> top > docs > PubMed:10945470 > annotations

PubMed:10945470 JSONTXT

Annnotations TAB JSON ListView MergeView

sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-74 Sentence denotes MEPE, a new gene expressed in bone marrow and tumors causing osteomalacia.
TextSentencer_T2 75-268 Sentence denotes Oncogenic hypophosphatemic osteomalacia (OHO) is characterized by a renal phosphate leak, hypophosphatemia, low-serum calcitriol (1,25-vitamin-D3), and abnormalities in skeletal mineralization.
TextSentencer_T3 269-425 Sentence denotes Resection of OHO tumors results in remission of the symptoms, and there is evidence that a circulating phosphaturic factor plays a role in the bone disease.
TextSentencer_T4 426-553 Sentence denotes This paper describes the characterization and cloning of a gene that is a candidate for the tumor-secreted phosphaturic factor.
TextSentencer_T5 554-902 Sentence denotes This new gene has been named MEPE (matrix extracellular phosphoglycoprotein) and has major similarities to a group of bone-tooth mineral matrix phospho-glycoproteins (osteopontin (OPN; HGMW-approved symbol SPP1), dentin sialo phosphoprotein (DSPP), dentin matrix protein 1 (DMP1), bone sialoprotein II (IBSP), and bone morphogenetic proteins (BMP).
TextSentencer_T6 903-1032 Sentence denotes All the proteins including MEPE contain RGD sequence motifs that are proposed to be essential for integrin-receptor interactions.
TextSentencer_T7 1033-1156 Sentence denotes Of further interest is the finding that MEPE, OPN, DSPP, DMP1, IBSP, and BMP3 all map to a defined region in chromosome 4q.
TextSentencer_T8 1157-1251 Sentence denotes Refined mapping localizes MEPE to 4q21.1 between ESTs D4S2785 (WI-6336) and D4S2844 (WI-3770).
TextSentencer_T9 1252-1322 Sentence denotes MEPE is 525 residues in length with a short N-terminal signal peptide.
TextSentencer_T10 1323-1399 Sentence denotes High-level expression of MEPE mRNA occurred in all four OHO tumors screened.
TextSentencer_T11 1400-1533 Sentence denotes Three of 11 non-OHO tumors screened contained trace levels of MEPE expression (detected only after RT-PCR and Southern 32P analysis).
TextSentencer_T12 1534-1667 Sentence denotes Normal tissue expression was found in bone marrow and brain with very-low-level expression found in lung, kidney, and human placenta.
TextSentencer_T13 1668-1840 Sentence denotes Evidence is also presented for the tumor secretion of clusterin (HGMW-approved symbol CLU) and its possible role as a cytotoxic factor in one of the OHO patients described.
T1 0-74 Sentence denotes MEPE, a new gene expressed in bone marrow and tumors causing osteomalacia.
T2 75-268 Sentence denotes Oncogenic hypophosphatemic osteomalacia (OHO) is characterized by a renal phosphate leak, hypophosphatemia, low-serum calcitriol (1,25-vitamin-D3), and abnormalities in skeletal mineralization.
T3 269-425 Sentence denotes Resection of OHO tumors results in remission of the symptoms, and there is evidence that a circulating phosphaturic factor plays a role in the bone disease.
T4 426-553 Sentence denotes This paper describes the characterization and cloning of a gene that is a candidate for the tumor-secreted phosphaturic factor.
T5 554-902 Sentence denotes This new gene has been named MEPE (matrix extracellular phosphoglycoprotein) and has major similarities to a group of bone-tooth mineral matrix phospho-glycoproteins (osteopontin (OPN; HGMW-approved symbol SPP1), dentin sialo phosphoprotein (DSPP), dentin matrix protein 1 (DMP1), bone sialoprotein II (IBSP), and bone morphogenetic proteins (BMP).
T6 903-1032 Sentence denotes All the proteins including MEPE contain RGD sequence motifs that are proposed to be essential for integrin-receptor interactions.
T7 1033-1156 Sentence denotes Of further interest is the finding that MEPE, OPN, DSPP, DMP1, IBSP, and BMP3 all map to a defined region in chromosome 4q.
T8 1157-1251 Sentence denotes Refined mapping localizes MEPE to 4q21.1 between ESTs D4S2785 (WI-6336) and D4S2844 (WI-3770).
T9 1252-1322 Sentence denotes MEPE is 525 residues in length with a short N-terminal signal peptide.
T10 1323-1399 Sentence denotes High-level expression of MEPE mRNA occurred in all four OHO tumors screened.
T11 1400-1533 Sentence denotes Three of 11 non-OHO tumors screened contained trace levels of MEPE expression (detected only after RT-PCR and Southern 32P analysis).
T12 1534-1667 Sentence denotes Normal tissue expression was found in bone marrow and brain with very-low-level expression found in lung, kidney, and human placenta.
T13 1668-1840 Sentence denotes Evidence is also presented for the tumor secretion of clusterin (HGMW-approved symbol CLU) and its possible role as a cytotoxic factor in one of the OHO patients described.

