PubMed:10837462
Annnotations
GlyCosmos15-Species-PubTator
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| 36 | 841-846 | Species | denotes | human | 9606 |
| 39 | 870-875 | Species | denotes | mouse | 10090 |
| 46 | 1263-1268 | Species | denotes | mouse | 10090 |
GlyCosmos6-Glycan-Motif-Image
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 89-95 | Glycan_Motif | denotes | SSEA-3 | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G99053DY|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G25129BT|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G19298OA |
| T4 | 89-93 | Glycan_Motif | denotes | SSEA | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G85497PI |
| T5 | 296-301 | Glycan_Motif | denotes | core3 | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00035MO |
| T6 | 628-637 | Glycan_Motif | denotes | globoside | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00061MO |
| T7 | 638-641 | Glycan_Motif | denotes | Gb4 | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00061MO |
| T8 | 679-682 | Glycan_Motif | denotes | Gb5 | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G99053DY|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G19298OA |
| T10 | 738-744 | Glycan_Motif | denotes | SSEA-3 | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G99053DY|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G25129BT|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G19298OA |
| T13 | 738-742 | Glycan_Motif | denotes | SSEA | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G85497PI |
| T14 | 751-757 | Glycan_Motif | denotes | SSEA-3 | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G99053DY|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G25129BT|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G19298OA |
| T17 | 751-755 | Glycan_Motif | denotes | SSEA | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G85497PI |
| T18 | 1051-1057 | Glycan_Motif | denotes | SSEA-3 | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G99053DY|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G25129BT|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G19298OA |
| T21 | 1051-1055 | Glycan_Motif | denotes | SSEA | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G85497PI |
| T22 | 1229-1235 | Glycan_Motif | denotes | SSEA-3 | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G99053DY|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G25129BT|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G19298OA |
| T25 | 1229-1233 | Glycan_Motif | denotes | SSEA | https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G85497PI |
Glycosmos6-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 89-95 | http://www.glycoepitope.jp/epitopes/EP0039 | denotes | SSEA-3 |
| T2 | 628-637 | http://www.glycoepitope.jp/epitopes/EP0073 | denotes | globoside |
| T3 | 738-744 | http://www.glycoepitope.jp/epitopes/EP0039 | denotes | SSEA-3 |
| T4 | 751-757 | http://www.glycoepitope.jp/epitopes/EP0039 | denotes | SSEA-3 |
| T5 | 1051-1057 | http://www.glycoepitope.jp/epitopes/EP0039 | denotes | SSEA-3 |
| T6 | 1229-1235 | http://www.glycoepitope.jp/epitopes/EP0039 | denotes | SSEA-3 |
sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-106 | Sentence | denotes | The beta 1,3-galactosyltransferase beta 3GalT-V is a stage-specific embryonic antigen-3 (SSEA-3) synthase. |
| T2 | 107-350 | Sentence | denotes | We have previously reported the molecular cloning of beta1, 3-galactosyltransferase-V (beta3GalT-V), which catalyzes the transfer of Gal to GlcNAc-based acceptors with a preference for the core3 O-linked glycan GlcNAc(beta1,3)GalNAc structure. |
| T3 | 351-517 | Sentence | denotes | Further characterization indicated that the recombinant beta3GalT-V enzyme expressed in Sf9 insect cells also utilized the glycolipid Lc3Cer as an efficient acceptor. |
| T4 | 518-746 | Sentence | denotes | Surprisingly, we also found that beta3GalT-V catalyzes the transfer of Gal to the terminal GalNAc unit of the globoside Gb4, thereby synthesizing the glycolipid Gb5, also known as the stage-specific embryonic antigen-3 (SSEA-3). |
| T5 | 747-1018 | Sentence | denotes | The SSEA-3 synthase activity of beta3GalT-V was confirmed in vivo by stable expression of the human beta3GalT-V gene in F9 mouse teratocarcinoma cells, as detected with the monoclonal antibody MC-631 by flow cytometry analysis and immunostaining of extracted glycolipids. |
