PubMed:10807548 JSONTXT

{"target":"https://pubannotation.org/docs/sourcedb/PubMed/sourceid/10807548","sourcedb":"PubMed","sourceid":"10807548","source_url":"http://www.ncbi.nlm.nih.gov/pubmed/10807548","text":"cDNA cloning, tissue expression, and chromosome mapping of human homolog of SOX18.\nThe SRY (sex-determining region Y) gene encodes a transcription factor characterized by a DNA-binding motif termed the HMG (high mobility group) domain. The SOX (Sry-box) genes comprise a large family related by homology to the HMG-box region. We isolated a cDNA clone with an open reading frame encoding a putative protein of 384 amino acids, which shared 83% identity to the mouse Sox18 protein. Northern blot analysis revealed that a 1.9-kb band of human SOX18 messenger RNAs was predominantly expressed in heart, although weak signals were seen in brain, liver, testis, and leukocyte. By polymerase chain reaction (PCR)-based analyses with both a human/rodent monochromosomal hybrid cell panel and a radiation hybrid panel, the gene was mapped to the chromosome 20q13.33 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