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PubMed:10627141 JSONTXT

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c_corpus

Id Subject Object Predicate Lexical cue
T3 26-29 SO:0000352 denotes DNA
T1 26-29 GO:0005574 denotes DNA
T2 26-29 CHEBI:16991 denotes DNA
T4 26-29 D004247 denotes DNA
T5 30-45 GO:0006298 denotes mismatch repair
T6 46-50 SO:0000704 denotes gene
T10 51-55 CVCL_G669 denotes MLH1
T7 51-55 PR:Q9ZRV4 denotes MLH1
T8 51-55 PR:P38920 denotes MLH1
T9 51-55 PR:Q54KD8 denotes MLH1
T11 51-55 PR:Q9JK91 denotes MLH1
T12 51-55 PR:P97679 denotes MLH1
T13 51-55 PR:Q9P7W6 denotes MLH1
T14 51-55 PR:000010442 denotes MLH1
T15 51-55 PR:P40692 denotes MLH1
T16 59-77 D015179 denotes colorectal cancers
T17 59-77 D015179 denotes colorectal cancers
T20 83-97 SO:0000289 denotes microsatellite
T21 83-109 D053842 denotes microsatellite instability
T22 83-109 D053842 denotes microsatellite instability
T23 171-188 D015179 denotes colorectal cancer
T24 171-188 D015179 denotes colorectal cancer
T25 237-245 SO:0000109 denotes mutation
T27 261-264 CHEBI:16991 denotes DNA
T29 261-264 D004247 denotes DNA
T26 261-264 GO:0005574 denotes DNA
T28 261-264 SO:0000352 denotes DNA
T30 265-280 GO:0006298 denotes mismatch repair
T31 363-381 D015179 denotes colorectal cancers
T32 363-381 D015179 denotes colorectal cancers
T37 395-398 SO:0000352 denotes DNA
T35 395-398 GO:0005574 denotes DNA
T36 395-398 CHEBI:16991 denotes DNA
T38 395-398 D004247 denotes DNA
T39 399-414 GO:0006298 denotes mismatch repair
T40 428-431 PR:000008976 denotes RER
T42 428-431 PR:Q9Z1M8 denotes RER
T43 428-431 PR:Q13123 denotes RER
T41 428-431 GO:0005791 denotes RER
T44 452-457 D009369 denotes tumor
T45 452-457 D009369 denotes tumor
T46 524-542 D015179 denotes colorectal cancers
T47 524-542 D015179 denotes colorectal cancers
T50 551-554 PR:000008976 denotes RER
T52 551-554 PR:Q9Z1M8 denotes RER
T53 551-554 PR:Q13123 denotes RER
T51 551-554 GO:0005791 denotes RER
T54 580-587 D009369 denotes cancers
T55 580-587 D009369 denotes cancers
T56 593-596 PR:000008976 denotes RER
T58 593-596 PR:Q9Z1M8 denotes RER
T59 593-596 PR:Q13123 denotes RER
T57 593-596 GO:0005791 denotes RER
T60 607-610 PR:000008976 denotes RER
T62 607-610 PR:Q9Z1M8 denotes RER
T63 607-610 PR:Q13123 denotes RER
T61 607-610 GO:0005791 denotes RER
T64 620-626 D009369 denotes tumors
T65 620-626 D009369 denotes tumors
T68 666-669 SO:0000352 denotes DNA
T66 666-669 GO:0005574 denotes DNA
T67 666-669 CHEBI:16991 denotes DNA
T69 666-669 D004247 denotes DNA
T70 670-685 GO:0006298 denotes mismatch repair
T71 686-690 SO:0000704 denotes gene
T75 691-695 CVCL_G669 denotes MLH1
T72 691-695 PR:Q9ZRV4 denotes MLH1
T73 691-695 PR:P38920 denotes MLH1
T74 691-695 PR:Q54KD8 denotes MLH1
T76 691-695 PR:Q9JK91 denotes MLH1
T77 691-695 PR:P97679 denotes MLH1
T78 691-695 PR:Q9P7W6 denotes MLH1
T79 691-695 PR:000010442 denotes MLH1
T80 691-695 PR:P40692 denotes MLH1
T81 709-715 SO:0001111 denotes strand
T82 869-883 SO:1000008 denotes point mutation
T85 887-892 D003062 denotes codon
T84 887-892 SO:0000360 denotes codon
T86 897-900 CHEBI:73837 denotes AGG
T88 907-910 PR:000013890 denotes arg
T90 907-910 PR:P42684 denotes arg
T91 907-910 PR:Q9P2R6 denotes arg
T93 907-910 PR:Q4JIM5 denotes arg
T97 907-910 PR:000003583 denotes arg
T89 907-910 CHEBI:32685 denotes arg
T92 907-910 CHEBI:16467 denotes arg
T94 907-910 CHEBI:32684 denotes arg
T95 907-910 CHEBI:29952 denotes arg
T96 907-910 CHEBI:32695 denotes arg
T87 907-910 SO:0001451 denotes arg
T102 929-933 CHEBI:22695 denotes base
T104 929-938 SO:0000028 denotes base pair
T105 939-947 SO:0000159 denotes deletion
T107 951-956 D003062 denotes codon
T106 951-956 SO:0000360 denotes codon
T109 1003-1013 D018388 denotes stop codon
T110 1003-1013 SO:0000319 denotes stop codon
T113 1014-1024 SO:0001633 denotes downstream
T114 1032-1046 SO:1000008 denotes point mutation
T117 1050-1055 D003062 denotes codon
T116 1050-1055 SO:0000360 denotes codon
T118 1061-1064 P0C1B4 denotes TAA
T120 1061-1064 P0C1B3 denotes TAA
T119 1061-1064 CHEBI:32497 denotes TAA
T121 1061-1064 CHEBI:73654 denotes TAA
T124 1108-1112 PR:Q9ZRV4 denotes MLH1
T125 1108-1112 PR:P38920 denotes MLH1
T126 1108-1112 PR:Q54KD8 denotes MLH1
T128 1108-1112 PR:Q9JK91 denotes MLH1
T129 1108-1112 PR:P97679 denotes MLH1
T130 1108-1112 PR:Q9P7W6 denotes MLH1
T131 1108-1112 PR:000010442 denotes MLH1
T132 1108-1112 PR:P40692 denotes MLH1
T127 1108-1112 CVCL_G669 denotes MLH1
T134 1113-1120 PR:000018264 denotes peptide
T136 1113-1120 PR:000018263 denotes peptide
T135 1113-1120 CHEBI:16670 denotes peptide
T133 1113-1120 SO:0001064 denotes peptide
T137 1134-1139 CHEBI:37527 denotes acids
T138 1152-1160 SO:0000109 denotes mutation
T139 1169-1173 CHEBI:22695 denotes base
T141 1169-1178 SO:0000028 denotes base pair
T142 1179-1188 SO:0000667 denotes insertion
T143 1193-1197 CHEBI:22695 denotes base
T144 1193-1197 SO:0001236 denotes base
T145 1223-1227 PR:P33696 denotes exon
T146 1223-1227 SO:0000147 denotes exon
T148 1315-1318 CHEBI:16991 denotes DNA
T150 1315-1318 D004247 denotes DNA
T149 1315-1318 SO:0000352 denotes DNA
T147 1315-1318 GO:0005574 denotes DNA
T151 1400-1403 PR:000008976 denotes RER
T153 1400-1403 PR:Q9Z1M8 denotes RER
T154 1400-1403 PR:Q13123 denotes RER
T152 1400-1403 GO:0005791 denotes RER

