denotes A-antigen https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G71832QJ
T2 203-216 Glycan_Motif denotes blood group A https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G58507AZ|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G17108EX
T4 376-385 Glycan_Motif denotes A antigen https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G71832QJ

Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 203-208 http://purl.obolibrary.org/obo/MAT_0000083 denotes blood
T2 203-208 http://purl.obolibrary.org/obo/MAT_0000315 denotes blood
T3 263-270 http://purl.obolibrary.org/obo/MAT_0000526 denotes colonic

sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-192 Sentence denotes Deletion of A-antigen in a human cancer cell line is associated with reduced promoter activity of CBF/NF-Y binding region, and possibly with enhanced DNA methylation of A transferase promoter.
TextSentencer_T2 193-447 Sentence denotes Employing blood group A- and A+ clones derived from the same parental colonic cancer cell lines, we studied the molecular mechanism of deletion/reduction vs. continuous expression of A antigen in A tumors, a crucial determinant of human tumor malignancy.
TextSentencer_T3 448-601 Sentence denotes A- transferase mRNA level in one of the A- clones (A- SW480) was undetectable, while that in A+ SW480 was strongly detectable by semiquantitative RT-PCR.
TextSentencer_T4 602-885 Sentence denotes Relatively lower (approximately 1/3) transcript level was detectable in another A- clone (A- HT29) in comparison to A+ HT29 by the same RT-PCR procedure, although none of these tumor cell lines showed detectable level of A transcript by Northern blotting or RNase protection methods.
TextSentencer_T5 886-964 Sentence denotes Therefore, subsequent studies were performed employing A- vs. A+ SW480 clones.
TextSentencer_T6 965-1166 Sentence denotes Deletion of A transcript in A- cells was not due to gene deletion, since Southern blot analysis showed equal presence of genomic DNA regardless of A- vs. A+ (SW480 or HT29) or B+ (KATOIII) tumor cells.
TextSentencer_T7 1167-1277 Sentence denotes Two transcriptional control mechanisms leading to differences of A expression in SW480 cells are indicated. i.
TextSentencer_T8 1278-1448 Sentence denotes Luciferase assay in A- and A+ SW480 cells showed that promoter activities of segments of 5' flanking sequence of ABO gene reflected transcript levels in these cell lines.
TextSentencer_T9 1449-1576 Sentence denotes The enhancing activity of a 43 bp tandem repeat unit located between -3899 to -3618 was reduced in A- compared to A+ cells. ii.
TextSentencer_T10 1577-1675 Sentence denotes Distinct differences in the pattern of CpG dinucleotide methylation were found in A- vs. A+ cells.
TextSentencer_T11 1676-1805 Sentence denotes Therefore, the methylation process of A promoter DNA may be another important factor controlling A activity in SW480 tumor cells.
TextSentencer_T12 1806-2043 Sentence denotes Since proliferation and motility of tumor cells are associated closely with A expression, transcription control mechanism for expression of A transferase as described above may be of crucial importance in defining human tumor malignancy.
T1 0-192 Sentence denotes Deletion of A-antigen in a human cancer cell line is associated with reduced promoter activity of CBF/NF-Y binding region, and possibly with enhanced DNA methylation of A transferase promoter.
T2 193-447 Sentence denotes Employing blood group A- and A+ clones derived from the same parental colonic cancer cell lines, we studied the molecular mechanism of deletion/reduction vs. continuous expression of A antigen in A tumors, a crucial determinant of human tumor malignancy.
T3 448-601 Sentence denotes A- transferase mRNA level in one of the A- clones (A- SW480) was undetectable, while that in A+ SW480 was strongly detectable by semiquantitative RT-PCR.
T4 602-885 Sentence denotes Relatively lower (approximately 1/3) transcript level was detectable in another A- clone (A- HT29) in comparison to A+ HT29 by the same RT-PCR procedure, although none of these tumor cell lines showed detectable level of A transcript by Northern blotting or RNase protection methods.
T5 886-964 Sentence denotes Therefore, subsequent studies were performed employing A- vs. A+ SW480 clones.
T6 965-1166 Sentence denotes Deletion of A transcript in A- cells was not due to gene deletion, since Southern blot analysis showed equal presence of genomic DNA regardless of A- vs. A+ (SW480 or HT29) or B+ (KATOIII) tumor cells.
T7 1167-1277 Sentence denotes Two transcriptional control mechanisms leading to differences of A expression in SW480 cells are indicated. i.
T8 1278-1448 Sentence denotes Luciferase assay in A- and A+ SW480 cells showed that promoter activities of segments of 5' flanking sequence of ABO gene reflected transcript levels in these cell lines.
T9 1449-1576 Sentence denotes The enhancing activity of a 43 bp tandem repeat unit located between -3899 to -3618 was reduced in A- compared to A+ cells. ii.
T10 1577-1675 Sentence denotes Distinct differences in the pattern of CpG dinucleotide methylation were found in A- vs. A+ cells.
T11 1676-1805 Sentence denotes Therefore, the methylation process of A promoter DNA may be another important factor controlling A activity in SW480 tumor cells.
T12 1806-2043 Sentence denotes Since proliferation and motility of tumor cells are associated closely with A expression, transcription control mechanism for expression of A transferase as described above may be of crucial importance in defining human tumor malignancy.

