PubMed:10972135 JSONTXT

{"project":"GlyCosmos6-Glycan-Motif-Image","denotations":[{"id":"T1","span":{"begin":949,"end":960},"obj":"Glycan_Motif"},{"id":"T2","span":{"begin":974,"end":980},"obj":"Glycan_Motif"},{"id":"T3","span":{"begin":1000,"end":1011},"obj":"Glycan_Motif"}],"attributes":[{"id":"A1","pred":"image","subj":"T1","obj":"https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81533KY"},{"id":"A2","pred":"image","subj":"T2","obj":"https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G82576YO"},{"id":"A3","pred":"image","subj":"T3","obj":"https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81533KY"}],"text":"Haptoglobin glycoforms in a case of carbohydrate-deficient glycoprotein syndrome.\nAlterations in haptoglobin (Hp) glycosylation were examined in the plasma of the first patient with carbohydrate-deficient glycoprotein syndrome (CDGS) who was described in Poland. Hp concentration in the CDGS patient plasma was low (240 mg/l) and the Hp phenotype was shown to be 2-2. Three glycoforms of the Hp beta subunit were observed in SDS-PAGE in CDGS. The densitometric analysis and molecular weight determinations suggested that 50% of glycoforms were fully glycosylated; 30% contained three out of four and 20% only two out of four glycan units compared to those that are present in Hp derived from healthy people. Results with lectins (concanavalin A and Sambucus nigra, Maackia amurensis and Alleuria aurantia agglutinins) indicate that all three glycoforms of beta subunit of CDGS-Hp contained biantennary complex glycans terminated with alpha2,6 bound sialic acid, but without fucose or alpha2,3 linked sialic acid. Hp glycosylation abnormalities described in this work suggest that this case was a type I carbohydrate-deficient glycoprotein syndrome."}

{"project":"GlyCosmos6-Glycan-Motif-Structure","denotations":[{"id":"T1","span":{"begin":949,"end":960},"obj":"https://glytoucan.org/Structures/Glycans/G81533KY"},{"id":"T2","span":{"begin":974,"end":980},"obj":"https://glytoucan.org/Structures/Glycans/G82576YO"},{"id":"T3","span":{"begin":1000,"end":1011},"obj":"https://glytoucan.org/Structures/Glycans/G81533KY"}],"text":"Haptoglobin glycoforms in a case of carbohydrate-deficient glycoprotein syndrome.\nAlterations in haptoglobin (Hp) glycosylation were examined in the plasma of the first patient with carbohydrate-deficient glycoprotein syndrome (CDGS) who was described in Poland. Hp concentration in the CDGS patient plasma was low (240 mg/l) and the Hp phenotype was shown to be 2-2. Three glycoforms of the Hp beta subunit were observed in SDS-PAGE in CDGS. The densitometric analysis and molecular weight determinations suggested that 50% of glycoforms were fully glycosylated; 30% contained three out of four and 20% only two out of four glycan units compared to those that are present in Hp derived from healthy people. Results with lectins (concanavalin A and Sambucus nigra, Maackia amurensis and Alleuria aurantia agglutinins) indicate that all three glycoforms of beta subunit of CDGS-Hp contained biantennary complex glycans terminated with alpha2,6 bound sialic acid, but without fucose or alpha2,3 linked sialic acid. Hp glycosylation abnormalities described in this work suggest that this case was a type I carbohydrate-deficient glycoprotein syndrome."}

{"project":"sentences","denotations":[{"id":"TextSentencer_T1","span":{"begin":0,"end":81},"obj":"Sentence"},{"id":"TextSentencer_T2","span":{"begin":82,"end":262},"obj":"Sentence"},{"id":"TextSentencer_T3","span":{"begin":263,"end":367},"obj":"Sentence"},{"id":"TextSentencer_T4","span":{"begin":368,"end":442},"obj":"Sentence"},{"id":"TextSentencer_T5","span":{"begin":443,"end":707},"obj":"Sentence"},{"id":"TextSentencer_T6","span":{"begin":708,"end":1012},"obj":"Sentence"},{"id":"TextSentencer_T7","span":{"begin":1013,"end":1148},"obj":"Sentence"},{"id":"T1","span":{"begin":0,"end":81},"obj":"Sentence"},{"id":"T2","span":{"begin":82,"end":262},"obj":"Sentence"},{"id":"T3","span":{"begin":263,"end":367},"obj":"Sentence"},{"id":"T4","span":{"begin":368,"end":442},"obj":"Sentence"},{"id":"T5","span":{"begin":443,"end":707},"obj":"Sentence"},{"id":"T6","span":{"begin":708,"end":1012},"obj":"Sentence"},{"id":"T7","span":{"begin":1013,"end":1148},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"text":"Haptoglobin glycoforms in a case of carbohydrate-deficient glycoprotein syndrome.\nAlterations in haptoglobin (Hp) glycosylation were examined in the plasma of the first patient with carbohydrate-deficient glycoprotein syndrome (CDGS) who was described in Poland. Hp concentration in the CDGS patient plasma was low (240 mg/l) and the Hp phenotype was shown to be 2-2. Three glycoforms of the Hp beta subunit were observed in SDS-PAGE in CDGS. The densitometric analysis and molecular weight determinations suggested that 50% of glycoforms were fully glycosylated; 30% contained three out of four and 20% only two out of four glycan units compared to those that are present in Hp derived from healthy people. Results with lectins (concanavalin A and Sambucus nigra, Maackia amurensis and Alleuria aurantia agglutinins) indicate that all three glycoforms of beta subunit of CDGS-Hp contained biantennary complex glycans terminated with alpha2,6 bound sialic acid, but without fucose or alpha2,3 linked sialic acid. Hp glycosylation abnormalities described in this work suggest that this case was a type I carbohydrate-deficient glycoprotein syndrome."}

