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PubMed:10622586 JSONTXT

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sentences

Id Subject Object Predicate Lexical cue
TextSentencer_T1 0-69 Sentence denotes Treatment of patients with chronic hepatitis C and normal ALT levels.
TextSentencer_T2 70-289 Sentence denotes A certain group of patients with chronic hepatitis C have normal serum alanine aminotransferase (ALT) levels, despite the replication of hepatitis C virus (HCV) in infected liver cells and detection of HCV RNA in serum.
TextSentencer_T3 290-406 Sentence denotes These patients are usually asymptomatic and are discovered fortuitously, generally after a volunteer blood donation.
TextSentencer_T4 407-613 Sentence denotes A standard definition for this group of patients is obviously needed, which should include the presence of anti-HCV, detectable serum HCV RNA by polymerase chain reaction and persistently normal ALT levels.
TextSentencer_T5 614-724 Sentence denotes These patients have minimal or mild necroinflammatory lesions in liver tissue specimens and cirrhosis is rare.
TextSentencer_T6 725-838 Sentence denotes The natural course of the disease in this epidemiologic setting is unknown, but the progression is probably good.
TextSentencer_T7 839-930 Sentence denotes Alpha-interferon has been administered in small pilot studies and three controlled studies.
TextSentencer_T8 931-1019 Sentence denotes Overall, the end of treatment response was 35% and the sustained virologic response 15%.
TextSentencer_T9 1020-1108 Sentence denotes These response rates are similar to those reported in patients with elevated ALT levels.
TextSentencer_T10 1109-1256 Sentence denotes More important, serum ALT levels became abnormal during therapy in 47% of the patients and levels remained elevated in some patients after therapy.
TextSentencer_T11 1257-1524 Sentence denotes Prospective studies on the long-term natural history of HCV infection in this setting are needed and well designed randomized controlled trials are necessary to determine whether these patients would benefit from IFN or a combination treatment with ribavirin regimen.
TextSentencer_T12 1525-1582 Sentence denotes Currently, there is no rationale to treat these patients.
T1 0-69 Sentence denotes Treatment of patients with chronic hepatitis C and normal ALT levels.
T2 70-289 Sentence denotes A certain group of patients with chronic hepatitis C have normal serum alanine aminotransferase (ALT) levels, despite the replication of hepatitis C virus (HCV) in infected liver cells and detection of HCV RNA in serum.
T3 290-406 Sentence denotes These patients are usually asymptomatic and are discovered fortuitously, generally after a volunteer blood donation.
T4 407-613 Sentence denotes A standard definition for this group of patients is obviously needed, which should include the presence of anti-HCV, detectable serum HCV RNA by polymerase chain reaction and persistently normal ALT levels.
T5 614-724 Sentence denotes These patients have minimal or mild necroinflammatory lesions in liver tissue specimens and cirrhosis is rare.
T6 725-838 Sentence denotes The natural course of the disease in this epidemiologic setting is unknown, but the progression is probably good.
T7 839-930 Sentence denotes Alpha-interferon has been administered in small pilot studies and three controlled studies.
T8 931-1019 Sentence denotes Overall, the end of treatment response was 35% and the sustained virologic response 15%.
T9 1020-1108 Sentence denotes These response rates are similar to those reported in patients with elevated ALT levels.
T10 1109-1256 Sentence denotes More important, serum ALT levels became abnormal during therapy in 47% of the patients and levels remained elevated in some patients after therapy.
T11 1257-1524 Sentence denotes Prospective studies on the long-term natural history of HCV infection in this setting are needed and well designed randomized controlled trials are necessary to determine whether these patients would benefit from IFN or a combination treatment with ribavirin regimen.
T12 1525-1582 Sentence denotes Currently, there is no rationale to treat these patients.

