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PubMed:10938272 JSONTXT

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sentences

Id Subject Object Predicate Lexical cue
T1 0-153 Sentence denotes Rapid induction of histone hyperacetylation and cellular differentiation in human breast tumor cell lines following degradation of histone deacetylase-1.
T2 154-264 Sentence denotes Quinidine inhibits proliferation and promotes cellular differentiation in human breast tumor epithelial cells.
T3 265-419 Sentence denotes Previously we showed quinidine arrested MCF-7 cells in G(1) phase of the cell cycle and led to a G(1) to G(0) transition followed by apoptotic cell death.
T4 420-597 Sentence denotes The present experiments demonstrated that MCF-7, MCF-7ras, T47D, MDA-MB-231, and MDA-MB-435 cells transiently differentiate before undergoing apoptosis in response to quinidine.
T5 598-688 Sentence denotes The cells accumulated lipid droplets, and the cytokeratin 18 cytoskeleton was reorganized.
T6 689-812 Sentence denotes Hyperacetylated histone H4 appeared within 2 h of the addition of quinidine to the medium, and levels were maximal by 24 h.
T7 813-1111 Sentence denotes Quinidine-treated MCF-7 cells showed elevated p21(WAF1), hypophosphorylation and suppression of retinoblastoma protein, and down-regulation of cyclin D1, similar to the cell cycle response observed with cells induced to differentiate by histone deacetylase inhibitors, trichostatin A, and trapoxin.
T8 1112-1217 Sentence denotes Quinidine did not show evidence for direct inhibition of histone deacetylase enzymatic activity in vitro.
T9 1218-1312 Sentence denotes HDAC1 was undetectable in MCF-7 cells 30 min after addition of quinidine to the growth medium.
T10 1313-1418 Sentence denotes The proteasome inhibitors MG-132 and lactacystin completely protected HDAC1 from the action of quinidine.
T11 1419-1559 Sentence denotes We conclude that quinidine is a breast tumor cell differentiating agent that causes the loss of HDAC1 via a proteasomal sensitive mechanism.

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 234-246 HP_0003002 denotes breast tumor
T2 234-246 HP_0100013 denotes breast tumor
T3 241-246 HP_0002664 denotes tumor
T4 909-923 HP_0009919 denotes retinoblastoma
T5 1451-1463 HP_0003002 denotes breast tumor
T6 1451-1463 HP_0100013 denotes breast tumor
T7 1458-1463 HP_0002664 denotes tumor

bionlp-st-epi-2011-training

Id Subject Object Predicate Lexical cue
T1 19-26 Protein denotes histone
T2 131-152 Protein denotes histone deacetylase-1
T3 644-658 Protein denotes cytokeratin 18
T4 705-715 Protein denotes histone H4
T5 859-862 Protein denotes p21
T6 863-867 Protein denotes WAF1
T7 909-923 Protein denotes retinoblastoma
T8 956-965 Protein denotes cyclin D1
T9 1050-1057 Protein denotes histone
T10 1169-1176 Protein denotes histone
T11 1218-1223 Protein denotes HDAC1
T12 1383-1388 Protein denotes HDAC1
T13 1515-1520 Protein denotes HDAC1

2015-BEL-Sample-2

Id Subject Object Predicate Lexical cue
BEL:20024938 813-1110 a(CHEBI:quinidine) decreases p(HGNC:CCND1) denotes Quinidine-treated MCF-7 cells showed elevated p21(WAF1), hypophosphorylation and suppression of retinoblastoma protein, and down-regulation of cyclin D1, similar to the cell cycle response observed with cells induced to differentiate by histone deacetylase inhibitors, trichostatin A, and trapoxin
BEL:20024940 813-1110 a(CHEBI:quinidine) increases p(HGNC:CDKN1A) denotes Quinidine-treated MCF-7 cells showed elevated p21(WAF1), hypophosphorylation and suppression of retinoblastoma protein, and down-regulation of cyclin D1, similar to the cell cycle response observed with cells induced to differentiate by histone deacetylase inhibitors, trichostatin A, and trapoxin
BEL:20024942 813-1110 a(CHEBI:quinidine) decreases p(HGNC:RB1) denotes Quinidine-treated MCF-7 cells showed elevated p21(WAF1), hypophosphorylation and suppression of retinoblastoma protein, and down-regulation of cyclin D1, similar to the cell cycle response observed with cells induced to differentiate by histone deacetylase inhibitors, trichostatin A, and trapoxin
BEL:20024944 813-1110 a(CHEBI:quinidine) decreases p(HGNC:RB1,pmod(P)) denotes Quinidine-treated MCF-7 cells showed elevated p21(WAF1), hypophosphorylation and suppression of retinoblastoma protein, and down-regulation of cyclin D1, similar to the cell cycle response observed with cells induced to differentiate by histone deacetylase inhibitors, trichostatin A, and trapoxin

GlyCosmos15-HP

Id Subject Object Predicate Lexical cue hp_id
T1 82-94 Phenotype denotes breast tumor HP:0100013
T2 234-246 Phenotype denotes breast tumor HP:0100013
T3 909-923 Phenotype denotes retinoblastoma HP:0009919
T4 1451-1463 Phenotype denotes breast tumor HP:0100013

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 82-94 Disease denotes breast tumor http://purl.obolibrary.org/obo/MONDO_0007254|http://purl.obolibrary.org/obo/MONDO_0021100
T3 234-246 Disease denotes breast tumor http://purl.obolibrary.org/obo/MONDO_0007254|http://purl.obolibrary.org/obo/MONDO_0021100
T5 909-923 Disease denotes retinoblastoma http://purl.obolibrary.org/obo/MONDO_0008380
T6 1451-1463 Disease denotes breast tumor http://purl.obolibrary.org/obo/MONDO_0007254|http://purl.obolibrary.org/obo/MONDO_0021100

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 76-81 OrganismTaxon denotes human 9606
T2 228-233 OrganismTaxon denotes human 9606

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 82-88 Body_part denotes breast http://purl.obolibrary.org/obo/UBERON_0000310
T2 234-240 Body_part denotes breast http://purl.obolibrary.org/obo/UBERON_0000310
T3 247-263 Body_part denotes epithelial cells http://purl.obolibrary.org/obo/CL_0000066
T4 338-348 Body_part denotes cell cycle http://purl.obolibrary.org/obo/UBERON_2000098
T5 659-671 Body_part denotes cytoskeleton http://purl.obolibrary.org/obo/GO_0005856
T6 982-992 Body_part denotes cell cycle http://purl.obolibrary.org/obo/UBERON_2000098
T7 1451-1457 Body_part denotes breast http://purl.obolibrary.org/obo/UBERON_0000310

Glycosmos15-CL

Id Subject Object Predicate Lexical cue cl_id
T1 89-99 Cell denotes tumor cell http://purl.obolibrary.org/obo/CL:0001063
T2 247-263 Cell denotes epithelial cells http://purl.obolibrary.org/obo/CL:0000066
T3 1458-1468 Cell denotes tumor cell http://purl.obolibrary.org/obo/CL:0001063