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GlyCosmos15-Species

Id Subject Object Predicate Lexical cue db_id
4 37-42 Species denotes human 9606
52 227-233 Species denotes Humans 9606
54 431-437 Species denotes humans 9606
56 535-540 Species denotes Human 9606
61 608-614 Species denotes humans 9606
64 707-713 Species denotes humans 9606
65 773-784 Species denotes chimpanzees 9598
67 949-954 Species denotes human 9606
68 1041-1046 Species denotes mouse 10090
71 1092-1097 Species denotes human 9606
73 1199-1204 Species denotes human 9606
76 1431-1437 Species denotes humans 9606
77 1439-1444 Species denotes Human 9606
85 1691-1696 Species denotes human 9606

GlyCosmos6-Glycan-Motif-Image

Id Subject Object Predicate Lexical cue image
T1 71-82 Glycan_Motif denotes sialic acid https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81533KY
T2 118-130 Glycan_Motif denotes sialic acids https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81533KY
T3 154-177 Glycan_Motif denotes N-acetylneuraminic acid https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81533KY|https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G50850NI
T5 179-185 Glycan_Motif denotes Neu5Ac https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81533KY
T6 281-292 Glycan_Motif denotes sialic acid https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81533KY
T7 421-427 Glycan_Motif denotes Neu5Ac https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81533KY
T8 521-533 Glycan_Motif denotes sialic acids https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81533KY
T9 582-588 Glycan_Motif denotes Neu5Ac https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81533KY
T10 1120-1126 Glycan_Motif denotes Neu5Ac https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81533KY
T11 1522-1528 Glycan_Motif denotes Neu5Ac https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81533KY
T12 1661-1667 Glycan_Motif denotes Neu5Ac https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G81533KY

sentences

Id Subject Object Predicate Lexical cue
T1 0-53 Sentence denotes Loss of N-glycolylneuraminic acid in human evolution.
T2 54-106 Sentence denotes Implications for sialic acid recognition by siglecs.
T3 107-226 Sentence denotes The common sialic acids of mammalian cells are N-acetylneuraminic acid (Neu5Ac) and N-glycolylneuraminic acid (Neu5Gc).
T4 227-363 Sentence denotes Humans are an exception, because of a mutation in CMP-sialic acid hydroxylase, which occurred after our common ancestor with great apes.
T5 364-534 Sentence denotes We asked if the resulting loss of Neu5Gc and increase in Neu5Ac in humans alters the biology of the siglecs, which are Ig superfamily members that recognize sialic acids.
T6 535-601 Sentence denotes Human siglec-1 (sialoadhesin) strongly prefers Neu5Ac over Neu5Gc.
T7 602-673 Sentence denotes Thus, humans have a higher density of siglec-1 ligands than great apes.
T8 674-876 Sentence denotes Siglec-1-positive macrophages in humans are found primarily in the perifollicular zone, whereas in chimpanzees they also occur in the marginal zone and surrounding the periarteriolar lymphocyte sheaths.
T9 877-980 Sentence denotes Although only a subset of chimpanzee macrophages express siglec-1, most human macrophages are positive.
T10 981-1140 Sentence denotes A known evolutionary difference is the strong preference of mouse siglec-2 (CD22) for Neu5Gc, contrasting with human siglec-2, which binds Neu5Ac equally well.
T11 1141-1331 Sentence denotes To ask when the preference for Neu5Gc was adjusted in the human lineage, we cloned the first three extracellular domains of siglec-2 from all of the great apes and examined their preference.
T12 1332-1438 Sentence denotes In fact, siglec-2 had evolved a higher degree of recognition flexibility before Neu5Gc was lost in humans.
T13 1439-1590 Sentence denotes Human siglec-3 (CD33) and siglec-6 (obesity-binding protein 1) also recognize both Neu5Ac and Neu5Gc, and siglec-5 may have some preference for Neu5Gc.
T14 1591-1680 Sentence denotes Others showed that siglec-4a (myelin-associated glycoprotein) prefers Neu5Ac over Neu5Gc.
T15 1681-1793 Sentence denotes Thus, the human loss of Neu5Gc may alter biological processes involving siglec-1, and possibly, siglec-4a or -5.

