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GlyCosmos6-Glycan-Motif-Image

Id Subject Object Predicate Lexical cue image
T1 96-99 Glycan_Motif denotes GM3 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G91237TK|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G56516VH
T3 101-104 Glycan_Motif denotes GM3 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G91237TK|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G56516VH
T5 381-384 Glycan_Motif denotes GM3 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G91237TK|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G56516VH
T7 428-431 Glycan_Motif denotes GM3 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G91237TK|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G56516VH
T9 472-475 Glycan_Motif denotes GM3 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G91237TK|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G56516VH
T11 789-792 Glycan_Motif denotes GM3 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G91237TK|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G56516VH
T13 911-914 Glycan_Motif denotes GM3 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G91237TK|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G56516VH
T15 968-971 Glycan_Motif denotes GM3 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G91237TK|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G56516VH
T17 1111-1114 Glycan_Motif denotes GM3 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G91237TK|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G56516VH
T19 1155-1158 Glycan_Motif denotes GM3 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G91237TK|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G56516VH
T21 1206-1209 Glycan_Motif denotes GM1 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G48558GR|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G46613JI
T23 1213-1217 Glycan_Motif denotes GD1a https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G69277LC|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G46677TE
T25 1239-1242 Glycan_Motif denotes GM3 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G91237TK|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G56516VH
T27 1359-1362 Glycan_Motif denotes GM3 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G91237TK|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G56516VH
T29 1556-1559 Glycan_Motif denotes GM3 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G91237TK|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G56516VH
T31 1629-1632 Glycan_Motif denotes GM3 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G91237TK|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G56516VH
T33 1769-1772 Glycan_Motif denotes GM3 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G91237TK|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G56516VH
T35 1972-1975 Glycan_Motif denotes GM3 https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G91237TK|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G56516VH

sentences

Id Subject Object Predicate Lexical cue
T1 0-100 Sentence denotes Reconstitution of membranes simulating "glycosignaling domain" and their susceptibility to lyso-GM3.
T2 101-423 Sentence denotes GM3 ganglioside at the surface of mouse melanoma B16 cells is clustered and organized with signal transducer molecules c-Src, Rho A, and focal adhesion kinase (FAK) to form a membrane unit separable from caveolae, which are enriched in cholesterol and caveolin but do not contain GM3 or the above three signal transducers.
T3 424-642 Sentence denotes The GM3-enriched membrane units are involved in GM3-dependent cell adhesion coupled with activation of c-Src, Rho A, and FAK and are termed the "glycosphingolipid signaling domain" or the "glycosignaling domain" (GSD).
T4 643-859 Sentence denotes In order to assess the essential components that display GSD function, membranes with properties similar to those of GSD were reconstituted using GM3, sphingomyelin, and c-Src, with or without other lipid components.
T5 860-1059 Sentence denotes The reconstituted membrane thus prepared displayed GM3-dependent adhesion to plates coated with Gg3 or anti-GM3 antibody, resulting in enhanced c-Src phosphorylation (c-Src phosphorylation response).
T6 1060-1234 Sentence denotes This response in reconstituted membrane depends on GM3 concentration and was not observed when GM3 was absent or replaced with other gangliosides GM1 or GD1a, or with LacCer.
T7 1235-1349 Sentence denotes The GM3-dependent c-Src phosphorylation response was enhanced when cholesterol and phosphatidylcholine were added.
T8 1350-1530 Sentence denotes Although GM3, sphingomyelin, and c-Src are essential for GSD function, a small quantity of cholesterol and phosphatidylcholine may act as an auxiliary factor to stabilize membrane.
T9 1531-1719 Sentence denotes GSD function in terms of GM3-dependent adhesion and signaling was blocked in the presence of lyso-GM3 or its analogue but not psychosine, lactosyl-sphingosine, or lyso-phosphatidylcholine.
T10 1720-1839 Sentence denotes Such susceptibility of reconstituted GSD to lyso-GM3 and other lyso compounds is the same as GSD of original B16 cells.
T11 1840-2025 Sentence denotes Thus, functional organization of the reconstituted membrane closely simulates that of GSD in B16 cells, which is based on clustered GM3 organized with c-Src as the essential components.