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 706-715 HP_0001394 denotes cirrhosis

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
10622586-1#71#95#gene2875 141-165 gene2875 denotes alanine aminotransferase
10622586-1#97#100#gene2875 167-170 gene2875 denotes ALT
10622586-1#137#148#diseaseC0019196 207-218 diseaseC0019196 denotes hepatitis C
10622586-1#33#52#diseaseC0524910 103-122 diseaseC0524910 denotes chronic hepatitis C
10622586-1#137#148#diseaseC0019196 207-218 diseaseC0019196 denotes hepatitis C
10622586-10#213#216#gene3439 1470-1473 gene3439 denotes IFN
10622586-10#213#216#gene3447 1470-1473 gene3447 denotes IFN
10622586-10#56#59#diseaseC0019196 1313-1316 diseaseC0019196 denotes HCV
71#95#gene2875137#148#diseaseC0019196 10622586-1#71#95#gene2875 10622586-1#137#148#diseaseC0019196 associated_with alanine aminotransferase,hepatitis C
71#95#gene287533#52#diseaseC0524910 10622586-1#71#95#gene2875 10622586-1#33#52#diseaseC0524910 associated_with alanine aminotransferase,chronic hepatitis C
71#95#gene2875137#148#diseaseC0019196 10622586-1#71#95#gene2875 10622586-1#137#148#diseaseC0019196 associated_with alanine aminotransferase,hepatitis C
97#100#gene2875137#148#diseaseC0019196 10622586-1#97#100#gene2875 10622586-1#137#148#diseaseC0019196 associated_with ALT,hepatitis C
97#100#gene287533#52#diseaseC0524910 10622586-1#97#100#gene2875 10622586-1#33#52#diseaseC0524910 associated_with ALT,chronic hepatitis C
97#100#gene2875137#148#diseaseC0019196 10622586-1#97#100#gene2875 10622586-1#137#148#diseaseC0019196 associated_with ALT,hepatitis C
213#216#gene343956#59#diseaseC0019196 10622586-10#213#216#gene3439 10622586-10#56#59#diseaseC0019196 associated_with IFN,HCV
213#216#gene344756#59#diseaseC0019196 10622586-10#213#216#gene3447 10622586-10#56#59#diseaseC0019196 associated_with IFN,HCV

performance-test

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 391-396 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
PD-UBERON-AE-B_T2 135-140 http://purl.obolibrary.org/obo/UBERON_0001977 denotes serum
PD-UBERON-AE-B_T3 283-288 http://purl.obolibrary.org/obo/UBERON_0001977 denotes serum
PD-UBERON-AE-B_T4 535-540 http://purl.obolibrary.org/obo/UBERON_0001977 denotes serum
PD-UBERON-AE-B_T5 1125-1130 http://purl.obolibrary.org/obo/UBERON_0001977 denotes serum
PD-UBERON-AE-B_T6 243-248 http://purl.obolibrary.org/obo/UBERON_0002107 denotes liver
PD-UBERON-AE-B_T7 679-684 http://purl.obolibrary.org/obo/UBERON_0002107 denotes liver
PD-UBERON-AE-B_T8 685-691 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissue

DisGeNet-2017-sample

Id Subject Object Predicate Lexical cue
T792 1470-1473 gene:3439 denotes IFN
T793 1313-1316 disease:C0019196 denotes HCV
R1 T792 T793 associated_with IFN,HCV
R2 T792 T793 associated_with IFN,HCV

UBERON-AE

Id Subject Object Predicate Lexical cue
PD-UBERON-AE-B_T1 135-140 http://purl.obolibrary.org/obo/UBERON_0001977 denotes serum
PD-UBERON-AE-B_T2 283-288 http://purl.obolibrary.org/obo/UBERON_0001977 denotes serum
PD-UBERON-AE-B_T3 535-540 http://purl.obolibrary.org/obo/UBERON_0001977 denotes serum
PD-UBERON-AE-B_T4 1125-1130 http://purl.obolibrary.org/obo/UBERON_0001977 denotes serum
PD-UBERON-AE-B_T5 243-248 http://purl.obolibrary.org/obo/UBERON_0002107 denotes liver
PD-UBERON-AE-B_T6 679-684 http://purl.obolibrary.org/obo/UBERON_0002107 denotes liver
PD-UBERON-AE-B_T7 391-396 http://purl.obolibrary.org/obo/UBERON_0000178 denotes blood
PD-UBERON-AE-B_T8 685-691 http://purl.obolibrary.org/obo/UBERON_0000479 denotes tissue