GlyCosmos6-Glycan-Motif-Structure

Id Subject Object Predicate Lexical cue
T1 12-21 https://glytoucan.org/Structures/Glycans/G71832QJ denotes A-antigen
T2 203-216 https://glytoucan.org/Structures/Glycans/G17108EX denotes blood group A
T3 203-216 https://glytoucan.org/Structures/Glycans/G58507AZ denotes blood group A
T4 376-385 https://glytoucan.org/Structures/Glycans/G71832QJ denotes A antigen

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 263-277 HP_0003003 denotes colonic cancer
T2 263-277 HP_0100273 denotes colonic cancer
T3 271-277 HP_0002664 denotes cancer
T4 391-397 HP_0002664 denotes tumors
T5 430-435 HP_0002664 denotes tumor
T6 779-784 HP_0002664 denotes tumor
T7 1154-1159 HP_0002664 denotes tumor
T8 1793-1798 HP_0002664 denotes tumor
T9 1842-1847 HP_0002664 denotes tumor
T10 2026-2031 HP_0002664 denotes tumor

DisGeNET

Id Subject Object Predicate Lexical cue
T0 98-101 gene:10153 denotes CBF
T1 33-39 disease:C0006826 denotes cancer
T2 98-101 gene:10153 denotes CBF
T3 33-39 disease:C1306459 denotes cancer
T4 169-182 gene:28 denotes A transferase
T5 33-39 disease:C0006826 denotes cancer
T6 169-182 gene:28 denotes A transferase
T7 33-39 disease:C1306459 denotes cancer
R1 T0 T1 associated_with CBF,cancer
R2 T2 T3 associated_with CBF,cancer
R3 T4 T5 associated_with A transferase,cancer
R4 T6 T7 associated_with A transferase,cancer

GlyCosmos15-Glycan

Id Subject Object Predicate Lexical cue image
T1 203-216 Glycan denotes blood group A https://api.glycosmos.org/wurcs2image/latest/png/binary/G00066MO

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 203-208 Body_part denotes blood http://purl.obolibrary.org/obo/MAT_0000083|http://purl.obolibrary.org/obo/MAT_0000315
T3 263-270 Body_part denotes colonic http://purl.obolibrary.org/obo/MAT_0000526

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 33-39 Phenotype denotes cancer HP:0002664
T2 263-277 Phenotype denotes colonic cancer HP:0003003
T3 430-435 Phenotype denotes tumor HP:0002664
T4 779-784 Phenotype denotes tumor HP:0002664
T5 1154-1159 Phenotype denotes tumor HP:0002664
T6 1793-1798 Phenotype denotes tumor HP:0002664
T7 1842-1847 Phenotype denotes tumor HP:0002664
T8 2026-2031 Phenotype denotes tumor HP:0002664

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 33-39 Disease denotes cancer http://purl.obolibrary.org/obo/MONDO_0004992
T2 263-277 Disease denotes colonic cancer http://purl.obolibrary.org/obo/MONDO_0021063
T3 391-397 Disease denotes tumors http://purl.obolibrary.org/obo/MONDO_0005070
T4 430-435 Disease denotes tumor http://purl.obolibrary.org/obo/MONDO_0005070
T5 779-784 Disease denotes tumor http://purl.obolibrary.org/obo/MONDO_0005070
T6 1154-1159 Disease denotes tumor http://purl.obolibrary.org/obo/MONDO_0005070
T7 1793-1798 Disease denotes tumor http://purl.obolibrary.org/obo/MONDO_0005070
T8 1842-1847 Disease denotes tumor http://purl.obolibrary.org/obo/MONDO_0005070
T9 2026-2031 Disease denotes tumor http://purl.obolibrary.org/obo/MONDO_0005070

GlyCosmos15-HP

Id Subject Object Predicate Lexical cue hp_id
T1 33-39 Phenotype denotes cancer HP:0002664
T2 271-277 Phenotype denotes cancer HP:0002664
T3 430-435 Phenotype denotes tumor HP:0002664
T4 779-784 Phenotype denotes tumor HP:0002664
T5 1154-1159 Phenotype denotes tumor HP:0002664
T6 1793-1798 Phenotype denotes tumor HP:0002664
T7 1842-1847 Phenotype denotes tumor HP:0002664
T8 2026-2031 Phenotype denotes tumor HP:0002664