| T6 | 1019-1286 | Sentence | denotes | The biological relation between SSEA-3 formation and beta3GalT-V was further documented by showing that F9 cells treated with the differentiation-inducing agent retinoic acid induced the expression of both the SSEA-3 epitope and the endogenous mouse beta3GalT-V gene. |
| T7 | 1287-1458 | Sentence | denotes | This study represents the first example of a glycosyltransferase, which utilizes two kinds of sugar acceptor substrates without requiring any additional modifier molecule. |
GlyCosmos6-Glycan-Motif-Structure
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 89-95 | https://glytoucan.org/Structures/Glycans/G19298OA | denotes | SSEA-3 |
| T2 | 89-95 | https://glytoucan.org/Structures/Glycans/G25129BT | denotes | SSEA-3 |
| T3 | 89-95 | https://glytoucan.org/Structures/Glycans/G99053DY | denotes | SSEA-3 |
| T4 | 89-93 | https://glytoucan.org/Structures/Glycans/G85497PI | denotes | SSEA |
| T5 | 628-637 | https://glytoucan.org/Structures/Glycans/G00061MO | denotes | globoside |
| T6 | 638-641 | https://glytoucan.org/Structures/Glycans/G00061MO | denotes | Gb4 |
| T7 | 679-682 | https://glytoucan.org/Structures/Glycans/G19298OA | denotes | Gb5 |
| T8 | 679-682 | https://glytoucan.org/Structures/Glycans/G99053DY | denotes | Gb5 |
| T9 | 738-744 | https://glytoucan.org/Structures/Glycans/G19298OA | denotes | SSEA-3 |
| T10 | 738-744 | https://glytoucan.org/Structures/Glycans/G25129BT | denotes | SSEA-3 |
| T11 | 738-744 | https://glytoucan.org/Structures/Glycans/G99053DY | denotes | SSEA-3 |
| T12 | 738-742 | https://glytoucan.org/Structures/Glycans/G85497PI | denotes | SSEA |
| T13 | 751-757 | https://glytoucan.org/Structures/Glycans/G19298OA | denotes | SSEA-3 |
| T14 | 751-757 | https://glytoucan.org/Structures/Glycans/G25129BT | denotes | SSEA-3 |
| T15 | 751-757 | https://glytoucan.org/Structures/Glycans/G99053DY | denotes | SSEA-3 |
| T16 | 751-755 | https://glytoucan.org/Structures/Glycans/G85497PI | denotes | SSEA |
| T17 | 1051-1057 | https://glytoucan.org/Structures/Glycans/G19298OA | denotes | SSEA-3 |
| T18 | 1051-1057 | https://glytoucan.org/Structures/Glycans/G25129BT | denotes | SSEA-3 |
| T19 | 1051-1057 | https://glytoucan.org/Structures/Glycans/G99053DY | denotes | SSEA-3 |
| T20 | 1051-1055 | https://glytoucan.org/Structures/Glycans/G85497PI | denotes | SSEA |
| T21 | 1229-1235 | https://glytoucan.org/Structures/Glycans/G19298OA | denotes | SSEA-3 |
| T22 | 1229-1235 | https://glytoucan.org/Structures/Glycans/G25129BT | denotes | SSEA-3 |
| T23 | 1229-1235 | https://glytoucan.org/Structures/Glycans/G99053DY | denotes | SSEA-3 |
| T24 | 1229-1233 | https://glytoucan.org/Structures/Glycans/G85497PI | denotes | SSEA |
NGLY1-deficiency
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| PD-NGLY1-deficiency-B_T1 | 247-253 | chem:24139 | denotes | GlcNAc |
| PD-NGLY1-deficiency-B_T2 | 318-324 | chem:24139 | denotes | GlcNAc |
GlyCosmos15-Glycan
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 89-95 | Glycan | denotes | SSEA-3 | |
| T2 | 296-301 | Glycan | denotes | core3 | |
| T3 | 333-339 | Glycan | denotes | GalNAc | |
| T4 | 609-615 | Glycan | denotes | GalNAc | |
| T5 | 628-637 | Glycan | denotes | globoside | |
| T6 | 638-641 | Glycan | denotes | Gb4 | |
| T7 | 679-682 | Glycan | denotes | Gb5 | |
| T8 | 738-744 | Glycan | denotes | SSEA-3 | |
| T9 | 751-757 | Glycan | denotes | SSEA-3 | |
| T10 | 1051-1057 | Glycan | denotes | SSEA-3 | |
| T11 | 1229-1235 | Glycan | denotes | SSEA-3 |
mondo_disease
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 876-891 | Disease | denotes | teratocarcinoma | http://purl.obolibrary.org/obo/MONDO_0002599 |
Glycan-GlyCosmos
| Id | Subject | Object | Predicate | Lexical cue | image |
|---|---|---|---|---|---|
| T1 | 89-95 | Glycan | denotes | SSEA-3 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G25129BT |
| T2 | 333-339 | Glycan | denotes | GalNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL |
| T3 | 609-615 | Glycan | denotes | GalNAc | https://api.glycosmos.org/wurcs2image/latest/png/binary/G39738WL |
| T4 | 628-637 | Glycan | denotes | globoside | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00061MO |
| T5 | 638-641 | Glycan | denotes | Gb4 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G00061MO |
| T6 | 679-682 | Glycan | denotes | Gb5 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G99053DY |
| T7 | 738-744 | Glycan | denotes | SSEA-3 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G25129BT |
