> top > docs > PubMed:10713102 > annotations

PubMed:10713102 JSONTXT

Annnotations TAB JSON ListView MergeView

sentences

Id Subject Object Predicate Lexical cue
T1 0-65 Sentence denotes TrkA amino acids controlling specificity for nerve growth factor.
T2 66-274 Sentence denotes Neurotrophins are important for the development and maintenance of the vertebrate nervous system, mediating their signal into the cell by specific interaction with tyrosine kinase receptors of the Trk family.
T3 275-483 Sentence denotes The extracellular portion of the Trk receptors has been previously proposed to consist of a cysteine-rich motif, a leucine-rich motif, a second cysteine-rich motif followed by two immunoglobulin-like domains.
T4 484-620 Sentence denotes Earlier studies have shown that a major neurotrophin-binding site in the Trk receptors resides in the second immunoglobulin-like domain.
T5 621-865 Sentence denotes Although the individual amino acids in TrkA involved in binding to nerve growth factor (NGF) and those in TrkC involved in binding to neurotrophin-3 have been mapped in this domain, the Trk amino acids that provide specificity remained unclear.
T6 866-1051 Sentence denotes In this study, a minimum set of residues in the human TrkC second immunoglobulin-like domain, which does not bind nerve growth factor (NGF), were substituted with those from human TrkA.
T7 1052-1268 Sentence denotes The resulting Trk variant recruited binding of NGF equivalent to TrkA, maintained neurotrophin-3 binding equivalent to TrkC, and also bound brain-derived neurotrophin, although with lower affinity compared with TrkB.
T8 1269-1401 Sentence denotes This implies that the amino acids in the second immunoglobulin-like domain that determine Trk specificity are distinct for each Trk.

Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 137-147 http://purl.obolibrary.org/obo/MAT_0000373 denotes vertebrate
T2 148-162 http://purl.obolibrary.org/obo/MAT_0000026 denotes nervous system
T3 1192-1197 http://purl.obolibrary.org/obo/MAT_0000098 denotes brain

FSU-PRGE

Id Subject Object Predicate Lexical cue
T1 0-4 protein denotes TrkA
T2 45-64 protein denotes nerve growth factor
T3 66-79 protein denotes Neurotrophins
T4 230-255 protein denotes tyrosine kinase receptors
T5 263-273 protein denotes Trk family
T6 308-311 protein denotes Trk
T7 455-469 protein denotes immunoglobulin
T8 524-536 protein denotes neurotrophin
T9 557-560 protein denotes Trk
T10 593-607 protein denotes immunoglobulin
T11 660-664 protein denotes TrkA
T12 688-707 protein denotes nerve growth factor
T13 709-712 protein denotes NGF
T14 727-731 protein denotes TrkC
T15 755-769 protein denotes neurotrophin-3
T16 807-810 protein denotes Trk
T17 920-924 protein denotes TrkC
T18 1001-1004 protein denotes NGF
T19 1046-1050 protein denotes TrkA
T20 1066-1069 protein denotes Trk
T21 1099-1102 protein denotes NGF
T22 1117-1121 protein denotes TrkA
T23 1134-1148 protein denotes neurotrophin-3
T24 1171-1175 protein denotes TrkC
T25 1192-1218 protein denotes brain-derived neurotrophin
T26 1263-1267 protein denotes TrkB
T27 1317-1331 protein denotes immunoglobulin
T28 1359-1362 protein denotes Trk
T29 1397-1400 protein denotes Trk

AIMed

Id Subject Object Predicate Lexical cue
T1 0-4 protein denotes TrkA
T2 660-664 protein denotes TrkA
T3 688-707 protein denotes nerve growth factor
T4 709-712 protein denotes NGF
T5 727-731 protein denotes TrkC
T6 755-769 protein denotes neurotrophin-3
T7 920-924 protein denotes TrkC
T8 980-999 protein denotes nerve growth factor
T9 1001-1004 protein denotes NGF
T10 1046-1050 protein denotes TrkA
T11 1099-1102 protein denotes NGF
T12 1117-1121 protein denotes TrkA
T13 1134-1148 protein denotes neurotrophin-3
T14 1171-1175 protein denotes TrkC
T15 1192-1218 protein denotes brain-derived neurotrophin
T16 1263-1267 protein denotes TrkB

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 137-147 Body_part denotes vertebrate http://purl.obolibrary.org/obo/MAT_0000373
T2 148-162 Body_part denotes nervous system http://purl.obolibrary.org/obo/MAT_0000026
T3 1192-1197 Body_part denotes brain http://purl.obolibrary.org/obo/MAT_0000098

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 914-919 OrganismTaxon denotes human 9606
T2 1040-1045 OrganismTaxon denotes human 9606

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 45-50 Body_part denotes nerve http://purl.obolibrary.org/obo/UBERON_0001021
T2 148-162 Body_part denotes nervous system http://purl.obolibrary.org/obo/UBERON_0001016
T3 279-292 Body_part denotes extracellular http://purl.obolibrary.org/obo/GO_0005576
T4 688-693 Body_part denotes nerve http://purl.obolibrary.org/obo/UBERON_0001021
T5 980-985 Body_part denotes nerve http://purl.obolibrary.org/obo/UBERON_0001021
T6 1192-1197 Body_part denotes brain http://purl.obolibrary.org/obo/UBERON_0000955|http://purl.obolibrary.org/obo/UBERON_6110636