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Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-148 Sentence denotes The gene for familial Mediterranean fever, MEFV, is expressed in early leukocyte development and is regulated in response to inflammatory mediators.
T2 149-288 Sentence denotes Familial Mediterranean fever (FMF) is a recessive disorder characterized by episodes of fever and neutrophil-mediated serosal inflammation.
T3 289-461 Sentence denotes We recently identified the gene causing FMF, designated MEFV, and found it to be expressed in mature neutrophils, suggesting that it functions as an inflammatory regulator.
T4 462-559 Sentence denotes To facilitate our understanding of the normal function of MEFV, we extended our previous studies.
T5 560-745 Sentence denotes MEFV messenger RNA was detected by reverse transcriptase-polymerase chain reaction in bone marrow leukocytes, with differential expression observed among cells by in situ hybridization.
T6 746-900 Sentence denotes CD34 hematopoietic stem-cell cultures induced toward the granulocytic lineage expressed MEFV at the myelocyte stage, concurrently with lineage commitment.
T7 901-1003 Sentence denotes The prepromyelocytic cell line HL60 expressed MEFV only at granulocytic and monocytic differentiation.
T8 1004-1071 Sentence denotes MEFV was also expressed in the monocytic cell lines U937 and THP-1.
T9 1072-1199 Sentence denotes Among peripheral blood leukocytes, MEFV expression was detected in neutrophils, eosinophils, and to varying degrees, monocytes.
T10 1200-1435 Sentence denotes Consistent with the tissue specificity of expression, complete sequencing and analysis of upstream regulatory regions of MEFV revealed homology to myeloid-specific promoters and to more broadly expressed inflammatory promoter elements.
T11 1436-1725 Sentence denotes In vitro stimulation of monocytes with the proinflammatory agents interferon (IFN) gamma, tumor necrosis factor, and lipopolysaccharide induced MEFV expression, whereas the antiinflammatory cytokines interleukin (IL) 4, IL-10, and transforming growth factor beta inhibited such expression.
T12 1726-1801 Sentence denotes Induction by IFN-gamma occurred rapidly and was resistant to cycloheximide.
T13 1802-1841 Sentence denotes IFN-alpha also induced MEFV expression.
T14 1842-1942 Sentence denotes In granulocytes, MEFV was up-regulated by IFN-gamma and the combination of IFN-alpha and colchicine.
T15 1943-2117 Sentence denotes These results refine understanding of MEFV by placing the gene in the myelomonocytic-specific proinflammatory pathway and identifying it as an IFN-gamma immediate early gene.
T1 0-148 Sentence denotes The gene for familial Mediterranean fever, MEFV, is expressed in early leukocyte development and is regulated in response to inflammatory mediators.
T2 149-288 Sentence denotes Familial Mediterranean fever (FMF) is a recessive disorder characterized by episodes of fever and neutrophil-mediated serosal inflammation.
T3 289-461 Sentence denotes We recently identified the gene causing FMF, designated MEFV, and found it to be expressed in mature neutrophils, suggesting that it functions as an inflammatory regulator.
T4 462-559 Sentence denotes To facilitate our understanding of the normal function of MEFV, we extended our previous studies.
T5 560-745 Sentence denotes MEFV messenger RNA was detected by reverse transcriptase-polymerase chain reaction in bone marrow leukocytes, with differential expression observed among cells by in situ hybridization.
T6 746-900 Sentence denotes CD34 hematopoietic stem-cell cultures induced toward the granulocytic lineage expressed MEFV at the myelocyte stage, concurrently with lineage commitment.
T7 901-1003 Sentence denotes The prepromyelocytic cell line HL60 expressed MEFV only at granulocytic and monocytic differentiation.
T8 1004-1071 Sentence denotes MEFV was also expressed in the monocytic cell lines U937 and THP-1.
T9 1072-1199 Sentence denotes Among peripheral blood leukocytes, MEFV expression was detected in neutrophils, eosinophils, and to varying degrees, monocytes.
T10 1200-1435 Sentence denotes Consistent with the tissue specificity of expression, complete sequencing and analysis of upstream regulatory regions of MEFV revealed homology to myeloid-specific promoters and to more broadly expressed inflammatory promoter elements.
T11 1436-1725 Sentence denotes In vitro stimulation of monocytes with the proinflammatory agents interferon (IFN) gamma, tumor necrosis factor, and lipopolysaccharide induced MEFV expression, whereas the antiinflammatory cytokines interleukin (IL) 4, IL-10, and transforming growth factor beta inhibited such expression.
T12 1726-1801 Sentence denotes Induction by IFN-gamma occurred rapidly and was resistant to cycloheximide.
T13 1802-1841 Sentence denotes IFN-alpha also induced MEFV expression.
T14 1842-1942 Sentence denotes In granulocytes, MEFV was up-regulated by IFN-gamma and the combination of IFN-alpha and colchicine.
T15 1943-2117 Sentence denotes These results refine understanding of MEFV by placing the gene in the myelomonocytic-specific proinflammatory pathway and identifying it as an IFN-gamma immediate early gene.

