PubMed:10716718
Annnotations
PubMed_ArguminSci
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 75-282 | DRI_Background | denotes | Motor incoordination, immune deficiencies, and an increased risk of cancer are the characteristic features of the hereditary disease ataxia-telangiectasia (A-T), which is caused by mutations in the ATM gene. |
| T2 | 283-366 | DRI_Approach | denotes | Through gene targeting, we have generated a line of Atm mutant mice, Atm(y/y) mice. |
| T3 | 367-500 | DRI_Outcome | denotes | In contrast to other Atm mutant mice, Atm(y/y) mice show a lower incidence of thymic lymphoma and survive beyond a few months of age. |
| T4 | 501-587 | DRI_Outcome | denotes | Atm(y/y) mice exhibit deficits in motor learning indicative of cerebellar dysfunction. |
| T5 | 588-763 | DRI_Outcome | denotes | Even though we found no gross cerebellar degeneration in older Atm(y/y) animals, ectopic and abnormally differentiated Purkinje cells were apparent in mutant mice of all ages. |
| T6 | 764-888 | DRI_Background | denotes | These findings establish that some neuropathological abnormalities seen in A-T patients also are present in Atm mutant mice. |
| T7 | 889-1018 | DRI_Outcome | denotes | In addition, we report a previously unrecognized effect of Atm deficiency on development or maintenance of CD4(+)8(+) thymocytes. |
| T8 | 1019-1177 | DRI_Challenge | denotes | We discuss these findings in the context of the hypothesis that abnormal development of Purkinje cells and lymphocytes contributes to the pathogenesis of A-T. |
PMID_GLOBAL
| Id | Subject | Object | Predicate | Lexical cue | mondo_id |
|---|---|---|---|---|---|
| T1 | 189-207 | DiseaseOrPhenotypicFeature | denotes | hereditary disease | 0003847 |
| T2 | 208-229 | DiseaseOrPhenotypicFeature | denotes | ataxia-telangiectasia | 0008840 |
| T3 | 445-460 | DiseaseOrPhenotypicFeature | denotes | thymic lymphoma | 0000951 |
| T4 | 618-641 | DiseaseOrPhenotypicFeature | denotes | cerebellar degeneration | 0022687 |
PubmedHPO
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 81-95 | HP_0002311 | denotes | incoordination |
| T2 | 97-116 | HP_0002721 | denotes | immune deficiencies |
| T3 | 143-149 | HP_0002664 | denotes | cancer |
| T4 | 208-214 | HP_0001251 | denotes | ataxia |
| T5 | 215-229 | HP_0001009 | denotes | telangiectasia |
| T6 | 452-460 | HP_0002665 | denotes | lymphoma |
NCBIDiseaseCorpus
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 75-95 | DiseaseClass:D002524 | denotes | Motor incoordination |
| T2 | 97-116 | DiseaseClass:D007154 | denotes | immune deficiencies |
| T3 | 143-149 | DiseaseClass:D009369 | denotes | cancer |
| T4 | 189-207 | DiseaseClass:D030342 | denotes | hereditary disease |
| T5 | 208-229 | SpecificDisease:D001260 | denotes | ataxia-telangiectasia |
| T6 | 231-234 | SpecificDisease:D001260 | denotes | A-T |
| T7 | 445-460 | SpecificDisease:D013953 | denotes | thymic lymphoma |
| T8 | 564-586 | DiseaseClass:D002526 | denotes | cerebellar dysfunction |
| T9 | 618-641 | DiseaseClass:D013132 | denotes | cerebellar degeneration |
| T10 | 799-830 | DiseaseClass:D009422 | denotes | neuropathological abnormalities |
| T11 | 839-842 | Modifier:D001260 | denotes | A-T |
| T12 | 948-962 | SpecificDisease:OMIM:208900 | denotes | Atm deficiency |
| T13 | 1173-1176 | SpecificDisease:D001260 | denotes | A-T |
NCBI-Disease-Train
| Id | Subject | Object | Predicate | Lexical cue | database_id |
|---|---|---|---|---|---|
| T4889 | 75-95 | DiseaseClass | denotes | Motor incoordination | D002524 |
| T4890 | 97-116 | DiseaseClass | denotes | immune deficiencies | D007154 |
| T4891 | 143-149 | DiseaseClass | denotes | cancer | D009369 |
| T4892 | 189-207 | DiseaseClass | denotes | hereditary disease | D030342 |
| T4893 | 208-229 | SpecificDisease | denotes | ataxia-telangiectasia | D001260 |
| T4894 | 231-234 | SpecificDisease | denotes | A-T | D001260 |
| T4895 | 445-460 | SpecificDisease | denotes | thymic lymphoma | D013953 |
| T4896 | 564-586 | DiseaseClass | denotes | cerebellar dysfunction | D002526 |
| T4897 | 618-641 | DiseaseClass | denotes | cerebellar degeneration | D013132 |
| T4898 | 799-830 | DiseaseClass | denotes | neuropathological abnormalities | D009422 |
| T4899 | 839-842 | Modifier | denotes | A-T | D001260 |
| T4900 | 948-962 | SpecificDisease | denotes | Atm deficiency | OMIM:208900 |
| T4901 | 1173-1176 | SpecificDisease | denotes | A-T | D001260 |
NCBI-Disease-Corpus-All
| Id | Subject | Object | Predicate | Lexical cue | database_id |
|---|---|---|---|---|---|
| T4889 | 75-95 | DiseaseClass | denotes | Motor incoordination | D002524 |
| T4890 | 97-116 | DiseaseClass | denotes | immune deficiencies | D007154 |