GlyCosmos6-Glycan-Motif-Structure

Id Subject Object Predicate Lexical cue
T1 96-99 https://glytoucan.org/Structures/Glycans/G56516VH denotes GM3
T2 96-99 https://glytoucan.org/Structures/Glycans/G91237TK denotes GM3
T3 101-104 https://glytoucan.org/Structures/Glycans/G56516VH denotes GM3
T4 101-104 https://glytoucan.org/Structures/Glycans/G91237TK denotes GM3
T5 381-384 https://glytoucan.org/Structures/Glycans/G56516VH denotes GM3
T6 381-384 https://glytoucan.org/Structures/Glycans/G91237TK denotes GM3
T7 428-431 https://glytoucan.org/Structures/Glycans/G56516VH denotes GM3
T8 428-431 https://glytoucan.org/Structures/Glycans/G91237TK denotes GM3
T9 472-475 https://glytoucan.org/Structures/Glycans/G56516VH denotes GM3
T10 472-475 https://glytoucan.org/Structures/Glycans/G91237TK denotes GM3
T11 789-792 https://glytoucan.org/Structures/Glycans/G56516VH denotes GM3
T12 789-792 https://glytoucan.org/Structures/Glycans/G91237TK denotes GM3
T13 911-914 https://glytoucan.org/Structures/Glycans/G56516VH denotes GM3
T14 911-914 https://glytoucan.org/Structures/Glycans/G91237TK denotes GM3
T15 968-971 https://glytoucan.org/Structures/Glycans/G56516VH denotes GM3
T16 968-971 https://glytoucan.org/Structures/Glycans/G91237TK denotes GM3
T17 1111-1114 https://glytoucan.org/Structures/Glycans/G56516VH denotes GM3
T18 1111-1114 https://glytoucan.org/Structures/Glycans/G91237TK denotes GM3
T19 1155-1158 https://glytoucan.org/Structures/Glycans/G56516VH denotes GM3
T20 1155-1158 https://glytoucan.org/Structures/Glycans/G91237TK denotes GM3
T21 1206-1209 https://glytoucan.org/Structures/Glycans/G46613JI denotes GM1
T22 1206-1209 https://glytoucan.org/Structures/Glycans/G48558GR denotes GM1
T23 1213-1217 https://glytoucan.org/Structures/Glycans/G46677TE denotes GD1a
T24 1213-1217 https://glytoucan.org/Structures/Glycans/G69277LC denotes GD1a
T25 1239-1242 https://glytoucan.org/Structures/Glycans/G56516VH denotes GM3
T26 1239-1242 https://glytoucan.org/Structures/Glycans/G91237TK denotes GM3
T27 1359-1362 https://glytoucan.org/Structures/Glycans/G56516VH denotes GM3
T28 1359-1362 https://glytoucan.org/Structures/Glycans/G91237TK denotes GM3
T29 1556-1559 https://glytoucan.org/Structures/Glycans/G56516VH denotes GM3
T30 1556-1559 https://glytoucan.org/Structures/Glycans/G91237TK denotes GM3
T31 1629-1632 https://glytoucan.org/Structures/Glycans/G56516VH denotes GM3
T32 1629-1632 https://glytoucan.org/Structures/Glycans/G91237TK denotes GM3
T33 1769-1772 https://glytoucan.org/Structures/Glycans/G56516VH denotes GM3
T34 1769-1772 https://glytoucan.org/Structures/Glycans/G91237TK denotes GM3
T35 1972-1975 https://glytoucan.org/Structures/Glycans/G56516VH denotes GM3
T36 1972-1975 https://glytoucan.org/Structures/Glycans/G91237TK denotes GM3

Glycosmos6-GlycoEpitope

Id Subject Object Predicate Lexical cue
T1 1206-1209 http://www.glycoepitope.jp/epitopes/EP0050 denotes GM1
T2 1213-1217 http://www.glycoepitope.jp/epitopes/EP0056 denotes GD1a

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 141-149 HP_0002861 denotes melanoma
T2 1657-1667 HP_0000709 denotes psychosine

Glycan-GlyCosmos

Id Subject Object Predicate Lexical cue image
T1 96-99 Glycan denotes GM3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK
T2 101-104 Glycan denotes GM3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK
T3 381-384 Glycan denotes GM3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK
T4 428-431 Glycan denotes GM3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK
T5 472-475 Glycan denotes GM3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK
T6 789-792 Glycan denotes GM3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK
T7 911-914 Glycan denotes GM3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK
T8 956-959 Glycan denotes Gg3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G90562PB
T9 968-971 Glycan denotes GM3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK
T10 1111-1114 Glycan denotes GM3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK
T11 1155-1158 Glycan denotes GM3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK
T12 1206-1209 Glycan denotes GM1 https://api.glycosmos.org/wurcs2image/latest/png/binary/G48558GR
T13 1213-1217 Glycan denotes GD1a https://api.glycosmos.org/wurcs2image/latest/png/binary/G46677TE
T14 1239-1242 Glycan denotes GM3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK
T15 1359-1362 Glycan denotes GM3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK
T16 1556-1559 Glycan denotes GM3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK
T17 1629-1632 Glycan denotes GM3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK
T18 1769-1772 Glycan denotes GM3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK
T19 1972-1975 Glycan denotes GM3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK

