PubMed:10942934 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/10942934","sourcedb":"PubMed","sourceid":"10942934","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/10942934","text":"Juvenile hemochromatosis associated with B-thalassemia treated by phlebotomy and recombinant human erythropoietin.\nJuvenile hemochromatosis is a rare genetic disorder that causes iron overload. Clinical complications, which include liver cirrhosis, heart failure, hypogonadotropic hypogonadism and diabetes, appear earlier and are more severe than in HFE-related hemochromatosis. This disorder, therefore, requires an aggressive therapeutic approach to achieve iron depletion. We report here the case of a young Italian female with juvenile hemochromatosis who was unable to tolerate frequent phlebotomy because of coexistent ss-thalassemia trait. The patient was successfully iron-depleted by combining phlebotomy with recombinant human erythropoietin.","tracks":[{"project":"performance-test","denotations":[{"id":"PD-UBERON-AE-B_T1","span":{"begin":249,"end":254},"obj":"http://purl.obolibrary.org/obo/UBERON_0000948"},{"id":"PD-UBERON-AE-B_T2","span":{"begin":232,"end":237},"obj":"http://purl.obolibrary.org/obo/UBERON_0002107"}],"attributes":[{"subj":"PD-UBERON-AE-B_T1","pred":"source","obj":"performance-test"},{"subj":"PD-UBERON-AE-B_T2","pred":"source","obj":"performance-test"}]},{"project":"PubmedHPO","denotations":[{"id":"T1","span":{"begin":238,"end":247},"obj":"HP_0001394"},{"id":"T2","span":{"begin":249,"end":262},"obj":"HP_0001635"},{"id":"T3","span":{"begin":264,"end":293},"obj":"HP_0000044"},{"id":"T4","span":{"begin":281,"end":293},"obj":"HP_0000135"},{"id":"T5","span":{"begin":418,"end":428},"obj":"HP_0000718"}],"attributes":[{"subj":"T1","pred":"source","obj":"PubmedHPO"},{"subj":"T2","pred":"source","obj":"PubmedHPO"},{"subj":"T3","pred":"source","obj":"PubmedHPO"},{"subj":"T4","pred":"source","obj":"PubmedHPO"},{"subj":"T5","pred":"source","obj":"PubmedHPO"}]},{"project":"DisGeNET5_gene_disease","denotations":[{"id":"10942934-0#99#113#gene2056","span":{"begin":99,"end":113},"obj":"gene2056"},{"id":"10942934-0#0#24#diseaseC0268060","span":{"begin":0,"end":24},"obj":"diseaseC0268060"},{"id":"10942934-2#157#160#gene3077","span":{"begin":351,"end":354},"obj":"gene3077"},{"id":"10942934-2#169#184#diseaseC0018995","span":{"begin":363,"end":378},"obj":"diseaseC0018995"},{"id":"10942934-2#169#184#diseaseC3469186","span":{"begin":363,"end":378},"obj":"diseaseC3469186"}],"relations":[{"id":"99#113#gene20560#24#diseaseC0268060","pred":"associated_with","subj":"10942934-0#99#113#gene2056","obj":"10942934-0#0#24#diseaseC0268060"},{"id":"157#160#gene3077169#184#diseaseC0018995","pred":"associated_with","subj":"10942934-2#157#160#gene3077","obj":"10942934-2#169#184#diseaseC0018995"},{"id":"157#160#gene3077169#184#diseaseC3469186","pred":"associated_with","subj":"10942934-2#157#160#gene3077","obj":"10942934-2#169#184#diseaseC3469186"}],"attributes":[{"subj":"10942934-0#99#113#gene2056","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"10942934-0#0#24#diseaseC0268060","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"10942934-2#157#160#gene3077","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"10942934-2#169#184#diseaseC0018995","pred":"source","obj":"DisGeNET5_gene_disease"},{"subj":"10942934-2#169#184#diseaseC3469186","pred":"source","obj":"DisGeNET5_gene_disease"}]},{"project":"PubCasesHPO","denotations":[{"id":"AB1","span":{"begin":238,"end":247},"obj":"HP:0001394"},{"id":"AB2","span":{"begin":281,"end":293},"obj":"HP:0000135"}],"attributes":[{"subj":"AB1","pred":"source","obj":"PubCasesHPO"},{"subj":"AB2","pred":"source","obj":"PubCasesHPO"}]},{"project":"sentences","denotations":[{"id":"TextSentencer_T1","span":{"begin":0,"end":114},"obj":"Sentence"},{"id":"TextSentencer_T2","span":{"begin":115,"end":193},"obj":"Sentence"},{"id":"TextSentencer_T3","span":{"begin":194,"end":379},"obj":"Sentence"},{"id":"TextSentencer_T4","span":{"begin":380,"end":476},"obj":"Sentence"},{"id":"TextSentencer_T5","span":{"begin":477,"end":647},"obj":"Sentence"},{"id":"TextSentencer_T6","span":{"begin":648,"end":753},"obj":"Sentence"},{"id":"T1","span":{"begin":0,"end":114},"obj":"Sentence"},{"id":"T2","span":{"begin":115,"end":193},"obj":"Sentence"},{"id":"T3","span":{"begin":194,"end":379},"obj":"Sentence"},{"id":"T4","span":{"begin":380,"end":476},"obj":"Sentence"},{"id":"T5","span":{"begin":477,"end":647},"obj":"Sentence"},{"id":"T6","span":{"begin":648,"end":753},"obj":"Sentence"}],"namespaces":[{"prefix":"_base","uri":"http://pubannotation.org/ontology/tao.owl#"}],"attributes":[{"subj":"TextSentencer_T1","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T2","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T3","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T4","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T5","pred":"source","obj":"sentences"},{"subj":"TextSentencer_T6","pred":"source","obj":"sentences"},{"subj":"T1","pred":"source","obj":"sentences"},{"subj":"T2","pred":"source","obj":"sentences"},{"subj":"T3","pred":"source","obj":"sentences"},{"subj":"T4","pred":"source","obj":"sentences"},{"subj":"T5","pred":"source","obj":"sentences"},{"subj":"T6","pred":"source","obj":"sentences"}]},{"project":"PubCasesORDO","denotations":[{"id":"AB1","span":{"begin":115,"end":139},"obj":"ORDO:79230"},{"id":"AB2","span":{"begin":532,"end":556},"obj":"ORDO:79230"}],"namespaces":[{"prefix":"ORDO","uri":"http://www.orpha.net/ORDO/Orphanet_"}],"attributes":[{"subj":"AB1","pred":"source","obj":"PubCasesORDO"},{"subj":"AB2","pred":"source","obj":"PubCasesORDO"}]},{"project":"UBERON-AE","denotations":[{"id":"PD-UBERON-AE-B_T1","span":{"begin":232,"end":237},"obj":"http://purl.obolibrary.org/obo/UBERON_0002107"},{"id":"PD-UBERON-AE-B_T2","span":{"begin":249,"end":254},"obj":"http://purl.obolibrary.org/obo/UBERO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