| Id |
Subject |
Object |
Predicate |
Lexical cue |
| T2 |
19-23 |
TranscriptionFactor |
denotes |
SOX9 |
| T3 |
27-37 |
SecondMessenger |
denotes |
cyclic AMP |
| T4 |
48-64 |
Enzyme |
denotes |
protein kinase A |
| T6 |
74-80 |
TranscriptionFactor |
denotes |
SOX9's |
| T8 |
108-114 |
Gene |
denotes |
Col2a1 |
| T9 |
115-126 |
Cell |
denotes |
chondrocyte |
| T10 |
136-144 |
Enhancer |
denotes |
enhancer |
| T11 |
146-150 |
TranscriptionFactor |
denotes |
Sox9 |
| T16 |
324-340 |
Protein |
denotes |
Son of Sevenless |
| T18 |
371-382 |
Cell |
denotes |
chondrocyte |
| T19 |
383-395 |
DNA |
denotes |
cDNA library |
| T20 |
425-432 |
ProteinSubunit |
denotes |
subunit |
| T22 |
448-452 |
SecondMessenger |
denotes |
cAMP |
| T23 |
464-480 |
Enzyme |
denotes |
protein kinase A |
| T24 |
482-492 |
Enzyme |
denotes |
PKA-Calpha |
| T26 |
523-527 |
TranscriptionFactor |
denotes |
SOX9 |
| T27 |
562-565 |
Enzyme |
denotes |
PKA |
| T29 |
582-587 |
AminoAcid |
denotes |
sites |
| T30 |
595-599 |
TranscriptionFactor |
denotes |
SOX9 |
| T32 |
627-630 |
Enzyme |
denotes |
PKA |
| T33 |
649-653 |
TranscriptionFactor |
denotes |
SOX9 |
| T35 |
681-691 |
Enzyme |
denotes |
PKA-Calpha |
| T36 |
704-715 |
Cell |
denotes |
COS-7 cells |
| T37 |
735-745 |
Enzyme |
denotes |
PKA-Calpha |
| T38 |
750-754 |
TranscriptionFactor |
denotes |
SOX9 |
| T40 |
766-774 |
DNA |
denotes |
plasmids |
| T41 |
776-779 |
Enzyme |
denotes |
PKA |
| T44 |
812-826 |
TranscriptionFactor |
denotes |
wild-type SOX9 |
| T45 |
1018-1022 |
TranscriptionFactor |
denotes |
SOX9 |
| T47 |
1041-1051 |
AminoAcid |
denotes |
serine 211 |
| T48 |
1068-1071 |
Enzyme |
denotes |
PKA |
| T50 |
1088-1093 |
AminoAcid |
denotes |
sites |
| T51 |
1128-1132 |
SecondMessenger |
denotes |
cAMP |
| T52 |
1136-1148 |
Cell |
denotes |
chondrocytes |
| T55 |
1202-1206 |
TranscriptionFactor |
denotes |
Sox9 |
| T56 |
1245-1250 |
Eukaryote |
denotes |
mouse |
| T57 |
1251-1267 |
Tissue |
denotes |
embryo hind legs |
| T58 |
1280-1284 |
TranscriptionFactor |
denotes |
Sox9 |
| T60 |
1303-1313 |
AminoAcid |
denotes |
serine 211 |
| T62 |
1347-1367 |
CellComponent |
denotes |
prehypertrophic zone |
| T67 |
1502-1506 |
SecondMessenger |
denotes |
cAMP |
| T69 |
1561-1565 |
MessengerRNA |
denotes |
mRNA |
| T70 |
1576-1582 |
Protein |
denotes |
Col2a1 |
| T71 |
1593-1609 |
MolecularEntity |
denotes |
specific markers |
| T73 |
1675-1678 |
Enzyme |
denotes |
PKA |
| T76 |
1726-1730 |
TranscriptionFactor |
denotes |
SOX9 |
| T77 |
1744-1756 |
SecondMessenger |
denotes |
8-bromo-cAMP |
| T78 |
1760-1772 |
Cell |
denotes |
chondrocytes |
| T80 |
1836-1840 |
TranscriptionFactor |
denotes |
SOX9 |
| T81 |
1857-1863 |
Gene |
denotes |
Col2a1 |
| T82 |
1864-1875 |
Cell |
denotes |
chondrocyte |
| T83 |
1885-1893 |
Enhancer |
denotes |
enhancer |
| T84 |
1924-1934 |