GlyCosmos15-Sentences

Id Subject Object Predicate Lexical cue
T1 0-192 Sentence denotes Deletion of A-antigen in a human cancer cell line is associated with reduced promoter activity of CBF/NF-Y binding region, and possibly with enhanced DNA methylation of A transferase promoter.
T2 193-447 Sentence denotes Employing blood group A- and A+ clones derived from the same parental colonic cancer cell lines, we studied the molecular mechanism of deletion/reduction vs. continuous expression of A antigen in A tumors, a crucial determinant of human tumor malignancy.
T3 448-601 Sentence denotes A- transferase mRNA level in one of the A- clones (A- SW480) was undetectable, while that in A+ SW480 was strongly detectable by semiquantitative RT-PCR.
T4 602-885 Sentence denotes Relatively lower (approximately 1/3) transcript level was detectable in another A- clone (A- HT29) in comparison to A+ HT29 by the same RT-PCR procedure, although none of these tumor cell lines showed detectable level of A transcript by Northern blotting or RNase protection methods.
T5 886-964 Sentence denotes Therefore, subsequent studies were performed employing A- vs. A+ SW480 clones.
T6 965-1166 Sentence denotes Deletion of A transcript in A- cells was not due to gene deletion, since Southern blot analysis showed equal presence of genomic DNA regardless of A- vs. A+ (SW480 or HT29) or B+ (KATOIII) tumor cells.
T7 1167-1277 Sentence denotes Two transcriptional control mechanisms leading to differences of A expression in SW480 cells are indicated. i.
T8 1278-1448 Sentence denotes Luciferase assay in A- and A+ SW480 cells showed that promoter activities of segments of 5' flanking sequence of ABO gene reflected transcript levels in these cell lines.
T9 1449-1576 Sentence denotes The enhancing activity of a 43 bp tandem repeat unit located between -3899 to -3618 was reduced in A- compared to A+ cells. ii.
T10 1577-1675 Sentence denotes Distinct differences in the pattern of CpG dinucleotide methylation were found in A- vs. A+ cells.
T11 1676-1805 Sentence denotes Therefore, the methylation process of A promoter DNA may be another important factor controlling A activity in SW480 tumor cells.
T12 1806-2043 Sentence denotes Since proliferation and motility of tumor cells are associated closely with A expression, transcription control mechanism for expression of A transferase as described above may be of crucial importance in defining human tumor malignancy.

GlyCosmos15-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T1 33-39 Disease denotes cancer MONDO:0004992
T2 263-277 Disease denotes colonic cancer MONDO:0002032|MONDO:0005575|MONDO:0021063
T5 430-435 Disease denotes tumor MONDO:0005070
T6 436-446 Disease denotes malignancy MONDO:0004992
T7 779-784 Disease denotes tumor MONDO:0005070
T8 1154-1159 Disease denotes tumor MONDO:0005070
T9 1793-1798 Disease denotes tumor MONDO:0005070
T10 1842-1847 Disease denotes tumor MONDO:0005070
T11 2026-2031 Disease denotes tumor MONDO:0005070
T12 2032-2042 Disease denotes malignancy MONDO:0004992

GlyCosmos15-Taxon

Id Subject Object Predicate Lexical cue db_id
T1 27-32 Organism denotes human 9606
T2 424-429 Organism denotes human 9606
T3 2020-2025 Organism denotes human 9606

GlyCosmos15-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 203-208 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T2 1355-1363 Body_part denotes segments http://purl.obolibrary.org/obo/UBERON_0000914

GlyCosmos15-FMA

Id Subject Object Predicate Lexical cue db_id
T1 203-208 Body_part denotes blood FMA:9670

GlyCosmos15-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 203-208 Body_part denotes blood http://purl.obolibrary.org/obo/MAT_0000315
T2 263-270 Body_part denotes colonic http://purl.obolibrary.org/obo/MAT_0000526

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 27-32 OrganismTaxon denotes human 9606
T2 424-429 OrganismTaxon denotes human 9606
T3 2020-2025 OrganismTaxon denotes human 9606

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 203-208 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T2 1355-1363 Body_part denotes segments http://purl.obolibrary.org/obo/UBERON_0000914

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 33-44 Cell denotes cancer cell http://purl.obolibrary.org/obo/CL:0001064
T2 271-282 Cell denotes cancer cell http://purl.obolibrary.org/obo/CL:0001064
T3 779-789 Cell denotes tumor cell http://purl.obolibrary.org/obo/CL:0001063
T4 1154-1165 Cell denotes tumor cells http://purl.obolibrary.org/obo/CL:0001063
T5 1793-1804 Cell denotes tumor cells http://purl.obolibrary.org/obo/CL:0001063
T6 1842-1853 Cell denotes tumor cells http://purl.obolibrary.org/obo/CL:0001063