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PubMed:10617653 JSONTXT

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sentences

Id Subject Object Predicate Lexical cue
T1 0-136 Sentence denotes Coregulator small nuclear RING finger protein (SNURF) enhances Sp1- and steroid receptor-mediated transcription by different mechanisms.
T2 137-319 Sentence denotes The small nuclear RING finger protein SNURF is not only a coactivator in steroid receptor-dependent transcription but also activates transcription from steroid-independent promoters.
T3 320-500 Sentence denotes In this work, we show that SNURF, via the RING finger domain, enhances protein binding to Sp1 elements/GC boxes and interacts and cooperates with Sp1 in transcriptional activation.
T4 501-672 Sentence denotes The activation of androgen receptor (AR) function requires regions other than the RING finger of SNURF, and SNURF does not influence binding of AR to cognate DNA elements.
T5 673-775 Sentence denotes The zinc finger region (ZFR) together with the hinge region of AR are sufficient for contacting SNURF.
T6 776-1049 Sentence denotes The nuclear localization signal in the boundary between ZFR and the hinge region participates in the association of AR with SNURF, and a receptor mutant lacking the C-terminal part of the bipartite nuclear localization signal shows attenuated response to coexpressed SNURF.
T7 1050-1284 Sentence denotes Some AR ZFR point mutations observed in patients with partial androgen insensitivity syndrome or male breast cancer impair the interaction of AR with SNURF and also render AR refractory to the transcription-activating effect of SNURF.
T8 1285-1483 Sentence denotes Collectively, SNURF modulates the transcriptional activities of androgen receptor and Sp1 via different domains, and it may act as a functional link between steroid- and Sp1-regulated transcription.

Glycosmos6-MAT

Id Subject Object Predicate Lexical cue
T1 1147-1151 http://purl.obolibrary.org/obo/MAT_0000029 denotes male

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 1152-1165 HP_0003002 denotes breast cancer
T2 1152-1165 HP_0100013 denotes breast cancer
T3 1159-1165 HP_0002664 denotes cancer

Ab3P-abbreviations

Id Subject Object Predicate Lexical cue
SF1 538-540 ABBR denotes AR
LF1 519-536 ABBR denotes androgen receptor
SF2 697-700 ABBR denotes ZFR
LF2 677-695 ABBR denotes zinc finger region
SF0 47-52 ABBR denotes SNURF
LF0 12-45 ABBR denotes small nuclear RING finger protein
R1 LF1 SF1 ShortForm androgen receptor,AR
R2 LF2 SF2 ShortForm zinc finger region,ZFR
R0 LF0 SF0 ShortForm small nuclear RING finger protein,SNURF

