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PubMed:10915780 JSONTXT

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PubMed_ArguminSci

Id Subject Object Predicate Lexical cue
T1 159-294 DRI_Outcome denotes The cyclin D1 gene encodes the regulatory subunit of a holoenzyme that phosphorylates and inactivates the pRB tumor suppressor protein.
T2 295-510 DRI_Approach denotes Cyclin D1 is overexpressed in 20-30% of human breast tumors and is induced both by oncogenes including those for Ras, Neu, and Src, and by the beta-catenin/lymphoid enhancer factor (LEF)/T cell factor (TCF) pathway.
T3 511-719 DRI_Approach denotes The ankyrin repeat containing serine-threonine protein kinase, integrin-linked kinase (ILK), binds to the cytoplasmic domain of beta(1) and beta(3) integrin subunits and promotes anchorage-independent growth.
T4 720-859 DRI_Outcome denotes We show here that ILK overexpression elevates cyclin D1 protein levels and directly induces the cyclin D1 gene in mammary epithelial cells.
T5 860-937 DRI_Background denotes ILK activation of the cyclin D1 promoter was abolished by point mutation of a
T6 970-1170 DRI_Background denotes protein (CREB)/ATF-2 binding site at nucleotide -54 in the cyclin D1 promoter, and by overexpression of either glycogen synthase kinase-3beta (GSK-3beta) or dominant negative mutants of CREB or ATF-2.
T7 1171-1325 DRI_Approach denotes Inhibition of the PI 3-kinase and AKT/protein kinase B, but not of the p38, ERK, or JNK signaling pathways, reduced ILK induction of cyclin D1 expression.
T8 1326-1406 DRI_Background denotes ILK induced CREB transactivation and CREB binding to the cyclin D1 promoter CRE.
T9 1407-1605 DRI_Background denotes Wnt-1 overexpression in mammary epithelial cells induced cyclin D1 mRNA and targeted overexpression of Wnt-1 in the mammary gland of transgenic mice increased both ILK activity and cyclin D1 levels.
T10 1606-1795 DRI_Outcome denotes We conclude that the cyclin D1 gene is regulated by the Wnt-1 and ILK signaling pathways and that ILK induction of cyclin D1 involves the CREB signaling pathway in mammary epithelial cells.

sentences

Id Subject Object Predicate Lexical cue
T1 0-158 Sentence denotes The integrin-linked kinase regulates the cyclin D1 gene through glycogen synthase kinase 3beta and cAMP-responsive element-binding protein-dependent pathways.
T2 159-294 Sentence denotes The cyclin D1 gene encodes the regulatory subunit of a holoenzyme that phosphorylates and inactivates the pRB tumor suppressor protein.
T3 295-510 Sentence denotes Cyclin D1 is overexpressed in 20-30% of human breast tumors and is induced both by oncogenes including those for Ras, Neu, and Src, and by the beta-catenin/lymphoid enhancer factor (LEF)/T cell factor (TCF) pathway.
T4 511-719 Sentence denotes The ankyrin repeat containing serine-threonine protein kinase, integrin-linked kinase (ILK), binds to the cytoplasmic domain of beta(1) and beta(3) integrin subunits and promotes anchorage-independent growth.
T5 720-859 Sentence denotes We show here that ILK overexpression elevates cyclin D1 protein levels and directly induces the cyclin D1 gene in mammary epithelial cells.
T6 860-1170 Sentence denotes ILK activation of the cyclin D1 promoter was abolished by point mutation of a cAMP-responsive element-binding protein (CREB)/ATF-2 binding site at nucleotide -54 in the cyclin D1 promoter, and by overexpression of either glycogen synthase kinase-3beta (GSK-3beta) or dominant negative mutants of CREB or ATF-2.
T7 1171-1325 Sentence denotes Inhibition of the PI 3-kinase and AKT/protein kinase B, but not of the p38, ERK, or JNK signaling pathways, reduced ILK induction of cyclin D1 expression.
T8 1326-1406 Sentence denotes ILK induced CREB transactivation and CREB binding to the cyclin D1 promoter CRE.
T9 1407-1605 Sentence denotes Wnt-1 overexpression in mammary epithelial cells induced cyclin D1 mRNA and targeted overexpression of Wnt-1 in the mammary gland of transgenic mice increased both ILK activity and cyclin D1 levels.
T10 1606-1795 Sentence denotes We conclude that the cyclin D1 gene is regulated by the Wnt-1 and ILK signaling pathways and that ILK induction of cyclin D1 involves the CREB signaling pathway in mammary epithelial cells.

Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 1523-1536 http://purl.obolibrary.org/obo/MAT_0000073 denotes mammary gland
T2 1531-1536 http://purl.obolibrary.org/obo/MAT_0000021 denotes gland

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 269-274 HP_0002664 denotes tumor
T2 341-354 HP_0003002 denotes breast tumors
T3 341-354 HP_0100013 denotes breast tumors
T4 348-354 HP_0002664 denotes tumors

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
10915780-2#0#9#gene595 295-304 gene595 denotes Cyclin D1
10915780-2#46#59#diseaseC1458155 341-354 diseaseC1458155 denotes breast tumors
0#9#gene59546#59#diseaseC1458155 10915780-2#0#9#gene595 10915780-2#46#59#diseaseC1458155 associated_with Cyclin D1,breast tumors

2015-BEL-Sample-2

Id Subject Object Predicate Lexical cue
BEL:20036752 720-860 kin(p(HGNC:ILK)) increases p(HGNC:CCND1) denotes We show here that ILK overexpression elevates cyclin D1 protein levels and directly induces the cyclin D1 gene in mammary epithelial cells.
BEL:20036754 720-860 kin(p(HGNC:ILK)) increases r(HGNC:CCND1) denotes We show here that ILK overexpression elevates cyclin D1 protein levels and directly induces the cyclin D1 gene in mammary epithelial cells.
BEL:20043424 0-1405 p(HGNC:ILK) increases r(HGNC:CCND1) denotes The integrin-linked kinase regulates the cyclin D1 gene through glycogen synthase kinase 3beta and cAMP-responsive element-binding protein-dependent pathways. The cyclin D1 gene encodes the regulatory subunit of a holoenzyme that phosphorylates and inactivates the pRB tumor suppressor protein. Cyclin D1 is overexpressed in 20-30% of human breast tumors and is induced both by oncogenes including those for Ras, Neu, and Src, and by the beta-catenin/lymphoid enhancer factor (LEF)/T cell factor (TCF) pathway. The ankyrin repeat containing serine-threonine protein kinase, integrin-linked kinase (ILK), binds to the cytoplasmic domain of beta(1) and beta(3) integrin subunits and promotes anchorage-independent growth. We show here that ILK overexpression elevates cyclin D1 protein levels and directly induces the cyclin D1 gene in mammary epithelial cells. ILK activation of the cyclin D1 promoter was abolished by point mutation of a cAMP-responsive element-binding protein (CREB)/ATF-2 binding site at nucleotide -54 in the cyclin D1 promoter, and by overexpression of either glycogen synthase kinase-3beta (GSK-3beta) or dominant negative mutants of CREB or ATF-2. Inhibition of the PI 3-kinase and AKT/protein kinase B, but not of the p38, ERK, or JNK signaling pathways, reduced ILK induction of cyclin D1 expression. ILK induced CREB transactivation and CREB binding to the cyclin D1 promoter CRE
BEL:20046110 1407-1604 p(HGNC:WNT1) increases r(HGNC:CCND1) denotes Wnt-1 overexpression in mammary epithelial cells induced cyclin D1 mRNA and targeted overexpression of Wnt-1 in the mammary gland of transgenic mice increased both ILK activity and cyclin D1 levels
BEL:20064584 1407-1604 p(MGI:Wnt1) increases kin(p(MGI:Ilk)) denotes Wnt-1 overexpression in mammary epithelial cells induced cyclin D1 mRNA and targeted overexpression of Wnt-1 in the mammary gland of transgenic mice increased both ILK activity and cyclin D1 levels

DisGeNET

Id Subject Object Predicate Lexical cue
T0 295-304 gene:595 denotes Cyclin D1
T1 341-354 disease:C1458155 denotes breast tumors
R1 T0 T1 associated_with Cyclin D1,breast tumors

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 269-274 Phenotype denotes tumor HP:0002664
T2 341-354 Phenotype denotes breast tumors HP:0100013

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 269-274 Disease denotes tumor http://purl.obolibrary.org/obo/MONDO_0005070
T2 341-354 Disease denotes breast tumors http://purl.obolibrary.org/obo/MONDO_0007254|http://purl.obolibrary.org/obo/MONDO_0021100

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 335-340 OrganismTaxon denotes human 9606
T2 1551-1555 OrganismTaxon denotes mice 10088

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 341-347 Body_part denotes breast http://purl.obolibrary.org/obo/UBERON_0000310
T2 482-488 Body_part denotes T cell http://purl.obolibrary.org/obo/CL_0000084
T3 617-628 Body_part denotes cytoplasmic http://purl.obolibrary.org/obo/GO_0005737
T4 834-858 Body_part denotes mammary epithelial cells http://purl.obolibrary.org/obo/CL_0002327
T5 1431-1455 Body_part denotes mammary epithelial cells http://purl.obolibrary.org/obo/CL_0002327
T6 1523-1536 Body_part denotes mammary gland http://purl.obolibrary.org/obo/UBERON_0001911|http://purl.obolibrary.org/obo/UBERON_0005200
T8 1770-1794 Body_part denotes mammary epithelial cells http://purl.obolibrary.org/obo/CL_0002327

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 1523-1536 Body_part denotes mammary gland http://purl.obolibrary.org/obo/MAT_0000073

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 482-488 Cell denotes T cell http://purl.obolibrary.org/obo/CL:0000084
T2 834-858 Cell denotes mammary epithelial cells http://purl.obolibrary.org/obo/CL:0002327
T3 1431-1455 Cell denotes mammary epithelial cells http://purl.obolibrary.org/obo/CL:0002327
T4 1770-1794 Cell denotes mammary epithelial cells http://purl.obolibrary.org/obo/CL:0002327