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bionlp-st-gro-2013-training

Id Subject Object Predicate Lexical cue
T1 0-5 Eukaryote denotes Human
T2 6-14 Protein denotes Sug1/p45
T3 34-44 ProteinComplex denotes proteasome
T5 70-73 TranscriptionFactor denotes Sp1
T6 79-103 TranscriptionFactor denotes transcription factor Sp1
T7 136-146 ProteinComplex denotes proteasome
T9 174-179 Cell denotes cells
T12 252-261 OrganicChemical denotes forskolin
T13 417-420 TranscriptionFactor denotes Sp1
T15 436-441 Eukaryote denotes human
T16 442-446 Protein denotes Sug1
T17 447-453 Protein denotes [hSug1
T18 469-472 Protein denotes p45
T19 476-520 Protein denotes thyroid-hormone-receptor interacting protein
T20 536-550 ProteinSubunit denotes ATPase subunit
T21 563-573 ProteinComplex denotes proteasome
T25 638-641 TranscriptionFactor denotes Sp1
T26 661-671 ProteinDomain denotes C-terminus
T27 675-680 Protein denotes hSug1
T28 682-692 ProteinDomain denotes the region
T29 721-734 ProteinDomain denotes ATPase domain
T30 738-750 Protein denotes this protein
T31 846-851 Protein denotes hSug1
T33 879-882 Eukaryote denotes rat
T34 883-889 Tissue denotes kidney
T35 890-895 Cell denotes cells
T36 907-924 Protein denotes full-length hSug1
T38 950-960 ProteinComplex denotes proteasome
T40 986-989 TranscriptionFactor denotes Sp1
T41 1000-1017 MutatedProtein denotes hSug1 truncations
T42 1066-1071 Protein denotes hSug1
T44 1110-1113 TranscriptionFactor denotes Sp1
T46 1145-1158 MutantProtein denotes ATPase mutant
T47 1162-1167 Protein denotes hSug1
T49 1194-1197 TranscriptionFactor denotes Sp1
T51 1237-1240 TranscriptionFactor denotes Sp1
T53 1311-1316 Protein denotes hSug1
T55 1351-1354 TranscriptionFactor denotes Sp1
T58 1382-1387 Protein denotes hSug1
T60 1446-1451 Protein denotes hSug1
T61 1471-1482 ProteinComplex denotes proteasomal
T62 1538-1548 ProteinComplex denotes proteasome
T64 1574-1577 TranscriptionFactor denotes Sp1
T65 1719-1724 Protein denotes hSug1
T67 1782-1785 TranscriptionFactor denotes Sp1
T68 1790-1800 ProteinComplex denotes proteasome
T11 225-250 OrganicChemical denotes adenylate cyclase inducer
T71 291-294 TranscriptionFactor denotes Sp1
T72 523-528 Protein denotes TRIP1
T22 589-614 TranscriptionRegulator denotes transcriptional modulator
T56 1621-1624 TranscriptionFactor denotes Sp1
T57 1588-1593 Protein denotes hSug1
T74 1644-1649 Cell denotes cells
E1 55-66 ProteinCatabolism denotes degradation
E2 157-168 ProteinCatabolism denotes degradation
E3 205-215 PositiveRegulation denotes stimulated
E5 421-430 BindingToProtein denotes interacts
E8 616-632 BindingOfTFToTFBindingSiteOfProtein denotes This interaction
E9 855-868 PositiveRegulationOfGeneExpression denotes overexpressed
E10 936-945 PositiveRegulation denotes stimulate
E11 971-982 ProteinCatabolism denotes degradation
E12 1099-1109 NegativeRegulation denotes inhibiting
E13 1114-1125 ProteinCatabolism denotes degradation
E14 1189-1193 BindingToProtein denotes bind
E15 1228-1236 NegativeRegulation denotes blocking
E16 1241-1252 ProteinCatabolism denotes degradation
E17 1336-1347 ProteinCatabolism denotes degradation
E18 1405-1417 ProteinCatabolism denotes this process
E19 1559-1570 ProteinCatabolism denotes degradation
E20 1775-1781 ProteinTargeting denotes target
E21 1801-1812 ProteinCatabolism denotes degradation
E4 295-314 ProteinCatabolism denotes degradation process
E6 1364-1378 CatabolicPathway denotes ATP hydrolysis
E7 1625-1636 ProteinCatabolism denotes degradation
R1 T2 T1 fromSpecies Sug1/p45,Human
R2 T16 T15 fromSpecies Sug1,human
R4 T27 T26 hasPart hSug1,C-terminus
R5 T28 T29 hasPart the region,ATPase domain
R7 E9 T35 locatedIn overexpressed,cells
R8 T34 T33 fromSpecies kidney,rat
R9 T35 T34 locatedIn cells,kidney
R3 T21 T20 hasPart proteasome,ATPase subunit
R6 T30 T28 hasPart this protein,the region
R10 E7 T74 locatedIn degradation,cells
R12 T5 E1 hasPatient Sp1,degradation
R13 T6 E2 hasPatient transcription factor Sp1,degradation
R14 T12 E3 hasAgent forskolin,stimulated
R15 T9 E3 hasPatient cells,stimulated
R16 T16 E5 hasPatient Sug1,interacts
R17 T13 E5 hasPatient Sp1,interacts
R18 T25 E8 hasAgent Sp1,This interaction
R19 T26 E8 hasPatient C-terminus,This interaction
R20 T31 E9 hasPatient hSug1,overexpressed
R21 T36 E10 hasAgent full-length hSug1,stimulate
R22 E11 E10 hasPatient degradation,stimulate
R23 T40 E11 hasPatient Sp1,degradation
R24 T41 E12 hasAgent hSug1 truncations,inhibiting
R25 E13 E12 hasPatient degradation,inhibiting
R26 T44 E13 hasPatient Sp1,degradation
R27 T49 E14 hasPatient Sp1,bind
R28 T46 E14 hasPatient ATPase mutant,bind
R29 T46 E15 hasAgent ATPase mutant,blocking
R30 E16 E15 hasPatient degradation,blocking
R31 T51 E16 hasPatient Sp1,degradation
R32 T55 E17 hasPatient Sp1,degradation
R33 T64 E19 hasPatient Sp1,degradation
R34 T65 E20 hasAgent hSug1,target
R35 T67 E20 hasPatient Sp1,target
R36 T67 E21 hasPatient Sp1,degradation
R37 T71 E4 hasPatient Sp1,degradation process
R38 T58 E6 hasAgent hSug1,ATP hydrolysis
R39 T56 E7 hasPatient Sp1,degradation

