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PubMed:10869358 JSONTXT

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CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 85-96 Cell denotes macrophages http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394
T3 400-410 Cell denotes macrophage http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394
T5 467-478 Cell denotes macrophages http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394
T7 728-736 Cell denotes monocyte http://purl.obolibrary.org/obo/CL:0000576|http://purl.obolibrary.org/obo/CL:0001054
T9 745-756 Cell denotes macrophages http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394
T11 1427-1438 Cell denotes macrophages http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394
T13 1570-1580 Cell denotes foam cells http://purl.obolibrary.org/obo/CL:0000891

sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-108 Sentence denotes Sterol 27-hydroxylase acts on 7-ketocholesterol in human atherosclerotic lesions and macrophages in culture.
TextSentencer_T2 109-230 Sentence denotes 27-Hydroxycholesterol (27OH) is the major oxysterol in human atherosclerotic lesions, followed by 7-ketocholesterol (7K).
TextSentencer_T3 231-508 Sentence denotes Whereas 7K probably originates nonenzymically, 27OH arises by the action of sterol 27-hydroxylase, a cytochrome P450 enzyme expressed at particularly high levels in the macrophage and proposed to represent an important pathway by which macrophages eliminate excess cholesterol.
TextSentencer_T4 509-681 Sentence denotes We hypothesized and here show that 27-hydroxylated 7-ketocholesterol (270H-7K) is present in human lesions, probably generated by the action of sterol 27-hydroxylase on 7K.
TextSentencer_T5 682-928 Sentence denotes Moreover, [(3)H]27OH-7K was produced by human monocyte-derived macrophages (HMDMs) supplied with [(3)H]7K but not in HMDMs from a patient with cerebrotendinous xanthomatosis (CTX) shown to have a splice-junction mutation of sterol 27-hydroxylase.
TextSentencer_T6 929-1065 Sentence denotes Whereas [(3)H]27OH-7K was predominantly secreted into the medium, [(3)H]-27OH formed from [(3)H]-cholesterol was mostly cell-associated.
TextSentencer_T7 1066-1230 Sentence denotes The majority of supplied [(3)H]7K was metabolized beyond 27OH-7K to aqueous-soluble products (apparently bile acids derived from the sterol 27-hydroxylase pathway).
TextSentencer_T8 1231-1343 Sentence denotes Metabolism to aqueous-soluble products was ablated by a sterol 27-hydroxylase inhibitor and absent in CTX cells.
TextSentencer_T9 1344-1501 Sentence denotes Sterol 27-hydroxylase therefore appears to represent an important pathway by which macrophages eliminate not only cholesterol but also oxysterols such as 7K.
TextSentencer_T10 1502-1756 Sentence denotes The fact that 7K (and cholesterol) still accumulates in lesions and foam cells indicates that this pathway may be perturbed in atherosclerosis and affords a new opportunity for the development of therapeutic strategies to regress atherosclerotic lesions.
T1 0-108 Sentence denotes Sterol 27-hydroxylase acts on 7-ketocholesterol in human atherosclerotic lesions and macrophages in culture.
T2 109-230 Sentence denotes 27-Hydroxycholesterol (27OH) is the major oxysterol in human atherosclerotic lesions, followed by 7-ketocholesterol (7K).
T3 231-508 Sentence denotes Whereas 7K probably originates nonenzymically, 27OH arises by the action of sterol 27-hydroxylase, a cytochrome P450 enzyme expressed at particularly high levels in the macrophage and proposed to represent an important pathway by which macrophages eliminate excess cholesterol.
T4 509-681 Sentence denotes We hypothesized and here show that 27-hydroxylated 7-ketocholesterol (270H-7K) is present in human lesions, probably generated by the action of sterol 27-hydroxylase on 7K.
T5 682-928 Sentence denotes Moreover, [(3)H]27OH-7K was produced by human monocyte-derived macrophages (HMDMs) supplied with [(3)H]7K but not in HMDMs from a patient with cerebrotendinous xanthomatosis (CTX) shown to have a splice-junction mutation of sterol 27-hydroxylase.
T6 929-1065 Sentence denotes Whereas [(3)H]27OH-7K was predominantly secreted into the medium, [(3)H]-27OH formed from [(3)H]-cholesterol was mostly cell-associated.
T7 1066-1230 Sentence denotes The majority of supplied [(3)H]7K was metabolized beyond 27OH-7K to aqueous-soluble products (apparently bile acids derived from the sterol 27-hydroxylase pathway).
T8 1231-1343 Sentence denotes Metabolism to aqueous-soluble products was ablated by a sterol 27-hydroxylase inhibitor and absent in CTX cells.
T9 1344-1501 Sentence denotes Sterol 27-hydroxylase therefore appears to represent an important pathway by which macrophages eliminate not only cholesterol but also oxysterols such as 7K.
T10 1502-1756 Sentence denotes The fact that 7K (and cholesterol) still accumulates in lesions and foam cells indicates that this pathway may be perturbed in atherosclerosis and affords a new opportunity for the development of therapeutic strategies to regress atherosclerotic lesions.

