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PubMed:10629558 JSONTXT

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sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-71 Sentence denotes Androgen receptor gene mutations in hormone-refractory prostate cancer.
TextSentencer_T2 72-161 Sentence denotes Prostate cancer is considered to be one of the most hormone-dependent human malignancies.
TextSentencer_T3 162-305 Sentence denotes As a key mediator of hormonal response, the androgen receptor (AR) is believed to have an important role in the progression of prostate cancer.
TextSentencer_T4 306-569 Sentence denotes Mutations in the coding region of the AR gene have been found in both untreated and hormone-refractory prostate cancer, but the frequency of such mutations at different stages of the disease is poorly documented and even contradictory results have been published.
TextSentencer_T5 570-843 Sentence denotes In the present study, the frequency of AR gene mutations was determined in 30 locally recurrent and two metastatic hormone-refractory prostate tumours using the polymerase chain reaction (PCR), non-radioactive single strand conformation polymorphism (SSCP), and sequencing.
TextSentencer_T6 844-1014 Sentence denotes The length of the polymorphic CAG repeat, which is inversely correlated with the ability of the AR to activate transcription, was also analysed as well as the GGC repeat.
TextSentencer_T7 1015-1077 Sentence denotes Twelve samples were known to contain an AR gene amplification.
TextSentencer_T8 1078-1243 Sentence denotes Altogether, one point mutation (Gly(674)-->Ala) and one microsatellite mutation (CAG(20)-->CAG(18)) were found, both in cancers containing the AR gene amplification.
TextSentencer_T9 1244-1356 Sentence denotes The mean lengths of the polymorphic CAG and GGC repeats were similar to those observed in the normal population.
TextSentencer_T10 1357-1526 Sentence denotes These results favour the view that mutations in the AR gene are rare in hormone-refractory prostate cancer and do not play an important role, at least, in local relapse.
TextSentencer_T11 1527-1702 Sentence denotes Instead, the amplification and consequent overexpression of the wild-type AR gene seem to be the most common alteration involving the AR in hormone-refractory prostate cancer.
T1 0-71 Sentence denotes Androgen receptor gene mutations in hormone-refractory prostate cancer.
T2 72-161 Sentence denotes Prostate cancer is considered to be one of the most hormone-dependent human malignancies.
T3 162-305 Sentence denotes As a key mediator of hormonal response, the androgen receptor (AR) is believed to have an important role in the progression of prostate cancer.
T4 306-569 Sentence denotes Mutations in the coding region of the AR gene have been found in both untreated and hormone-refractory prostate cancer, but the frequency of such mutations at different stages of the disease is poorly documented and even contradictory results have been published.
T5 570-843 Sentence denotes In the present study, the frequency of AR gene mutations was determined in 30 locally recurrent and two metastatic hormone-refractory prostate tumours using the polymerase chain reaction (PCR), non-radioactive single strand conformation polymorphism (SSCP), and sequencing.
T6 844-1014 Sentence denotes The length of the polymorphic CAG repeat, which is inversely correlated with the ability of the AR to activate transcription, was also analysed as well as the GGC repeat.
T7 1015-1077 Sentence denotes Twelve samples were known to contain an AR gene amplification.
T8 1078-1243 Sentence denotes Altogether, one point mutation (Gly(674)-->Ala) and one microsatellite mutation (CAG(20)-->CAG(18)) were found, both in cancers containing the AR gene amplification.
T9 1244-1356 Sentence denotes The mean lengths of the polymorphic CAG and GGC repeats were similar to those observed in the normal population.
T10 1357-1526 Sentence denotes These results favour the view that mutations in the AR gene are rare in hormone-refractory prostate cancer and do not play an important role, at least, in local relapse.
T11 1527-1702 Sentence denotes Instead, the amplification and consequent overexpression of the wild-type AR gene seem to be the most common alteration involving the AR in hormone-refractory prostate cancer.

