PubMed:10614532 JSONTXT

{"project":"PubmedHPO","denotations":[{"id":"T1","span":{"begin":141,"end":149},"obj":"HP_0002014"},{"id":"T2","span":{"begin":208,"end":221},"obj":"HP_0003072"},{"id":"T3","span":{"begin":301,"end":320},"obj":"HP_0100568"},{"id":"T4","span":{"begin":311,"end":320},"obj":"HP_0002664"},{"id":"T5","span":{"begin":512,"end":539},"obj":"HP_0008200"},{"id":"T6","span":{"begin":520,"end":539},"obj":"HP_0000843"},{"id":"T7","span":{"begin":822,"end":842},"obj":"HP_0100634"},{"id":"T8","span":{"begin":837,"end":842},"obj":"HP_0002664"},{"id":"T9","span":{"begin":848,"end":853},"obj":"HP_0002664"},{"id":"T10","span":{"begin":900,"end":909},"obj":"HP_0100570"},{"id":"T11","span":{"begin":1116,"end":1122},"obj":"HP_0002664"}],"text":"Thymic carcinoid and parathyroid hyperplasia detection with 99mTc-MIBI men type 1.\nWe report a case of a 35-year-old male, with a history of diarrhea, renal lithiasis with frequent expulsions of calculus and hypercalcemia during the last 2 years. The patient was studied and diagnosed with a multiple endocrine neoplasia type I (MEN I), familiar (mother with MEN I). A scintigraphic study with 99mTc-MIBI was performed in order to localize hyperfunctioning parathyroid glands because of biochemical diagnosis of primary hyperparathyroidism. Double phase 99mTc-MIBI scan detected one hyperfunctioning parathyroid gland and a large anterior mediastinal mass. Subsequent, plain radiograph and CT of the chest showed a soft-tissue mass in that localization. Punch biopsy of the lesion guided by CT revealed malignant cells of neuroendocrine tumor. The tumor was removed and histologically confirmed as a carcinoid within a thymus in a MEN type I syndrome. MEN I patients can benefit from the examination with this agent which can potentially localize not only parathyroid endocrine pathology but also unknown associated tumors."}

{"project":"PubCasesHPO","denotations":[{"id":"TI1","span":{"begin":21,"end":44},"obj":"HP:0008208"},{"id":"AB1","span":{"begin":141,"end":149},"obj":"HP:0002014"},{"id":"AB2","span":{"begin":208,"end":221},"obj":"HP:0003072"},{"id":"AB3","span":{"begin":512,"end":539},"obj":"HP:0008200"}],"text":"Thymic carcinoid and parathyroid hyperplasia detection with 99mTc-MIBI men type 1.\nWe report a case of a 35-year-old male, with a history of diarrhea, renal lithiasis with frequent expulsions of calculus and hypercalcemia during the last 2 years. The patient was studied and diagnosed with a multiple endocrine neoplasia type I (MEN I), familiar (mother with MEN I). A scintigraphic study with 99mTc-MIBI was performed in order to localize hyperfunctioning parathyroid glands because of biochemical diagnosis of primary hyperparathyroidism. Double phase 99mTc-MIBI scan detected one hyperfunctioning parathyroid gland and a large anterior mediastinal mass. Subsequent, plain radiograph and CT of the chest showed a soft-tissue mass in that localization. Punch biopsy of the lesion guided by CT revealed malignant cells of neuroendocrine tumor. The tumor was removed and histologically confirmed as a carcinoid within a thymus in a MEN type I syndrome. MEN I patients can benefit from the examination with this agent which can potentially localize not only parathyroid endocrine pathology but also unknown associated tumors."}