Enzyme |
denotes |
PKA-Calpha |
| T86 |
1961-1974 |
Enhancer |
denotes |
this enhancer |
| T88 |
1997-2000 |
Enzyme |
denotes |
PKA |
| T90 |
2027-2032 |
AminoAcid |
denotes |
sites |
| T91 |
2036-2040 |
TranscriptionFactor |
denotes |
SOX9 |
| T93 |
2064-2074 |
Enzyme |
denotes |
PKA-Calpha |
| T95 |
2089-2102 |
Enhancer |
denotes |
this enhancer |
| T96 |
2106-2110 |
TranscriptionFactor |
denotes |
SOX9 |
| T97 |
2112-2115 |
Enzyme |
denotes |
PKA |
| T99 |
2196-2200 |
Protein |
denotes |
SOX9 |
| T100 |
2219-2226 |
Nucleus |
denotes |
nuclear |
| T103 |
2269-2273 |
TranscriptionFactor |
denotes |
SOX9 |
| T104 |
2277-2280 |
Enzyme |
denotes |
PKA |
| T105 |
2308-2311 |
DNA |
denotes |
DNA |
| T107 |
2338-2342 |
TranscriptionFactor |
denotes |
SOX9 |
| T108 |
2358-2362 |
SecondMessenger |
denotes |
cAMP |
| T111 |
2401-2405 |
TranscriptionFactor |
denotes |
SOX9 |
| T112 |
2409-2412 |
Enzyme |
denotes |
PKA |
| T114 |
2422-2425 |
TranscriptionFactor |
denotes |
its |
| T116 |
2446-2449 |
DNA |
denotes |
DNA |
| T118 |
2476-2481 |
Peptide |
denotes |
PTHrP |
| T121 |
2507-2511 |
SecondMessenger |
denotes |
cAMP |
| T122 |
2553-2557 |
TranscriptionFactor |
denotes |
Sox9 |
| T123 |
2573-2578 |
Peptide |
denotes |
PTHrP |
| T125 |
2596-2608 |
Tissue |
denotes |
growth plate |
| T127 |
2632-2640 |
TranscriptionFactorActivity |
denotes |
activity |
| T128 |
2644-2648 |
TranscriptionFactor |
denotes |
Sox9 |
| T130 |
2677-2682 |
Peptide |
denotes |
PTHrP |
| T132 |
2702-2707 |
Cell |
denotes |
cells |
| T133 |
2711-2739 |
Cell |
denotes |
nonhypertrophic chondrocytes |
| T7 |
81-105 |
TranscriptionActivatorActivity |
denotes |
ability to transactivate |
| T12 |
156-214 |
HMGTF |
denotes |
high-mobility-group domain-containing transcription factor |
| T13 |
342-345 |
Protein |
denotes |
SOS |
| T134 |
415-424 |
CatalyticActivity |
denotes |
catalytic |
| T21 |
436-446 |
SecondMessenger |
denotes |
cyclic AMP |
| T136 |
867-879 |
TranscriptionFactor |
denotes |
SOX9 protein |
| T137 |
897-922 |
AminoAcid |
denotes |
PKA phosphorylation sites |
| T138 |
924-929 |
AminoAcid |
denotes |
S(64) |
| T139 |
934-940 |
AminoAcid |
denotes |
S(211) |
| T64 |
1442-1477 |
Peptide |
denotes |
parathyroid hormone-related peptide |
| T65 |
1479-1484 |
Peptide |
denotes |
PTHrP |
| T66 |
1486-1494 |
Protein |
denotes |
receptor |
| T141 |
1714-1722 |
TranscriptionFactorActivity |
denotes |
activity |
| T145 |
2167-2170 |
Enzyme |
denotes |
PKA |
| T147 |
2187-2192 |
AminoAcid |
denotes |
sites |
| T115 |
2426-2441 |
TranscriptionFactorActivity |
denotes |
transcriptional |
| E1 |
0-15 |
Phosphorylation |
denotes |
Phosphorylation |
| E2 |
65-73 |
Increase |
denotes |
enhances |
| E4 |
228-255 |
CellDifferentiation |
denotes |
chondrocyte differentiation |
| E5 |
260-279 |
DevelopmentalProcess |
denotes |
cartilage formation |
