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PubMed_ArguminSci

Id Subject Object Predicate Lexical cue
T1 87-244 DRI_Challenge denotes DNA mismatch repair is important because of its role in maintaining genomic integrity and its association with hereditary non-polyposis colon cancer (HNPCC).
T2 245-380 DRI_Approach denotes To identify new human mismatch repair proteins, we probed nuclear extracts with the conserved carboxy-terminal MLH1 interaction domain.
T3 381-522 DRI_Outcome denotes Here we describe the cloning and complete genomic sequence of MLH3, which encodes a new DNA mismatch repair protein that interacts with MLH1.
T4 523-734 DRI_Background denotes MLH3 is more similar to mismatch repair proteins from yeast, plants, worms and bacteria than to any known mammalian protein, suggesting that its conserved sequence may confer unique functions in mice and humans.
T5 735-771 DRI_Background denotes Cells in culture stably expressing a
T6 795-838 DRI_Background denotes protein exhibit microsatellite instability.
T7 839-985 DRI_Background denotes Mlh3 is highly expressed in gastrointestinal epithelium and physically maps to the mouse complex trait locus colon cancer susceptibility I (Ccs1).
T8 986-1121 DRI_Approach denotes Although we were unable to identify a mutation in the protein-coding region of Mlh3 in the susceptible mouse strain, colon tumours from
T9 1136-1176 DRI_Approach denotes mice exhibit microsatellite instability.
T10 1177-1369 DRI_Background denotes Functional redundancy among Mlh3, Pms1 and Pms2 may explain why neither Pms1 nor Pms2 mutant mice develop colon cancer, and why PMS1 and PMS2 mutations are only rarely found in HNPCC families.

