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c_corpus

Id Subject Object Predicate Lexical cue
T4 0-36 C044256 denotes 17 beta-Hydroxysteroid dehydrogenase
T8 0-43 P51656 denotes 17 beta-Hydroxysteroid dehydrogenase type 1
T9 0-43 P51657 denotes 17 beta-Hydroxysteroid dehydrogenase type 1
T10 0-43 Q1WNP0 denotes 17 beta-Hydroxysteroid dehydrogenase type 1
T11 0-43 PR:000008773 denotes 17 beta-Hydroxysteroid dehydrogenase type 1
T12 0-43 P14061 denotes 17 beta-Hydroxysteroid dehydrogenase type 1
T15 3-36 GO:0033237 denotes beta-Hydroxysteroid dehydrogenase
T16 3-36 GO:0070524 denotes beta-Hydroxysteroid dehydrogenase
T17 3-36 GO:0003845 denotes beta-Hydroxysteroid dehydrogenase
T23 58-82 D002285 denotes ductal carcinoma in situ
T24 58-82 D002285 denotes ductal carcinoma in situ
T29 128-133 D006801 denotes human
T30 134-140 UBERON:0000310 denotes breast
T32 142-179 D015067 denotes 17 beta-hydroxysteroid dehydrogenases
T38 184-188 CHEBI:10545 denotes beta
T39 184-188 CHEBI:30225 denotes beta
T40 189-193 PR:P19705 denotes HSDs
T41 189-193 PR:P06187 denotes HSDs
T42 189-193 PR:P19704 denotes HSDs
T43 189-193 PR:P06991 denotes HSDs
T44 189-193 PR:P05719 denotes HSDs
T45 189-193 PR:P06990 denotes HSDs
T46 189-193 PR:P10485 denotes HSDs
T47 189-193 PR:P20132 denotes HSDs
T48 189-193 PR:000022930 denotes HSDs
T49 189-193 PR:P07990 denotes HSDs
T50 271-279 D013256 denotes steroids
T51 271-279 CHEBI:35341 denotes steroids
T52 271-279 D013256 denotes steroids
T53 338-348 GO:0008152 denotes metabolism
T54 352-360 D004967 denotes estrogen
T55 352-360 D004967 denotes estrogen
T56 352-360 CHEBI:50114 denotes estrogen
T57 372-380 D004967 denotes estrogen
T58 372-380 D004967 denotes estrogen
T59 372-380 CHEBI:50114 denotes estrogen
T62 400-411 C032690 denotes 17 beta-HSD
T60 400-411 GO:0004303 denotes 17 beta-HSD
T61 400-411 GO:0047035 denotes 17 beta-HSD
T65 408-411 PR:P35492 denotes HSD
T67 408-411 PR:000008437 denotes HSD
T66 408-411 143095 denotes HSD
T68 443-452 MOP:0000569 denotes reduction
T71 456-463 4103 denotes estrone
T69 456-463 CHEBI:17263 denotes estrone
T70 456-463 D004970 denotes estrone
T72 456-463 D004970 denotes estrone
T76 472-481 4083 denotes estradiol
T73 472-481 CHEBI:16469 denotes estradiol
T74 472-481 CHEBI:23965 denotes estradiol
T75 472-481 D004958 denotes estradiol
T77 472-481 D004958 denotes estradiol
T80 496-507 C032690 denotes 17 beta-HSD
T78 496-507 GO:0004303 denotes 17 beta-HSD
T79 496-507 GO:0047035 denotes 17 beta-HSD
T83 504-507 PR:P35492 denotes HSD
T85 504-507 PR:000008437 denotes HSD
T84 504-507 143095 denotes HSD
T86 539-548 MOP:0000568 denotes oxidation
T87 610-618 D004967 denotes estrogen
T88 610-618 D004967 denotes estrogen
T89 610-618 CHEBI:50114 denotes estrogen
T90 632-640 D007527 denotes isozymes
T91 644-649 D006801 denotes human
T92 650-656 UBERON:0000310 denotes breast
T93 650-663 D001943 denotes breast cancer
T94 650-663 D001943 denotes breast cancer