DisGeNET5_gene_disease

Id Subject Object Predicate Lexical cue
10617653-6#5#7#gene367 1055-1057 gene367 denotes AR
10617653-6#142#144#gene367 1192-1194 gene367 denotes AR
10617653-6#150#155#gene6047 1200-1205 gene6047 denotes SNURF
10617653-6#172#174#gene367 1222-1224 gene367 denotes AR
10617653-6#228#233#gene6047 1278-1283 gene6047 denotes SNURF
10617653-6#5#7#gene367 1055-1057 gene367 denotes AR
10617653-6#172#174#gene367 1222-1224 gene367 denotes AR
10617653-6#228#233#gene6047 1278-1283 gene6047 denotes SNURF
10617653-6#97#115#diseaseC0238033 1147-1165 diseaseC0238033 denotes male breast cancer
10617653-6#97#115#diseaseC0242787 1147-1165 diseaseC0242787 denotes male breast cancer
10617653-6#97#115#diseaseC0238033 1147-1165 diseaseC0238033 denotes male breast cancer
10617653-6#97#115#diseaseC0242787 1147-1165 diseaseC0242787 denotes male breast cancer
10617653-6#97#115#diseaseC0238033 1147-1165 diseaseC0238033 denotes male breast cancer
10617653-6#97#115#diseaseC0242787 1147-1165 diseaseC0242787 denotes male breast cancer
10617653-6#97#115#diseaseC0238033 1147-1165 diseaseC0238033 denotes male breast cancer
10617653-6#97#115#diseaseC0242787 1147-1165 diseaseC0242787 denotes male breast cancer
10617653-6#97#115#diseaseC0238033 1147-1165 diseaseC0238033 denotes male breast cancer
10617653-6#97#115#diseaseC0242787 1147-1165 diseaseC0242787 denotes male breast cancer
10617653-6#54#93#diseaseC0268301 1104-1143 diseaseC0268301 denotes partial androgen insensitivity syndrome
5#7#gene36797#115#diseaseC0238033 10617653-6#5#7#gene367 10617653-6#97#115#diseaseC0238033 associated_with AR,male breast cancer
5#7#gene36797#115#diseaseC0242787 10617653-6#5#7#gene367 10617653-6#97#115#diseaseC0242787 associated_with AR,male breast cancer
5#7#gene36797#115#diseaseC0238033 10617653-6#5#7#gene367 10617653-6#97#115#diseaseC0238033 associated_with AR,male breast cancer
5#7#gene36797#115#diseaseC0242787 10617653-6#5#7#gene367 10617653-6#97#115#diseaseC0242787 associated_with AR,male breast cancer
5#7#gene36797#115#diseaseC0238033 10617653-6#5#7#gene367 10617653-6#97#115#diseaseC0238033 associated_with AR,male breast cancer
5#7#gene36797#115#diseaseC0242787 10617653-6#5#7#gene367 10617653-6#97#115#diseaseC0242787 associated_with AR,male breast cancer
5#7#gene36797#115#diseaseC0238033 10617653-6#5#7#gene367 10617653-6#97#115#diseaseC0238033 associated_with AR,male breast cancer
5#7#gene36797#115#diseaseC0242787 10617653-6#5#7#gene367 10617653-6#97#115#diseaseC0242787 associated_with AR,male breast cancer
5#7#gene36797#115#diseaseC0238033 10617653-6#5#7#gene367 10617653-6#97#115#diseaseC0238033 associated_with AR,male breast cancer
5#7#gene36797#115#diseaseC0242787 10617653-6#5#7#gene367 10617653-6#97#115#diseaseC0242787 associated_with AR,male breast cancer
5#7#gene36754#93#diseaseC0268301 10617653-6#5#7#gene367 10617653-6#54#93#diseaseC0268301 associated_with AR,partial androgen insensitivity syndrome
142#144#gene36797#115#diseaseC0238033 10617653-6#142#144#gene367 10617653-6#97#115#diseaseC0238033 associated_with AR,male breast cancer
142#144#gene36797#115#diseaseC0242787 10617653-6#142#144#gene367 10617653-6#97#115#diseaseC0242787 associated_with AR,male breast cancer
142#144#gene36797#115#diseaseC0238033 10617653-6#142#144#gene367 10617653-6#97#115#diseaseC0238033 associated_with AR,male breast cancer
142#144#gene36797#115#diseaseC0242787 10617653-6#142#144#gene367 10617653-6#97#115#diseaseC0242787 associated_with AR,male breast cancer
