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PubMed:10788475 JSONTXT

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GlyCosmos6-Glycan-Motif-Image

Id Subject Object Predicate Lexical cue image
T1 1002-1009 Glycan_Motif denotes heparin https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G54161DR|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G00021MO

GlyCosmos6-Glycan-Motif-Structure

Id Subject Object Predicate Lexical cue
T1 1002-1009 https://glytoucan.org/Structures/Glycans/G00021MO denotes heparin
T2 1002-1009 https://glytoucan.org/Structures/Glycans/G54161DR denotes heparin

sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-124 Sentence denotes Arginine-rich anti-vascular endothelial growth factor peptides inhibit tumor growth and metastasis by blocking angiogenesis.
TextSentencer_T2 125-209 Sentence denotes Tumor angiogenesis is a critical step for the growth and metastasis of solid tumors.
TextSentencer_T3 210-378 Sentence denotes Vascular endothelial growth factor (VEGF) is a specific and potent angiogenic factor and contributes to the development of solid tumors by promoting tumor angiogenesis.
TextSentencer_T4 379-482 Sentence denotes Therefore, it is a prime therapeutic target for the development of antagonists for treatment of cancer.
TextSentencer_T5 483-634 Sentence denotes We identified from peptide libraries arginine-rich hexapeptides that inhibit the interaction of VEGF(165) with VEGF receptor (IC(50) = 2-4 micrometer).
TextSentencer_T6 635-721 Sentence denotes They have no effect on binding of basic fibroblast growth factor to cellular receptor.
TextSentencer_T7 722-845 Sentence denotes The hexapeptides inhibit the proliferation of human umbilical vein endothelial cells induced by VEGF(165) without toxicity.
TextSentencer_T8 846-1053 Sentence denotes The peptides bind to VEGF and inhibit binding of both VEGF(165) and VEGF(121), suggesting that the peptides interact with the main body of VEGF but not the heparin-binding domain that is absent in VEGF(121).
TextSentencer_T9 1054-1190 Sentence denotes The identified peptides block the angiogenesis induced by VEGF(165) in vivo in the chick chorioallantoic membrane and the rabbit cornea.
TextSentencer_T10 1191-1333 Sentence denotes Furthermore, one of the hexapeptides, RRKRRR, blocks the growth and metastasis of VEGF-secreting HM7 human colon carcinoma cells in nude mice.
TextSentencer_T11 1334-1597 Sentence denotes Based on our results, the arginine-rich hexapeptides may be effective for the treatment of various human tumors and other angiogenesis-dependent diseases that are related to the action of VEGF and could also serve as leads for development of more effective drugs.
T1 0-124 Sentence denotes Arginine-rich anti-vascular endothelial growth factor peptides inhibit tumor growth and metastasis by blocking angiogenesis.
T2 125-209 Sentence denotes Tumor angiogenesis is a critical step for the growth and metastasis of solid tumors.
T3 210-378 Sentence denotes Vascular endothelial growth factor (VEGF) is a specific and potent angiogenic factor and contributes to the development of solid tumors by promoting tumor angiogenesis.
T4 379-482 Sentence denotes Therefore, it is a prime therapeutic target for the development of antagonists for treatment of cancer.
T5 483-634 Sentence denotes We identified from peptide libraries arginine-rich hexapeptides that inhibit the interaction of VEGF(165) with VEGF receptor (IC(50) = 2-4 micrometer).
T6 635-721 Sentence denotes They have no effect on binding of basic fibroblast growth factor to cellular receptor.
T7 722-845 Sentence denotes The hexapeptides inhibit the proliferation of human umbilical vein endothelial cells induced by VEGF(165) without toxicity.
T8 846-1053 Sentence denotes The peptides bind to VEGF and inhibit binding of both VEGF(165) and VEGF(121), suggesting that the peptides interact with the main body of VEGF but not the heparin-binding domain that is absent in VEGF(121).
T9 1054-1190 Sentence denotes The identified peptides block the angiogenesis induced by VEGF(165) in vivo in the chick chorioallantoic membrane and the rabbit cornea.
T10 1191-1333 Sentence denotes Furthermore, one of the hexapeptides, RRKRRR, blocks the growth and metastasis of VEGF-secreting HM7 human colon carcinoma cells in nude mice.
T11 1334-1597 Sentence denotes Based on our results, the arginine-rich hexapeptides may be effective for the treatment of various human tumors and other angiogenesis-dependent diseases that are related to the action of VEGF and could also serve as leads for development of more effective drugs.

Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 784-788 http://purl.obolibrary.org/obo/MAT_0000037 denotes vein
T2 1298-1303 http://purl.obolibrary.org/obo/MAT_0000526 denotes colon

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 125-130 HP_0002664 denotes Tumor
T2 202-208 HP_0002664 denotes tumors
T3 339-345 HP_0002664 denotes tumors
T4 359-364 HP_0002664 denotes tumor
T5 475-481 HP_0002664 denotes cancer
T6 1439-1445 HP_0002664 denotes tumors

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
10788475-0#19#53#gene7422 19-53 gene7422 denotes vascular endothelial growth factor
10788475-0#88#98#diseaseC0027627 88-98 diseaseC0027627 denotes metastasis
10788475-2#0#34#gene7422 210-244 gene7422 denotes Vascular endothelial growth factor
10788475-2#36#40#gene7422 246-250 gene7422 denotes VEGF
10788475-2#123#135#diseaseC0280100 333-345 diseaseC0280100 denotes solid tumors
10788475-2#149#167#diseaseC1519670 359-377 diseaseC1519670 denotes tumor angiogenesis
10788475-2#123#135#diseaseC0280100 333-345 diseaseC0280100 denotes solid tumors
10788475-2#149#167#diseaseC1519670 359-377 diseaseC1519670 denotes tumor angiogenesis
10788475-9#82#86#gene7422 1273-1277 gene7422 denotes VEGF
10788475-9#107#122#diseaseC0699790 1298-1313 diseaseC0699790 denotes colon carcinoma
19#53#gene742288#98#diseaseC0027627 10788475-0#19#53#gene7422 10788475-0#88#98#diseaseC0027627 associated_with vascular endothelial growth factor,metastasis
0#34#gene7422123#135#diseaseC0280100 10788475-2#0#34#gene7422 10788475-2#123#135#diseaseC0280100 associated_with Vascular endothelial growth factor,solid tumors
0#34#gene7422149#167#diseaseC1519670 10788475-2#0#34#gene7422 10788475-2#149#167#diseaseC1519670 associated_with Vascular endothelial growth factor,tumor angiogenesis
0#34#gene7422123#135#diseaseC0280100 10788475-2#0#34#gene7422 10788475-2#123#135#diseaseC0280100 associated_with Vascular endothelial growth factor,solid tumors
0#34#gene7422149#167#diseaseC1519670 10788475-2#0#34#gene7422 10788475-2#149#167#diseaseC1519670 associated_with Vascular endothelial growth factor,tumor angiogenesis
36#40#gene7422123#135#diseaseC0280100 10788475-2#36#40#gene7422 10788475-2#123#135#diseaseC0280100 associated_with VEGF,solid tumors
36#40#gene7422149#167#diseaseC1519670 10788475-2#36#40#gene7422 10788475-2#149#167#diseaseC1519670 associated_with VEGF,tumor angiogenesis
36#40#gene7422123#135#diseaseC0280100 10788475-2#36#40#gene7422 10788475-2#123#135#diseaseC0280100 associated_with VEGF,solid tumors
36#40#gene7422149#167#diseaseC1519670 10788475-2#36#40#gene7422 10788475-2#149#167#diseaseC1519670 associated_with VEGF,tumor angiogenesis
82#86#gene7422107#122#diseaseC0699790 10788475-9#82#86#gene7422 10788475-9#107#122#diseaseC0699790 associated_with VEGF,colon carcinoma

DisGeNet-2017-sample

Id Subject Object Predicate Lexical cue
T2776 19-53 gene:7422 denotes vascular endothelial growth factor
T2777 88-98 disease:C0027627 denotes metastasis
R1 T2776 T2777 associated_with vascular endothelial growth factor,metastasis