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 182-188 HP_0002664 denotes cancer
T2 288-305 HP_0001428 denotes Somatic mutations
T3 374-381 HP_0002664 denotes cancers
T4 452-457 HP_0002664 denotes tumor
T5 535-542 HP_0002664 denotes cancers
T6 580-587 HP_0002664 denotes cancers
T7 620-626 HP_0002664 denotes tumors

UseCases_ArguminSci_Discourse

Id Subject Object Predicate Lexical cue
T1 0-110 DRI_Approach denotes Four new mutations in the DNA mismatch repair gene MLH1 in colorectal cancers with microsatellite instability.
T2 111-133 DRI_Unspecified denotes Mutations in brief no.
T3 134-138 DRI_Unspecified denotes 157.
T4 139-146 DRI_Unspecified denotes Online.
T5 147-287 DRI_Background denotes Hereditary nonpolyposis colorectal cancer (HNPCC) is frequently associated with inherited mutation in one of four DNA mismatch repair genes.
T6 288-382 DRI_Background denotes Somatic mutations in the same genes are also found in a subset of sporadic colorectal cancers.
T7 383-468 DRI_Approach denotes A defect in DNA mismatch repair results in a RER (replication error) tumor phenotype.
T8 469-565 DRI_Approach denotes We screened 110 archival and 11 prospectively acquired colorectal cancers for the RER phenotype.
T9 566-606 DRI_Background denotes A total of 22 cancers were RER-positive.
T10 607-758 DRI_Approach denotes RER-positive tumors were investigated for mutations in the DNA mismatch repair gene MLH1 using single-strand-conformation-polymorphism (SSCP) analysis.
T11 759-837 DRI_Approach denotes We identified four previously undescribed mutations in four different samples.
T12 838-1140 DRI_Approach denotes Three mutations were exonic: a point mutation at codon 69 (AGG-->AAG(arg-->lys]); a single base pair deletion at codon 42/43 (GCAAAATCC-->GCAAATCC) leading to a new stop codon downstream; and a point mutation at codon 757 (TAA-->TAT [termination-->tyr] which extend the MLH1 peptide by 36 ammino acids.
T13 1141-1254 DRI_Approach denotes The fourth mutation was a 1 base pair insertion six base pairs 5' to the start of exon 14 (tttgtttt-->tttggtttt).
T14 1255-1319 DRI_Approach denotes The mutations were not seen in the patients' constitutional DNA.
T15 1320-1414 DRI_Background denotes The somatic MLHI mutations identified appear to be causally associated with the RER phenotype.

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
10627141-0#51#55#gene4292 51-55 gene4292 denotes MLH1
10627141-0#59#77#diseaseC1527249 59-77 diseaseC1527249 denotes colorectal cancers
51#55#gene429259#77#diseaseC1527249 10627141-0#51#55#gene4292 10627141-0#59#77#diseaseC1527249 associated_with MLH1,colorectal cancers

DisGeNET

Id Subject Object Predicate Lexical cue
T0 903-906 gene:4350 denotes AAG
T1 1061-1064 disease:C0162872 denotes TAA
T2 1067-1070 gene:6898 denotes TAT
T3 1061-1064 disease:C0162872 denotes TAA
T4 1067-1070 gene:79969 denotes TAT
T5 1061-1064 disease:C0162872 denotes TAA
R1 T0 T1 associated_with AAG,TAA
R2 T2 T3 associated_with TAT,TAA
R3 T4 T5 associated_with TAT,TAA