142#144#gene36797#115#diseaseC0238033 10617653-6#142#144#gene367 10617653-6#97#115#diseaseC0238033 associated_with AR,male breast cancer
142#144#gene36797#115#diseaseC0242787 10617653-6#142#144#gene367 10617653-6#97#115#diseaseC0242787 associated_with AR,male breast cancer
142#144#gene36797#115#diseaseC0238033 10617653-6#142#144#gene367 10617653-6#97#115#diseaseC0238033 associated_with AR,male breast cancer
142#144#gene36797#115#diseaseC0242787 10617653-6#142#144#gene367 10617653-6#97#115#diseaseC0242787 associated_with AR,male breast cancer
142#144#gene36797#115#diseaseC0238033 10617653-6#142#144#gene367 10617653-6#97#115#diseaseC0238033 associated_with AR,male breast cancer
142#144#gene36797#115#diseaseC0242787 10617653-6#142#144#gene367 10617653-6#97#115#diseaseC0242787 associated_with AR,male breast cancer
142#144#gene36754#93#diseaseC0268301 10617653-6#142#144#gene367 10617653-6#54#93#diseaseC0268301 associated_with AR,partial androgen insensitivity syndrome
150#155#gene604797#115#diseaseC0238033 10617653-6#150#155#gene6047 10617653-6#97#115#diseaseC0238033 associated_with SNURF,male breast cancer
150#155#gene604797#115#diseaseC0242787 10617653-6#150#155#gene6047 10617653-6#97#115#diseaseC0242787 associated_with SNURF,male breast cancer
150#155#gene604797#115#diseaseC0238033 10617653-6#150#155#gene6047 10617653-6#97#115#diseaseC0238033 associated_with SNURF,male breast cancer
150#155#gene604797#115#diseaseC0242787 10617653-6#150#155#gene6047 10617653-6#97#115#diseaseC0242787 associated_with SNURF,male breast cancer
150#155#gene604797#115#diseaseC0238033 10617653-6#150#155#gene6047 10617653-6#97#115#diseaseC0238033 associated_with SNURF,male breast cancer
150#155#gene604797#115#diseaseC0242787 10617653-6#150#155#gene6047 10617653-6#97#115#diseaseC0242787 associated_with SNURF,male breast cancer
150#155#gene604797#115#diseaseC0238033 10617653-6#150#155#gene6047 10617653-6#97#115#diseaseC0238033 associated_with SNURF,male breast cancer
150#155#gene604797#115#diseaseC0242787 10617653-6#150#155#gene6047 10617653-6#97#115#diseaseC0242787 associated_with SNURF,male breast cancer
150#155#gene604797#115#diseaseC0238033 10617653-6#150#155#gene6047 10617653-6#97#115#diseaseC0238033 associated_with SNURF,male breast cancer
150#155#gene604797#115#diseaseC0242787 10617653-6#150#155#gene6047 10617653-6#97#115#diseaseC0242787 associated_with SNURF,male breast cancer
150#155#gene604754#93#diseaseC0268301 10617653-6#150#155#gene6047 10617653-6#54#93#diseaseC0268301 associated_with SNURF,partial androgen insensitivity syndrome
172#174#gene36797#115#diseaseC0238033 10617653-6#172#174#gene367 10617653-6#97#115#diseaseC0238033 associated_with AR,male breast cancer
172#174#gene36797#115#diseaseC0242787 10617653-6#172#174#gene367 10617653-6#97#115#diseaseC0242787 associated_with AR,male breast cancer
172#174#gene36797#115#diseaseC0238033 10617653-6#172#174#gene367 10617653-6#97#115#diseaseC0238033 associated_with AR,male breast cancer
172#174#gene36797#115#diseaseC0242787 10617653-6#172#174#gene367 10617653-6#97#115#diseaseC0242787 associated_with AR,male breast cancer
172#174#gene36797#115#diseaseC0238033 10617653-6#172#174#gene367 10617653-6#97#115#diseaseC0238033 associated_with AR,male breast cancer
172#174#gene36797#115#diseaseC0242787 10617653-6#172#174#gene367 10617653-6#97#115#diseaseC0242787 associated_with AR,male breast cancer