c_corpus

Id Subject Object Predicate Lexical cue
T1 0-4 PR:F4JN26 denotes MLH3
T2 0-4 PR:Q12083 denotes MLH3
T3 0-4 PR:000010443 denotes MLH3
T4 0-4 PR:Q9UHC1 denotes MLH3
T5 6-11 D044704 denotes a DNA
T8 8-11 SO:0000352 denotes DNA
T6 8-11 GO:0005574 denotes DNA
T10 12-27 GO:0006298 denotes mismatch repair
T11 28-32 SO:0000704 denotes gene
T12 59-73 SO:0000289 denotes microsatellite
T13 59-85 D053842 denotes microsatellite instability
T14 59-85 D053842 denotes microsatellite instability
T15 91-106 GO:0006298 denotes mismatch repair
T16 223-228 UBERON:0001155 denotes colon
T17 223-235 D003110 denotes colon cancer
T18 223-235 D015179 denotes colon cancer
T19 223-235 D003110 denotes colon cancer
T20 261-266 D006801 denotes human
T21 267-282 GO:0006298 denotes mismatch repair
T22 283-291 CHEBI:36080 denotes proteins
T23 329-338 SO:0000856 denotes conserved
T24 339-346 CHEBI:46883 denotes carboxy
T28 356-360 CVCL_G669 denotes MLH1
T25 356-360 PR:Q9ZRV4 denotes MLH1
T26 356-360 PR:P38920 denotes MLH1
T27 356-360 PR:Q54KD8 denotes MLH1
T29 356-360 PR:Q9JK91 denotes MLH1
T30 356-360 PR:P97679 denotes MLH1
T31 356-360 PR:Q9P7W6 denotes MLH1
T32 356-360 PR:000010442 denotes MLH1
T33 356-360 PR:P40692 denotes MLH1
T34 373-379 SO:0000417 denotes domain
T35 431-439 SO:0000001 denotes sequence
T36 443-447 PR:F4JN26 denotes MLH3
T37 443-447 PR:Q12083 denotes MLH3
T38 443-447 PR:000010443 denotes MLH3
T39 443-447 PR:Q9UHC1 denotes MLH3
T42 469-472 SO:0000352 denotes DNA
T41 469-472 CHEBI:16991 denotes DNA
T43 469-472 D004247 denotes DNA
T40 469-472 GO:0005574 denotes DNA
T44 473-488 GO:0006298 denotes mismatch repair
T49 489-496 SO:0000104 denotes protein
T48 489-496 PR:000000001 denotes protein
T46 489-496 CHEBI:36080 denotes protein
T47 489-496 CHEBI:11122 denotes protein
T45 489-496 GO:0003675 denotes protein
T53 517-521 CVCL_G669 denotes MLH1
T50 517-521 PR:Q9ZRV4 denotes MLH1
T51 517-521 PR:P38920 denotes MLH1
T52 517-521 PR:Q54KD8 denotes MLH1
T54 517-521 PR:Q9JK91 denotes MLH1
T55 517-521 PR:P97679 denotes MLH1
T56 517-521 PR:Q9P7W6 denotes MLH1
T57 517-521 PR:000010442 denotes MLH1
T58 517-521 PR:P40692 denotes MLH1
T59 523-527 PR:F4JN26 denotes MLH3
T60 523-527 PR:Q12083 denotes MLH3
T61 523-527 PR:000010443 denotes MLH3
T62 523-527 PR:Q9UHC1 denotes MLH3
T63 547-562 GO:0006298 denotes mismatch repair
T64 563-571 CHEBI:36080 denotes proteins
T66 577-582 214355 denotes yeast
T65 577-582 D015003 denotes yeast
T71 639-646 SO:0000104 denotes protein
T70 639-646 PR:000000001 denotes protein
T67 639-646 GO:0003675 denotes protein
T68 639-646 CHEBI:36080 denotes protein
T69 639-646 CHEBI:11122 denotes protein
T72 668-677 SO:0000856 denotes conserved
T73 678-686 SO:0000001 denotes sequence
T74 718-722 PR:000005054 denotes mice
T76 718-722 O89094 denotes mice
T75 718-722 D051379 denotes mice
T77 718-722 10095 denotes mice
T78 772-789 SO:0002052 denotes dominant-negative
T79 790-794 PR:F4JN26 denotes MLH3
T80 790-794 PR:Q12083 denotes MLH3
T81 790-794 PR:000010443 denotes MLH3
T82 790-794 PR:Q9UHC1 denotes MLH3
T86 795-802 PR:000000001 denotes protein
T83 795-802 GO:0003675 denotes protein
T87 795-802 SO:0000104 denotes protein
T84 795-802 CHEBI:36080 denotes protein
T85 795-802 CHEBI:11122 denotes protein
T88 811-825 SO:0000289 denotes microsatellite
T89 811-837 D053842 denotes microsatellite instability
T90 811-837 D053842 denotes microsatellite instability
T91 839-843 PR:F4JN26 denotes Mlh3
T92 839-843 PR:Q12083 denotes Mlh3
T93 839-843 PR:000010443 denotes Mlh3
T94 839-843 PR:Q9UHC1 denotes Mlh3
T95 884-894 UBERON:0000483 denotes epithelium
T96 922-927 10090 denotes mouse
T97 922-927 D051379 denotes mouse
T98 948-953 UBERON:0001155 denotes colon
T99 948-960 D003110 denotes colon cancer
T100 948-960 D015179 denotes colon cancer
T101 948-960 D003110 denotes colon cancer
T102 961-975 D004198 denotes susceptibility
T103 961-975 D004198 denotes susceptibility