| E6 |
347-358 |
Transport |
denotes |
recruitment |
| E7 |
494-504 |
BindingToProtein |
denotes |
interacted |
| E8 |
566-581 |
Phosphorylation |
denotes |
phosphorylation |
| E9 |
609-623 |
Phosphorylation |
denotes |
phosphorylated |
| E10 |
663-677 |
Phosphorylation |
denotes |
phosphorylated |
| E11 |
755-765 |
GeneExpression |
denotes |
expression |
| E12 |
780-788 |
Increase |
denotes |
enhanced |
| E13 |
793-808 |
Phosphorylation |
denotes |
phosphorylation |
| E14 |
1023-1037 |
Phosphorylation |
denotes |
phosphorylated |
| E15 |
1072-1087 |
Phosphorylation |
denotes |
phosphorylation |
| E16 |
1158-1167 |
Increase |
denotes |
increased |
| E17 |
1172-1187 |
Phosphorylation |
denotes |
phosphorylation |
| E18 |
1285-1299 |
Phosphorylation |
denotes |
phosphorylated |
| E19 |
1330-1339 |
Localization |
denotes |
localized |
| E20 |
1424-1434 |
GeneExpression |
denotes |
expression |
| E21 |
1548-1556 |
Increase |
denotes |
increase |
| E22 |
1613-1640 |
CellDifferentiation |
denotes |
chondrocyte differentiation |
| E23 |
1679-1694 |
Phosphorylation |
denotes |
phosphorylation |
| E24 |
1701-1709 |
RegulatoryProcess |
denotes |
modulate |
| E25 |
1784-1793 |
Increase |
denotes |
increased |
| E26 |
1935-1944 |
Increase |
denotes |
increased |
| E27 |
1976-1985 |
Mutation |
denotes |
Mutations |
| E28 |
2001-2016 |
Phosphorylation |
denotes |
phosphorylation |
| E29 |
2050-2059 |
Decrease |
denotes |
decreased |
| E30 |
2075-2085 |
PositiveRegulation |
denotes |
activation |
| E31 |
2116-2131 |
Phosphorylation |
denotes |
phosphorylation |
| E32 |
2227-2239 |
Localization |
denotes |
localization |
| E33 |
2250-2265 |
Phosphorylation |
denotes |
phosphorylation |
| E34 |
2312-2319 |
BindingOfTranscriptionFactorToDNA |
denotes |
binding |
| E35 |
2363-2372 |
SignalingPathway |
denotes |
signaling |
| E36 |
2382-2397 |
Phosphorylation |
denotes |
phosphorylation |
| E37 |
2413-2421 |
Increase |
denotes |
enhances |
| E39 |
2450-2457 |
BindingOfTranscriptionFactorToDNA |
denotes |
binding |
| E40 |
2482-2491 |
SignalingPathway |
denotes |
signaling |
| E41 |
2495-2503 |
RegulatoryProcess |
denotes |
mediated |
| E42 |
2579-2588 |
SignalingPathway |
denotes |
signaling |
| E43 |
2622-2631 |
Increase |
denotes |
increased |
| E44 |
2655-2662 |
RegulatoryProcess |
denotes |
mediate |
| E45 |
2686-2697 |
Maintenance |
denotes |
maintaining |
| E3 |
846-861 |
Phosphorylation |
denotes |
phosphorylation |
| E46 |
947-954 |
Mutation |
denotes |
mutated |
| E47 |
1798-1806 |
Transcription |
denotes |
activity |
| E48 |
1949-1957 |
Transcription |
denotes |
activity |
| E49 |
2140-2149 |
Mutation |
denotes |
mutations |
| E50 |
2171-2186 |
Phosphorylation |
denotes |
phosphorylation |
| E38 |
1548-1556 |
Increase |
denotes |
increase |
| E51 |
2075-2085 |
PositiveRegulation |
denotes |