T95 679-693 D063646 denotes carcinogenesis
T96 679-693 D063646 denotes carcinogenesis
T97 701-706 D006801 denotes human
T98 707-713 UBERON:0000310 denotes breast
T99 783-792 D004967 denotes estrogens
T100 783-792 D004967 denotes estrogens
T101 783-792 CHEBI:50114 denotes estrogens
T102 816-821 D006801 denotes human
T103 822-828 UBERON:0000310 denotes breast
T104 829-843 D063646 denotes carcinogenesis
T105 829-843 D063646 denotes carcinogenesis
T108 888-899 C032690 denotes 17 beta-HSD
T106 888-899 GO:0004303 denotes 17 beta-HSD
T107 888-899 GO:0047035 denotes 17 beta-HSD
T111 896-899 PR:P35492 denotes HSD
T113 896-899 PR:000008437 denotes HSD
T112 896-899 143095 denotes HSD
T114 918-926 D007527 denotes isozymes
T118 931-948 Q9PVZ9 denotes estrogen receptor
T119 931-948 Q9YHT3 denotes estrogen receptor
T120 931-948 P57717 denotes estrogen receptor
T121 931-948 Q9QZJ5 denotes estrogen receptor
T122 931-948 Q29040 denotes estrogen receptor
T123 931-948 P49886 denotes estrogen receptor
T124 931-948 P50240 denotes estrogen receptor
T125 931-948 Q91424 denotes estrogen receptor
T126 931-948 Q9YHZ7 denotes estrogen receptor
T127 931-948 P06211 denotes estrogen receptor
T128 931-948 P16058 denotes estrogen receptor
T129 931-948 P50242 denotes estrogen receptor
T130 931-948 Q53AD2 denotes estrogen receptor
T131 931-948 P49885 denotes estrogen receptor
T132 931-948 P49884 denotes estrogen receptor
T133 931-948 P19785 denotes estrogen receptor
T134 931-948 Q91250 denotes estrogen receptor
T135 931-948 P81559 denotes estrogen receptor
T136 931-948 Q9TV98 denotes estrogen receptor
T137 931-948 PR:000007204 denotes estrogen receptor
T138 931-948 Q9YH33 denotes estrogen receptor
T139 931-948 P50241 denotes estrogen receptor
T140 931-948 P06212 denotes estrogen receptor
T141 931-948 P03372 denotes estrogen receptor
T142 931-948 O42132 denotes estrogen receptor
T143 931-948 P57753 denotes estrogen receptor
T144 931-954 D047628 denotes estrogen receptor alpha
T146 955-963 Q9PVZ9 denotes ER alpha
T147 955-963 Q9YHT3 denotes ER alpha
T148 955-963 P57717 denotes ER alpha
T149 955-963 Q9QZJ5 denotes ER alpha
T150 955-963 Q29040 denotes ER alpha
T151 955-963 P49886 denotes ER alpha
T152 955-963 P50240 denotes ER alpha
T153 955-963 Q91424 denotes ER alpha
T154 955-963 Q9YHZ7 denotes ER alpha
T155 955-963 P06211 denotes ER alpha
T156 955-963 P16058 denotes ER alpha
T157 955-963 P50242 denotes ER alpha
T158 955-963 Q53AD2 denotes ER alpha
T159 955-963 P49885 denotes ER alpha
T160 955-963 P49884 denotes ER alpha
T161 955-963 P19785 denotes ER alpha
T162 955-963 Q91250 denotes ER alpha
T163 955-963 P81559 denotes ER alpha
T164 955-963 Q9TV98 denotes ER alpha
T165 955-963 PR:000007204 denotes ER alpha
T166 955-963 Q9YH33 denotes ER alpha
T167 955-963 P50241 denotes ER alpha
T168 955-963 P06212 denotes ER alpha
T169 955-963 P03372 denotes ER alpha
T170 955-963 O42132 denotes ER alpha
T171 955-963 P57753 denotes ER alpha
