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PubMed:10764831 JSONTXT

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Glycan-Motif

Id Subject Object Predicate Lexical cue
T1 12-23 https://glytoucan.org/Structures/Glycans/G81533KY denotes sialic acid
T2 122-133 https://glytoucan.org/Structures/Glycans/G81533KY denotes sialic acid
T3 489-500 https://glytoucan.org/Structures/Glycans/G81533KY denotes sialic acid
T4 739-750 https://glytoucan.org/Structures/Glycans/G81533KY denotes sialic acid
T5 964-975 https://glytoucan.org/Structures/Glycans/G81533KY denotes sialic acid
T6 1038-1049 https://glytoucan.org/Structures/Glycans/G81533KY denotes sialic acid
T7 1494-1505 https://glytoucan.org/Structures/Glycans/G81533KY denotes sialic acid

GlyCosmos6-Glycan-Motif-Image

Id Subject Object Predicate Lexical cue image
T1 12-23 Glycan_Motif denotes sialic acid https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81533KY
T2 122-133 Glycan_Motif denotes sialic acid https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81533KY
T3 489-500 Glycan_Motif denotes sialic acid https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81533KY
T4 739-750 Glycan_Motif denotes sialic acid https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81533KY
T5 964-975 Glycan_Motif denotes sialic acid https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81533KY
T6 1038-1049 Glycan_Motif denotes sialic acid https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81533KY
T7 1494-1505 Glycan_Motif denotes sialic acid https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81533KY

Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 1410-1416 http://purl.obolibrary.org/obo/MAT_0000085 denotes spleen
T2 1429-1434 http://purl.obolibrary.org/obo/MAT_0000083 denotes blood
T3 1429-1434 http://purl.obolibrary.org/obo/MAT_0000315 denotes blood
T4 1451-1456 http://purl.obolibrary.org/obo/MAT_0000097 denotes liver

sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-73 Sentence denotes Siglec-7: a sialic acid-binding lectin of the immunoglobulin superfamily.
TextSentencer_T2 74-189 Sentence denotes The Siglecs are a recently discovered family of sialic acid-binding lectins of the immunoglobulin (Ig) superfamily.
TextSentencer_T3 190-343 Sentence denotes We report a molecule showing homology to the six first reported Siglecs, with the closest relationship to Siglec-3(CD33), Siglec-5, and Siglec-6(OBBP-1).
TextSentencer_T4 344-530 Sentence denotes The extracellular portion has two Ig-like domains, with the amino-terminal V-set Ig domain including amino acid residues known to be involved in sialic acid recognition by other Siglecs.
TextSentencer_T5 531-695 Sentence denotes The cytoplasmic domain has putative sites of tyrosine phosphorylation shared with some Siglecs, including an Immuno-receptor Tyrosine-based Inhibitory Motif (ITIM).
TextSentencer_T6 696-791 Sentence denotes Expression of the full-length cDNA induces sialic acid-dependent binding to human erythrocytes.
TextSentencer_T7 792-976 Sentence denotes A recombinant chimeric form containing the extracellular Ig domains selectively recognizes the sequence Neu5Acalpha2-6Galbeta1-4Glc, and binding requires the side chain of sialic acid.
TextSentencer_T8 977-1086 Sentence denotes Mutation of an arginine residue predicted to be critical for sialic acid binding abolishes both interactions.
TextSentencer_T9 1087-1164 Sentence denotes Taken together, our findings justify designation of the molecule as Siglec-7.
TextSentencer_T10 1165-1352 Sentence denotes Analysis of bacterial artificial chromosome (BAC) clones spanning the known human genomic location of Siglec-3 indicates that the Siglec-7 gene is also located on chromosome 19q13.3-13.4.
TextSentencer_T11 1353-1457 Sentence denotes Human tissues show strong expression of Siglec-7 mRNA in spleen, peripheral blood leukocytes, and liver.
TextSentencer_T12 1458-1640 Sentence denotes The combination of an extracellular sialic acid binding site and an intracellular ITIM motif suggests that this molecule is involved in trans-membrane regulatory signaling reactions.
T1 0-73 Sentence denotes Siglec-7: a sialic acid-binding lectin of the immunoglobulin superfamily.
T2 74-189 Sentence denotes The Siglecs are a recently discovered family of sialic acid-binding lectins of the immunoglobulin (Ig) superfamily.
T3 190-343 Sentence denotes We report a molecule showing homology to the six first reported Siglecs, with the closest relationship to Siglec-3(CD33), Siglec-5, and Siglec-6(OBBP-1).
T4 344-695 Sentence denotes The extracellular portion has two Ig-like domains, with the amino-terminal V-set Ig domain including amino acid residues known to be involved in sialic acid recognition by other Siglecs. The cytoplasmic domain has putative sites of tyrosine phosphorylation shared with some Siglecs, including an Immuno-receptor Tyrosine-based Inhibitory Motif (ITIM).
T5 696-791 Sentence denotes Expression of the full-length cDNA induces sialic acid-dependent binding to human erythrocytes.
T6 792-976 Sentence denotes A recombinant chimeric form containing the extracellular Ig domains selectively recognizes the sequence Neu5Acalpha2-6Galbeta1-4Glc, and binding requires the side chain of sialic acid.
T7 977-1086 Sentence denotes Mutation of an arginine residue predicted to be critical for sialic acid binding abolishes both interactions.
T8 1087-1164 Sentence denotes Taken together, our findings justify designation of the molecule as Siglec-7.
T9 1165-1352 Sentence denotes Analysis of bacterial artificial chromosome (BAC) clones spanning the known human genomic location of Siglec-3 indicates that the Siglec-7 gene is also located on chromosome 19q13.3-13.4.
T10 1353-1457 Sentence denotes Human tissues show strong expression of Siglec-7 mRNA in spleen, peripheral blood leukocytes, and liver.
T11 1458-1640 Sentence denotes The combination of an extracellular sialic acid binding site and an intracellular ITIM motif suggests that this molecule is involved in trans-membrane regulatory signaling reactions.
T1 0-73 Sentence denotes Siglec-7: a sialic acid-binding lectin of the immunoglobulin superfamily.
T2 74-189 Sentence denotes The Siglecs are a recently discovered family of sialic acid-binding lectins of the immunoglobulin (Ig) superfamily.
T3 190-343 Sentence denotes We report a molecule showing homology to the six first reported Siglecs, with the closest relationship to Siglec-3(CD33), Siglec-5, and Siglec-6(OBBP-1).
T4 344-530 Sentence denotes The extracellular portion has two Ig-like domains, with the amino-terminal V-set Ig domain including amino acid residues known to be involved in sialic acid recognition by other Siglecs.
T5 531-695 Sentence denotes The cytoplasmic domain has putative sites of tyrosine phosphorylation shared with some Siglecs, including an Immuno-receptor Tyrosine-based Inhibitory Motif (ITIM).
T6 696-791 Sentence denotes Expression of the full-length cDNA induces sialic acid-dependent binding to human erythrocytes.
T7 792-976 Sentence denotes A recombinant chimeric form containing the extracellular Ig domains selectively recognizes the sequence Neu5Acalpha2-6Galbeta1-4Glc, and binding requires the side chain of sialic acid.
T8 977-1086 Sentence denotes Mutation of an arginine residue predicted to be critical for sialic acid binding abolishes both interactions.
T9 1087-1164 Sentence denotes Taken together, our findings justify designation of the molecule as Siglec-7.
T10 1165-1352 Sentence denotes Analysis of bacterial artificial chromosome (BAC) clones spanning the known human genomic location of Siglec-3 indicates that the Siglec-7 gene is also located on chromosome 19q13.3-13.4.
T11 1353-1457 Sentence denotes Human tissues show strong expression of Siglec-7 mRNA in spleen, peripheral blood leukocytes, and liver.
T12 1458-1640 Sentence denotes The combination of an extracellular sialic acid binding site and an intracellular ITIM motif suggests that this molecule is involved in trans-membrane regulatory signaling reactions.