GlyCosmos15-Glycan

Id Subject Object Predicate Lexical cue image
T1 96-99 Glycan denotes GM3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK
T2 101-104 Glycan denotes GM3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK
T3 381-384 Glycan denotes GM3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK
T4 428-431 Glycan denotes GM3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK
T5 472-475 Glycan denotes GM3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK
T6 789-792 Glycan denotes GM3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK
T7 911-914 Glycan denotes GM3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK
T8 956-959 Glycan denotes Gg3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G90562PB
T9 968-971 Glycan denotes GM3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK
T10 1111-1114 Glycan denotes GM3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK
T11 1155-1158 Glycan denotes GM3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK
T12 1206-1209 Glycan denotes GM1 https://api.glycosmos.org/wurcs2image/latest/png/binary/G48558GR
T13 1213-1217 Glycan denotes GD1a https://api.glycosmos.org/wurcs2image/latest/png/binary/G46677TE
T14 1239-1242 Glycan denotes GM3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK
T15 1359-1362 Glycan denotes GM3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK
T16 1556-1559 Glycan denotes GM3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK
T17 1629-1632 Glycan denotes GM3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK
T18 1769-1772 Glycan denotes GM3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK
T19 1972-1975 Glycan denotes GM3 https://api.glycosmos.org/wurcs2image/latest/png/binary/G91237TK

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 141-149 Disease denotes melanoma http://purl.obolibrary.org/obo/MONDO_0005105
T2 637-640 Disease denotes GSD http://purl.obolibrary.org/obo/MONDO_0002412|http://purl.obolibrary.org/obo/MONDO_0007656
T4 700-703 Disease denotes GSD http://purl.obolibrary.org/obo/MONDO_0002412|http://purl.obolibrary.org/obo/MONDO_0007656
T6 760-763 Disease denotes GSD http://purl.obolibrary.org/obo/MONDO_0002412|http://purl.obolibrary.org/obo/MONDO_0007656
T8 1407-1410 Disease denotes GSD http://purl.obolibrary.org/obo/MONDO_0002412|http://purl.obolibrary.org/obo/MONDO_0007656
T10 1531-1534 Disease denotes GSD http://purl.obolibrary.org/obo/MONDO_0002412|http://purl.obolibrary.org/obo/MONDO_0007656
T12 1757-1760 Disease denotes GSD http://purl.obolibrary.org/obo/MONDO_0002412|http://purl.obolibrary.org/obo/MONDO_0007656
T14 1813-1816 Disease denotes GSD http://purl.obolibrary.org/obo/MONDO_0002412|http://purl.obolibrary.org/obo/MONDO_0007656
T16 1926-1929 Disease denotes GSD http://purl.obolibrary.org/obo/MONDO_0002412|http://purl.obolibrary.org/obo/MONDO_0007656

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 141-149 Phenotype denotes melanoma HP:0002861

GlyCosmos-GlycoEpitope

Id Subject Object Predicate Lexical cue glycoepitope_id
T1 1206-1209 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes GM1 http://www.glycoepitope.jp/epitopes/EP0050
T2 1213-1217 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes GD1a http://www.glycoepitope.jp/epitopes/EP0056

GlyCosmos15-HP

Id Subject Object Predicate Lexical cue hp_id
T1 141-149 Phenotype denotes melanoma HP:0002861

GlyCosmos15-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 18-27 Body_part denotes membranes http://purl.obolibrary.org/obo/UBERON_0000094
T2 276-284 Body_part denotes membrane http://purl.obolibrary.org/obo/UBERON_0000094
T3 441-449 Body_part denotes membrane http://purl.obolibrary.org/obo/UBERON_0000094
T4 714-723 Body_part denotes membranes http://purl.obolibrary.org/obo/UBERON_0000094
T5 878-886 Body_part denotes membrane http://purl.obolibrary.org/obo/UBERON_0000094
T6 1091-1099 Body_part denotes membrane http://purl.obolibrary.org/obo/UBERON_0000094
T7 1521-1529 Body_part denotes membrane http://purl.obolibrary.org/obo/UBERON_0000094
T8 1891-1899 Body_part denotes membrane http://purl.obolibrary.org/obo/UBERON_0000094

GlyCosmos15-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T1 141-149 Disease denotes melanoma MONDO:0005105

GlyCosmos15-GlycoEpitope

Id Subject Object Predicate Lexical cue glycoepitope_id
T1 1206-1209 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes GM1 http://www.glycoepitope.jp/epitopes/EP0050
T2 1213-1217 http://purl.jp/bio/12/glyco/glycan#Glycan_epitope denotes GD1a http://www.glycoepitope.jp/epitopes/EP0056