T172 958-963 CHEBI:30216 denotes alpha
T173 980-985 D006801 denotes human
T174 986-992 UBERON:0000310 denotes breast
T175 993-999 UBERON:0000479 denotes tissue
T176 1007-1013 UBERON:0000310 denotes breast
T177 1014-1021 D009369 denotes cancers
T178 1014-1021 D009369 denotes cancers
T181 1033-1057 D002285 denotes ductal carcinoma in situ
T182 1033-1057 D002285 denotes ductal carcinoma in situ
T188 1059-1063 CVCL_5552 denotes DCIS
T187 1059-1063 D002285 denotes DCIS
T189 1059-1063 D002285 denotes DCIS
T190 1080-1087 D004194 denotes disease
T191 1080-1087 D004194 denotes disease
T192 1125-1132 D004194 denotes disease
T193 1125-1132 D004194 denotes disease
T194 1137-1164 D002285 denotes atypical ductal hyperplasia
T195 1137-1164 D002285 denotes atypical ductal hyperplasia
T198 1166-1169 P0A388 denotes ADH
T199 1166-1169 PR:P06525 denotes ADH
T200 1166-1169 Q8NXU1 denotes ADH
T201 1166-1169 Q6GBM4 denotes ADH
T202 1166-1169 Q47945 denotes ADH
T203 1166-1169 P0A389 denotes ADH
T204 1166-1169 Q5HRD6 denotes ADH
T205 1166-1169 P28036 denotes ADH
T206 1166-1169 P42327 denotes ADH
T207 1166-1169 PR:P00332 denotes ADH
T210 1166-1169 P81786 denotes ADH
T211 1166-1169 P18278 denotes ADH
T212 1166-1169 Q44002 denotes ADH
T213 1166-1169 Q7A742 denotes ADH
T214 1166-1169 O05542 denotes ADH
T215 1166-1169 Q2YSX0 denotes ADH
T216 1166-1169 Q6GJ63 denotes ADH
T217 1166-1169 PR:P00334 denotes ADH
T219 1166-1169 Q24857 denotes ADH
T220 1166-1169 Q8CQ56 denotes ADH
T221 1166-1169 Q2FJ31 denotes ADH
T222 1166-1169 Q2G0G1 denotes ADH
T223 1166-1169 PR:Q2G0G1 denotes ADH
T225 1166-1169 Q5HI63 denotes ADH
T226 1166-1169 Q99W07 denotes ADH
T227 1166-1169 Q04983 denotes ADH
T208 1166-1169 CHEBI:34543 denotes ADH
T224 1166-1169 CHEBI:9937 denotes ADH
T209 1166-1169 GO:0047636 denotes ADH
T218 1166-1169 GO:0004022 denotes ADH
T228 1241-1253 D019394 denotes Ki67 antigen
T229 1241-1253 D019394 denotes Ki67 antigen
T234 1255-1267 8727 denotes progesterone
T237 1255-1276 Q9GLW0 denotes progesterone receptor
T238 1255-1276 A7XW16 denotes progesterone receptor
T239 1255-1276 A7X8C2 denotes progesterone receptor
T240 1255-1276 Q00175 denotes progesterone receptor
T241 1255-1276 A7X8B5 denotes progesterone receptor
T242 1255-1276 Q8AYI2 denotes progesterone receptor
T243 1255-1276 A7X8C7 denotes progesterone receptor
T244 1255-1276 Q63449 denotes progesterone receptor
T245 1255-1276 A7X8C9 denotes progesterone receptor
T246 1255-1276 Q28590 denotes progesterone receptor
T247 1255-1276 A7X8B9 denotes progesterone receptor
T248 1255-1276 A7X8D4 denotes progesterone receptor
T249 1255-1276 A7X8B3 denotes progesterone receptor
T250 1255-1276 P07812 denotes progesterone receptor
T251 1255-1276 A7XW20 denotes progesterone receptor
T252 1255-1276 A7X8B7 denotes progesterone receptor
T253 1255-1276 A7XW25 denotes progesterone receptor
T254 1255-1276 P06401 denotes progesterone receptor
T255 1255-1276 PR:000012621 denotes progesterone receptor