activation |
| E52 |
2413-2421 |
Increase |
denotes |
enhances |
| E53 |
2050-2059 |
Decrease |
denotes |
decreased |
| R1 |
T8 |
T10 |
hasPart |
Col2a1,enhancer |
| R2 |
T10 |
T9 |
locatedIn |
enhancer,chondrocyte |
| R4 |
T19 |
T18 |
locatedIn |
cDNA library,chondrocyte |
| R5 |
T23 |
T20 |
hasPart |
protein kinase A,subunit |
| R6 |
T30 |
T29 |
hasPart |
SOX9,sites |
| R8 |
T45 |
T47 |
hasPart |
SOX9,serine 211 |
| R9 |
E16 |
T52 |
locatedIn |
increased,chondrocytes |
| R10 |
T57 |
T56 |
fromSpecies |
embryo hind legs,mouse |
| R11 |
T58 |
T60 |
hasPart |
Sox9,serine 211 |
| R12 |
E19 |
T62 |
locatedIn |
localized,prehypertrophic zone |
| R14 |
E25 |
T78 |
locatedIn |
increased,chondrocytes |
| R15 |
T83 |
T82 |
locatedIn |
enhancer,chondrocyte |
| R16 |
T91 |
T90 |
hasPart |
SOX9,sites |
| R17 |
E32 |
T100 |
locatedIn |
localization,nuclear |
| R19 |
E42 |
T125 |
locatedIn |
signaling,growth plate |
| R20 |
T128 |
T127 |
hasFunction |
Sox9,activity |
| R21 |
T6 |
T7 |
hasFunction |
SOX9's,ability to transactivate |
| R3 |
T20 |
T134 |
hasFunction |
subunit,catalytic |
| R22 |
T40 |
T37 |
encodes |
plasmids,PKA-Calpha |
| R23 |
T40 |
T38 |
encodes |
plasmids,SOX9 |
| R7 |
T40 |
T36 |
locatedIn |
plasmids,COS-7 cells |
| R24 |
T136 |
T137 |
hasPart |
SOX9 protein,PKA phosphorylation sites |
| R13 |
T69 |
T70 |
encodes |
mRNA,Col2a1 |
| R25 |
T76 |
T141 |
hasFunction |
SOX9,activity |
| R26 |
T81 |
T83 |
hasPart |
Col2a1,enhancer |
| R27 |
T99 |
T147 |
hasPart |
SOX9,sites |
| R28 |
T114 |
T115 |
hasFunction |
its,transcriptional |
| R30 |
T4 |
E1 |
hasAgent |
protein kinase A,Phosphorylation |
| R31 |
T2 |
E1 |
hasPatient |
SOX9,Phosphorylation |
| R32 |
E1 |
E2 |
hasAgent |
Phosphorylation,enhances |
| R33 |
T7 |
E2 |
hasPatient |
ability to transactivate,enhances |
| R34 |
T16 |
E6 |
hasPatient |
Son of Sevenless,recruitment |
| R35 |
T26 |
E7 |
hasPatient |
SOX9,interacted |
| R36 |
T20 |
E7 |
hasPatient |
subunit,interacted |
| R37 |
T27 |
E8 |
hasAgent |
PKA,phosphorylation |
| R38 |
T29 |
E8 |
hasPatient |
sites,phosphorylation |
| R39 |
T32 |
E9 |
hasAgent |
PKA,phosphorylated |
| R40 |
T29 |
E9 |
hasPatient |
sites,phosphorylated |
| R41 |
T35 |
E10 |
hasAgent |
PKA-Calpha,phosphorylated |
| R42 |
T33 |
E10 |
hasPatient |
SOX9,phosphorylated |
| R43 |
T40 |
E11 |
hasPatient |
plasmids,expression |
| R44 |
T41 |
E12 |
hasAgent |
PKA,enhanced |
| R45 |
E13 |
E12 |
hasPatient |
phosphorylation,enhanced |
| R46 |
T44 |
E13 |
hasPatient |
wild-type SOX9,phosphorylation |
| R47 |
T47 |
E14 |
hasPatient |
serine 211,phosphorylated |
| R48 |
T48 |
E15 |
hasAgent |
PKA,phosphorylation |
| R49 |
T50 |
E15 |
hasPatient |
sites,phosphorylation |
| R50 |
T51 |
E16 |
hasAgent |
cAMP,increased |
| R51 |
E17 |
E16 |
hasPatient |
phosphorylation,increased |
| R52 |
T55 |
E17 |
hasPatient |