GlyCosmos6-Glycan-Motif-Structure

Id Subject Object Predicate Lexical cue
T1 12-23 https://glytoucan.org/Structures/Glycans/G81533KY denotes sialic acid
T2 122-133 https://glytoucan.org/Structures/Glycans/G81533KY denotes sialic acid
T3 489-500 https://glytoucan.org/Structures/Glycans/G81533KY denotes sialic acid
T4 739-750 https://glytoucan.org/Structures/Glycans/G81533KY denotes sialic acid
T5 964-975 https://glytoucan.org/Structures/Glycans/G81533KY denotes sialic acid
T6 1038-1049 https://glytoucan.org/Structures/Glycans/G81533KY denotes sialic acid
T7 1494-1505 https://glytoucan.org/Structures/Glycans/G81533KY denotes sialic acid

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 778-790 HP_0001901 denotes erythrocytes

GlycoBiology-FMA

Id Subject Object Predicate Lexical cue
_T1 46-60 FMAID:167183 denotes immunoglobulin
_T2 46-60 FMAID:62874 denotes immunoglobulin
_T3 46-60 FMAID:62871 denotes immunoglobulin
_T4 46-60 FMAID:167181 denotes immunoglobulin
_T5 46-60 FMAID:62873 denotes immunoglobulin
_T6 46-60 FMAID:167177 denotes immunoglobulin
_T7 46-60 FMAID:167187 denotes immunoglobulin
_T8 46-60 FMAID:167178 denotes immunoglobulin
_T9 46-60 FMAID:62872 denotes immunoglobulin
_T10 46-60 FMAID:62876 denotes immunoglobulin
_T11 46-60 FMAID:167185 denotes immunoglobulin
_T12 46-60 FMAID:62875 denotes immunoglobulin
_T13 157-171 FMAID:167185 denotes immunoglobulin
_T14 157-171 FMAID:167187 denotes immunoglobulin
_T15 157-171 FMAID:62876 denotes immunoglobulin
_T16 157-171 FMAID:62875 denotes immunoglobulin
_T17 157-171 FMAID:167177 denotes immunoglobulin
_T18 157-171 FMAID:62874 denotes immunoglobulin
_T19 157-171 FMAID:62871 denotes immunoglobulin
_T20 157-171 FMAID:62873 denotes immunoglobulin
_T21 157-171 FMAID:167181 denotes immunoglobulin
_T22 157-171 FMAID:167183 denotes immunoglobulin
_T23 157-175 FMAID:62872 denotes immunoglobulin (Ig
_T24 157-175 FMAID:167178 denotes immunoglobulin (Ig
_T25 445-455 FMAID:82739 denotes amino acid
_T26 445-455 FMAID:196728 denotes amino acid
_T27 535-546 FMAID:165187 denotes cytoplasmic
_T28 535-546 FMAID:164989 denotes cytoplasmic
_T29 535-546 FMAID:66835 denotes cytoplasmic
_T30 576-584 FMAID:196757 denotes tyrosine
_T31 576-584 FMAID:82768 denotes tyrosine
_T32 656-664 FMAID:196757 denotes Tyrosine
_T33 656-664 FMAID:82768 denotes Tyrosine
_T34 778-790 FMAID:167137 denotes erythrocytes
_T35 778-790 FMAID:62845 denotes erythrocytes
_T36 992-1000 FMAID:82763 denotes arginine
_T37 992-1000 FMAID:196752 denotes arginine
_T38 1198-1208 FMAID:226764 denotes chromosome
_T39 1198-1208 FMAID:67093 denotes chromosome
_T40 1198-1208 FMAID:197979 denotes chromosome
_T41 1198-1208 FMAID:165175 denotes chromosome
_T42 1198-1208 FMAID:197978 denotes chromosome
_T43 1198-1208 FMAID:84055 denotes chromosome
_T44 1198-1208 FMAID:84056 denotes chromosome
_T45 1247-1254 FMAID:198062 denotes genomic
_T46 1247-1254 FMAID:84116 denotes genomic
_T47 1304-1308 FMAID:198663 denotes gene
_T48 1328-1338 FMAID:84055 denotes chromosome
_T49 1328-1338 FMAID:197978 denotes chromosome
_T50 1328-1338 FMAID:67093 denotes chromosome
_T51 1328-1338 FMAID:165175 denotes chromosome
_T52 1328-1338 FMAID:226764 denotes chromosome
_T53 1328-1338 FMAID:84056 denotes chromosome
_T54 1328-1338 FMAID:197979 denotes chromosome
_T55 1359-1366 FMAID:256050 denotes tissues
_T56 1410-1416 FMAID:188495 denotes spleen
_T57 1410-1416 FMAID:7196 denotes spleen
_T58 1410-1416 FMAID:93671 denotes spleen
_T59 1418-1428 FMAID:179289 denotes peripheral
_T60 1418-1428 FMAID:222825 denotes peripheral
_T61 1418-1428 FMAID:74552 denotes peripheral
_T62 1418-1434 FMAID:201651 denotes peripheral blood
_T63 1418-1434 FMAID:86697 denotes peripheral blood
_T64 1418-1445 FMAID:201668 denotes peripheral blood leukocytes
_T65 1429-1434 FMAID:256053 denotes blood
_T66 1435-1445 FMAID:167148 denotes leukocytes
_T67 1435-1445 FMAID:62852 denotes leukocytes
_T68 1451-1456 FMAID:7197 denotes liver
_T69 1451-1456 FMAID:93672 denotes liver
_T70 1594-1608 FMAID:9595 denotes trans-membrane
_T71 1594-1608 FMAID:97471 denotes trans-membrane