GlyCosmos15-Taxon

Id Subject Object Predicate Lexical cue db_id
T1 135-140 Organism denotes mouse 10088|10090

GlyCosmos15-Sentences

Id Subject Object Predicate Lexical cue
T1 0-100 Sentence denotes Reconstitution of membranes simulating "glycosignaling domain" and their susceptibility to lyso-GM3.
T2 101-423 Sentence denotes GM3 ganglioside at the surface of mouse melanoma B16 cells is clustered and organized with signal transducer molecules c-Src, Rho A, and focal adhesion kinase (FAK) to form a membrane unit separable from caveolae, which are enriched in cholesterol and caveolin but do not contain GM3 or the above three signal transducers.
T3 424-642 Sentence denotes The GM3-enriched membrane units are involved in GM3-dependent cell adhesion coupled with activation of c-Src, Rho A, and FAK and are termed the "glycosphingolipid signaling domain" or the "glycosignaling domain" (GSD).
T4 643-859 Sentence denotes In order to assess the essential components that display GSD function, membranes with properties similar to those of GSD were reconstituted using GM3, sphingomyelin, and c-Src, with or without other lipid components.
T5 860-1059 Sentence denotes The reconstituted membrane thus prepared displayed GM3-dependent adhesion to plates coated with Gg3 or anti-GM3 antibody, resulting in enhanced c-Src phosphorylation (c-Src phosphorylation response).
T6 1060-1234 Sentence denotes This response in reconstituted membrane depends on GM3 concentration and was not observed when GM3 was absent or replaced with other gangliosides GM1 or GD1a, or with LacCer.
T7 1235-1349 Sentence denotes The GM3-dependent c-Src phosphorylation response was enhanced when cholesterol and phosphatidylcholine were added.
T8 1350-1530 Sentence denotes Although GM3, sphingomyelin, and c-Src are essential for GSD function, a small quantity of cholesterol and phosphatidylcholine may act as an auxiliary factor to stabilize membrane.
T9 1531-1719 Sentence denotes GSD function in terms of GM3-dependent adhesion and signaling was blocked in the presence of lyso-GM3 or its analogue but not psychosine, lactosyl-sphingosine, or lyso-phosphatidylcholine.
T10 1720-1839 Sentence denotes Such susceptibility of reconstituted GSD to lyso-GM3 and other lyso compounds is the same as GSD of original B16 cells.
T11 1840-2025 Sentence denotes Thus, functional organization of the reconstituted membrane closely simulates that of GSD in B16 cells, which is based on clustered GM3 organized with c-Src as the essential components.

GlyCosmos15-FMA

Id Subject Object Predicate Lexical cue db_id
T1 305-313 Body_part denotes caveolae FMA:0327007

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 135-140 OrganismTaxon denotes mouse 10088|10090

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 18-27 Body_part denotes membranes http://purl.obolibrary.org/obo/GO_0016020|http://purl.obolibrary.org/obo/UBERON_0000094|http://purl.obolibrary.org/obo/UBERON_0000158
T4 276-284 Body_part denotes membrane http://purl.obolibrary.org/obo/GO_0016020|http://purl.obolibrary.org/obo/UBERON_0000094|http://purl.obolibrary.org/obo/UBERON_0000158
T7 441-449 Body_part denotes membrane http://purl.obolibrary.org/obo/GO_0016020|http://purl.obolibrary.org/obo/UBERON_0000094|http://purl.obolibrary.org/obo/UBERON_0000158
T10 714-723 Body_part denotes membranes http://purl.obolibrary.org/obo/GO_0016020|http://purl.obolibrary.org/obo/UBERON_0000094|http://purl.obolibrary.org/obo/UBERON_0000158
T13 878-886 Body_part denotes membrane http://purl.obolibrary.org/obo/GO_0016020|http://purl.obolibrary.org/obo/UBERON_0000094|http://purl.obolibrary.org/obo/UBERON_0000158
T16 1091-1099 Body_part denotes membrane http://purl.obolibrary.org/obo/GO_0016020|http://purl.obolibrary.org/obo/UBERON_0000094|http://purl.obolibrary.org/obo/UBERON_0000158
T19 1521-1529 Body_part denotes membrane http://purl.obolibrary.org/obo/GO_0016020|http://purl.obolibrary.org/obo/UBERON_0000094|http://purl.obolibrary.org/obo/UBERON_0000158
T22 1891-1899 Body_part denotes membrane http://purl.obolibrary.org/obo/GO_0016020|http://purl.obolibrary.org/obo/UBERON_0000094|http://purl.obolibrary.org/obo/UBERON_0000158