T111 979-982 UBERON:0002586 denotes Ccs
T105 979-982 GO:0034019 denotes Ccs
T109 979-982 GO:0052728 denotes Ccs
T113 979-982 GO:0052727 denotes Ccs
T114 979-983 PR:Q10357 denotes Ccs1
T115 979-983 PR:P19158 denotes Ccs1
T116 979-983 PR:Q9XIA4 denotes Ccs1
T117 979-983 PR:P40202 denotes Ccs1
T118 1024-1032 SO:0000109 denotes mutation
T120 1040-1047 CHEBI:36080 denotes protein
T121 1040-1047 CHEBI:11122 denotes protein
T122 1040-1047 PR:000000001 denotes protein
T119 1040-1047 GO:0003675 denotes protein
T124 1040-1054 SO:0000010 denotes protein-coding
T125 1065-1069 PR:F4JN26 denotes Mlh3
T126 1065-1069 PR:Q12083 denotes Mlh3
T127 1065-1069 PR:000010443 denotes Mlh3
T128 1065-1069 PR:Q9UHC1 denotes Mlh3
T129 1089-1094 10090 denotes mouse
T130 1089-1094 D051379 denotes mouse
T131 1103-1108 UBERON:0001155 denotes colon
T139 1131-1134 UBERON:0002586 denotes Ccs
T133 1131-1134 GO:0034019 denotes Ccs
T137 1131-1134 GO:0052728 denotes Ccs
T141 1131-1134 GO:0052727 denotes Ccs
T142 1131-1135 PR:Q10357 denotes Ccs1
T143 1131-1135 PR:P19158 denotes Ccs1
T144 1131-1135 PR:Q9XIA4 denotes Ccs1
T145 1131-1135 PR:P40202 denotes Ccs1
T146 1136-1140 PR:000005054 denotes mice
T148 1136-1140 O89094 denotes mice
T147 1136-1140 D051379 denotes mice
T149 1136-1140 10095 denotes mice
T150 1149-1163 SO:0000289 denotes microsatellite
T151 1149-1175 D053842 denotes microsatellite instability
T152 1149-1175 D053842 denotes microsatellite instability
T153 1205-1209 PR:F4JN26 denotes Mlh3
T154 1205-1209 PR:Q12083 denotes Mlh3
T155 1205-1209 PR:000010443 denotes Mlh3
T156 1205-1209 PR:Q9UHC1 denotes Mlh3
T163 1211-1215 PR:P14242 denotes Pms1
T164 1211-1215 PR:000012913 denotes Pms1
T167 1211-1215 PR:Q941I6 denotes Pms1
T168 1211-1215 PR:P54280 denotes Pms1
T169 1211-1215 PR:Q5NC83 denotes Pms1
T170 1211-1215 PR:P54277 denotes Pms1
T171 1211-1215 PR:Q54QA0 denotes Pms1
T165 1211-1215 C102203 denotes Pms1
T166 1211-1215 C102203 denotes Pms1
T172 1220-1223 CHEBI:53396 denotes Pms
T175 1220-1223 CHEBI:53430 denotes Pms
T177 1220-1223 CHEBI:8055 denotes Pms
T178 1220-1224 PR:P54279 denotes Pms2
T179 1220-1224 PR:F1NQJ3 denotes Pms2
T180 1220-1224 PR:P38920 denotes Pms2
T181 1220-1224 PR:000012914 denotes Pms2
T182 1220-1224 PR:P54278 denotes Pms2
T189 1249-1253 PR:P14242 denotes Pms1
T190 1249-1253 PR:000012913 denotes Pms1
T193 1249-1253 PR:Q941I6 denotes Pms1
T194 1249-1253 PR:P54280 denotes Pms1
T195 1249-1253 PR:Q5NC83 denotes Pms1
T196 1249-1253 PR:P54277 denotes Pms1
T197 1249-1253 PR:Q54QA0 denotes Pms1
T191 1249-1253 C102203 denotes Pms1
T192 1249-1253 C102203 denotes Pms1
T198 1258-1261 CHEBI:53396 denotes Pms
T201 1258-1261 CHEBI:53430 denotes Pms
T203 1258-1261 CHEBI:8055 denotes Pms
T204 1258-1262 PR:P54279 denotes Pms2
T205 1258-1262 PR:F1NQJ3 denotes Pms2
T206 1258-1262 PR:P38920 denotes Pms2
T207 1258-1262 PR:000012914 denotes Pms2
T208 1258-1262 PR:P54278 denotes Pms2
T209 1270-1274 PR:000005054 denotes mice
T211 1270-1274 O89094 denotes mice
T210 1270-1274 D051379 denotes mice
T212 1270-1274 10095 denotes mice
T213 1283-1288 UBERON:0001155 denotes colon
T214 1283-1295 D003110 denotes colon cancer
T215 1283-1295 D015179 denotes colon cancer
T216 1283-1295 D003110 denotes colon cancer
T223 1305-1309 PR:P14242 denotes PMS1
T224 1305-1309 PR:000012913 denotes PMS1
T227 1305-1309 PR:Q941I6 denotes PMS1
T228 1305-1309 PR:P54280 denotes PMS1
T229 1305-1309 PR:Q5NC83 denotes PMS1
T230 1305-1309 PR:P54277 denotes PMS1
T231 1305-1309 PR:Q54QA0 denotes PMS1
T225 1305-1309 C102203 denotes PMS1
T226 1305-1309 C102203 denotes PMS1
T232 1314-1317 CHEBI:53396 denotes PMS
T235 1314-1317 CHEBI:53430 denotes PMS
T237 1314-1317 CHEBI:8055 denotes PMS
T238 1314-1318 PR:P54279 denotes PMS2
T239 1314-1318 PR:F1NQJ3 denotes PMS2
T240 1314-1318 PR:P38920 denotes PMS2
T241 1314-1318 PR:000012914 denotes PMS2
T242 1314-1318 PR:P54278 denotes PMS2