uniprot-human

Id Subject Object Predicate Lexical cue
T1 0-8 http://www.uniprot.org/uniprot/Q9Y286 denotes Siglec-7
T2 1155-1163 http://www.uniprot.org/uniprot/Q9Y286 denotes Siglec-7
T3 1295-1303 http://www.uniprot.org/uniprot/Q9Y286 denotes Siglec-7
T4 1393-1401 http://www.uniprot.org/uniprot/Q9Y286 denotes Siglec-7
T5 122-149 http://www.uniprot.org/uniprot/Q96RL6 denotes sialic acid-binding lectins
T6 296-304 http://www.uniprot.org/uniprot/P20138 denotes Siglec-3
T7 305-309 http://www.uniprot.org/uniprot/P20138 denotes CD33
T8 312-320 http://www.uniprot.org/uniprot/O15389 denotes Siglec-5
T9 326-334 http://www.uniprot.org/uniprot/O43699 denotes Siglec-6

uniprot-mouse

Id Subject Object Predicate Lexical cue
T1 296-304 http://www.uniprot.org/uniprot/Q63994 denotes Siglec-3
T2 305-309 http://www.uniprot.org/uniprot/Q63994 denotes CD33
T3 312-320 http://www.uniprot.org/uniprot/Q920G3 denotes Siglec-5
T4 312-320 http://www.uniprot.org/uniprot/Q91Y57 denotes Siglec-5

GlycoBiology-NCBITAXON

Id Subject Object Predicate Lexical cue
T1 1107-1115 http://purl.bioontology.org/ontology/STY/T033 denotes findings
T2 1359-1366 http://purl.bioontology.org/ontology/STY/T024 denotes tissues

GO-BP

Id Subject Object Predicate Lexical cue
T1 585-600 http://purl.obolibrary.org/obo/GO_0016310 denotes phosphorylation
T2 1620-1629 http://purl.obolibrary.org/obo/GO_0023052 denotes signaling

