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PubMed:10622679 JSONTXT

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PubmedHPO

Id Subject Object Predicate Lexical cue
T1 108-128 HP_0001370 denotes rheumatoid arthritis
T2 119-128 HP_0001369 denotes arthritis
T3 293-299 HP_0002664 denotes cancer

Inflammaging

Id Subject Object Predicate Lexical cue
T1 0-78 Sentence denotes The incidence of cancer associated with the treatment of rheumatoid arthritis.
T2 79-90 Sentence denotes OBJECTIVES:
T3 91-233 Sentence denotes The treatment of rheumatoid arthritis (RA) targets inflammation either by inhibiting the activation of immune cells or their clonal expansion.
T4 234-329 Sentence denotes We evaluated the available evidence concerning the risk of cancer associated with RA treatment.
T5 330-337 Sentence denotes METHOD:
T6 338-442 Sentence denotes Articles published between 1966 and 1998 reporting the incidence of cancer in RA patients were reviewed.
T7 443-451 Sentence denotes RESULTS:
T8 452-594 Sentence denotes Large follow-up studies suggest the relative risk (RR) of lymphomas associated with RA is about twofold higher than in the general population.
T9 595-743 Sentence denotes A role for azathioprine in the development of lymphomas and a role for cyclophosphamide in cancers, particularly bladder cancer, has been suggested.
T10 744-837 Sentence denotes However, no studies have shown that methotrexate increases the risk of cancer in RA patients.
T11 838-1041 Sentence denotes Studies that showed an increased risk of cancer associated with gold or cyclosporine therapy in RA patients are inconclusive as they have used cancer incidence in the general population as the reference.
T12 1042-1205 Sentence denotes One study measured the RR of cancer in a group of cyclosporine-treated RA patients (1.6 year on average) using RA patients as a control and found no enhanced risk.
T13 1206-1218 Sentence denotes CONCLUSIONS:
T14 1219-1431 Sentence denotes Although evidence suggests an increased risk of specific cancers associated with the use of some treatments, this may be outweighed by the potential benefit of therapy, especially in patients with severe disease.
T1 0-78 Sentence denotes The incidence of cancer associated with the treatment of rheumatoid arthritis.
T2 79-90 Sentence denotes OBJECTIVES:
T3 91-233 Sentence denotes The treatment of rheumatoid arthritis (RA) targets inflammation either by inhibiting the activation of immune cells or their clonal expansion.
T4 234-329 Sentence denotes We evaluated the available evidence concerning the risk of cancer associated with RA treatment.
T5 330-337 Sentence denotes METHOD:
T6 338-442 Sentence denotes Articles published between 1966 and 1998 reporting the incidence of cancer in RA patients were reviewed.
T7 443-451 Sentence denotes RESULTS:
T8 452-594 Sentence denotes Large follow-up studies suggest the relative risk (RR) of lymphomas associated with RA is about twofold higher than in the general population.
T9 595-743 Sentence denotes A role for azathioprine in the development of lymphomas and a role for cyclophosphamide in cancers, particularly bladder cancer, has been suggested.
T10 744-837 Sentence denotes However, no studies have shown that methotrexate increases the risk of cancer in RA patients.
T11 838-1041 Sentence denotes Studies that showed an increased risk of cancer associated with gold or cyclosporine therapy in RA patients are inconclusive as they have used cancer incidence in the general population as the reference.
T12 1042-1205 Sentence denotes One study measured the RR of cancer in a group of cyclosporine-treated RA patients (1.6 year on average) using RA patients as a control and found no enhanced risk.
T13 1206-1218 Sentence denotes CONCLUSIONS:
T14 1219-1431 Sentence denotes Although evidence suggests an increased risk of specific cancers associated with the use of some treatments, this may be outweighed by the potential benefit of therapy, especially in patients with severe disease.