PubMed:10859164 / 596-1122
Annnotations
PubMed_ArguminSci
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T4 | 0-91 | DRI_Outcome | denotes | CHK1 heterozygosity modestly enhances the tumorigenesis phenotype of WNT-1 transgenic mice. |
| T5 | 92-209 | DRI_Outcome | denotes | We show that in human cells, Chk1 is phosphorylated on serine 345 (S345) in response to UV, IR, and hydroxyurea (HU). |
| T6 | 210-372 | DRI_Outcome | denotes | Overexpression of wild-type Atr enhances, whereas overexpression of the kinase-defective mutant Atr inhibits S345 phosphorylation of Chk1 induced by UV treatment. |
PMID_GLOBAL
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T6 | 510-515 | DiseaseOrPhenotypicFeature | denotes | tumor | 0005070 |
PubmedHPO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 510-515 | HP_0002664 | denotes | tumor |
DisGeNET5_gene_disease
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| 10859164-4#0#4#gene1111 | 0-4 | gene1111 | denotes | CHK1 |
| 10859164-4#69#74#gene7471 | 69-74 | gene7471 | denotes | WNT-1 |
| 10859164-4#42#55#diseaseC0596263 | 42-55 | diseaseC0596263 | denotes | tumorigenesis |
| 0#4#gene111142#55#diseaseC0596263 | 10859164-4#0#4#gene1111 | 10859164-4#42#55#diseaseC0596263 | associated_with | CHK1,tumorigenesis |
| 69#74#gene747142#55#diseaseC0596263 | 10859164-4#69#74#gene7471 | 10859164-4#42#55#diseaseC0596263 | associated_with | WNT-1,tumorigenesis |
2015-BEL-Sample
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 414-526 | kin(p(MGI:Chek1)) decreases path(MESHD:Neoplasms) | denotes | Chk1 plays an essential role in the mammalian DNA damage checkpoint, embryonic development, and tumor suppressio |
2015-BEL-Sample-2
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| BEL:20000178 | 414-526 | kin(p(MGI:Chek1)) decreases path(MESHD:Neoplasms) | denotes | Chk1 plays an essential role in the mammalian DNA damage checkpoint, embryonic development, and tumor suppressio |
| BEL:20000178 | 414-526 | kin(p(MGI:Chek1)) decreases path(MESHD:Neoplasms) | denotes | Chk1 plays an essential role in the mammalian DNA damage checkpoint, embryonic development, and tumor suppressio |
| BEL:20037822 | 0-526 | kin(p(MGI:Chek1)) decreases path(MESHD:Neoplasms) | denotes | CHK1 heterozygosity modestly enhances the tumorigenesis phenotype of WNT-1 transgenic mice. We show that in human cells, Chk1 is phosphorylated on serine 345 (S345) in response to UV, IR, and hydroxyurea (HU). Overexpression of wild-type Atr enhances, whereas overexpression of the kinase-defective mutant Atr inhibits S345 phosphorylation of Chk1 induced by UV treatment. Taken together, these data indicate that Chk1 plays an essential role in the mammalian DNA damage checkpoint, embryonic development, and tumor suppressio |
DisGeNET
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T0 | 0-4 | gene:1111 | denotes | CHK1 |
| T1 | 42-55 | disease:C0596263 | denotes | tumorigenesis |
| T2 | 69-74 | gene:7471 | denotes | WNT-1 |
| T3 | 42-55 | disease:C0596263 | denotes | tumorigenesis |
| R1 | T0 | T1 | associated_with | CHK1,tumorigenesis |
| R2 | T2 | T3 | associated_with | WNT-1,tumorigenesis |