GO-MF

Id Subject Object Predicate Lexical cue
T1 24-31 http://purl.obolibrary.org/obo/GO_0070026 denotes binding
T2 134-141 http://purl.obolibrary.org/obo/GO_0070026 denotes binding
T3 761-768 http://purl.obolibrary.org/obo/GO_0070026 denotes binding
T4 929-936 http://purl.obolibrary.org/obo/GO_0070026 denotes binding
T5 1050-1057 http://purl.obolibrary.org/obo/GO_0070026 denotes binding
T6 1506-1513 http://purl.obolibrary.org/obo/GO_0070026 denotes binding
T7 24-31 http://purl.obolibrary.org/obo/GO_0003680 denotes binding
T8 134-141 http://purl.obolibrary.org/obo/GO_0003680 denotes binding
T9 761-768 http://purl.obolibrary.org/obo/GO_0003680 denotes binding
T10 929-936 http://purl.obolibrary.org/obo/GO_0003680 denotes binding
T11 1050-1057 http://purl.obolibrary.org/obo/GO_0003680 denotes binding
T12 1506-1513 http://purl.obolibrary.org/obo/GO_0003680 denotes binding
T13 24-31 http://purl.obolibrary.org/obo/GO_0017091 denotes binding
T14 134-141 http://purl.obolibrary.org/obo/GO_0017091 denotes binding
T15 761-768 http://purl.obolibrary.org/obo/GO_0017091 denotes binding
T16 929-936 http://purl.obolibrary.org/obo/GO_0017091 denotes binding
T17 1050-1057 http://purl.obolibrary.org/obo/GO_0017091 denotes binding
T18 1506-1513 http://purl.obolibrary.org/obo/GO_0017091 denotes binding
T19 24-31 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T20 134-141 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T21 761-768 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T22 929-936 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T23 1050-1057 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T24 1506-1513 http://purl.obolibrary.org/obo/GO_0005488 denotes binding
T25 46-60 http://purl.obolibrary.org/obo/GO_0003823 denotes immunoglobulin
T26 157-171 http://purl.obolibrary.org/obo/GO_0003823 denotes immunoglobulin
T27 1038-1057 http://purl.obolibrary.org/obo/GO_0033691 denotes sialic acid binding
T28 1494-1513 http://purl.obolibrary.org/obo/GO_0033691 denotes sialic acid binding

GO-CC

Id Subject Object Predicate Lexical cue
T1 348-361 http://purl.obolibrary.org/obo/GO_0005576 denotes extracellular
T2 835-848 http://purl.obolibrary.org/obo/GO_0005576 denotes extracellular
T3 1480-1493 http://purl.obolibrary.org/obo/GO_0005576 denotes extracellular
T4 535-546 http://purl.obolibrary.org/obo/GO_0005737 denotes cytoplasmic
T5 1198-1208 http://purl.obolibrary.org/obo/GO_0005694 denotes chromosome
T6 1328-1338 http://purl.obolibrary.org/obo/GO_0005694 denotes chromosome
T7 1526-1539 http://purl.obolibrary.org/obo/GO_0005622 denotes intracellular
T8 1600-1608 http://purl.obolibrary.org/obo/GO_0016020 denotes membrane

UBERON-AE

Id Subject Object Predicate Lexical cue
T1 1359-1366 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissues
T2 1410-1416 http://purl.obolibrary.org/obo/UBERON_0002106 denotes spleen
T3 1429-1434 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
T4 1451-1456 http://purl.obolibrary.org/obo/UBERON_0002107 denotes liver