performance-test

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 1588-1593 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
PD-UBERON-AE-B_T2 1541-1547 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissue
PD-UBERON-AE-B_T3 1634-1638 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
PD-UBERON-AE-B_T4 30-41 http://purl.obolibrary.org/obo/UBERON_0002371 denotes bone marrow
PD-UBERON-AE-B_T5 1572-1583 http://purl.obolibrary.org/obo/UBERON_0002371 denotes bone marrow
PD-UBERON-AE-B_T6 187-192 http://purl.obolibrary.org/obo/UBERON_0001977 denotes serum
PD-UBERON-AE-B_T7 767-773 http://purl.obolibrary.org/obo/UBERON_0001751 denotes dentin
PD-UBERON-AE-B_T8 803-809 http://purl.obolibrary.org/obo/UBERON_0001751 denotes dentin
PD-UBERON-AE-B_T9 1640-1646 http://purl.obolibrary.org/obo/UBERON_0002113 denotes kidney
PD-UBERON-AE-B_T10 1658-1666 http://purl.obolibrary.org/obo/UBERON_0001987 denotes placenta

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 102-114 HP_0002749 denotes osteomalacia
T2 165-181 HP_0002148 denotes hypophosphatemia
T3 227-252 HP_0000924 denotes abnormalities in skeletal
T4 286-292 HP_0002664 denotes tumors
T5 518-523 HP_0002664 denotes tumor
T6 1383-1389 HP_0002664 denotes tumors
T7 1420-1426 HP_0002664 denotes tumors
T8 1703-1708 HP_0002664 denotes tumor

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
10945470-0#0#4#gene56955 0-4 gene56955 denotes MEPE
10945470-0#61#73#diseaseC3887650 61-73 diseaseC3887650 denotes osteomalacia
0#4#gene5695561#73#diseaseC3887650 10945470-0#0#4#gene56955 10945470-0#61#73#diseaseC3887650 associated_with MEPE,osteomalacia

PubCasesHPO

Id Subject Object Predicate Lexical cue
AB1 102-114 HP:0002749 denotes osteomalacia
TI1 61-73 HP:0002749 denotes osteomalacia
AB2 165-181 HP:0002148 denotes hypophosphatemia
AB3 183-203 HP:0012052 denotes low-serum calcitriol

PubCasesORDO

Id Subject Object Predicate Lexical cue
AB1 75-114 ORDO:352540 denotes Oncogenic hypophosphatemic osteomalacia

UBERON-AE

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 30-41 http://purl.obolibrary.org/obo/UBERON_0002371 denotes bone marrow
PD-UBERON-AE-B_T2 1572-1583 http://purl.obolibrary.org/obo/UBERON_0002371 denotes bone marrow
PD-UBERON-AE-B_T3 187-192 http://purl.obolibrary.org/obo/UBERON_0001977 denotes serum
PD-UBERON-AE-B_T4 767-773 http://purl.obolibrary.org/obo/UBERON_0001751 denotes dentin
PD-UBERON-AE-B_T5 803-809 http://purl.obolibrary.org/obo/UBERON_0001751 denotes dentin
PD-UBERON-AE-B_T6 1541-1547 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissue
PD-UBERON-AE-B_T7 1588-1593 http://purl.obolibrary.org/obo/UBERON_0000955 denotes brain
PD-UBERON-AE-B_T8 1634-1638 http://purl.obolibrary.org/obo/UBERON_0002048 denotes lung
PD-UBERON-AE-B_T9 1640-1646 http://purl.obolibrary.org/obo/UBERON_0002113 denotes kidney
PD-UBERON-AE-B_T10 1658-1666 http://purl.obolibrary.org/obo/UBERON_0001987 denotes placenta

DisGeNET

Id Subject Object Predicate Lexical cue
T0 1722-1731 gene:1191 denotes clusterin
T1 1817-1820 disease:C0029442 denotes OHO
T2 1754-1757 gene:1191 denotes CLU
T3 1817-1820 disease:C0029442 denotes OHO
R1 T0 T1 associated_with clusterin,OHO
R2 T2 T3 associated_with CLU,OHO