172#174#gene36797#115#diseaseC0238033 10617653-6#172#174#gene367 10617653-6#97#115#diseaseC0238033 associated_with AR,male breast cancer
172#174#gene36797#115#diseaseC0242787 10617653-6#172#174#gene367 10617653-6#97#115#diseaseC0242787 associated_with AR,male breast cancer
172#174#gene36797#115#diseaseC0238033 10617653-6#172#174#gene367 10617653-6#97#115#diseaseC0238033 associated_with AR,male breast cancer
172#174#gene36797#115#diseaseC0242787 10617653-6#172#174#gene367 10617653-6#97#115#diseaseC0242787 associated_with AR,male breast cancer
172#174#gene36754#93#diseaseC0268301 10617653-6#172#174#gene367 10617653-6#54#93#diseaseC0268301 associated_with AR,partial androgen insensitivity syndrome
228#233#gene604797#115#diseaseC0238033 10617653-6#228#233#gene6047 10617653-6#97#115#diseaseC0238033 associated_with SNURF,male breast cancer
228#233#gene604797#115#diseaseC0242787 10617653-6#228#233#gene6047 10617653-6#97#115#diseaseC0242787 associated_with SNURF,male breast cancer
228#233#gene604797#115#diseaseC0238033 10617653-6#228#233#gene6047 10617653-6#97#115#diseaseC0238033 associated_with SNURF,male breast cancer
228#233#gene604797#115#diseaseC0242787 10617653-6#228#233#gene6047 10617653-6#97#115#diseaseC0242787 associated_with SNURF,male breast cancer
228#233#gene604797#115#diseaseC0238033 10617653-6#228#233#gene6047 10617653-6#97#115#diseaseC0238033 associated_with SNURF,male breast cancer
228#233#gene604797#115#diseaseC0242787 10617653-6#228#233#gene6047 10617653-6#97#115#diseaseC0242787 associated_with SNURF,male breast cancer
228#233#gene604797#115#diseaseC0238033 10617653-6#228#233#gene6047 10617653-6#97#115#diseaseC0238033 associated_with SNURF,male breast cancer
228#233#gene604797#115#diseaseC0242787 10617653-6#228#233#gene6047 10617653-6#97#115#diseaseC0242787 associated_with SNURF,male breast cancer
228#233#gene604797#115#diseaseC0238033 10617653-6#228#233#gene6047 10617653-6#97#115#diseaseC0238033 associated_with SNURF,male breast cancer
228#233#gene604797#115#diseaseC0242787 10617653-6#228#233#gene6047 10617653-6#97#115#diseaseC0242787 associated_with SNURF,male breast cancer
228#233#gene604754#93#diseaseC0268301 10617653-6#228#233#gene6047 10617653-6#54#93#diseaseC0268301 associated_with SNURF,partial androgen insensitivity syndrome
5#7#gene36797#115#diseaseC0238033 10617653-6#5#7#gene367 10617653-6#97#115#diseaseC0238033 associated_with AR,male breast cancer
5#7#gene36797#115#diseaseC0242787 10617653-6#5#7#gene367 10617653-6#97#115#diseaseC0242787 associated_with AR,male breast cancer
5#7#gene36797#115#diseaseC0238033 10617653-6#5#7#gene367 10617653-6#97#115#diseaseC0238033 associated_with AR,male breast cancer
5#7#gene36797#115#diseaseC0242787 10617653-6#5#7#gene367 10617653-6#97#115#diseaseC0242787 associated_with AR,male breast cancer
5#7#gene36797#115#diseaseC0238033 10617653-6#5#7#gene367 10617653-6#97#115#diseaseC0238033 associated_with AR,male breast cancer
5#7#gene36797#115#diseaseC0242787 10617653-6#5#7#gene367 10617653-6#97#115#diseaseC0242787 associated_with AR,male breast cancer
5#7#gene36797#115#diseaseC0238033 10617653-6#5#7#gene367 10617653-6#97#115#diseaseC0238033 associated_with AR,male breast cancer
5#7#gene36797#115#diseaseC0242787 10617653-6#5#7#gene367 10617653-6#97#115#diseaseC0242787 associated_with AR,male breast cancer
5#7#gene36797#115#diseaseC0238033 10617653-6#5#7#gene367 10617653-6#97#115#diseaseC0238033 associated_with AR,male breast cancer