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 842-855 HP_0000991 denotes xanthomatosis
T2 1570-1580 HP_0003651 denotes foam cells
T3 1629-1644 HP_0002621 denotes atherosclerosis

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
10869358-7#56#77#gene1593 1287-1308 gene1593 denotes sterol 27-hydroxylase
10869358-7#102#105#diseaseC0238052 1333-1336 diseaseC0238052 denotes CTX
56#77#gene1593102#105#diseaseC0238052 10869358-7#56#77#gene1593 10869358-7#102#105#diseaseC0238052 associated_with sterol 27-hydroxylase,CTX

PubCasesHPO

Id Subject Object Predicate Lexical cue
AB1 842-855 HP:0000991 denotes xanthomatosis
AB2 1570-1580 HP:0003651 denotes foam cells
AB3 1629-1644 HP:0002621 denotes atherosclerosis

PubCasesORDO

Id Subject Object Predicate Lexical cue
AB1 825-855 ORDO:909 denotes cerebrotendinous xanthomatosis
AB2 857-860 ORDO:909 denotes CTX
AB3 1333-1336 ORDO:909 denotes CTX

UBERON-AE

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 1171-1175 http://purl.obolibrary.org/obo/UBERON_0001970 denotes bile

performance-test

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 1171-1175 http://purl.obolibrary.org/obo/UBERON_0001970 denotes bile

DisGeNET

Id Subject Object Predicate Lexical cue
T0 1287-1308 gene:1593 denotes sterol 27-hydroxylase
T1 1333-1336 disease:C0238052 denotes CTX
R1 T0 T1 associated_with sterol 27-hydroxylase,CTX

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 825-855 Disease denotes cerebrotendinous xanthomatosis http://purl.obolibrary.org/obo/MONDO_0008948
T2 857-860 Disease denotes CTX http://purl.obolibrary.org/obo/MONDO_0008948
T3 1333-1336 Disease denotes CTX http://purl.obolibrary.org/obo/MONDO_0008948
T4 1629-1644 Disease denotes atherosclerosis http://purl.obolibrary.org/obo/MONDO_0005311

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 57-80 Phenotype denotes atherosclerotic lesions HP:0031678
T2 170-193 Phenotype denotes atherosclerotic lesions HP:0031678
T3 842-855 Phenotype denotes xanthomatosis HP:0000991
T4 1570-1580 Phenotype denotes foam cells HP:0003651
T5 1629-1644 Phenotype denotes atherosclerosis HP:0002621
T6 1732-1755 Phenotype denotes atherosclerotic lesions HP:0031678

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 51-56 OrganismTaxon denotes human 9606
T2 164-169 OrganismTaxon denotes human 9606
T3 602-607 OrganismTaxon denotes human 9606
T4 722-727 OrganismTaxon denotes human 9606
T5 812-819 OrganismTaxon denotes patient 9606

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 85-96 Body_part denotes macrophages http://purl.obolibrary.org/obo/CL_0000235
T2 400-410 Body_part denotes macrophage http://purl.obolibrary.org/obo/CL_0000235
T3 467-478 Body_part denotes macrophages http://purl.obolibrary.org/obo/CL_0000235
T4 728-736 Body_part denotes monocyte http://purl.obolibrary.org/obo/CL_0000576|http://purl.obolibrary.org/obo/CL_0001054
T6 745-756 Body_part denotes macrophages http://purl.obolibrary.org/obo/CL_0000235
T7 885-893 Body_part denotes junction http://purl.obolibrary.org/obo/UBERON_0007651
T8 1171-1175 Body_part denotes bile http://purl.obolibrary.org/obo/UBERON_0001970
T9 1427-1438 Body_part denotes macrophages http://purl.obolibrary.org/obo/CL_0000235