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PubMed:10950949 JSONTXT

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sentences

Id Subject Object Predicate Lexical cue
T1 0-117 Sentence denotes Identification of residues important both for primary receptor binding and specificity in fibroblast growth factor-7.
T2 118-275 Sentence denotes Fibroblast growth factors (FGFs) mediate a multitude of physiological and pathological processes by activating a family of tyrosine kinase receptors (FGFRs).
T3 276-390 Sentence denotes Each FGFR binds to a unique subset of FGFs and ligand binding specificity is essential in regulating FGF activity.
T4 391-587 Sentence denotes FGF-7 recognizes one FGFR isoform known as the FGFR2 IIIb isoform or keratinocyte growth factor receptor (KGFR), whereas FGF-2 binds well to FGFR1, FGFR2, and FGFR4 but interacts poorly with KGFR.
T5 588-746 Sentence denotes Previously, mutations in FGF-2 identified a set of residues that are important for high affinity receptor binding, known as the primary receptor-binding site.
T6 747-838 Sentence denotes FGF-7 contains this primary site as well as a region that restricts interaction with FGFR1.
T7 839-928 Sentence denotes The sequences that confer on FGF-7 its specific binding to KGFR have not been identified.
T8 929-1143 Sentence denotes By utilizing domain swapping and site-directed mutagenesis we have found that the loop connecting the beta4-beta5 strands of FGF-7 contributes to high affinity receptor binding and is critical for KGFR recognition.
T9 1144-1337 Sentence denotes Replacement of this loop with the homologous loop from FGF-2 dramatically reduced both the affinity of FGF-7 for KGFR and its biological potency but did not result in the ability to bind FGFR1.
T10 1338-1449 Sentence denotes Point mutations in residues comprising this loop of FGF-7 reduced both binding affinity and biological potency.
T11 1450-1553 Sentence denotes The reciprocal loop replacement mutant (FGF2-L4/7) retained FGF-2 like affinity for FGFR1 and for KGFR.
T12 1554-1780 Sentence denotes Our results show that topologically similar regions in these two FGFs have different roles in regulating receptor binding specificity and suggest that specificity may require the concerted action of distinct regions of an FGF.

FSU-PRGE

Id Subject Object Predicate Lexical cue
T1 90-116 protein denotes fibroblast growth factor-7
T2 118-143 protein denotes Fibroblast growth factors
T3 145-149 protein denotes FGFs
T4 231-266 protein denotes family of tyrosine kinase receptors
T5 268-273 protein denotes FGFRs
T6 281-285 protein denotes FGFR
T7 314-318 protein denotes FGFs
T8 377-380 protein denotes FGF
T9 391-396 protein denotes FGF-7
T10 412-416 protein denotes FGFR
T11 438-443 protein denotes FGFR2
T12 460-495 protein denotes keratinocyte growth factor receptor
T13 497-501 protein denotes KGFR
T14 512-517 protein denotes FGF-2
T15 532-537 protein denotes FGFR1
T16 539-544 protein denotes FGFR2
T17 550-555 protein denotes FGFR4
T18 582-586 protein denotes KGFR
T19 613-618 protein denotes FGF-2
T20 747-752 protein denotes FGF-7
T21 832-837 protein denotes FGFR1
T22 868-873 protein denotes FGF-7
T23 898-902 protein denotes KGFR
T24 1054-1059 protein denotes FGF-7
T25 1126-1130 protein denotes KGFR
T26 1199-1204 protein denotes FGF-2
T27 1247-1252 protein denotes FGF-7
T28 1257-1261 protein denotes KGFR
T29 1331-1336 protein denotes FGFR1
T30 1390-1395 protein denotes FGF-7
T31 1490-1494 protein denotes FGF2
T32 1510-1515 protein denotes FGF-2
T33 1534-1539 protein denotes FGFR1
T34 1548-1552 protein denotes KGFR
T35 1619-1623 protein denotes FGFs
T36 1776-1779 protein denotes FGF

AIMed

Id Subject Object Predicate Lexical cue
T1 90-116 protein denotes fibroblast growth factor-7
T2 391-396 protein denotes FGF-7
T3 438-448 protein denotes FGFR2 IIIb
T4 460-495 protein denotes keratinocyte growth factor receptor
T5 497-501 protein denotes KGFR
T6 512-517 protein denotes FGF-2
T7 532-537 protein denotes FGFR1
T8 539-544 protein denotes FGFR2
T9 550-555 protein denotes FGFR4
T10 582-586 protein denotes KGFR
T11 613-618 protein denotes FGF-2
T12 747-752 protein denotes FGF-7
T13 832-837 protein denotes FGFR1
T14 868-873 protein denotes FGF-7
T15 898-902 protein denotes KGFR
T16 1054-1059 protein denotes FGF-7
T17 1126-1130 protein denotes KGFR
T18 1199-1204 protein denotes FGF-2
T19 1247-1252 protein denotes FGF-7
T20 1257-1261 protein denotes KGFR
T21 1331-1336 protein denotes FGFR1
T22 1390-1395 protein denotes FGF-7
T23 1490-1494 protein denotes FGF2
T24 1510-1515 protein denotes FGF-2
T25 1534-1539 protein denotes FGFR1
T26 1548-1552 protein denotes KGFR

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 90-100 Body_part denotes fibroblast http://purl.obolibrary.org/obo/CL_0000057
T2 118-128 Body_part denotes Fibroblast http://purl.obolibrary.org/obo/CL_0000057
T3 460-472 Body_part denotes keratinocyte http://purl.obolibrary.org/obo/CL_0000312

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 90-100 Cell denotes fibroblast http://purl.obolibrary.org/obo/CL:0000057
T2 118-128 Cell denotes Fibroblast http://purl.obolibrary.org/obo/CL:0000057
T3 460-472 Cell denotes keratinocyte http://purl.obolibrary.org/obo/CL:0000312