| Id |
Subject |
Object |
Predicate |
Lexical cue |
| TextSentencer_T1 |
0-131 |
Sentence |
denotes |
Submicroscopic deletion in cousins with Prader-Willi syndrome causes a grandmatrilineal inheritance pattern: effects of imprinting. |
| TextSentencer_T2 |
132-218 |
Sentence |
denotes |
The Prader-Willi syndrome (PWS) critical region on 15q11-q13 is subject to imprinting. |
| TextSentencer_T3 |
219-308 |
Sentence |
denotes |
PWS becomes apparent when genes on the paternally inherited chromosome are not expressed. |
| TextSentencer_T4 |
309-330 |
Sentence |
denotes |
Familial PWS is rare. |
| TextSentencer_T5 |
331-457 |
Sentence |
denotes |
We report on a family in which a male and a female paternal first cousin both have PWS with cytogenetically normal karyotypes. |
| TextSentencer_T6 |
458-622 |
Sentence |
denotes |
Fluorescence in situ hybridization (FISH) analysis shows a submicroscopic deletion of SNRPN, but not the closely associated loci D15S10, D15S11, D15S63, and GABRB3. |
| TextSentencer_T7 |
623-716 |
Sentence |
denotes |
The cousins' fathers and two paternal aunts have the same deletion and are clinically normal. |
| TextSentencer_T8 |
717-836 |
Sentence |
denotes |
The grandmother of the cousins is deceased and not available for study, and their grandfather is not deleted for SNRPN. |
| TextSentencer_T9 |
837-1121 |
Sentence |
denotes |
DNA methylation analysis of D15S63 is consistent with an abnormality of the imprinting center associated with PWS. "Grandmatrilineal" inheritance occurs when a woman with deletion of an imprinted, paternally expressed gene is at risk of having affected grandchildren through her sons. |
| TextSentencer_T10 |
1122-1227 |
Sentence |
denotes |
In this case, PWS does not become evident as long as the deletion is passed through the matrilineal line. |
| TextSentencer_T11 |
1228-1291 |
Sentence |
denotes |
This represents a unique inheritance pattern due to imprinting. |
| T1 |
0-131 |
Sentence |
denotes |
Submicroscopic deletion in cousins with Prader-Willi syndrome causes a grandmatrilineal inheritance pattern: effects of imprinting. |
| T2 |
132-218 |
Sentence |
denotes |
The Prader-Willi syndrome (PWS) critical region on 15q11-q13 is subject to imprinting. |
| T3 |
219-308 |
Sentence |
denotes |
PWS becomes apparent when genes on the paternally inherited chromosome are not expressed. |
| T4 |
309-330 |
Sentence |
denotes |
Familial PWS is rare. |
| T5 |
331-457 |
Sentence |
denotes |
We report on a family in which a male and a female paternal first cousin both have PWS with cytogenetically normal karyotypes. |
| T6 |
458-622 |
Sentence |
denotes |
Fluorescence in situ hybridization (FISH) analysis shows a submicroscopic deletion of SNRPN, but not the closely associated loci D15S10, D15S11, D15S63, and GABRB3. |
| T7 |
623-716 |
Sentence |
denotes |
The cousins' fathers and two paternal aunts have the same deletion and are clinically normal. |
| T8 |
717-836 |
Sentence |
denotes |
The grandmother of the cousins is deceased and not available for study, and their grandfather is not deleted for SNRPN. |
| T9 |
837-1121 |
Sentence |
denotes |
DNA methylation analysis of D15S63 is consistent with an abnormality of the imprinting center associated with PWS. "Grandmatrilineal" inheritance occurs when a woman with deletion of an imprinted, paternally expressed gene is at risk of having affected grandchildren through her sons. |
| T10 |
1122-1227 |
Sentence |
denotes |
In this case, PWS does not become evident as long as the deletion is passed through the matrilineal line. |
| T11 |
1228-1291 |
Sentence |
denotes |
This represents a unique inheritance pattern due to imprinting. |