| T8 | 751-757 | Glycan | denotes | SSEA-3 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G25129BT |
| T9 | 1051-1057 | Glycan | denotes | SSEA-3 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G25129BT |
| T10 | 1229-1235 | Glycan | denotes | SSEA-3 | https://api.glycosmos.org/wurcs2image/latest/png/binary/G25129BT |
GlyCosmos-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue | glycoepitope_id |
|---|---|---|---|---|---|
| T1 | 89-95 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | SSEA-3 | http://www.glycoepitope.jp/epitopes/EP0039 |
| T2 | 628-637 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | globoside | http://www.glycoepitope.jp/epitopes/EP0073 |
| T3 | 738-744 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | SSEA-3 | http://www.glycoepitope.jp/epitopes/EP0039 |
| T4 | 751-757 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | SSEA-3 | http://www.glycoepitope.jp/epitopes/EP0039 |
| T5 | 1051-1057 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | SSEA-3 | http://www.glycoepitope.jp/epitopes/EP0039 |
| T6 | 1229-1235 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | SSEA-3 | http://www.glycoepitope.jp/epitopes/EP0039 |
GlyCosmos15-MONDO
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 876-891 | Disease | denotes | teratocarcinoma | MONDO:0002599 |
GlyCosmos15-Sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-106 | Sentence | denotes | The beta 1,3-galactosyltransferase beta 3GalT-V is a stage-specific embryonic antigen-3 (SSEA-3) synthase. |
| T2 | 107-350 | Sentence | denotes | We have previously reported the molecular cloning of beta1, 3-galactosyltransferase-V (beta3GalT-V), which catalyzes the transfer of Gal to GlcNAc-based acceptors with a preference for the core3 O-linked glycan GlcNAc(beta1,3)GalNAc structure. |
| T3 | 351-517 | Sentence | denotes | Further characterization indicated that the recombinant beta3GalT-V enzyme expressed in Sf9 insect cells also utilized the glycolipid Lc3Cer as an efficient acceptor. |
| T4 | 518-746 | Sentence | denotes | Surprisingly, we also found that beta3GalT-V catalyzes the transfer of Gal to the terminal GalNAc unit of the globoside Gb4, thereby synthesizing the glycolipid Gb5, also known as the stage-specific embryonic antigen-3 (SSEA-3). |
| T5 | 747-1018 | Sentence | denotes | The SSEA-3 synthase activity of beta3GalT-V was confirmed in vivo by stable expression of the human beta3GalT-V gene in F9 mouse teratocarcinoma cells, as detected with the monoclonal antibody MC-631 by flow cytometry analysis and immunostaining of extracted glycolipids. |
| T6 | 1019-1286 | Sentence | denotes | The biological relation between SSEA-3 formation and beta3GalT-V was further documented by showing that F9 cells treated with the differentiation-inducing agent retinoic acid induced the expression of both the SSEA-3 epitope and the endogenous mouse beta3GalT-V gene. |
| T7 | 1287-1458 | Sentence | denotes | This study represents the first example of a glycosyltransferase, which utilizes two kinds of sugar acceptor substrates without requiring any additional modifier molecule. |
GlyCosmos15-GlycoEpitope
| Id | Subject | Object | Predicate | Lexical cue | glycoepitope_id |
|---|---|---|---|---|---|
| T1 | 89-95 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | SSEA-3 | http://www.glycoepitope.jp/epitopes/EP0039 |
| T2 | 628-637 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | globoside | http://www.glycoepitope.jp/epitopes/EP0073 |
| T3 | 738-744 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | SSEA-3 | http://www.glycoepitope.jp/epitopes/EP0039 |
| T4 | 751-757 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | SSEA-3 | http://www.glycoepitope.jp/epitopes/EP0039 |
| T5 | 1051-1057 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | SSEA-3 | http://www.glycoepitope.jp/epitopes/EP0039 |
| T6 | 1229-1235 | http://purl.jp/bio/12/glyco/glycan#Glycan_epitope | denotes | SSEA-3 | http://www.glycoepitope.jp/epitopes/EP0039 |
GlyCosmos15-NCBITAXON
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 841-846 | OrganismTaxon | denotes | human | 9606 |
| T2 | 870-875 | OrganismTaxon | denotes | mouse | 10088|10090 |
| T4 | 1263-1268 | OrganismTaxon | denotes | mouse | 10088|10090 |
NCBITAXON
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 841-846 | OrganismTaxon | denotes | human | 9606 |
| T2 | 870-875 | OrganismTaxon | denotes | mouse | 10088|10090 |
| T4 | 1263-1268 | OrganismTaxon | denotes | mouse | 10088|10090 |