PubmedHPO

Id Subject Object Predicate Lexical cue
T1 223-235 HP_0003003 denotes colon cancer
T2 223-235 HP_0100273 denotes colon cancer
T3 229-235 HP_0002664 denotes cancer
T4 948-960 HP_0003003 denotes colon cancer
T5 948-960 HP_0100273 denotes colon cancer
T6 954-960 HP_0002664 denotes cancer
T7 1103-1116 HP_0003003 denotes colon tumours
T8 1103-1116 HP_0100273 denotes colon tumours
T9 1109-1116 HP_0002664 denotes tumours
T10 1283-1295 HP_0003003 denotes colon cancer
T11 1283-1295 HP_0100273 denotes colon cancer
T12 1289-1295 HP_0002664 denotes cancer

UseCases_ArguminSci_Discourse

Id Subject Object Predicate Lexical cue
T4 381-522 DRI_Outcome denotes Here we describe the cloning and complete genomic sequence of MLH3, which encodes a new DNA mismatch repair protein that interacts with MLH1.
T1 0-86 DRI_Outcome denotes MLH3: a DNA mismatch repair gene associated with mammalian microsatellite instability.
T2 87-244 DRI_Challenge denotes DNA mismatch repair is important because of its role in maintaining genomic integrity and its association with hereditary non-polyposis colon cancer (HNPCC).
T3 245-380 DRI_Approach denotes To identify new human mismatch repair proteins, we probed nuclear extracts with the conserved carboxy-terminal MLH1 interaction domain.
T5 523-734 DRI_Background denotes MLH3 is more similar to mismatch repair proteins from yeast, plants, worms and bacteria than to any known mammalian protein, suggesting that its conserved sequence may confer unique functions in mice and humans.
T6 735-771 DRI_Background denotes Cells in culture stably expressing a
T7 772-794 Token_Label.OUTSIDE denotes dominant-negative MLH3
T8 795-838 DRI_Background denotes protein exhibit microsatellite instability.
T9 839-985 DRI_Background denotes Mlh3 is highly expressed in gastrointestinal epithelium and physically maps to the mouse complex trait locus colon cancer susceptibility I (Ccs1).
T10 986-1121 DRI_Approach denotes Although we were unable to identify a mutation in the protein-coding region of Mlh3 in the susceptible mouse strain, colon tumours from
T11 1122-1135 Token_Label.OUTSIDE denotes congenic Ccs1
T12 1136-1176 DRI_Approach denotes mice exhibit microsatellite instability.
T13 1177-1369 DRI_Background denotes Functional redundancy among Mlh3, Pms1 and Pms2 may explain why neither Pms1 nor Pms2 mutant mice develop colon cancer, and why PMS1 and PMS2 mutations are only rarely found in HNPCC families.

DisGeNET

Id Subject Object Predicate Lexical cue
T0 839-843 gene:27030 denotes Mlh3
T1 948-960 disease:C0699790 denotes colon cancer
T2 839-843 gene:27030 denotes Mlh3
T3 948-960 disease:C0007102 denotes colon cancer
T4 1305-1309 gene:5378 denotes PMS1
T5 1354-1359 disease:C1333990 denotes HNPCC
T6 1258-1262 gene:5395 denotes Pms2
T7 1283-1295 disease:C0699790 denotes colon cancer
T8 1258-1262 gene:5395 denotes Pms2
T9 1283-1295 disease:C0007102 denotes colon cancer
T10 1314-1318 gene:5395 denotes PMS2
T11 1354-1359 disease:C1333990 denotes HNPCC
T12 1220-1224 gene:5395 denotes Pms2
T13 1283-1295 disease:C0699790 denotes colon cancer
T14 1220-1224 gene:5395 denotes Pms2
T15 1283-1295 disease:C0007102 denotes colon cancer
R1 T0 T1 associated_with Mlh3,colon cancer
R2 T2 T3 associated_with Mlh3,colon cancer
R3 T4 T5 associated_with PMS1,HNPCC
R4 T6 T7 associated_with Pms2,colon cancer
R5 T8 T9 associated_with Pms2,colon cancer
R6 T10 T11 associated_with PMS2,HNPCC
R7 T12 T13 associated_with Pms2,colon cancer
R8 T14 T15 associated_with Pms2,colon cancer