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PubMed:10880444 JSONTXT

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AIMed

Id Subject Object Predicate Lexical cue
T1 0-5 protein denotes BMP-2
T2 91-98 protein denotes BMPR-II
T3 101-128 protein denotes one morphogenetic protein-2
T4 130-135 protein denotes BMP-2
T5 262-267 protein denotes BMP-2
T6 332-363 protein denotes transforming growth factor-beta
T7 365-373 protein denotes TGF-beta
T8 502-507 protein denotes BMP-2
T9 512-519 protein denotes BMPR-IA
T10 533-540 protein denotes BMPR-II
T11 544-551 protein denotes ActR-II
T12 587-592 protein denotes BMP-2
T13 701-708 protein denotes BMPR-IA
T14 760-765 protein denotes BMP-2
T15 825-832 protein denotes BMPR-II
T16 965-970 protein denotes BMP-2
T17 1162-1167 protein denotes BMP-2
T18 1293-1301 protein denotes TGF-beta

FSU-PRGE

Id Subject Object Predicate Lexical cue
T1 0-5 protein denotes BMP-2
T2 91-98 protein denotes BMPR-II
T3 100-128 protein denotes Bone morphogenetic protein-2
T4 130-135 protein denotes BMP-2
T5 262-267 protein denotes BMP-2
T6 332-386 protein denotes transforming growth factor-beta (TGF-beta) superfamily
T7 413-455 protein denotes type I and type II receptor serine-kinases
T8 502-507 protein denotes BMP-2
T9 512-519 protein denotes BMPR-IA
T10 533-540 protein denotes BMPR-II
T11 544-551 protein denotes ActR-II
T12 587-592 protein denotes BMP-2
T13 701-708 protein denotes BMPR-IA
T14 760-765 protein denotes BMP-2
T15 825-832 protein denotes BMPR-II
T16 965-970 protein denotes BMP-2
T17 1162-1167 protein denotes BMP-2
T18 1289-1313 protein denotes BMP/TGF-beta superfamily

PMID_GLOBAL

Id Subject Object Predicate Lexical cue
T1 0-99 Sentence denotes BMP-2 antagonists emerge from alterations in the low-affinity binding epitope for receptor BMPR-II.
T2 100-261 Sentence denotes Bone morphogenetic protein-2 (BMP-2) induces bone formation and regeneration in adult vertebrates and regulates important developmental processes in all animals.
T3 262-477 Sentence denotes BMP-2 is a homodimeric cysteine knot protein that, as a member of the transforming growth factor-beta (TGF-beta) superfamily, signals by oligomerizing type I and type II receptor serine-kinases in the cell membrane.
T4 478-664 Sentence denotes The binding epitopes of BMP-2 for BMPR-IA (type I) and BMPR-II or ActR-II (type II) were characterized using BMP-2 mutant proteins for analysis of interactions with receptor ectodomains.
T5 665-772 Sentence denotes A large epitope 1 for high-affinity BMPR-IA binding was detected spanning the interface of the BMP-2 dimer.
T6 773-895 Sentence denotes A smaller epitope 2 for the low-affinity binding of BMPR-II was found to be assembled by determinants of a single monomer.
T7 896-977 Sentence denotes Symmetry-related pairs of the two juxtaposed epitopes occur near the BMP-2 poles.
T8 978-1177 Sentence denotes Mutations in both epitopes yielded variants with reduced biological activity in C2C12 cells; however, only epitope 2 variants behaved as antagonists partially or completely inhibiting BMP-2 activity.
T9 1178-1314 Sentence denotes These findings provide a framework for the molecular description of receptor recognition and activation in the BMP/TGF-beta superfamily.