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PubMed:10809758 JSONTXT

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CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 13-21 Cell denotes neuronal http://purl.obolibrary.org/obo/CL:0000540
T2 602-613 Cell denotes neural cell http://purl.obolibrary.org/obo/CL:0002319
T3 703-711 Cell denotes neuronal http://purl.obolibrary.org/obo/CL:0000540

sentences

Id Subject Object Predicate Lexical cue
T1 0-74 Sentence denotes Induction of neuronal differentiation by p73 in a neuroblastoma cell line.
T2 75-193 Sentence denotes The p53-related p73 and p63 genes encode proteins that share considerable structural and functional homology with p53.
T3 194-325 Sentence denotes Despite similarities, their deletion in mice has different outcomes, implying that the three genes may play distinct roles in vivo.
T4 326-728 Sentence denotes Here we show that endogenous p73 levels increase in neuroblastoma cells induced to differentiate by retinoic acid and that exogenously expressed p73, but not p53, is sufficient to induce both morphological (neurite outgrowth) and biochemical (expression of neurofilaments and neural cell adhesion molecule (N-CAM); down-regulation of N-MYC and up-regulation of pRB) markers of neuronal differentiation.
T5 729-876 Sentence denotes This activity is shared, to different extents, by all p73 isoforms, whereas the transcriptionally inactive mutants of p73 isoforms are ineffective.
T6 877-1036 Sentence denotes Conversely, blockage of endogenous p73 isoforms with a dominant negative p73 results in the abrogation of retinoid-induced N-CAM promoter-driven transcription.
T7 1037-1194 Sentence denotes Our results indicate that the p73 isoforms activate a pathway that is not shared by p53 and that is required for neuroblastoma cell differentiation in vitro.

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 378-391 HP_0003006 denotes neuroblastoma
T2 1150-1163 HP_0003006 denotes neuroblastoma

PennBioIE

Id Subject Object Predicate Lexical cue
T1 13-21 protein denotes neuronal
T2 22-37 protein denotes differentiation
T3 41-44 protein denotes p73
T4 50-63 protein denotes neuroblastoma
T5 79-82 protein denotes p53
T6 91-94 protein denotes p73
T7 99-102 protein denotes p63
T8 189-192 protein denotes p53
T9 222-230 protein denotes deletion
T10 355-358 protein denotes p73
T11 378-391 protein denotes neuroblastoma
T12 409-422 protein denotes differentiate
T13 471-474 protein denotes p73
T14 484-487 protein denotes p53
T15 583-597 protein denotes neurofilaments
T16 602-631 protein denotes neural cell adhesion molecule
T17 633-638 protein denotes N-CAM
T18 660-665 protein denotes N-MYC
T19 687-690 protein denotes pRB
T20 703-711 protein denotes neuronal
T21 712-727 protein denotes differentiation
T22 783-795 protein denotes p73 isoforms
T23 847-859 protein denotes p73 isoforms
T24 912-924 protein denotes p73 isoforms
T25 950-953 protein denotes p73
T26 1000-1005 protein denotes N-CAM
T27 1067-1079 protein denotes p73 isoforms
T28 1121-1124 protein denotes p53
T29 1150-1163 protein denotes neuroblastoma
T30 1169-1184 protein denotes differentiation

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 50-63 Phenotype denotes neuroblastoma HP:0003006
T2 378-391 Phenotype denotes neuroblastoma HP:0003006
T3 1150-1163 Phenotype denotes neuroblastoma HP:0003006

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 50-63 Disease denotes neuroblastoma http://purl.obolibrary.org/obo/MONDO_0005072
T2 378-391 Disease denotes neuroblastoma http://purl.obolibrary.org/obo/MONDO_0005072
T3 1150-1163 Disease denotes neuroblastoma http://purl.obolibrary.org/obo/MONDO_0005072

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 234-238 OrganismTaxon denotes mice 10088

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 533-540 Body_part denotes neurite http://purl.obolibrary.org/obo/GO_0043005
T2 602-613 Body_part denotes neural cell http://purl.obolibrary.org/obo/CL_0002319