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PubMed:10617596 JSONTXT

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CL-cell

Id Subject Object Predicate Lexical cue cl_id
T1 401-412 Cell denotes fungal cell http://purl.obolibrary.org/obo/CL:0000521

GlyCosmos6-Glycan-Motif-Image

Id Subject Object Predicate Lexical cue image
T1 317-336 Glycan_Motif denotes N-acetylglucosamine https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G64581RP
T2 1338-1345 Glycan_Motif denotes glucose https://api.glycosmos.org/wurcs2image/0.10.0/png/binary/G15021LG

sentences

Id Subject Object Predicate Lexical cue
T1 0-99 Sentence denotes Inhibition of Escherichia coli glucosamine-6-phosphate synthase by reactive intermediate analogues.
T2 100-146 Sentence denotes The role of the 2-amino function in catalysis.
T3 147-308 Sentence denotes Glucosamine-6-phosphate synthase (GlmS) catalyzes the formation of D-glucosamine 6-phosphate from D-fructose 6-phosphate using L-glutamine as the ammonia source.
T4 309-499 Sentence denotes Because N-acetylglucosamine is an essential building block of both bacterial cell walls and fungal cell wall chitin, the enzyme is a potential target for antibacterial and antifungal agents.
T5 500-692 Sentence denotes The most potent carbohydrate-based inhibitor of GlmS reported to date is 2-amino-2-deoxy-D-glucitol 6-phosphate, an analogue of the putative cis-enolamine intermediate formed during catalysis.
T6 693-805 Sentence denotes The interaction of a series of structurally related cis-enolamine intermediate analogues with GlmS is described.
T7 806-936 Sentence denotes Although arabinose oxime 5-phosphate is identified as a good competitive inhibitor of GlmS with an inhibition constant equal to 1.
T8 937-1052 Sentence denotes 2 (+/-0.3) mM, the presence of the amino function at the 2-position is shown to be important for potent inhibition.
T9 1053-1276 Sentence denotes Comparison of the binding affinities of 2-deoxy-D-glucitol 6-phosphate and 2-amino-2-deoxy-D-glucitol 6-phosphate indicates that the amino function contributes -4.1 (+/-0.1) kcal/mol to the free energy of inhibitor binding.
T10 1277-1495 Sentence denotes Similarly, comparison of the binding affinities of 2-deoxy-D-glucose 6-phosphate and D-glucosamine 6-phosphate indicates that the amino function contributes -3.0 (+/-0.1) kcal/mol to the free energy of product binding.
T11 1496-1822 Sentence denotes Interactions between GlmS and the 2-amino function of its ligands contribute to the uniform binding of the product and the cis-enolamine intermediate as evidenced by the similar contribution of the amino group to the free energy of binding of D-glucosamine 6-phosphate and 2-amino-2-deoxy-D-glucitol 6-phosphate, respectively.

GlyCosmos6-Glycan-Motif-Structure

Id Subject Object Predicate Lexical cue
T1 317-336 https://glytoucan.org/Structures/Glycans/G64581RP denotes N-acetylglucosamine
T2 1338-1345 https://glytoucan.org/Structures/Glycans/G15021LG denotes glucose

GlyCosmos15-Glycan

Id Subject Object Predicate Lexical cue image
T1 418-424 Glycan denotes chitin https://api.glycosmos.org/wurcs2image/latest/png/binary/G97099AY

Glycan-GlyCosmos

Id Subject Object Predicate Lexical cue image
T1 418-424 Glycan denotes chitin https://api.glycosmos.org/wurcs2image/latest/png/binary/G97099AY

GlyCosmos15-CL

Id Subject Object Predicate Lexical cue cl_id
T1 401-412 Cell denotes fungal cell http://purl.obolibrary.org/obo/CL:0000521

GlyCosmos15-Taxon

Id Subject Object Predicate Lexical cue db_id
T1 14-30 Organism denotes Escherichia coli 562
T2 293-300 Organism denotes ammonia 29189

GlyCosmos15-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 401-412 Body_part denotes fungal cell http://purl.obolibrary.org/obo/CL_0000521
T2 413-417 Body_part denotes wall http://purl.obolibrary.org/obo/UBERON_0000060

GlyCosmos15-Sentences

Id Subject Object Predicate Lexical cue
T1 0-99 Sentence denotes Inhibition of Escherichia coli glucosamine-6-phosphate synthase by reactive intermediate analogues.
T2 100-146 Sentence denotes The role of the 2-amino function in catalysis.
T3 147-308 Sentence denotes Glucosamine-6-phosphate synthase (GlmS) catalyzes the formation of D-glucosamine 6-phosphate from D-fructose 6-phosphate using L-glutamine as the ammonia source.
T4 309-499 Sentence denotes Because N-acetylglucosamine is an essential building block of both bacterial cell walls and fungal cell wall chitin, the enzyme is a potential target for antibacterial and antifungal agents.
T5 500-692 Sentence denotes The most potent carbohydrate-based inhibitor of GlmS reported to date is 2-amino-2-deoxy-D-glucitol 6-phosphate, an analogue of the putative cis-enolamine intermediate formed during catalysis.
T6 693-805 Sentence denotes The interaction of a series of structurally related cis-enolamine intermediate analogues with GlmS is described.
T7 806-936 Sentence denotes Although arabinose oxime 5-phosphate is identified as a good competitive inhibitor of GlmS with an inhibition constant equal to 1.
T8 937-1052 Sentence denotes 2 (+/-0.3) mM, the presence of the amino function at the 2-position is shown to be important for potent inhibition.
T9 1053-1276 Sentence denotes Comparison of the binding affinities of 2-deoxy-D-glucitol 6-phosphate and 2-amino-2-deoxy-D-glucitol 6-phosphate indicates that the amino function contributes -4.1 (+/-0.1) kcal/mol to the free energy of inhibitor binding.
T10 1277-1495 Sentence denotes Similarly, comparison of the binding affinities of 2-deoxy-D-glucose 6-phosphate and D-glucosamine 6-phosphate indicates that the amino function contributes -3.0 (+/-0.1) kcal/mol to the free energy of product binding.
T11 1496-1822 Sentence denotes Interactions between GlmS and the 2-amino function of its ligands contribute to the uniform binding of the product and the cis-enolamine intermediate as evidenced by the similar contribution of the amino group to the free energy of binding of D-glucosamine 6-phosphate and 2-amino-2-deoxy-D-glucitol 6-phosphate, respectively.

NCBITAXON

Id Subject Object Predicate Lexical cue db_id
T1 14-30 OrganismTaxon denotes Escherichia coli 562
T2 293-300 OrganismTaxon denotes ammonia 29189

Anatomy-UBERON

Id Subject Object Predicate Lexical cue uberon_id
T1 401-412 Body_part denotes fungal cell http://purl.obolibrary.org/obo/CL_0000521
T2 413-417 Body_part denotes wall http://purl.obolibrary.org/obo/UBERON_0000060