{"project":"PubmedHPO","denotations":[{"id":"T1","span":{"begin":1016,"end":1043},"obj":"HP_0012345"}],"text":"Haptoglobin glycoforms in a case of carbohydrate-deficient glycoprotein syndrome.\nAlterations in haptoglobin (Hp) glycosylation were examined in the plasma of the first patient with carbohydrate-deficient glycoprotein syndrome (CDGS) who was described in Poland. Hp concentration in the CDGS patient plasma was low (240 mg/l) and the Hp phenotype was shown to be 2-2. Three glycoforms of the Hp beta subunit were observed in SDS-PAGE in CDGS. The densitometric analysis and molecular weight determinations suggested that 50% of glycoforms were fully glycosylated; 30% contained three out of four and 20% only two out of four glycan units compared to those that are present in Hp derived from healthy people. Results with lectins (concanavalin A and Sambucus nigra, Maackia amurensis and Alleuria aurantia agglutinins) indicate that all three glycoforms of beta subunit of CDGS-Hp contained biantennary complex glycans terminated with alpha2,6 bound sialic acid, but without fucose or alpha2,3 linked sialic acid. Hp glycosylation abnormalities described in this work suggest that this case was a type I carbohydrate-deficient glycoprotein syndrome."}

{"project":"mondo_disease","denotations":[{"id":"T1","span":{"begin":36,"end":80},"obj":"Disease"},{"id":"T2","span":{"begin":182,"end":226},"obj":"Disease"},{"id":"T3","span":{"begin":228,"end":232},"obj":"Disease"},{"id":"T4","span":{"begin":287,"end":291},"obj":"Disease"},{"id":"T5","span":{"begin":437,"end":441},"obj":"Disease"},{"id":"T6","span":{"begin":872,"end":876},"obj":"Disease"},{"id":"T7","span":{"begin":1103,"end":1147},"obj":"Disease"}],"attributes":[{"id":"A1","pred":"mondo_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/MONDO_0015286"},{"id":"A2","pred":"mondo_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/MONDO_0015286"},{"id":"A3","pred":"mondo_id","subj":"T3","obj":"http://purl.obolibrary.org/obo/MONDO_0015286"},{"id":"A4","pred":"mondo_id","subj":"T4","obj":"http://purl.obolibrary.org/obo/MONDO_0015286"},{"id":"A5","pred":"mondo_id","subj":"T5","obj":"http://purl.obolibrary.org/obo/MONDO_0015286"},{"id":"A6","pred":"mondo_id","subj":"T6","obj":"http://purl.obolibrary.org/obo/MONDO_0015286"},{"id":"A7","pred":"mondo_id","subj":"T7","obj":"http://purl.obolibrary.org/obo/MONDO_0015286"}],"text":"Haptoglobin glycoforms in a case of carbohydrate-deficient glycoprotein syndrome.\nAlterations in haptoglobin (Hp) glycosylation were examined in the plasma of the first patient with carbohydrate-deficient glycoprotein syndrome (CDGS) who was described in Poland. Hp concentration in the CDGS patient plasma was low (240 mg/l) and the Hp phenotype was shown to be 2-2. Three glycoforms of the Hp beta subunit were observed in SDS-PAGE in CDGS. The densitometric analysis and molecular weight determinations suggested that 50% of glycoforms were fully glycosylated; 30% contained three out of four and 20% only two out of four glycan units compared to those that are present in Hp derived from healthy people. Results with lectins (concanavalin A and Sambucus nigra, Maackia amurensis and Alleuria aurantia agglutinins) indicate that all three glycoforms of beta subunit of CDGS-Hp contained biantennary complex glycans terminated with alpha2,6 bound sialic acid, but without fucose or alpha2,3 linked sialic acid. Hp glycosylation abnormalities described in this work suggest that this case was a type I carbohydrate-deficient glycoprotein syndrome."}