| T4891 | 143-149 | DiseaseClass | denotes | cancer | D009369 |
| T4892 | 189-207 | DiseaseClass | denotes | hereditary disease | D030342 |
| T4893 | 208-229 | SpecificDisease | denotes | ataxia-telangiectasia | D001260 |
| T4894 | 231-234 | SpecificDisease | denotes | A-T | D001260 |
| T4895 | 445-460 | SpecificDisease | denotes | thymic lymphoma | D013953 |
| T4896 | 564-586 | DiseaseClass | denotes | cerebellar dysfunction | D002526 |
| T4897 | 618-641 | DiseaseClass | denotes | cerebellar degeneration | D013132 |
| T4898 | 799-830 | DiseaseClass | denotes | neuropathological abnormalities | D009422 |
| T4899 | 839-842 | Modifier | denotes | A-T | D001260 |
| T4900 | 948-962 | SpecificDisease | denotes | Atm deficiency | OMIM:208900 |
| T4901 | 1173-1176 | SpecificDisease | denotes | A-T | D001260 |
NCBI-Disease-Corpus-2stage-All
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 143-149 | DiseaseClass | denotes | cancer |
| T2 | 208-229 | SpecificDisease | denotes | ataxia-telangiectasia |
| T3 | 231-234 | SpecificDisease | denotes | A-T |
| T4 | 452-460 | SpecificDisease | denotes | lymphoma |
| T5 | 839-842 | SpecificDisease | denotes | A-T |
| T6 | 1173-1176 | SpecificDisease | denotes | A-T |
NCBI-Disease-Corpus-rezarta-All
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 143-149 | DiseaseClass | denotes | cancer |
| T2 | 208-229 | SpecificDisease | denotes | ataxia-telangiectasia |
| T3 | 231-234 | SpecificDisease | denotes | A-T |
| T4 | 452-460 | SpecificDisease | denotes | lymphoma |
| T5 | 839-842 | SpecificDisease | denotes | A-T |
| T6 | 1173-1176 | SpecificDisease | denotes | A-T |
NCBI-Disease-Corpus-4oGuideline-All
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 58-73 | Modifier | denotes | Atm mutant mice |
| T2 | 75-95 | DiseaseClass | denotes | Motor incoordination |
| T3 | 97-116 | DiseaseClass | denotes | immune deficiencies |
| T4 | 143-149 | Modifier | denotes | cancer |
| T5 | 208-235 | SpecificDisease | denotes | ataxia-telangiectasia (A-T) |
| T6 | 335-350 | Modifier | denotes | Atm mutant mice |
| T7 | 352-365 | Modifier | denotes | Atm(y/y) mice |
| T8 | 388-403 | Modifier | denotes | Atm mutant mice |
| T9 | 405-418 | Modifier | denotes | Atm(y/y) mice |
| T10 | 445-460 | SpecificDisease | denotes | thymic lymphoma |
| T11 | 501-514 | Modifier | denotes | Atm(y/y) mice |
| T12 | 535-549 | DiseaseClass | denotes | motor learning |
| T13 | 564-586 | DiseaseClass | denotes | cerebellar dysfunction |
| T14 | 618-641 | DiseaseClass | denotes | cerebellar degeneration |
| T15 | 651-667 | Modifier | denotes | Atm(y/y) animals |
| T16 | 839-851 | SpecificDisease | denotes | A-T patients |
| T17 | 872-887 | Modifier | denotes | Atm mutant mice |
| T18 | 948-962 | Modifier | denotes | Atm deficiency |
| T19 | 1173-1176 | Modifier | denotes | A-T |
NCBI-Disease-Corpus-Simple-All
| Id | Subject | Object | Predicate | Lexical cue |
|---|---|---|---|---|
| T1 | 0-8 | Modifier | denotes | Abnormal |
| T2 | 24-73 | SpecificDisease | denotes | Purkinje cells and lymphocytes in Atm mutant mice |
| T3 | 75-80 | Modifier | denotes | Motor |
| T4 | 97-116 | DiseaseClass | denotes | immune deficiencies |
| T5 | 125-134 | Modifier | denotes | increased |
| T6 | 143-149 | DiseaseClass | denotes | cancer |
| T7 | 200-235 | SpecificDisease | denotes | disease ataxia-telangiectasia (A-T) |
| T8 | 273-281 | SpecificDisease | denotes | ATM gene |
| T9 | 335-350 | SpecificDisease | denotes | Atm mutant mice |
| T10 | 352-365 | SpecificDisease | denotes | Atm(y/y) mice |
| T11 | 388-403 | SpecificDisease | denotes | Atm mutant mice |
| T12 | 405-418 | SpecificDisease | denotes | Atm(y/y) mice |
| T13 | 445-460 | SpecificDisease | denotes | thymic lymphoma |
| T14 | 501-514 | SpecificDisease | denotes | Atm(y/y) mice |
| T15 | 535-540 | Modifier | denotes | motor |
| T16 | 564-586 | SpecificDisease | denotes | cerebellar dysfunction |
| T17 | 618-641 | SpecificDisease | denotes | cerebellar degeneration |
| T18 | 651-667 | SpecificDisease | denotes | Atm(y/y) animals |
| T19 | 707-721 | SpecificDisease | denotes | Purkinje cells |
| T20 | 739-750 | SpecificDisease | denotes | mutant mice |
| T21 | 839-851 | SpecificDisease | denotes | A-T patients |
| T22 | 872-887 | SpecificDisease | denotes | Atm mutant mice |
| T23 | 948-962 | SpecificDisease | denotes | Atm deficiency |
| T24 | 996-1017 | SpecificDisease | denotes | CD4(+)8(+) thymocytes |
| T25 | 1083-1091 | Modifier | denotes | abnormal |
| T26 | 1107-1137 | SpecificDisease | denotes | Purkinje cells and lymphocytes |
| T27 | 1173-1176 | SpecificDisease | denotes | A-T |