GlyCosmos6-Glycan-Motif-Structure

Id Subject Object Predicate Lexical cue
T1 71-82 https://glytoucan.org/Structures/Glycans/G81533KY denotes sialic acid
T2 118-130 https://glytoucan.org/Structures/Glycans/G81533KY denotes sialic acids
T3 154-177 https://glytoucan.org/Structures/Glycans/G50850NI denotes N-acetylneuraminic acid
T4 154-177 https://glytoucan.org/Structures/Glycans/G81533KY denotes N-acetylneuraminic acid
T5 179-185 https://glytoucan.org/Structures/Glycans/G81533KY denotes Neu5Ac
T6 281-292 https://glytoucan.org/Structures/Glycans/G81533KY denotes sialic acid
T7 421-427 https://glytoucan.org/Structures/Glycans/G81533KY denotes Neu5Ac
T8 521-533 https://glytoucan.org/Structures/Glycans/G81533KY denotes sialic acids
T9 582-588 https://glytoucan.org/Structures/Glycans/G81533KY denotes Neu5Ac
T10 1120-1126 https://glytoucan.org/Structures/Glycans/G81533KY denotes Neu5Ac
T11 1522-1528 https://glytoucan.org/Structures/Glycans/G81533KY denotes Neu5Ac
T12 1661-1667 https://glytoucan.org/Structures/Glycans/G81533KY denotes Neu5Ac

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 1475-1482 HP_0001513 denotes obesity

GlyCosmos15-Glycan

Id Subject Object Predicate Lexical cue image
T1 179-185 Glycan denotes Neu5Ac https://api.glycosmos.org/wurcs2image/latest/png/binary/G76685HR
T2 421-427 Glycan denotes Neu5Ac https://api.glycosmos.org/wurcs2image/latest/png/binary/G76685HR
T3 582-588 Glycan denotes Neu5Ac https://api.glycosmos.org/wurcs2image/latest/png/binary/G76685HR
T4 1120-1126 Glycan denotes Neu5Ac https://api.glycosmos.org/wurcs2image/latest/png/binary/G76685HR
T5 1522-1528 Glycan denotes Neu5Ac https://api.glycosmos.org/wurcs2image/latest/png/binary/G76685HR
T6 1661-1667 Glycan denotes Neu5Ac https://api.glycosmos.org/wurcs2image/latest/png/binary/G76685HR

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 1475-1482 Disease denotes obesity http://purl.obolibrary.org/obo/MONDO_0011122

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 1475-1482 Phenotype denotes obesity HP:0001513

Glycan-GlyCosmos

Id Subject Object Predicate Lexical cue image
T1 179-185 Glycan denotes Neu5Ac https://api.glycosmos.org/wurcs2image/latest/png/binary/G76685HR
T2 421-427 Glycan denotes Neu5Ac https://api.glycosmos.org/wurcs2image/latest/png/binary/G76685HR
T3 582-588 Glycan denotes Neu5Ac https://api.glycosmos.org/wurcs2image/latest/png/binary/G76685HR
T4 1120-1126 Glycan denotes Neu5Ac https://api.glycosmos.org/wurcs2image/latest/png/binary/G76685HR
T5 1522-1528 Glycan denotes Neu5Ac https://api.glycosmos.org/wurcs2image/latest/png/binary/G76685HR
T6 1661-1667 Glycan denotes Neu5Ac https://api.glycosmos.org/wurcs2image/latest/png/binary/G76685HR

GlyCosmos15-HP

Id Subject Object Predicate Lexical cue hp_id
T1 1475-1482 Phenotype denotes obesity HP:0001513

GlyCosmos15-CL

Id Subject Object Predicate Lexical cue cl_id
T1 692-703 Cell denotes macrophages http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394
T3 857-867 Cell denotes lymphocyte http://purl.obolibrary.org/obo/CL:0000542
T4 914-925 Cell denotes macrophages http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394
T6 955-966 Cell denotes macrophages http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394

GlyCosmos15-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 692-703 Body_part denotes macrophages http://purl.obolibrary.org/obo/CL_0000235
T2 808-821 Body_part denotes marginal zone http://purl.obolibrary.org/obo/UBERON_0001251|http://purl.obolibrary.org/obo/UBERON_0004879|http://purl.obolibrary.org/obo/UBERON_0014935
T5 857-867 Body_part denotes lymphocyte http://purl.obolibrary.org/obo/CL_0000542
T6 914-925 Body_part denotes macrophages http://purl.obolibrary.org/obo/CL_0000235
T7 955-966 Body_part denotes macrophages http://purl.obolibrary.org/obo/CL_0000235
T8 1240-1253 Body_part denotes extracellular http://purl.obolibrary.org/obo/GO_0005576
T9 1621-1627 Body_part denotes myelin http://purl.obolibrary.org/obo/UBERON_0000345

GlyCosmos15-MONDO

Id Subject Object Predicate Lexical cue mondo_id
T1 1475-1482 Disease denotes obesity MONDO:0011122