5#7#gene36797#115#diseaseC0242787 10617653-6#5#7#gene367 10617653-6#97#115#diseaseC0242787 associated_with AR,male breast cancer
5#7#gene36754#93#diseaseC0268301 10617653-6#5#7#gene367 10617653-6#54#93#diseaseC0268301 associated_with AR,partial androgen insensitivity syndrome
172#174#gene36797#115#diseaseC0238033 10617653-6#172#174#gene367 10617653-6#97#115#diseaseC0238033 associated_with AR,male breast cancer
172#174#gene36797#115#diseaseC0242787 10617653-6#172#174#gene367 10617653-6#97#115#diseaseC0242787 associated_with AR,male breast cancer
172#174#gene36797#115#diseaseC0238033 10617653-6#172#174#gene367 10617653-6#97#115#diseaseC0238033 associated_with AR,male breast cancer
172#174#gene36797#115#diseaseC0242787 10617653-6#172#174#gene367 10617653-6#97#115#diseaseC0242787 associated_with AR,male breast cancer
172#174#gene36797#115#diseaseC0238033 10617653-6#172#174#gene367 10617653-6#97#115#diseaseC0238033 associated_with AR,male breast cancer
172#174#gene36797#115#diseaseC0242787 10617653-6#172#174#gene367 10617653-6#97#115#diseaseC0242787 associated_with AR,male breast cancer
172#174#gene36797#115#diseaseC0238033 10617653-6#172#174#gene367 10617653-6#97#115#diseaseC0238033 associated_with AR,male breast cancer
172#174#gene36797#115#diseaseC0242787 10617653-6#172#174#gene367 10617653-6#97#115#diseaseC0242787 associated_with AR,male breast cancer
172#174#gene36797#115#diseaseC0238033 10617653-6#172#174#gene367 10617653-6#97#115#diseaseC0238033 associated_with AR,male breast cancer
172#174#gene36797#115#diseaseC0242787 10617653-6#172#174#gene367 10617653-6#97#115#diseaseC0242787 associated_with AR,male breast cancer
172#174#gene36754#93#diseaseC0268301 10617653-6#172#174#gene367 10617653-6#54#93#diseaseC0268301 associated_with AR,partial androgen insensitivity syndrome
228#233#gene604797#115#diseaseC0238033 10617653-6#228#233#gene6047 10617653-6#97#115#diseaseC0238033 associated_with SNURF,male breast cancer
228#233#gene604797#115#diseaseC0242787 10617653-6#228#233#gene6047 10617653-6#97#115#diseaseC0242787 associated_with SNURF,male breast cancer
228#233#gene604797#115#diseaseC0238033 10617653-6#228#233#gene6047 10617653-6#97#115#diseaseC0238033 associated_with SNURF,male breast cancer
228#233#gene604797#115#diseaseC0242787 10617653-6#228#233#gene6047 10617653-6#97#115#diseaseC0242787 associated_with SNURF,male breast cancer
228#233#gene604797#115#diseaseC0238033 10617653-6#228#233#gene6047 10617653-6#97#115#diseaseC0238033 associated_with SNURF,male breast cancer
228#233#gene604797#115#diseaseC0242787 10617653-6#228#233#gene6047 10617653-6#97#115#diseaseC0242787 associated_with SNURF,male breast cancer
228#233#gene604797#115#diseaseC0238033 10617653-6#228#233#gene6047 10617653-6#97#115#diseaseC0238033 associated_with SNURF,male breast cancer
228#233#gene604797#115#diseaseC0242787 10617653-6#228#233#gene6047 10617653-6#97#115#diseaseC0242787 associated_with SNURF,male breast cancer
228#233#gene604797#115#diseaseC0238033 10617653-6#228#233#gene6047 10617653-6#97#115#diseaseC0238033 associated_with SNURF,male breast cancer
228#233#gene604797#115#diseaseC0242787 10617653-6#228#233#gene6047 10617653-6#97#115#diseaseC0242787 associated_with SNURF,male breast cancer
228#233#gene604754#93#diseaseC0268301 10617653-6#228#233#gene6047 10617653-6#54#93#diseaseC0268301 associated_with SNURF,partial androgen insensitivity syndrome