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 72-87 HP_0012125 denotes Prostate cancer
T2 81-87 HP_0002664 denotes cancer
T3 289-304 HP_0012125 denotes prostate cancer
T4 298-304 HP_0002664 denotes cancer
T5 409-424 HP_0012125 denotes prostate cancer
T6 418-424 HP_0002664 denotes cancer
T7 704-720 HP_0012125 denotes prostate tumours
T8 713-720 HP_0002664 denotes tumours
T9 1198-1205 HP_0002664 denotes cancers
T10 1448-1463 HP_0012125 denotes prostate cancer
T11 1457-1463 HP_0002664 denotes cancer
T12 1686-1701 HP_0012125 denotes prostate cancer
T13 1695-1701 HP_0002664 denotes cancer

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
10629558-0#0#17#gene367 609-869 gene367 denotes AR gene mutations was determined in 30 locally recurrent and two metastatic hormone-refractory prostate tumours using the polymerase chain reaction (PCR), non-radioactive single strand conformation polymorphism (SSCP), and sequencing. The length of the polymor
10629558-0#36#70#diseaseC1328504 1193-1463 diseaseC1328504 denotes h in cancers containing the AR gene amplification. The mean lengths of the polymorphic CAG and GGC repeats were similar to those observed in the normal population. These results favour the view that mutations in the AR gene are rare in hormone-refractory prostate cancer
10629558-2#44#61#gene367 206-223 gene367 denotes androgen receptor
10629558-2#63#65#gene367 225-227 gene367 denotes AR
10629558-2#127#142#diseaseC0376358 289-304 diseaseC0376358 denotes prostate cancer
10629558-2#127#142#diseaseC0600139 289-304 diseaseC0600139 denotes prostate cancer
10629558-2#127#142#diseaseC0376358 289-304 diseaseC0376358 denotes prostate cancer
10629558-2#127#142#diseaseC0600139 289-304 diseaseC0600139 denotes prostate cancer
10629558-4#39#41#gene367 609-611 gene367 denotes AR
10629558-4#134#150#diseaseC0033578 704-720 diseaseC0033578 denotes prostate tumours
0#17#gene36736#70#diseaseC1328504 10629558-0#0#17#gene367 10629558-0#36#70#diseaseC1328504 associated_with "AR gene mutations was determined in 30 locally recurrent and two metastatic hormone-refractory prostate tumours using the polymerase chain reaction (PCR), non-radioactive single strand conformation polymorphism (SSCP), and sequencing. The length of the polymor",h in cancers containing the AR gene amplification. The mean lengths of the polymorphic CAG and GGC repeats were similar to those observed in the normal population. These results favour the view that mutations in the AR gene are rare in hormone-refractory prostate cancer
44#61#gene367127#142#diseaseC0376358 10629558-2#44#61#gene367 10629558-2#127#142#diseaseC0376358 associated_with androgen receptor,prostate cancer
44#61#gene367127#142#diseaseC0600139 10629558-2#44#61#gene367 10629558-2#127#142#diseaseC0600139 associated_with androgen receptor,prostate cancer
44#61#gene367127#142#diseaseC0376358 10629558-2#44#61#gene367 10629558-2#127#142#diseaseC0376358 associated_with androgen receptor,prostate cancer
44#61#gene367127#142#diseaseC0600139 10629558-2#44#61#gene367 10629558-2#127#142#diseaseC0600139 associated_with androgen receptor,prostate cancer
63#65#gene367127#142#diseaseC0376358 10629558-2#63#65#gene367 10629558-2#127#142#diseaseC0376358 associated_with AR,prostate cancer
63#65#gene367127#142#diseaseC0600139 10629558-2#63#65#gene367 10629558-2#127#142#diseaseC0600139 associated_with AR,prostate cancer
63#65#gene367127#142#diseaseC0376358 10629558-2#63#65#gene367 10629558-2#127#142#diseaseC0376358 associated_with AR,prostate cancer
63#65#gene367127#142#diseaseC0600139 10629558-2#63#65#gene367 10629558-2#127#142#diseaseC0600139 associated_with AR,prostate cancer
39#41#gene367134#150#diseaseC0033578 10629558-4#39#41#gene367 10629558-4#134#150#diseaseC0033578 associated_with AR,prostate tumours

DisGeNet-2017-sample

Id Subject Object Predicate Lexical cue
T1762 206-223 gene:367 denotes androgen receptor
T1763 289-304 disease:C0376358 denotes prostate cancer
T1764 225-227 gene:367 denotes AR
R1 T1762 T1763 associated_with androgen receptor,prostate cancer
R2 T1762 T1763 associated_with androgen receptor,prostate cancer
R3 T1764 T1763 associated_with AR,prostate cancer
R4 T1764 T1763 associated_with AR,prostate cancer

DisGeNET

Id Subject Object Predicate Lexical cue
T0 0-17 gene:367 denotes Androgen receptor
T1 36-70 disease:C1328504 denotes hormone-refractory prostate cancer
R1 T0 T1 associated_with Androgen receptor,hormone-refractory prostate cancer