GlyCosmos15-Sentences

Id Subject Object Predicate Lexical cue
T1 0-53 Sentence denotes Loss of N-glycolylneuraminic acid in human evolution.
T2 54-106 Sentence denotes Implications for sialic acid recognition by siglecs.
T3 107-226 Sentence denotes The common sialic acids of mammalian cells are N-acetylneuraminic acid (Neu5Ac) and N-glycolylneuraminic acid (Neu5Gc).
T4 227-363 Sentence denotes Humans are an exception, because of a mutation in CMP-sialic acid hydroxylase, which occurred after our common ancestor with great apes.
T5 364-534 Sentence denotes We asked if the resulting loss of Neu5Gc and increase in Neu5Ac in humans alters the biology of the siglecs, which are Ig superfamily members that recognize sialic acids.
T6 535-601 Sentence denotes Human siglec-1 (sialoadhesin) strongly prefers Neu5Ac over Neu5Gc.
T7 602-673 Sentence denotes Thus, humans have a higher density of siglec-1 ligands than great apes.
T8 674-876 Sentence denotes Siglec-1-positive macrophages in humans are found primarily in the perifollicular zone, whereas in chimpanzees they also occur in the marginal zone and surrounding the periarteriolar lymphocyte sheaths.
T9 877-980 Sentence denotes Although only a subset of chimpanzee macrophages express siglec-1, most human macrophages are positive.
T10 981-1140 Sentence denotes A known evolutionary difference is the strong preference of mouse siglec-2 (CD22) for Neu5Gc, contrasting with human siglec-2, which binds Neu5Ac equally well.
T11 1141-1331 Sentence denotes To ask when the preference for Neu5Gc was adjusted in the human lineage, we cloned the first three extracellular domains of siglec-2 from all of the great apes and examined their preference.
T12 1332-1438 Sentence denotes In fact, siglec-2 had evolved a higher degree of recognition flexibility before Neu5Gc was lost in humans.
T13 1439-1590 Sentence denotes Human siglec-3 (CD33) and siglec-6 (obesity-binding protein 1) also recognize both Neu5Ac and Neu5Gc, and siglec-5 may have some preference for Neu5Gc.
T14 1591-1680 Sentence denotes Others showed that siglec-4a (myelin-associated glycoprotein) prefers Neu5Ac over Neu5Gc.
T15 1681-1793 Sentence denotes Thus, the human loss of Neu5Gc may alter biological processes involving siglec-1, and possibly, siglec-4a or -5.

Lectin-Jamboree-Sentence

Id Subject Object Predicate Lexical cue
T1 0-53 Sentence denotes Loss of N-glycolylneuraminic acid in human evolution.
T2 54-106 Sentence denotes Implications for sialic acid recognition by siglecs.
T3 107-226 Sentence denotes The common sialic acids of mammalian cells are N-acetylneuraminic acid (Neu5Ac) and N-glycolylneuraminic acid (Neu5Gc).
T4 227-363 Sentence denotes Humans are an exception, because of a mutation in CMP-sialic acid hydroxylase, which occurred after our common ancestor with great apes.
T5 364-534 Sentence denotes We asked if the resulting loss of Neu5Gc and increase in Neu5Ac in humans alters the biology of the siglecs, which are Ig superfamily members that recognize sialic acids.
T6 535-601 Sentence denotes Human siglec-1 (sialoadhesin) strongly prefers Neu5Ac over Neu5Gc.
T7 602-673 Sentence denotes Thus, humans have a higher density of siglec-1 ligands than great apes.
T8 674-876 Sentence denotes Siglec-1-positive macrophages in humans are found primarily in the perifollicular zone, whereas in chimpanzees they also occur in the marginal zone and surrounding the periarteriolar lymphocyte sheaths.
T9 877-980 Sentence denotes Although only a subset of chimpanzee macrophages express siglec-1, most human macrophages are positive.
T10 981-1140 Sentence denotes A known evolutionary difference is the strong preference of mouse siglec-2 (CD22) for Neu5Gc, contrasting with human siglec-2, which binds Neu5Ac equally well.
T11 1141-1331 Sentence denotes To ask when the preference for Neu5Gc was adjusted in the human lineage, we cloned the first three extracellular domains of siglec-2 from all of the great apes and examined their preference.
T12 1332-1438 Sentence denotes In fact, siglec-2 had evolved a higher degree of recognition flexibility before Neu5Gc was lost in humans.
T13 1439-1590 Sentence denotes Human siglec-3 (CD33) and siglec-6 (obesity-binding protein 1) also recognize both Neu5Ac and Neu5Gc, and siglec-5 may have some preference for Neu5Gc.
T14 1591-1680 Sentence denotes Others showed that siglec-4a (myelin-associated glycoprotein) prefers Neu5Ac over Neu5Gc.
T15 1681-1793 Sentence denotes Thus, the human loss of Neu5Gc may alter biological processes involving siglec-1, and possibly, siglec-4a or -5.