DisGeNET

Id Subject Object Predicate Lexical cue
T0 1055-1057 gene:367 denotes AR
T1 1104-1143 disease:C0268301 denotes partial androgen insensitivity syndrome
T2 1055-1057 gene:367 denotes AR
T3 1147-1165 disease:C0238033 denotes male breast cancer
T4 1055-1057 gene:367 denotes AR
T5 1147-1165 disease:C0242787 denotes male breast cancer
T6 1192-1194 gene:367 denotes AR
T7 1147-1165 disease:C0238033 denotes male breast cancer
T8 1192-1194 gene:367 denotes AR
T9 1147-1165 disease:C0242787 denotes male breast cancer
T10 1200-1205 gene:6047 denotes SNURF
T11 1147-1165 disease:C0238033 denotes male breast cancer
T12 1200-1205 gene:6047 denotes SNURF
T13 1147-1165 disease:C0242787 denotes male breast cancer
T14 1222-1224 gene:367 denotes AR
T15 1147-1165 disease:C0238033 denotes male breast cancer
T16 1222-1224 gene:367 denotes AR
T17 1147-1165 disease:C0242787 denotes male breast cancer
T18 1278-1283 gene:6047 denotes SNURF
T19 1104-1143 disease:C0268301 denotes partial androgen insensitivity syndrome
T20 1278-1283 gene:6047 denotes SNURF
T21 1147-1165 disease:C0238033 denotes male breast cancer
T22 1278-1283 gene:6047 denotes SNURF
T23 1147-1165 disease:C0242787 denotes male breast cancer
R1 T0 T1 associated_with AR,partial androgen insensitivity syndrome
R2 T2 T3 associated_with AR,male breast cancer
R3 T4 T5 associated_with AR,male breast cancer
R4 T6 T7 associated_with AR,male breast cancer
R5 T8 T9 associated_with AR,male breast cancer
R6 T10 T11 associated_with SNURF,male breast cancer
R7 T12 T13 associated_with SNURF,male breast cancer
R8 T14 T15 associated_with AR,male breast cancer
R9 T16 T17 associated_with AR,male breast cancer
R10 T18 T19 associated_with SNURF,partial androgen insensitivity syndrome
R11 T20 T21 associated_with SNURF,male breast cancer
R12 T22 T23 associated_with SNURF,male breast cancer

mondo_disease

Id Subject Object Predicate Lexical cue mondo_id
T1 780-807 Disease denotes nuclear localization signal http://purl.obolibrary.org/obo/MONDO_0000179
T2 974-1001 Disease denotes nuclear localization signal http://purl.obolibrary.org/obo/MONDO_0000179
T3 1104-1143 Disease denotes partial androgen insensitivity syndrome http://purl.obolibrary.org/obo/MONDO_0010720
T4 1147-1165 Disease denotes male breast cancer http://purl.obolibrary.org/obo/MONDO_0005628

Anatomy-MAT

Id Subject Object Predicate Lexical cue mat_id
T1 1147-1151 Body_part denotes male http://purl.obolibrary.org/obo/MAT_0000029

HP-phenotype

Id Subject Object Predicate Lexical cue hp_id
T1 1152-1165 Phenotype denotes breast cancer HP:0003002

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 26-37 Body_part denotes RING finger http://purl.obolibrary.org/obo/UBERON_0003624
T2 155-166 Body_part denotes RING finger http://purl.obolibrary.org/obo/UBERON_0003624
T3 362-373 Body_part denotes RING finger http://purl.obolibrary.org/obo/UBERON_0003624
T4 583-594 Body_part denotes RING finger http://purl.obolibrary.org/obo/UBERON_0003624
T5 682-688 Body_part denotes finger http://purl.obolibrary.org/obo/UBERON_0002389
T6 1147-1158 Body_part denotes male breast http://purl.obolibrary.org/obo/UBERON_0016410