T256 1255-1276 P79373 denotes progesterone receptor
T257 1255-1276 P06186 denotes progesterone receptor
T258 1255-1276 A7X8C4 denotes progesterone receptor
T260 1255-1276 A7X8D2 denotes progesterone receptor
T259 1255-1276 D011980 denotes progesterone receptor
T261 1283-1289 PR:P04412 denotes c-erbB
T264 1285-1291 PR:P70424 denotes erbB-2
T265 1285-1291 PR:P06494 denotes erbB-2
T266 1285-1291 PR:P04626 denotes erbB-2
T267 1285-1291 PR:000002082 denotes erbB-2
T268 1297-1300 PR:P04637 denotes p53
T269 1297-1300 PR:000003035 denotes p53
T270 1297-1300 PR:P02340 denotes p53
T271 1297-1300 PR:Q42578 denotes p53
T272 1297-1300 PR:P10361 denotes p53
T275 1302-1313 C032690 denotes 17 beta-HSD
T273 1302-1313 GO:0004303 denotes 17 beta-HSD
T274 1302-1313 GO:0047035 denotes 17 beta-HSD
T278 1310-1313 PR:P35492 denotes HSD
T280 1310-1313 PR:000008437 denotes HSD
T279 1310-1313 143095 denotes HSD
T281 1429-1435 UBERON:0000310 denotes breast
T282 1451-1457 UBERON:0000310 denotes breast
T283 1451-1467 D001943 denotes breast carcinoma
T284 1451-1467 D001943 denotes breast carcinoma
T289 1475-1486 C032690 denotes 17 beta-HSD
T287 1475-1486 GO:0004303 denotes 17 beta-HSD
T288 1475-1486 GO:0047035 denotes 17 beta-HSD
T292 1483-1486 PR:P35492 denotes HSD
T294 1483-1486 PR:000008437 denotes HSD
T293 1483-1486 143095 denotes HSD
T295 1566-1569 P0A388 denotes ADH
T296 1566-1569 PR:P06525 denotes ADH
T297 1566-1569 Q8NXU1 denotes ADH
T298 1566-1569 Q6GBM4 denotes ADH
T299 1566-1569 Q47945 denotes ADH
T300 1566-1569 P0A389 denotes ADH
T301 1566-1569 Q5HRD6 denotes ADH
T302 1566-1569 P28036 denotes ADH
T303 1566-1569 P42327 denotes ADH
T304 1566-1569 PR:P00332 denotes ADH
T307 1566-1569 P81786 denotes ADH
T308 1566-1569 P18278 denotes ADH
T309 1566-1569 Q44002 denotes ADH
T310 1566-1569 Q7A742 denotes ADH
T311 1566-1569 O05542 denotes ADH
T312 1566-1569 Q2YSX0 denotes ADH
T313 1566-1569 Q6GJ63 denotes ADH
T314 1566-1569 PR:P00334 denotes ADH
T316 1566-1569 Q24857 denotes ADH
T317 1566-1569 Q8CQ56 denotes ADH
T318 1566-1569 Q2FJ31 denotes ADH
T319 1566-1569 Q2G0G1 denotes ADH
T320 1566-1569 PR:Q2G0G1 denotes ADH
T322 1566-1569 Q5HI63 denotes ADH
T323 1566-1569 Q99W07 denotes ADH
T324 1566-1569 Q04983 denotes ADH
T305 1566-1569 CHEBI:34543 denotes ADH
T321 1566-1569 CHEBI:9937 denotes ADH
T306 1566-1569 GO:0047636 denotes ADH
T315 1566-1569 GO:0004022 denotes ADH
T326 1595-1599 CVCL_5552 denotes DCIS
T325 1595-1599 D002285 denotes DCIS
T327 1595-1599 D002285 denotes DCIS
T330 1621-1632 C032690 denotes 17 beta-HSD
T328 1621-1632 GO:0004303 denotes 17 beta-HSD
T329 1621-1632 GO:0047035 denotes 17 beta-HSD
T333 1629-1632 PR:P35492 denotes HSD
T335 1629-1632 PR:000008437 denotes HSD
T334 1629-1632 143095 denotes HSD
T341 1766-1772 PR:P04412 denotes c-erbB
T344 1768-1774 PR:P70424 denotes erbB-2
T345 1768-1774 PR:P06494 denotes erbB-2
T346 1768-1774 PR:P04626 denotes erbB-2
T347 1768-1774 PR:000002082 denotes erbB-2