Lectin_function

Id Subject Object Predicate Lexical cue
T1 541-549 GL_001125 denotes siglec-1
T2 551-563 GL_001125 denotes sialoadhesin
T3 551-563 GL_001126 denotes sialoadhesin
T4 551-563 GL_001127 denotes sialoadhesin
T5 640-648 GL_001125 denotes siglec-1
T6 674-682 GL_001125 denotes Siglec-1
T7 934-942 GL_001125 denotes siglec-1
T8 1057-1061 GL_000078 denotes CD22
T9 1455-1459 GL_000781 denotes CD33
T10 1545-1553 GL_002074 denotes siglec-5
T11 1621-1651 GL_000778 denotes myelin-associated glycoprotein
T12 1621-1651 GL_000779 denotes myelin-associated glycoprotein
T13 1621-1651 GL_000780 denotes myelin-associated glycoprotein
T14 1753-1761 GL_001125 denotes siglec-1

GlyCosmos15-NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 37-42 OrganismTaxon denotes human 9606
T2 134-143 OrganismTaxon denotes mammalian 40674
T3 535-540 OrganismTaxon denotes Human 9606
T4 949-954 OrganismTaxon denotes human 9606
T5 1041-1046 OrganismTaxon denotes mouse 10088|10090
T7 1092-1097 OrganismTaxon denotes human 9606
T8 1199-1204 OrganismTaxon denotes human 9606
T9 1439-1444 OrganismTaxon denotes Human 9606
T10 1691-1696 OrganismTaxon denotes human 9606

GlyCosmos15-FMA

Id Subject Object Predicate Lexical cue db_id
T1 692-703 Body_part denotes macrophages FMA:63261
T2 857-867 Body_part denotes lymphocyte FMA:62863
T3 914-925 Body_part denotes macrophages FMA:63261
T4 955-966 Body_part denotes macrophages FMA:63261

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 37-42 OrganismTaxon denotes human 9606
T2 535-540 OrganismTaxon denotes Human 9606
T3 949-954 OrganismTaxon denotes human 9606
T4 1041-1046 OrganismTaxon denotes mouse 10088|10090
T6 1092-1097 OrganismTaxon denotes human 9606
T7 1199-1204 OrganismTaxon denotes human 9606
T8 1439-1444 OrganismTaxon denotes Human 9606
T9 1691-1696 OrganismTaxon denotes human 9606

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 692-703 Body_part denotes macrophages http://purl.obolibrary.org/obo/CL_0000235
T2 808-821 Body_part denotes marginal zone http://purl.obolibrary.org/obo/UBERON_0001251|http://purl.obolibrary.org/obo/UBERON_0004879|http://purl.obolibrary.org/obo/UBERON_0014935
T5 857-867 Body_part denotes lymphocyte http://purl.obolibrary.org/obo/CL_0000542
T6 914-925 Body_part denotes macrophages http://purl.obolibrary.org/obo/CL_0000235
T7 955-966 Body_part denotes macrophages http://purl.obolibrary.org/obo/CL_0000235
T8 1240-1253 Body_part denotes extracellular http://purl.obolibrary.org/obo/GO_0005576
T9 1621-1627 Body_part denotes myelin http://purl.obolibrary.org/obo/UBERON_0000345

GlyCosmos15-Lectin

Id Subject Object Predicate Lexical cue
T1 541-549 GL_001127 denotes siglec-1
T2 640-648 GL_001127 denotes siglec-1
T3 674-682 GL_001127 denotes Siglec-1
T4 934-942 GL_001127 denotes siglec-1
T5 1445-1453 GL_000782 denotes siglec-3
T6 1753-1761 GL_001127 denotes siglec-1

Lectin_test

Id Subject Object Predicate Lexical cue
T1 541-549 GL_001127 denotes siglec-1
T2 640-648 GL_001127 denotes siglec-1
T3 674-682 GL_001127 denotes Siglec-1
T4 934-942 GL_001127 denotes siglec-1
T5 1445-1453 GL_000782 denotes siglec-3
T6 1753-1761 GL_001127 denotes siglec-1

CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 692-703 Cell denotes macrophages http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394
T3 857-867 Cell denotes lymphocyte http://purl.obolibrary.org/obo/CL:0000542
T4 914-925 Cell denotes macrophages http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394
T6 955-966 Cell denotes macrophages http://purl.obolibrary.org/obo/CL:0000235|http://purl.obolibrary.org/obo/CL:0000394