EDAM-topics

Id Subject Object Predicate Lexical cue
T1 202-210 http://edamontology.org/topic_2839 denotes molecule
T2 410-418 http://edamontology.org/topic_0749 denotes terminal
T3 445-455 http://edamontology.org/topic_0154 denotes amino acid
T4 535-546 http://edamontology.org/topic_0616 denotes cytoplasmic
T5 682-687 http://edamontology.org/topic_0158 denotes Motif
T6 726-730 http://edamontology.org/topic_3512 denotes cDNA
T7 772-777 http://edamontology.org/topic_2815 denotes human
T8 887-895 http://edamontology.org/topic_3168 denotes sequence
T9 887-895 http://edamontology.org/topic_0080 denotes sequence
T10 977-985 http://edamontology.org/topic_0199 denotes Mutation
T11 1073-1085 http://edamontology.org/topic_0602 denotes interactions
T12 1143-1151 http://edamontology.org/topic_2839 denotes molecule
T13 1198-1208 http://edamontology.org/topic_0624 denotes chromosome
T14 1198-1208 http://edamontology.org/topic_0654 denotes chromosome
T15 1241-1246 http://edamontology.org/topic_2815 denotes human
T16 1247-1254 http://edamontology.org/topic_0622 denotes genomic
T17 1328-1338 http://edamontology.org/topic_0654 denotes chromosome
T18 1328-1338 http://edamontology.org/topic_0624 denotes chromosome
T19 1353-1358 http://edamontology.org/topic_2815 denotes Human
T20 1545-1550 http://edamontology.org/topic_0158 denotes motif
T21 1570-1578 http://edamontology.org/topic_2839 denotes molecule

EDAM-DFO

Id Subject Object Predicate Lexical cue
T1 61-72 http://edamontology.org/data_3143 denotes superfamily
T2 173-175 http://edamontology.org/format_1942 denotes Ig
T3 177-188 http://edamontology.org/data_3143 denotes superfamily
T4 193-199 http://edamontology.org/data_2048 denotes report
T5 245-253 http://edamontology.org/data_2048 denotes reported
T6 378-380 http://edamontology.org/format_1942 denotes Ig
T7 425-427 http://edamontology.org/format_1942 denotes Ig
T8 456-464 http://edamontology.org/data_1756 denotes residues
T9 501-512 http://edamontology.org/operation_2423 denotes recognition
T10 849-851 http://edamontology.org/format_1942 denotes Ig
T11 887-895 http://edamontology.org/data_2044 denotes sequence
T12 887-895 http://edamontology.org/operation_3218 denotes sequence
T13 1001-1008 http://edamontology.org/data_1756 denotes residue
T14 1009-1018 http://edamontology.org/operation_2423 denotes predicted
T15 1124-1135 http://edamontology.org/operation_2430 denotes designation
T16 1165-1173 http://edamontology.org/operation_2945 denotes Analysis

GlycoBiology-MAT

Id Subject Object Predicate Lexical cue
T1 1410-1416 http://purl.obolibrary.org/obo/MAT_0000085 denotes spleen
T2 1429-1434 http://purl.obolibrary.org/obo/MAT_0000083 denotes blood
T3 1429-1434 http://purl.obolibrary.org/obo/MAT_0000315 denotes blood
T4 1451-1456 http://purl.obolibrary.org/obo/MAT_0000097 denotes liver

Lectin

Id Subject Object Predicate Lexical cue
Lectin_T1 296-309 https://acgg.asia/db/lfdb/LfDB0074 denotes Siglec-3(CD33

GlyTouCan-IUPAC

Id Subject Object Predicate Lexical cue
GlycanIUPAC_T1 1210-1213 "http://rdf.glycoinfo.org/glycan/G71051OE" denotes BAC
GlycanIUPAC_T2 1210-1213 "http://rdf.glycoinfo.org/glycan/G39568OT" denotes BAC

performance-test

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 1429-1434 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
PD-UBERON-AE-B_T2 1359-1366 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissues
PD-UBERON-AE-B_T3 1451-1456 http://purl.obolibrary.org/obo/UBERON_0002107 denotes liver
PD-UBERON-AE-B_T4 1410-1416 http://purl.obolibrary.org/obo/UBERON_0002106 denotes spleen

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 1410-1416 Body_part denotes spleen http://purl.obolibrary.org/obo/MAT_0000085
T2 1429-1434 Body_part denotes blood http://purl.obolibrary.org/obo/MAT_0000083|http://purl.obolibrary.org/obo/MAT_0000315
T4 1451-1456 Body_part denotes liver http://purl.obolibrary.org/obo/MAT_0000097

Lectin-Jamboree

Id Subject Object Predicate Lexical cue
T1 32-38 lectin denotes lectin
T2 142-149 lectin denotes lectins