T348 1838-1846 Q9PVZ9 denotes ER alpha
T349 1838-1846 Q9YHT3 denotes ER alpha
T350 1838-1846 P57717 denotes ER alpha
T351 1838-1846 Q9QZJ5 denotes ER alpha
T352 1838-1846 Q29040 denotes ER alpha
T353 1838-1846 P49886 denotes ER alpha
T354 1838-1846 P50240 denotes ER alpha
T355 1838-1846 Q91424 denotes ER alpha
T356 1838-1846 Q9YHZ7 denotes ER alpha
T357 1838-1846 P06211 denotes ER alpha
T358 1838-1846 P16058 denotes ER alpha
T359 1838-1846 P50242 denotes ER alpha
T360 1838-1846 Q53AD2 denotes ER alpha
T361 1838-1846 P49885 denotes ER alpha
T362 1838-1846 P49884 denotes ER alpha
T363 1838-1846 P19785 denotes ER alpha
T364 1838-1846 Q91250 denotes ER alpha
T365 1838-1846 P81559 denotes ER alpha
T366 1838-1846 Q9TV98 denotes ER alpha
T367 1838-1846 PR:000007204 denotes ER alpha
T368 1838-1846 Q9YH33 denotes ER alpha
T369 1838-1846 P50241 denotes ER alpha
T370 1838-1846 P06212 denotes ER alpha
T371 1838-1846 P03372 denotes ER alpha
T372 1838-1846 O42132 denotes ER alpha
T373 1838-1846 P57753 denotes ER alpha
T374 1841-1846 CHEBI:30216 denotes alpha
T377 1854-1865 C032690 denotes 17 beta-HSD
T375 1854-1865 GO:0004303 denotes 17 beta-HSD
T376 1854-1865 GO:0047035 denotes 17 beta-HSD
T380 1862-1865 PR:P35492 denotes HSD
T382 1862-1865 PR:000008437 denotes HSD
T381 1862-1865 143095 denotes HSD
T383 1932-1940 Q9PVZ9 denotes ER alpha
T384 1932-1940 Q9YHT3 denotes ER alpha
T385 1932-1940 P57717 denotes ER alpha
T386 1932-1940 Q9QZJ5 denotes ER alpha
T387 1932-1940 Q29040 denotes ER alpha
T388 1932-1940 P49886 denotes ER alpha
T389 1932-1940 P50240 denotes ER alpha
T390 1932-1940 Q91424 denotes ER alpha
T391 1932-1940 Q9YHZ7 denotes ER alpha
T392 1932-1940 P06211 denotes ER alpha
T393 1932-1940 P16058 denotes ER alpha
T394 1932-1940 P50242 denotes ER alpha
T395 1932-1940 Q53AD2 denotes ER alpha
T396 1932-1940 P49885 denotes ER alpha
T397 1932-1940 P49884 denotes ER alpha
T398 1932-1940 P19785 denotes ER alpha
T399 1932-1940 Q91250 denotes ER alpha
T400 1932-1940 P81559 denotes ER alpha
T401 1932-1940 Q9TV98 denotes ER alpha
T402 1932-1940 PR:000007204 denotes ER alpha
T403 1932-1940 Q9YH33 denotes ER alpha
T404 1932-1940 P50241 denotes ER alpha
T405 1932-1940 P06212 denotes ER alpha
T406 1932-1940 P03372 denotes ER alpha
T407 1932-1940 O42132 denotes ER alpha
T408 1932-1940 P57753 denotes ER alpha
T409 1935-1940 CHEBI:30216 denotes alpha
T410 2014-2022 Q9PVZ9 denotes ER alpha
T411 2014-2022 Q9YHT3 denotes ER alpha
T412 2014-2022 P57717 denotes ER alpha
T413 2014-2022 Q9QZJ5 denotes ER alpha
T414 2014-2022 Q29040 denotes ER alpha
T415 2014-2022 P49886 denotes ER alpha
T416 2014-2022 P50240 denotes ER alpha
T417 2014-2022 Q91424 denotes ER alpha
T418 2014-2022 Q9YHZ7 denotes ER alpha
T419 2014-2022 P06211 denotes ER alpha
T420 2014-2022 P16058 denotes ER alpha
T421 2014-2022 P50242 denotes ER alpha
T422 2014-2022 Q53AD2 denotes ER alpha
T423 2014-2022 P49885 denotes ER alpha
T424 2014-2022 P49884 denotes ER alpha