UBERON-AE

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 774-788 http://purl.obolibrary.org/obo/UBERON_0002066 denotes umbilical vein
PD-UBERON-AE-B_T2 774-800 http://purl.obolibrary.org/obo/UBERON_0007777 denotes umbilical vein endothelial
PD-UBERON-AE-B_T3 784-788 http://purl.obolibrary.org/obo/UBERON_0001638 denotes vein
PD-UBERON-AE-B_T4 1143-1167 http://purl.obolibrary.org/obo/UBERON_0005335 denotes chorioallantoic membrane
PD-UBERON-AE-B_T5 1183-1189 http://purl.obolibrary.org/obo/UBERON_0000964 denotes cornea
PD-UBERON-AE-B_T6 1298-1303 http://purl.obolibrary.org/obo/UBERON_0001155 denotes colon

performance-test

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 1298-1303 http://purl.obolibrary.org/obo/UBERON_0001155 denotes colon
PD-UBERON-AE-B_T2 774-788 http://purl.obolibrary.org/obo/UBERON_0002066 denotes umbilical vein
PD-UBERON-AE-B_T3 774-800 http://purl.obolibrary.org/obo/UBERON_0007777 denotes umbilical vein endothelial
PD-UBERON-AE-B_T4 784-788 http://purl.obolibrary.org/obo/UBERON_0001638 denotes vein
PD-UBERON-AE-B_T5 1143-1167 http://purl.obolibrary.org/obo/UBERON_0005335 denotes chorioallantoic membrane
PD-UBERON-AE-B_T6 1183-1189 http://purl.obolibrary.org/obo/UBERON_0000964 denotes cornea

DisGeNET

Id Subject Object Predicate Lexical cue
T0 210-244 gene:7422 denotes Vascular endothelial growth factor
T1 333-345 disease:C0280100 denotes solid tumors
T2 210-244 gene:7422 denotes Vascular endothelial growth factor
T3 359-377 disease:C1519670 denotes tumor angiogenesis
T4 246-250 gene:7422 denotes VEGF
T5 333-345 disease:C0280100 denotes solid tumors
T6 246-250 gene:7422 denotes VEGF
T7 359-377 disease:C1519670 denotes tumor angiogenesis
R1 T0 T1 associated_with Vascular endothelial growth factor,solid tumors
R2 T2 T3 associated_with Vascular endothelial growth factor,tumor angiogenesis
R3 T4 T5 associated_with VEGF,solid tumors
R4 T6 T7 associated_with VEGF,tumor angiogenesis

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 784-788 Body_part denotes vein http://purl.obolibrary.org/obo/MAT_0000037
T2 1298-1303 Body_part denotes colon http://purl.obolibrary.org/obo/MAT_0000526

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 71-76 Phenotype denotes tumor HP:0002664
T2 125-130 Phenotype denotes Tumor HP:0002664
T3 359-364 Phenotype denotes tumor HP:0002664
T4 475-481 Phenotype denotes cancer HP:0002664
T5 1304-1313 Phenotype denotes carcinoma HP:0030731

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 71-76 Disease denotes tumor http://purl.obolibrary.org/obo/MONDO_0005070
T2 125-130 Disease denotes Tumor http://purl.obolibrary.org/obo/MONDO_0005070
T3 202-208 Disease denotes tumors http://purl.obolibrary.org/obo/MONDO_0005070
T4 339-345 Disease denotes tumors http://purl.obolibrary.org/obo/MONDO_0005070
T5 359-364 Disease denotes tumor http://purl.obolibrary.org/obo/MONDO_0005070
T6 475-481 Disease denotes cancer http://purl.obolibrary.org/obo/MONDO_0004992
T7 1298-1313 Disease denotes colon carcinoma http://purl.obolibrary.org/obo/MONDO_0002032
T8 1439-1445 Disease denotes tumors http://purl.obolibrary.org/obo/MONDO_0005070

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 768-773 OrganismTaxon denotes human 9606
T2 1292-1297 OrganismTaxon denotes human 9606
T3 1328-1332 OrganismTaxon denotes mice 10088
T4 1433-1438 OrganismTaxon denotes human 9606

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 675-685 Body_part denotes fibroblast http://purl.obolibrary.org/obo/CL_0000057
T2 774-788 Body_part denotes umbilical vein http://purl.obolibrary.org/obo/UBERON_0002066
T3 789-806 Body_part denotes endothelial cells http://purl.obolibrary.org/obo/CL_0000115
T4 1143-1167 Body_part denotes chorioallantoic membrane http://purl.obolibrary.org/obo/UBERON_0005335
T5 1183-1189 Body_part denotes cornea http://purl.obolibrary.org/obo/UBERON_0000964
T6 1298-1303 Body_part denotes colon http://purl.obolibrary.org/obo/UBERON_0001155

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 675-685 Cell denotes fibroblast http://purl.obolibrary.org/obo/CL:0000057
T2 784-806 Cell denotes vein endothelial cells http://purl.obolibrary.org/obo/CL:0002543