PMID_GLOBAL

Id Subject Object Predicate Lexical cue
T1 0-74 Sentence denotes Human Sug1/p45 is involved in the proteasome-dependent degradation of Sp1.
T2 75-262 Sentence denotes The transcription factor Sp1 was previously shown to undergo proteasome-dependent degradation when cells were glucose-starved and stimulated with the adenylate cyclase inducer, forskolin.
T3 263-334 Sentence denotes However, the control of the Sp1 degradation process is largely unknown.
T4 335-615 Sentence denotes Using in vitro and in vivo interaction studies, we show in the present study that Sp1 interacts with human Sug1 [hSug1, also known as p45 or thyroid-hormone-receptor interacting protein ('TRIP1')], an ATPase subunit of the 26 S proteasome and a putative transcriptional modulator.
T5 616-751 Sentence denotes This interaction with Sp1 occurs through the C-terminus of hSug1, the region that contains the conserved ATPase domain in this protein.
T6 752-990 Sentence denotes Both in vitro studies, in reconstituted degradation assays, and in vivo experiments, in which hSug1 is overexpressed in normal rat kidney cells, show that full-length hSug1 is able to stimulate the proteasome-dependent degradation of Sp1.
T7 991-1135 Sentence denotes However, hSug1 truncations that lack either the N- or C-terminal domain of hSug1 act as dominant negatives, inhibiting Sp1 degradation in vitro.
T8 1136-1279 Sentence denotes Also, an ATPase mutant of hSug1, while still able to bind Sp1, acts as a dominant negative, blocking Sp1 degradation both in vitro and in vivo.
T9 1280-1418 Sentence denotes These results demonstrate that hSug1 is involved in the degradation of Sp1 and that ATP hydrolysis by hSug1 is necessary for this process.
T10 1419-1578 Sentence denotes Our findings indicate that hSug1 is an exchangeable proteasomal component that plays a critical regulatory role in the proteasome-dependent degradation of Sp1.
T11 1579-1675 Sentence denotes However, hSug1 is not the factor limiting Sp1 degradation in the cells treated with glucosamine.
T12 1676-1813 Sentence denotes This and other considerations suggest that hSug1 co-operation with other molecules is necessary to target Sp1 for proteasome degradation.