T425 2014-2022 P19785 denotes ER alpha
T426 2014-2022 Q91250 denotes ER alpha
T427 2014-2022 P81559 denotes ER alpha
T428 2014-2022 Q9TV98 denotes ER alpha
T429 2014-2022 PR:000007204 denotes ER alpha
T430 2014-2022 Q9YH33 denotes ER alpha
T431 2014-2022 P50241 denotes ER alpha
T432 2014-2022 P06212 denotes ER alpha
T433 2014-2022 P03372 denotes ER alpha
T434 2014-2022 O42132 denotes ER alpha
T435 2014-2022 P57753 denotes ER alpha
T436 2017-2022 CHEBI:30216 denotes alpha
T438 2038-2042 CVCL_5552 denotes DCIS
T437 2038-2042 D002285 denotes DCIS
T439 2038-2042 D002285 denotes DCIS
T440 2077-2085 Q9PVZ9 denotes ER alpha
T441 2077-2085 Q9YHT3 denotes ER alpha
T442 2077-2085 P57717 denotes ER alpha
T443 2077-2085 Q9QZJ5 denotes ER alpha
T444 2077-2085 Q29040 denotes ER alpha
T445 2077-2085 P49886 denotes ER alpha
T446 2077-2085 P50240 denotes ER alpha
T447 2077-2085 Q91424 denotes ER alpha
T448 2077-2085 Q9YHZ7 denotes ER alpha
T449 2077-2085 P06211 denotes ER alpha
T450 2077-2085 P16058 denotes ER alpha
T451 2077-2085 P50242 denotes ER alpha
T452 2077-2085 Q53AD2 denotes ER alpha
T453 2077-2085 P49885 denotes ER alpha
T454 2077-2085 P49884 denotes ER alpha
T455 2077-2085 P19785 denotes ER alpha
T456 2077-2085 Q91250 denotes ER alpha
T457 2077-2085 P81559 denotes ER alpha
T458 2077-2085 Q9TV98 denotes ER alpha
T459 2077-2085 PR:000007204 denotes ER alpha
T460 2077-2085 Q9YH33 denotes ER alpha
T461 2077-2085 P50241 denotes ER alpha
T462 2077-2085 P06212 denotes ER alpha
T463 2077-2085 P03372 denotes ER alpha
T464 2077-2085 O42132 denotes ER alpha
T465 2077-2085 P57753 denotes ER alpha
T466 2080-2085 CHEBI:30216 denotes alpha
T467 2101-2104 P0A388 denotes ADH
T468 2101-2104 PR:P06525 denotes ADH
T469 2101-2104 Q8NXU1 denotes ADH
T470 2101-2104 Q6GBM4 denotes ADH
T471 2101-2104 Q47945 denotes ADH
T472 2101-2104 P0A389 denotes ADH
T473 2101-2104 Q5HRD6 denotes ADH
T474 2101-2104 P28036 denotes ADH
T475 2101-2104 P42327 denotes ADH
T476 2101-2104 PR:P00332 denotes ADH
T479 2101-2104 P81786 denotes ADH
T480 2101-2104 P18278 denotes ADH
T481 2101-2104 Q44002 denotes ADH
T482 2101-2104 Q7A742 denotes ADH
T483 2101-2104 O05542 denotes ADH
T484 2101-2104 Q2YSX0 denotes ADH
T485 2101-2104 Q6GJ63 denotes ADH
T486 2101-2104 PR:P00334 denotes ADH
T488 2101-2104 Q24857 denotes ADH
T489 2101-2104 Q8CQ56 denotes ADH
T490 2101-2104 Q2FJ31 denotes ADH
T491 2101-2104 Q2G0G1 denotes ADH
T492 2101-2104 PR:Q2G0G1 denotes ADH
T494 2101-2104 Q5HI63 denotes ADH
T495 2101-2104 Q99W07 denotes ADH
T496 2101-2104 Q04983 denotes ADH
T477 2101-2104 CHEBI:34543 denotes ADH
T493 2101-2104 CHEBI:9937 denotes ADH
T478 2101-2104 GO:0047636 denotes ADH
T487 2101-2104 GO:0004022 denotes ADH
T497 2136-2141 D006801 denotes human
T498 2142-2148 UBERON:0000310 denotes breast
T499 2182-2185 P0A388 denotes ADH
T500 2182-2185 PR:P06525 denotes ADH
T501 2182-2185 Q8NXU1 denotes ADH
T502 2182-2185 Q6GBM4 denotes ADH
