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PubMed:10747965 JSONTXT

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sentences

Id Subject Object Predicate Lexical cue
T1 0-93 Sentence denotes Maf transcriptionally activates the mouse p53 promoter and causes a p53-dependent cell death.
T2 94-198 Sentence denotes An increase in the level of the tumor suppressor protein p53 can induce cell cycle arrest or cell death.
T3 199-443 Sentence denotes Although mechanisms for regulating the life span of p53 have been described, there is growing evidence that transcriptional regulation of the p53 gene contributes significantly to controlling p53 protein levels and therefore the fate of a cell.
T4 444-564 Sentence denotes However, the signal transduction pathways that lead to transcriptional activation of the p53 gene are poorly understood.
T5 565-744 Sentence denotes The oncoprotein v-Maf and its cellular counterparts belong to the large combinatorially complex basic leucine zipper family of transcription factors, which include the AP1 family.
T6 745-804 Sentence denotes To date few cellular targets of c-Maf have been identified.
T7 805-964 Sentence denotes It is demonstrated here that v-Maf can bind as a homodimer to a variant Maf recognition element located between -66 and -54 upstream in the mouse p53 promoter.
T8 965-1056 Sentence denotes V-Maf and its cellular counterparts are shown to activate p53 expression through this site.
T9 1057-1140 Sentence denotes The ability of v-Maf to activate p53 expression is modulated by AP1 family members.
T10 1141-1231 Sentence denotes In addition, overexpression of v-Maf in primary cells leads to a p53-dependent cell death.
T11 1232-1346 Sentence denotes Thus, Maf and members of the AP1 family are able to regulate p53 expression through this site in the p53 promoter.

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 126-131 HP_0002664 denotes tumor

2015-BEL-Sample-2

Id Subject Object Predicate Lexical cue
BEL:20064026 94-196 p(MGI:Trp53) decreases bp(GOBP:"cell cycle") denotes An increase in the level of the tumor suppressor protein p53 can induce cell cycle arrest or cell deat
BEL:20064030 94-196 p(MGI:Trp53) increases bp(GOBP:"cell death") denotes An increase in the level of the tumor suppressor protein p53 can induce cell cycle arrest or cell deat

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 126-131 Phenotype denotes tumor HP:0002664

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 126-131 Disease denotes tumor http://purl.obolibrary.org/obo/MONDO_0005070

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 36-41 OrganismTaxon denotes mouse 10088|10090
T3 945-950 OrganismTaxon denotes mouse 10088|10090

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 166-176 Body_part denotes cell cycle http://purl.obolibrary.org/obo/UBERON_2000098