PubMed:10781616
Annnotations
sentences
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-146 | Sentence | denotes | A novel binding factor facilitates nuclear translocation and transcriptional activation function of the pituitary tumor-transforming gene product. |
| T2 | 147-313 | Sentence | denotes | Pituitary tumor-transforming gene (PTTG) is a recently characterized oncogene whose expression product contains a transcriptional activation domain at the C terminus. |
| T3 | 314-462 | Sentence | denotes | To understand the mechanisms involved in PTTG biological functions, we used yeast two-hybrid screening to identify proteins that interact with PTTG. |
| T4 | 463-554 | Sentence | denotes | This study reports the isolation and characterization of a novel PTTG-binding factor (PBF). |
| T5 | 555-651 | Sentence | denotes | PBF contains an open reading frame of 179 amino acids with a predicted molecular mass of 22 kDa. |
| T6 | 652-732 | Sentence | denotes | In Northern blot analyses, PBF mRNA was ubiquitously expressed in human tissues. |
| T7 | 733-900 | Sentence | denotes | Glutathione S-transferase pull-down and co-immunoprecipitation assays demonstrate that PBF interacts specifically with PTTG under both in vitro and in vivo conditions. |
| T8 | 901-1030 | Sentence | denotes | The PTTG binding domain in PBF was located within the C-terminal 30-amino acid region that contain a nuclear localization signal. |
| T9 | 1031-1247 | Sentence | denotes | Immunofluorescence and subcellular fractionation studies showed that PTTG is predominantly expressed in the cytoplasm with partial nuclear localization, whereas PBF is localized both in the cytoplasm and the nucleus. |
| T10 | 1248-1350 | Sentence | denotes | The interaction between PBF and PTTG facilitated PTTG translocation from the cytoplasm to the nucleus. |
| T11 | 1351-1453 | Sentence | denotes | Furthermore, PBF is required for transcriptional activation of basic fibroblast growth factor by PTTG. |
| T12 | 1454-1617 | Sentence | denotes | In summary, we have characterized a novel PTTG-binding protein that facilitates PTTG nuclear translocation and potentiates its transcriptional activation function. |
Glycosmos6-MAT
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 104-113 | http://purl.obolibrary.org/obo/MAT_0000077 | denotes | pituitary |
| T2 | 147-156 | http://purl.obolibrary.org/obo/MAT_0000077 | denotes | Pituitary |
PubmedHPO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 157-162 | HP_0002664 | denotes | tumor |
2015-BEL-Sample
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 1248-1349 | complex(p(HGNC:PTTG1IP),p(HGNC:PTTG1)) directlyIncreases tloc(p(HGNC:PTTG1),GOCCID:0005737,GOCCID:0005634) | denotes | The interaction between PBF and PTTG facilitated PTTG translocation from the cytoplasm to the nucleus |
2015-BEL-Sample-2
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| BEL:20000154 | 1248-1349 | complex(p(HGNC:PTTG1IP),p(HGNC:PTTG1)) directlyIncreases tloc(p(HGNC:PTTG1),GOCCID:0005737,GOCCID:0005634) | denotes | The interaction between PBF and PTTG facilitated PTTG translocation from the cytoplasm to the nucleus |
Anatomy-MAT
| Id | Subject | Object | Predicate | Lexical cue | mat_id |
|---|---|---|---|---|---|
| T1 | 104-113 | Body_part | denotes | pituitary | http://purl.obolibrary.org/obo/MAT_0000077 |
| T2 | 147-156 | Body_part | denotes | Pituitary | http://purl.obolibrary.org/obo/MAT_0000077 |
HP-phenotype
| Id | Subject | Object | Predicate | Lexical cue | hp_id |
|---|---|---|---|---|---|
| T1 | 114-119 | Phenotype | denotes | tumor | HP:0002664 |
| T2 | 157-162 | Phenotype | denotes | tumor | HP:0002664 |
mondo_disease
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 88-119 | Disease | denotes | function of the pituitary tumor | http://purl.obolibrary.org/obo/MONDO_0003604 |
| T2 | 147-162 | Disease | denotes | Pituitary tumor | http://purl.obolibrary.org/obo/MONDO_0017611 |
| T3 | 1002-1029 | Disease | denotes | nuclear localization signal | http://purl.obolibrary.org/obo/MONDO_0000179 |
NCBITAXON
| Id | Subject | Object | Predicate | Lexical cue | db_id |
|---|---|---|---|---|---|
| T1 | 718-723 | OrganismTaxon | denotes | human | 9606 |
Anatomy-UBERON
| Id | Subject | Object | Predicate | Lexical cue | uberon_id |
|---|---|---|---|---|---|
| T1 | 104-113 | Body_part | denotes | pituitary | http://purl.obolibrary.org/obo/UBERON_0000007 |
| T2 | 147-156 | Body_part | denotes | Pituitary | http://purl.obolibrary.org/obo/UBERON_0000007 |
| T3 | 1139-1148 | Body_part | denotes | cytoplasm | http://purl.obolibrary.org/obo/GO_0005737 |
| T4 | 1221-1230 | Body_part | denotes | cytoplasm | http://purl.obolibrary.org/obo/GO_0005737 |
| T5 | 1239-1246 | Body_part | denotes | nucleus | http://purl.obolibrary.org/obo/GO_0005634|http://purl.obolibrary.org/obo/UBERON_0000125 |
| T7 | 1325-1334 | Body_part | denotes | cytoplasm | http://purl.obolibrary.org/obo/GO_0005737 |
| T8 | 1342-1349 | Body_part | denotes | nucleus | http://purl.obolibrary.org/obo/GO_0005634|http://purl.obolibrary.org/obo/UBERON_0000125 |
| T10 | 1420-1430 | Body_part | denotes | fibroblast | http://purl.obolibrary.org/obo/CL_0000057 |
CL-cell
| Id | Subject | Object | Predicate | Lexical cue | cl_id |
|---|---|---|---|---|---|
| T1 | 1420-1430 | Cell | denotes | fibroblast | http://purl.obolibrary.org/obo/CL:0000057 |