T503 2182-2185 Q47945 denotes ADH
T504 2182-2185 P0A389 denotes ADH
T505 2182-2185 Q5HRD6 denotes ADH
T506 2182-2185 P28036 denotes ADH
T507 2182-2185 P42327 denotes ADH
T508 2182-2185 PR:P00332 denotes ADH
T511 2182-2185 P81786 denotes ADH
T512 2182-2185 P18278 denotes ADH
T513 2182-2185 Q44002 denotes ADH
T514 2182-2185 Q7A742 denotes ADH
T515 2182-2185 O05542 denotes ADH
T516 2182-2185 Q2YSX0 denotes ADH
T517 2182-2185 Q6GJ63 denotes ADH
T518 2182-2185 PR:P00334 denotes ADH
T520 2182-2185 Q24857 denotes ADH
T521 2182-2185 Q8CQ56 denotes ADH
T522 2182-2185 Q2FJ31 denotes ADH
T523 2182-2185 Q2G0G1 denotes ADH
T524 2182-2185 PR:Q2G0G1 denotes ADH
T526 2182-2185 Q5HI63 denotes ADH
T527 2182-2185 Q99W07 denotes ADH
T528 2182-2185 Q04983 denotes ADH
T509 2182-2185 CHEBI:34543 denotes ADH
T525 2182-2185 CHEBI:9937 denotes ADH
T510 2182-2185 GO:0047636 denotes ADH
T519 2182-2185 GO:0004022 denotes ADH
T530 2190-2194 CVCL_5552 denotes DCIS
T529 2190-2194 D002285 denotes DCIS
T531 2190-2194 D002285 denotes DCIS
T532 2247-2256 CHEBI:50114 denotes oestrogen
T534 2267-2299 GO:0042127 denotes regulation of cell proliferation
T536 2286-2299 UBERON:2000098 denotes proliferation

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 650-663 HP_0003002 denotes breast cancer
T2 650-663 HP_0100013 denotes breast cancer
T3 657-663 HP_0002664 denotes cancer
T4 1007-1021 HP_0003002 denotes breast cancers
T5 1007-1021 HP_0100013 denotes breast cancers
T6 1014-1021 HP_0002664 denotes cancers
T7 1451-1467 HP_0003002 denotes breast carcinoma

UseCases_ArguminSci_Discourse

Id Subject Object Predicate Lexical cue
T1 0-141 DRI_Outcome denotes 17 beta-Hydroxysteroid dehydrogenase type 1 and type 2 in ductal carcinoma in situ and intraductal proliferative lesions of the human breast.
T2 142-399 DRI_Approach denotes 17 beta-hydroxysteroid dehydrogenases (17 beta-HSDs) are involved in the interconversion of biologically active and inactive sex steroids and are considered to play important roles in the in situ metabolism of estrogen in various estrogen dependent tissues.
T3 400-561 DRI_Background denotes 17 beta-HSD type 1 catalyzes primarily the reduction of estrone (E1) to estradiol (E2), whereas 17 beta-HSD type 2 catalyzes primarily the oxidation of E2 to E1.
T4 562-748 DRI_Background denotes However, the possible biological roles of these estrogen metabolizing isozymes in human breast cancer, especially in carcinogenesis of the human breast, have not been examined in detail.
T5 749-1171 DRI_Outcome denotes Because of the potential roles of estrogens in the early stages of human breast carcinogenesis, we have examined the immunolocalization of 17 beta-HSD type 1 and type 2 isozymes and estrogen receptor alpha(ER alpha) in both normal human breast tissue and in breast cancers, including ductal carcinoma in situ (DCIS), proliferative disease without atypia (PDWA) or fibrocystic disease and atypical ductal hyperplasia (ADH).