{"project":"NCBITAXON","denotations":[{"id":"T1","span":{"begin":169,"end":176},"obj":"OrganismTaxon"},{"id":"T2","span":{"begin":292,"end":299},"obj":"OrganismTaxon"},{"id":"T3","span":{"begin":749,"end":763},"obj":"OrganismTaxon"},{"id":"T4","span":{"begin":765,"end":782},"obj":"OrganismTaxon"}],"attributes":[{"id":"A1","pred":"db_id","subj":"T1","obj":"9606"},{"id":"A2","pred":"db_id","subj":"T2","obj":"9606"},{"id":"A3","pred":"db_id","subj":"T3","obj":"4202"},{"id":"A4","pred":"db_id","subj":"T4","obj":"37501"}],"text":"Haptoglobin glycoforms in a case of carbohydrate-deficient glycoprotein syndrome.\nAlterations in haptoglobin (Hp) glycosylation were examined in the plasma of the first patient with carbohydrate-deficient glycoprotein syndrome (CDGS) who was described in Poland. Hp concentration in the CDGS patient plasma was low (240 mg/l) and the Hp phenotype was shown to be 2-2. Three glycoforms of the Hp beta subunit were observed in SDS-PAGE in CDGS. The densitometric analysis and molecular weight determinations suggested that 50% of glycoforms were fully glycosylated; 30% contained three out of four and 20% only two out of four glycan units compared to those that are present in Hp derived from healthy people. Results with lectins (concanavalin A and Sambucus nigra, Maackia amurensis and Alleuria aurantia agglutinins) indicate that all three glycoforms of beta subunit of CDGS-Hp contained biantennary complex glycans terminated with alpha2,6 bound sialic acid, but without fucose or alpha2,3 linked sialic acid. Hp glycosylation abnormalities described in this work suggest that this case was a type I carbohydrate-deficient glycoprotein syndrome."}

{"project":"Anatomy-UBERON","denotations":[{"id":"T1","span":{"begin":149,"end":155},"obj":"Body_part"},{"id":"T2","span":{"begin":300,"end":306},"obj":"Body_part"}],"attributes":[{"id":"A1","pred":"uberon_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/UBERON_0001969"},{"id":"A2","pred":"uberon_id","subj":"T2","obj":"http://purl.obolibrary.org/obo/UBERON_0001969"}],"text":"Haptoglobin glycoforms in a case of carbohydrate-deficient glycoprotein syndrome.\nAlterations in haptoglobin (Hp) glycosylation were examined in the plasma of the first patient with carbohydrate-deficient glycoprotein syndrome (CDGS) who was described in Poland. Hp concentration in the CDGS patient plasma was low (240 mg/l) and the Hp phenotype was shown to be 2-2. Three glycoforms of the Hp beta subunit were observed in SDS-PAGE in CDGS. The densitometric analysis and molecular weight determinations suggested that 50% of glycoforms were fully glycosylated; 30% contained three out of four and 20% only two out of four glycan units compared to those that are present in Hp derived from healthy people. Results with lectins (concanavalin A and Sambucus nigra, Maackia amurensis and Alleuria aurantia agglutinins) indicate that all three glycoforms of beta subunit of CDGS-Hp contained biantennary complex glycans terminated with alpha2,6 bound sialic acid, but without fucose or alpha2,3 linked sialic acid. Hp glycosylation abnormalities described in this work suggest that this case was a type I carbohydrate-deficient glycoprotein syndrome."}

{"project":"CL-cell","denotations":[{"id":"T1","span":{"begin":1096,"end":1102},"obj":"Cell"}],"attributes":[{"id":"A1","pred":"cl_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/CL:0004120"},{"id":"A2","pred":"cl_id","subj":"T1","obj":"http://purl.obolibrary.org/obo/CL:0004138"}],"text":"Haptoglobin glycoforms in a case of carbohydrate-deficient glycoprotein syndrome.\nAlterations in haptoglobin (Hp) glycosylation were examined in the plasma of the first patient with carbohydrate-deficient glycoprotein syndrome (CDGS) who was described in Poland. Hp concentration in the CDGS patient plasma was low (240 mg/l) and the Hp phenotype was shown to be 2-2. Three glycoforms of the Hp beta subunit were observed in SDS-PAGE in CDGS. The densitometric analysis and molecular weight determinations suggested that 50% of glycoforms were fully glycosylated; 30% contained three out of four and 20% only two out of four glycan units compared to those that are present in Hp derived from healthy people. Results with lectins (concanavalin A and Sambucus nigra, Maackia amurensis and Alleuria aurantia agglutinins) indicate that all three glycoforms of beta subunit of CDGS-Hp contained biantennary complex glycans terminated with alpha2,6 bound sialic acid, but without fucose or alpha2,3 linked sialic acid. Hp glycosylation abnormalities described in this work suggest that this case was a type I carbohydrate-deficient glycoprotein syndrome."}