Lectin-Jamboree-Sentence

Id Subject Object Predicate Lexical cue
T1 0-73 Sentence denotes Siglec-7: a sialic acid-binding lectin of the immunoglobulin superfamily.
T2 74-189 Sentence denotes The Siglecs are a recently discovered family of sialic acid-binding lectins of the immunoglobulin (Ig) superfamily.
T3 190-343 Sentence denotes We report a molecule showing homology to the six first reported Siglecs, with the closest relationship to Siglec-3(CD33), Siglec-5, and Siglec-6(OBBP-1).
T4 344-695 Sentence denotes The extracellular portion has two Ig-like domains, with the amino-terminal V-set Ig domain including amino acid residues known to be involved in sialic acid recognition by other Siglecs. The cytoplasmic domain has putative sites of tyrosine phosphorylation shared with some Siglecs, including an Immuno-receptor Tyrosine-based Inhibitory Motif (ITIM).
T5 696-791 Sentence denotes Expression of the full-length cDNA induces sialic acid-dependent binding to human erythrocytes.
T6 792-976 Sentence denotes A recombinant chimeric form containing the extracellular Ig domains selectively recognizes the sequence Neu5Acalpha2-6Galbeta1-4Glc, and binding requires the side chain of sialic acid.
T7 977-1086 Sentence denotes Mutation of an arginine residue predicted to be critical for sialic acid binding abolishes both interactions.
T8 1087-1164 Sentence denotes Taken together, our findings justify designation of the molecule as Siglec-7.
T9 1165-1352 Sentence denotes Analysis of bacterial artificial chromosome (BAC) clones spanning the known human genomic location of Siglec-3 indicates that the Siglec-7 gene is also located on chromosome 19q13.3-13.4.
T10 1353-1457 Sentence denotes Human tissues show strong expression of Siglec-7 mRNA in spleen, peripheral blood leukocytes, and liver.
T11 1458-1640 Sentence denotes The combination of an extracellular sialic acid binding site and an intracellular ITIM motif suggests that this molecule is involved in trans-membrane regulatory signaling reactions.

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 772-777 OrganismTaxon denotes human 9606
T2 1241-1246 OrganismTaxon denotes human 9606
T3 1353-1358 OrganismTaxon denotes Human 9606

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 348-361 Body_part denotes extracellular http://purl.obolibrary.org/obo/GO_0005576
T2 535-546 Body_part denotes cytoplasmic http://purl.obolibrary.org/obo/GO_0005737
T3 778-790 Body_part denotes erythrocytes http://purl.obolibrary.org/obo/CL_0000232
T4 835-848 Body_part denotes extracellular http://purl.obolibrary.org/obo/GO_0005576
T5 1198-1208 Body_part denotes chromosome http://purl.obolibrary.org/obo/GO_0005694
T6 1328-1338 Body_part denotes chromosome http://purl.obolibrary.org/obo/GO_0005694
T7 1410-1416 Body_part denotes spleen http://purl.obolibrary.org/obo/UBERON_0002106
T8 1429-1434 Body_part denotes blood http://purl.obolibrary.org/obo/UBERON_0000178
T9 1435-1445 Body_part denotes leukocytes http://purl.obolibrary.org/obo/CL_0000738
T10 1451-1456 Body_part denotes liver http://purl.obolibrary.org/obo/UBERON_0002107
T11 1480-1493 Body_part denotes extracellular http://purl.obolibrary.org/obo/GO_0005576
T12 1526-1539 Body_part denotes intracellular http://purl.obolibrary.org/obo/GO_0005622
T13 1600-1608 Body_part denotes membrane http://purl.obolibrary.org/obo/GO_0016020|http://purl.obolibrary.org/obo/UBERON_0000094|http://purl.obolibrary.org/obo/UBERON_0000158

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 778-790 Cell denotes erythrocytes http://purl.obolibrary.org/obo/CL:0000232
T2 1435-1445 Cell denotes leukocytes http://purl.obolibrary.org/obo/CL:0000738