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 172-177 HP_0001945 denotes fever
T2 225-242 HP_0001954 denotes episodes of fever
T3 237-242 HP_0001945 denotes fever
T4 1526-1531 HP_0002664 denotes tumor

NCBIDiseaseCorpus

Id Subject Object Predicate Lexical cue
T1 13-41 SpecificDisease:D010505 denotes familial Mediterranean fever
T2 149-177 SpecificDisease:D010505 denotes Familial Mediterranean fever
T3 179-182 SpecificDisease:D010505 denotes FMF
T4 189-207 DiseaseClass:D030342 denotes recessive disorder
T5 237-242 DiseaseClass:D005334 denotes fever
T6 247-287 SpecificDisease:D007249 denotes neutrophil-mediated serosal inflammation
T7 329-332 SpecificDisease:D010505 denotes FMF
T8 1526-1531 Modifier:D009369 denotes tumor

NCBI-Disease-Train

Id Subject Object Predicate Lexical cue database_id
T2590 13-41 SpecificDisease denotes familial Mediterranean fever D010505
T2591 149-177 SpecificDisease denotes Familial Mediterranean fever D010505
T2592 179-182 SpecificDisease denotes FMF D010505
T2593 189-207 DiseaseClass denotes recessive disorder D030342
T2594 237-242 DiseaseClass denotes fever D005334
T2595 247-287 SpecificDisease denotes neutrophil-mediated serosal inflammation D007249
T2596 329-332 SpecificDisease denotes FMF D010505
T2597 1526-1531 Modifier denotes tumor D009369

NCBI-Disease-Corpus-All

Id Subject Object Predicate Lexical cue database_id
T2590 13-41 SpecificDisease denotes familial Mediterranean fever D010505
T2591 149-177 SpecificDisease denotes Familial Mediterranean fever D010505
T2592 179-182 SpecificDisease denotes FMF D010505
T2593 189-207 DiseaseClass denotes recessive disorder D030342
T2594 237-242 DiseaseClass denotes fever D005334
T2595 247-287 SpecificDisease denotes neutrophil-mediated serosal inflammation D007249
T2596 329-332 SpecificDisease denotes FMF D010505
T2597 1526-1531 Modifier denotes tumor D009369

NCBI-Disease-Corpus-2stage-All

Id Subject Object Predicate Lexical cue
T1 13-41 Modifier denotes familial Mediterranean fever
T2 149-177 SpecificDisease denotes Familial Mediterranean fever
T3 179-182 SpecificDisease denotes FMF
T4 329-332 SpecificDisease denotes FMF

NCBI-Disease-Corpus-rezarta-All

Id Subject Object Predicate Lexical cue
T1 13-41 SpecificDisease denotes familial Mediterranean fever
T2 149-177 SpecificDisease denotes Familial Mediterranean fever
T3 179-182 SpecificDisease denotes FMF
T4 329-332 Modifier denotes FMF
T5 1526-1547 DiseaseClass denotes tumor necrosis factor

NCBI-Disease-Corpus-4oGuideline-All

Id Subject Object Predicate Lexical cue
T1 13-41 SpecificDisease denotes familial Mediterranean fever
T2 149-177 SpecificDisease denotes Familial Mediterranean fever
T3 329-332 SpecificDisease denotes FMF

NCBI-Disease-Corpus-Simple-All

Id Subject Object Predicate Lexical cue
T1 13-41 SpecificDisease denotes familial Mediterranean fever
T2 149-183 SpecificDisease denotes Familial Mediterranean fever (FMF)
T3 329-332 SpecificDisease denotes FMF
T4 1526-1547 Modifier denotes tumor necrosis factor
T5 1931-1941 Modifier denotes colchicine