> top > docs > PubMed:10712517 > annotations

PubMed:10712517 JSONTXT

Annnotations TAB JSON ListView MergeView

AIMed

Id Subject Object Predicate Lexical cue
T1 379-410 protein denotes transforming growth factor-beta
T2 412-420 protein denotes TGF-beta
T3 677-685 protein denotes TGF-beta
T4 999-1004 protein denotes BR-Ia
T5 1009-1014 protein denotes BR-Ib
T6 1024-1044 protein denotes BMP type II receptor
T7 1046-1051 protein denotes BR-II
T8 1271-1276 protein denotes BMP-2
T9 1450-1455 protein denotes BR-II
T10 1456-1461 protein denotes BR-Ia
T11 1466-1471 protein denotes BR-II
T12 1472-1477 protein denotes BR-Ib
T13 1494-1499 protein denotes BR-II
T14 1500-1505 protein denotes BR-II
T15 1507-1512 protein denotes BR-Ia
T16 1514-1519 protein denotes BR-Ia
T17 1521-1526 protein denotes BR-Ib
T18 1528-1533 protein denotes BR-Ib
T19 1544-1549 protein denotes BR-Ia
T20 1551-1556 protein denotes BR-Ib
T21 1594-1599 protein denotes BMP-2
T22 1681-1686 protein denotes BR-II
T23 1746-1750 protein denotes BR-I
T24 1793-1801 protein denotes TGF-beta
T25 2114-2122 protein denotes TGF-beta

FSU-PRGE

Id Subject Object Predicate Lexical cue
T1 0-35 protein denotes Bone morphogenetic protein receptor
T2 107-140 protein denotes serine/threonine kinase receptors
T3 146-173 protein denotes bone morphogenetic proteins
T4 175-179 protein denotes BMPs
T5 247-260 protein denotes BMP receptors
T6 275-318 protein denotes family of serine/threonine kinase receptors
T7 379-440 protein denotes transforming growth factor-beta (TGF-beta) receptor subfamily
T8 480-493 protein denotes BMP receptors
T9 677-695 protein denotes TGF-beta receptors
T10 757-770 protein denotes BMP receptors
T11 977-997 protein denotes BMP type I receptors
T12 999-1004 protein denotes BR-Ia
T13 1009-1014 protein denotes BR-Ib
T14 1024-1044 protein denotes BMP type II receptor
T15 1046-1051 protein denotes BR-II
T16 1160-1172 protein denotes BMP receptor
T17 1271-1276 protein denotes BMP-2
T18 1450-1455 protein denotes BR-II
T19 1456-1461 protein denotes BR-Ia
T20 1466-1471 protein denotes BR-II
T21 1472-1477 protein denotes BR-Ib
T22 1494-1499 protein denotes BR-II
T23 1500-1505 protein denotes BR-II
T24 1507-1512 protein denotes BR-Ia
T25 1514-1519 protein denotes BR-Ia
T26 1521-1526 protein denotes BR-Ib
T27 1528-1533 protein denotes BR-Ib
T28 1544-1549 protein denotes BR-Ia
T29 1551-1556 protein denotes BR-Ib
T30 1594-1599 protein denotes BMP-2
T31 1681-1686 protein denotes BR-II
T32 1746-1750 protein denotes BR-I
T33 1793-1811 protein denotes TGF-beta receptors
T34 2003-2016 protein denotes BMP receptors
T35 2114-2132 protein denotes TGF-beta receptors

PMID_GLOBAL

Id Subject Object Predicate Lexical cue
T1 0-141 Sentence denotes Bone morphogenetic protein receptor complexes on the surface of live cells: a new oligomerization mode for serine/threonine kinase receptors.
T2 142-242 Sentence denotes The bone morphogenetic proteins (BMPs) play important roles in embryogenesis and normal cell growth.
T3 243-441 Sentence denotes The BMP receptors belong to the family of serine/threonine kinase receptors, whose activation has been investigated intensively for the transforming growth factor-beta (TGF-beta) receptor subfamily.
T4 442-696 Sentence denotes However, the interactions between the BMP receptors, the composition of the active receptor complex, and the role of the ligand in its formation have not yet been investigated and were usually assumed to follow the same pattern as the TGF-beta receptors.
T5 697-845 Sentence denotes Here we demonstrate that the oligomerization pattern of the BMP receptors is different and is more flexible and susceptible to modulation by ligand.
T6 846-1053 Sentence denotes Using several complementary approaches, we investigated the formation of homomeric and heteromeric complexes between the two known BMP type I receptors (BR-Ia and BR-Ib) and the BMP type II receptor (BR-II).
T7 1054-1209 Sentence denotes Coimmunoprecipitation studies detected the formation of heteromeric and homomeric complexes among all the BMP receptor types even in the absence of ligand.
T8 1210-1303 Sentence denotes These complexes were also detected at the cell surface after BMP-2 binding and cross-linking.
T9 1304-1593 Sentence denotes Using antibody-mediated immunofluorescence copatching of epitope-tagged receptors, we provide evidence in live cells for preexisting heteromeric (BR-II/BR-Ia and BR-II/BR-Ib) and homomeric (BR-II/BR-II, BR-Ia/ BR-Ia, BR-Ib/ BR-Ib, and also BR-Ia/ BR-Ib) oligomers in the absence of ligand.
T10 1594-1752 Sentence denotes BMP-2 binding significantly increased hetero- and homo-oligomerization (except for the BR-II homo-oligomer, which binds ligand poorly in the absence of BR-I).
T11 1753-1948 Sentence denotes In contrast to previous observations on TGF-beta receptors, which were found to be fully homodimeric in the absence of ligand, the BMP receptors show a much more flexible oligomerization pattern.
T12 1949-2133 Sentence denotes This novel feature in the oligomerization mode of the BMP receptors allows higher variety and flexibility in their responses to various ligands as compared with the TGF-beta receptors.