T6 1172-1301 DRI_Approach denotes We also correlated these findings with clinicopathological findings, Ki67 antigen, progesterone receptor (PR), c-erbB-2, and p53.
T7 1302-1474 DRI_Background denotes 17 beta-HSD type 2 immunoreactivity was sporadically detected in non-proliferative or Ki67 negative ductal epithelia of normal breast, but rarely in breast carcinoma cells.
T8 1475-1620 DRI_Outcome denotes 17 beta-HSD type 1 immunoreactivity was detected in 12/22 (54.5%) PDWA cases, 8/26 (30.8%) ADH cases, and 25/40 (62.5%) DCIS cases, respectively.
T9 1621-1765 DRI_Unspecified denotes 17 beta-HSD type 1 immunoreactivity was not statistically correlated with the age of the patients, Ki67 labeling index (LI), and PR LI, p-53 and
T10 1766-1791 Token_Label.OUTSIDE denotes c-erbB-2 immunoreactivity
T11 1791-1792 DRI_Unspecified denotes .
T12 1793-1890 DRI_Background denotes There was no significant correlation between ER alpha LI and 17 beta-HSD type 1 immunoreactivity.
T13 1891-2043 DRI_Unspecified denotes There was a positive correlation between ER alpha and Ki67 LI in PDWA, whereas a negative correlation was detected between ER alpha and Ki67 LI in DCIS.
T14 2044-2105 DRI_Background denotes There was no correlation between ER alpha and Ki67 LI in ADH.
T15 2106-2300 DRI_Background denotes These results suggest that in human breast epithelial cells, development of ADH and DCIS may be associated with the loss and/or deviation of oestrogen dependent regulation of cell proliferation.

PubMed_ArguminSci

Id Subject Object Predicate Lexical cue
T1 142-399 DRI_Approach denotes 17 beta-hydroxysteroid dehydrogenases (17 beta-HSDs) are involved in the interconversion of biologically active and inactive sex steroids and are considered to play important roles in the in situ metabolism of estrogen in various estrogen dependent tissues.
T2 400-561 DRI_Background denotes 17 beta-HSD type 1 catalyzes primarily the reduction of estrone (E1) to estradiol (E2), whereas 17 beta-HSD type 2 catalyzes primarily the oxidation of E2 to E1.
T3 562-748 DRI_Background denotes However, the possible biological roles of these estrogen metabolizing isozymes in human breast cancer, especially in carcinogenesis of the human breast, have not been examined in detail.
T4 749-1171 DRI_Outcome denotes Because of the potential roles of estrogens in the early stages of human breast carcinogenesis, we have examined the immunolocalization of 17 beta-HSD type 1 and type 2 isozymes and estrogen receptor alpha(ER alpha) in both normal human breast tissue and in breast cancers, including ductal carcinoma in situ (DCIS), proliferative disease without atypia (PDWA) or fibrocystic disease and atypical ductal hyperplasia (ADH).
T5 1172-1301 DRI_Approach denotes We also correlated these findings with clinicopathological findings, Ki67 antigen, progesterone receptor (PR), c-erbB-2, and p53.
T6 1302-1474 DRI_Background denotes 17 beta-HSD type 2 immunoreactivity was sporadically detected in non-proliferative or Ki67 negative ductal epithelia of normal breast, but rarely in breast carcinoma cells.
T7 1475-1620 DRI_Outcome denotes 17 beta-HSD type 1 immunoreactivity was detected in 12/22 (54.5%) PDWA cases, 8/26 (30.8%) ADH cases, and 25/40 (62.5%) DCIS cases, respectively.
T8 1793-1890 DRI_Background denotes There was no significant correlation between ER alpha LI and 17 beta-HSD type 1 immunoreactivity.
T9 2044-2105 DRI_Background denotes There was no correlation between ER alpha and Ki67 LI in ADH.
T10 2106-2300 DRI_Background denotes These results suggest that in human breast epithelial cells, development of ADH and DCIS may be associated with the loss and/or deviation of oestrogen dependent regulation of cell proliferation.