Sox9,phosphorylation |
| R53 |
T60 |
E18 |
hasPatient |
serine 211,phosphorylated |
| R54 |
T58 |
E19 |
hasPatient |
Sox9,localized |
| R55 |
T66 |
E20 |
hasPatient |
receptor,expression |
| R56 |
T67 |
E21 |
hasAgent |
cAMP,increase |
| R57 |
T69 |
E21 |
hasPatient |
mRNA,increase |
| R58 |
T73 |
E23 |
hasAgent |
PKA,phosphorylation |
| R59 |
E23 |
E24 |
hasAgent |
phosphorylation,modulate |
| R60 |
T141 |
E24 |
hasPatient |
activity,modulate |
| R61 |
T77 |
E25 |
hasAgent |
8-bromo-cAMP,increased |
| R62 |
E47 |
E25 |
hasPatient |
activity,increased |
| R63 |
T84 |
E26 |
hasAgent |
PKA-Calpha,increased |
| R64 |
E48 |
E26 |
hasPatient |
activity,increased |
| R65 |
T90 |
E27 |
hasPatient |
sites,Mutations |
| R66 |
T88 |
E28 |
hasAgent |
PKA,phosphorylation |
| R67 |
T90 |
E28 |
hasPatient |
sites,phosphorylation |
| R68 |
E27 |
E29 |
hasAgent |
Mutations,decreased |
| R69 |
E30 |
E29 |
hasPatient |
activation,decreased |
| R70 |
T96 |
E30 |
hasAgent |
SOX9,activation |
| R71 |
T95 |
E30 |
hasPatient |
this enhancer,activation |
| R72 |
T97 |
E31 |
hasAgent |
PKA,phosphorylation |
| R73 |
T99 |
E32 |
hasPatient |
SOX9,localization |
| R74 |
T104 |
E33 |
hasAgent |
PKA,phosphorylation |
| R75 |
T103 |
E33 |
hasPatient |
SOX9,phosphorylation |
| R76 |
T105 |
E34 |
hasPatient |
DNA,binding |
| R77 |
T112 |
E36 |
hasAgent |
PKA,phosphorylation |
| R78 |
T111 |
E36 |
hasPatient |
SOX9,phosphorylation |
| R79 |
E36 |
E37 |
hasAgent |
phosphorylation,enhances |
| R80 |
E39 |
E37 |
hasPatient |
binding,enhances |
| R81 |
T114 |
E39 |
hasAgent |
its,binding |
| R82 |
T116 |
E39 |
hasPatient |
DNA,binding |
| R83 |
T121 |
E41 |
hasAgent |
cAMP,mediated |
| R84 |
E40 |
E41 |
hasPatient |
signaling,mediated |
| R85 |
T127 |
E43 |
hasPatient |
activity,increased |
| R86 |
E43 |
E44 |
hasAgent |
increased,mediate |
| R87 |
T130 |
E44 |
hasPatient |
PTHrP,mediate |
| R88 |
T130 |
E45 |
hasAgent |
PTHrP,maintaining |
| R89 |
T132 |
E45 |
hasPatient |
cells,maintaining |
| R90 |
T136 |
E3 |
hasPatient |
SOX9 protein,phosphorylation |
| R91 |
T137 |
E46 |
hasPatient |
PKA phosphorylation sites,mutated |
| R92 |
T83 |
E47 |
hasAgent |
enhancer,activity |
| R93 |
T86 |
E48 |
hasAgent |
this enhancer,activity |
| R94 |
T147 |
E49 |
hasPatient |
sites,mutations |
| R95 |
T145 |
E50 |
hasAgent |
PKA,phosphorylation |
| R96 |
T147 |
E50 |
hasPatient |
sites,phosphorylation |
| R97 |
T67 |
E38 |
hasAgent |
cAMP,increase |
| R98 |
T71 |
E38 |
hasPatient |
specific markers,increase |
| R99 |
T93 |
E51 |
hasAgent |
PKA-Calpha,activation |
| R100 |
T95 |
E51 |
hasPatient |
this enhancer,activation |
| R101 |
E36 |
E52 |
hasAgent |
phosphorylation,enhances |
| R102 |
T115 |
E52 |
hasPatient |
transcriptional,enhances |
| R103 |
E27 |
E53 |
hasAgent |
Mutations,decreased |
| R104 |
E51 |
E53 |
hasPatient |
activation,decreased |
